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James O Marx - One of the best experts on this subject based on the ideXlab platform.
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hydromorphone induced neurostimulation in a yorkshire swine sus scrofa after Myocardial Infarction Surgery
Journal of The American Association for Laboratory Animal Science, 2019Co-Authors: Ines Rodriguez, Blythe H Philips, Emily L Miedel, Lauren A Bright, Philip C Latourette, Anthony J Carty, Walter R T Witschey, Robert C Gorman, Joseph H Gorman, James O MarxAbstract:Opiates play an important role in the control of pain associated with thoracotomy in both people and animals. However, key side effects, including sedation and respiratory depression, could limit the use of opiates in animals that are lethargic due to cardiac disease. In addition, a rare side effect-neuroexcitation resulting in pathologic behavioral changes (seizures, mania, muscle fasciculation)-after the administration of morphine or hydromorphone is well-documented in many species. In pigs, however, these drugs have been shown to stimulate an increase in normal activity. In the case presented, we describe a Yorkshire-cross pig which, after Myocardial Infarction Surgery, went from nonresponsive to alert, responsive, and eating within 30 min of an injection of hydromorphone. This pig was not demonstrating any signs associated with pain at this time, suggesting that the positive response was due to neural stimulation. This case report is the first to describe the use of hydromorphone-a potent, pure μ opiate agonist-for its neurostimulatory effect in pigs with experimentally-induced cardiac disease.
Ines Rodriguez - One of the best experts on this subject based on the ideXlab platform.
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hydromorphone induced neurostimulation in a yorkshire swine sus scrofa after Myocardial Infarction Surgery
Journal of The American Association for Laboratory Animal Science, 2019Co-Authors: Ines Rodriguez, Blythe H Philips, Emily L Miedel, Lauren A Bright, Philip C Latourette, Anthony J Carty, Walter R T Witschey, Robert C Gorman, Joseph H Gorman, James O MarxAbstract:Opiates play an important role in the control of pain associated with thoracotomy in both people and animals. However, key side effects, including sedation and respiratory depression, could limit the use of opiates in animals that are lethargic due to cardiac disease. In addition, a rare side effect-neuroexcitation resulting in pathologic behavioral changes (seizures, mania, muscle fasciculation)-after the administration of morphine or hydromorphone is well-documented in many species. In pigs, however, these drugs have been shown to stimulate an increase in normal activity. In the case presented, we describe a Yorkshire-cross pig which, after Myocardial Infarction Surgery, went from nonresponsive to alert, responsive, and eating within 30 min of an injection of hydromorphone. This pig was not demonstrating any signs associated with pain at this time, suggesting that the positive response was due to neural stimulation. This case report is the first to describe the use of hydromorphone-a potent, pure μ opiate agonist-for its neurostimulatory effect in pigs with experimentally-induced cardiac disease.
Joseph H Gorman - One of the best experts on this subject based on the ideXlab platform.
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hydromorphone induced neurostimulation in a yorkshire swine sus scrofa after Myocardial Infarction Surgery
Journal of The American Association for Laboratory Animal Science, 2019Co-Authors: Ines Rodriguez, Blythe H Philips, Emily L Miedel, Lauren A Bright, Philip C Latourette, Anthony J Carty, Walter R T Witschey, Robert C Gorman, Joseph H Gorman, James O MarxAbstract:Opiates play an important role in the control of pain associated with thoracotomy in both people and animals. However, key side effects, including sedation and respiratory depression, could limit the use of opiates in animals that are lethargic due to cardiac disease. In addition, a rare side effect-neuroexcitation resulting in pathologic behavioral changes (seizures, mania, muscle fasciculation)-after the administration of morphine or hydromorphone is well-documented in many species. In pigs, however, these drugs have been shown to stimulate an increase in normal activity. In the case presented, we describe a Yorkshire-cross pig which, after Myocardial Infarction Surgery, went from nonresponsive to alert, responsive, and eating within 30 min of an injection of hydromorphone. This pig was not demonstrating any signs associated with pain at this time, suggesting that the positive response was due to neural stimulation. This case report is the first to describe the use of hydromorphone-a potent, pure μ opiate agonist-for its neurostimulatory effect in pigs with experimentally-induced cardiac disease.
Robert C Gorman - One of the best experts on this subject based on the ideXlab platform.
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hydromorphone induced neurostimulation in a yorkshire swine sus scrofa after Myocardial Infarction Surgery
Journal of The American Association for Laboratory Animal Science, 2019Co-Authors: Ines Rodriguez, Blythe H Philips, Emily L Miedel, Lauren A Bright, Philip C Latourette, Anthony J Carty, Walter R T Witschey, Robert C Gorman, Joseph H Gorman, James O MarxAbstract:Opiates play an important role in the control of pain associated with thoracotomy in both people and animals. However, key side effects, including sedation and respiratory depression, could limit the use of opiates in animals that are lethargic due to cardiac disease. In addition, a rare side effect-neuroexcitation resulting in pathologic behavioral changes (seizures, mania, muscle fasciculation)-after the administration of morphine or hydromorphone is well-documented in many species. In pigs, however, these drugs have been shown to stimulate an increase in normal activity. In the case presented, we describe a Yorkshire-cross pig which, after Myocardial Infarction Surgery, went from nonresponsive to alert, responsive, and eating within 30 min of an injection of hydromorphone. This pig was not demonstrating any signs associated with pain at this time, suggesting that the positive response was due to neural stimulation. This case report is the first to describe the use of hydromorphone-a potent, pure μ opiate agonist-for its neurostimulatory effect in pigs with experimentally-induced cardiac disease.
Walter R T Witschey - One of the best experts on this subject based on the ideXlab platform.
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hydromorphone induced neurostimulation in a yorkshire swine sus scrofa after Myocardial Infarction Surgery
Journal of The American Association for Laboratory Animal Science, 2019Co-Authors: Ines Rodriguez, Blythe H Philips, Emily L Miedel, Lauren A Bright, Philip C Latourette, Anthony J Carty, Walter R T Witschey, Robert C Gorman, Joseph H Gorman, James O MarxAbstract:Opiates play an important role in the control of pain associated with thoracotomy in both people and animals. However, key side effects, including sedation and respiratory depression, could limit the use of opiates in animals that are lethargic due to cardiac disease. In addition, a rare side effect-neuroexcitation resulting in pathologic behavioral changes (seizures, mania, muscle fasciculation)-after the administration of morphine or hydromorphone is well-documented in many species. In pigs, however, these drugs have been shown to stimulate an increase in normal activity. In the case presented, we describe a Yorkshire-cross pig which, after Myocardial Infarction Surgery, went from nonresponsive to alert, responsive, and eating within 30 min of an injection of hydromorphone. This pig was not demonstrating any signs associated with pain at this time, suggesting that the positive response was due to neural stimulation. This case report is the first to describe the use of hydromorphone-a potent, pure μ opiate agonist-for its neurostimulatory effect in pigs with experimentally-induced cardiac disease.
