The Experts below are selected from a list of 12 Experts worldwide ranked by ideXlab platform
Natalia Dziekan - One of the best experts on this subject based on the ideXlab platform.
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Research Article Effect of Imperatorin on the Spontaneous Motor Activity of Rat Isolated Jejunum Strips
2016Co-Authors: Marta Mendel, Krystyna Skalicka-wofniak, Magdalena Chbopecka, Natalia DziekanAbstract:which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Imperatorin, a psoralen-type furanocoumarin, is a potent Myorelaxant Agent acting as a calcium antagonist on vascular smooth muscle. Its effects on other types of smooth muscle remain unknown. Therefore, the aim of this study was to investigate the hypothesized Myorelaxant effect of imperatorin on gut motor activity and, possibly, to define the underlying mechanism of action. Imperatorin was made available for pharmacological studies from the fruits of the widely available Angelica officinalis through the application of high-performance countercurrent chromatography (HPCCC). Imperatorin generated reversible relaxation of jejunum strips dose-dependently (1–10
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Effect of Imperatorin on the Spontaneous Motor Activity of Rat Isolated Jejunum Strips
Evidence-based Complementary and Alternative Medicine, 2015Co-Authors: Marta Mendel, Magdalena Chłopecka, Krystyna Skalicka-woźniak, Natalia DziekanAbstract:Imperatorin, a psoralen-type furanocoumarin, is a potent Myorelaxant Agent acting as a calcium antagonist on vascular smooth muscle. Its effects on other types of smooth muscle remain unknown. Therefore, the aim of this study was to investigate the hypothesized Myorelaxant effect of imperatorin on gut motor activity and, possibly, to define the underlying mechanism of action. Imperatorin was made available for pharmacological studies from the fruits of the widely available Angelica officinalis through the application of high-performance countercurrent chromatography (HPCCC). Imperatorin generated reversible relaxation of jejunum strips dose-dependently (1–100 μ M). At 25 and 50 μ M, imperatorin caused relaxation comparable to the strength of the reaction induced by isoproterenol (Isop) at 0.1 μ M. The observed response resulted neither from the activation of soluble guanylate cyclase, nor from β -adrenoreceptor involvement, nor from Ca 2+ -activated potassium channels. Imperatorin relaxed intestine strips precontracted with high potassium concentration, attenuated the force and duration of K + -induced contractions, and modulated the response of jejunum strips to acetylcholine. The results suggest that imperatorin probably interacts with various Ca 2+ influx pathways in intestine smooth muscle. The types of some calcium channels involved in the activity of imperatorin will be examined in a subsequent study.
Marta Mendel - One of the best experts on this subject based on the ideXlab platform.
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Research Article Effect of Imperatorin on the Spontaneous Motor Activity of Rat Isolated Jejunum Strips
2016Co-Authors: Marta Mendel, Krystyna Skalicka-wofniak, Magdalena Chbopecka, Natalia DziekanAbstract:which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Imperatorin, a psoralen-type furanocoumarin, is a potent Myorelaxant Agent acting as a calcium antagonist on vascular smooth muscle. Its effects on other types of smooth muscle remain unknown. Therefore, the aim of this study was to investigate the hypothesized Myorelaxant effect of imperatorin on gut motor activity and, possibly, to define the underlying mechanism of action. Imperatorin was made available for pharmacological studies from the fruits of the widely available Angelica officinalis through the application of high-performance countercurrent chromatography (HPCCC). Imperatorin generated reversible relaxation of jejunum strips dose-dependently (1–10
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Effect of Imperatorin on the Spontaneous Motor Activity of Rat Isolated Jejunum Strips
Evidence-based Complementary and Alternative Medicine, 2015Co-Authors: Marta Mendel, Magdalena Chłopecka, Krystyna Skalicka-woźniak, Natalia DziekanAbstract:Imperatorin, a psoralen-type furanocoumarin, is a potent Myorelaxant Agent acting as a calcium antagonist on vascular smooth muscle. Its effects on other types of smooth muscle remain unknown. Therefore, the aim of this study was to investigate the hypothesized Myorelaxant effect of imperatorin on gut motor activity and, possibly, to define the underlying mechanism of action. Imperatorin was made available for pharmacological studies from the fruits of the widely available Angelica officinalis through the application of high-performance countercurrent chromatography (HPCCC). Imperatorin generated reversible relaxation of jejunum strips dose-dependently (1–100 μ M). At 25 and 50 μ M, imperatorin caused relaxation comparable to the strength of the reaction induced by isoproterenol (Isop) at 0.1 μ M. The observed response resulted neither from the activation of soluble guanylate cyclase, nor from β -adrenoreceptor involvement, nor from Ca 2+ -activated potassium channels. Imperatorin relaxed intestine strips precontracted with high potassium concentration, attenuated the force and duration of K + -induced contractions, and modulated the response of jejunum strips to acetylcholine. The results suggest that imperatorin probably interacts with various Ca 2+ influx pathways in intestine smooth muscle. The types of some calcium channels involved in the activity of imperatorin will be examined in a subsequent study.
Magdalena Chłopecka - One of the best experts on this subject based on the ideXlab platform.
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Effect of Imperatorin on the Spontaneous Motor Activity of Rat Isolated Jejunum Strips
Evidence-based Complementary and Alternative Medicine, 2015Co-Authors: Marta Mendel, Magdalena Chłopecka, Krystyna Skalicka-woźniak, Natalia DziekanAbstract:Imperatorin, a psoralen-type furanocoumarin, is a potent Myorelaxant Agent acting as a calcium antagonist on vascular smooth muscle. Its effects on other types of smooth muscle remain unknown. Therefore, the aim of this study was to investigate the hypothesized Myorelaxant effect of imperatorin on gut motor activity and, possibly, to define the underlying mechanism of action. Imperatorin was made available for pharmacological studies from the fruits of the widely available Angelica officinalis through the application of high-performance countercurrent chromatography (HPCCC). Imperatorin generated reversible relaxation of jejunum strips dose-dependently (1–100 μ M). At 25 and 50 μ M, imperatorin caused relaxation comparable to the strength of the reaction induced by isoproterenol (Isop) at 0.1 μ M. The observed response resulted neither from the activation of soluble guanylate cyclase, nor from β -adrenoreceptor involvement, nor from Ca 2+ -activated potassium channels. Imperatorin relaxed intestine strips precontracted with high potassium concentration, attenuated the force and duration of K + -induced contractions, and modulated the response of jejunum strips to acetylcholine. The results suggest that imperatorin probably interacts with various Ca 2+ influx pathways in intestine smooth muscle. The types of some calcium channels involved in the activity of imperatorin will be examined in a subsequent study.
Krystyna Skalicka-woźniak - One of the best experts on this subject based on the ideXlab platform.
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Effect of Imperatorin on the Spontaneous Motor Activity of Rat Isolated Jejunum Strips
Evidence-based Complementary and Alternative Medicine, 2015Co-Authors: Marta Mendel, Magdalena Chłopecka, Krystyna Skalicka-woźniak, Natalia DziekanAbstract:Imperatorin, a psoralen-type furanocoumarin, is a potent Myorelaxant Agent acting as a calcium antagonist on vascular smooth muscle. Its effects on other types of smooth muscle remain unknown. Therefore, the aim of this study was to investigate the hypothesized Myorelaxant effect of imperatorin on gut motor activity and, possibly, to define the underlying mechanism of action. Imperatorin was made available for pharmacological studies from the fruits of the widely available Angelica officinalis through the application of high-performance countercurrent chromatography (HPCCC). Imperatorin generated reversible relaxation of jejunum strips dose-dependently (1–100 μ M). At 25 and 50 μ M, imperatorin caused relaxation comparable to the strength of the reaction induced by isoproterenol (Isop) at 0.1 μ M. The observed response resulted neither from the activation of soluble guanylate cyclase, nor from β -adrenoreceptor involvement, nor from Ca 2+ -activated potassium channels. Imperatorin relaxed intestine strips precontracted with high potassium concentration, attenuated the force and duration of K + -induced contractions, and modulated the response of jejunum strips to acetylcholine. The results suggest that imperatorin probably interacts with various Ca 2+ influx pathways in intestine smooth muscle. The types of some calcium channels involved in the activity of imperatorin will be examined in a subsequent study.
Lucia Guerra - One of the best experts on this subject based on the ideXlab platform.
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open experience with a new Myorelaxant Agent for low back pain
Advances in Therapy, 2008Co-Authors: Silvana Sartini, Lucia GuerraAbstract:Eperisone hydrochloride has been recently proposed as a muscle relaxant for the treatment of muscle contracture and chronic low back pain (LBP) as it is devoid of clinically relevant sedative effects on the central nervous system (CNS). We tested this hypothesis by performing a study of patients with LBP and muscle contracture who were treated with full-dose eperisone. Patients with moderate to severe, acute, or relapsing LBP received eperisone 100 mg three times daily for 10 consecutive days. Assessments included: spontaneous pain, pain on movement, resistance to passive movement, antalgic rigidity, and tolerability. In total, 100 patients were enrolled into the study. The treatment achieved a consistent analgesic and muscle relaxant activity across all patients. Both spontaneous pain and pain on movement were significantly decreased, as was resistance encountered by the investigator to passive movements, antalgic rigidity, and muscle contracture. As a consequence, treatment with eperisone resulted in a lower rigidity of the lower back and an improved motility for patients. Only seven adverse reactions were reported, including light-headedness (1), occasional vertigo and/or loss of equilibrium (3), mild somnolence (2), and epigastric pain (1). In almost all cases, there was no need to interrupt the treatment and the adverse reaction resolved spontaneously. Eperisone had an analgesic and muscle relaxant effect in patients with LBP. It should be noted that while it is common practice in rheumatology to combine a pain killer with a muscle relaxant in order to achieve a satisfactory result on both symptoms, the present results with eperisone were achieved with a single drug. With an improved tolerability profile compared with nonsteroidal anti-inflammatory drugs, and a lack of significant adverse effects on the CNS, eperisone hydrochloride represents a valuable alternative to traditional analgesics and muscle relaxants for the treatment of LBP.
