The Experts below are selected from a list of 963 Experts worldwide ranked by ideXlab platform
Pierre-alain Schneider - One of the best experts on this subject based on the ideXlab platform.
-
prevention of deep vein thrombosis after total knee replacement randomised comparison between a low molecular weight heparin Nadroparin and mechanical prophylaxis with a foot pump system
Journal of Bone and Joint Surgery-british Volume, 1999Co-Authors: J. Blanchard, Dominique Didier, Henri Bounameaux, Jean-yves Meuwly, Pierre-françois Leyvraz, Marie-josé Miron, Pierre Hoffmeyer, Pierre-alain SchneiderAbstract:The optimal regime of antithrombotic prophylaxis for patients undergoing total knee arthroplasty (TKA) has not been established. Many surgeons employ intermittent pneumatic compression while others use low-molecular-weight heparins (LMWH) which were primarily developed for total hip arthroplasty. We compared the efficacy and safety of these two techniques in a randomised study with blinded assessment of the endpoint by phlebography. We randomised 130 patients, scheduled for elective TKA, to receive one daily subcutaneous injection of Nadroparin Calcium (dosage adapted to body-weight) or continuous intermittent pneumatic compression of the foot by means of the arteriovenous impulse system. A total of 108 patients (60 in the LMWH group and 48 in the mechanical prophylaxis group) had phlebography eight to 12 days after surgery. Of the 47 with deep-vein thrombosis, 16 had received LMWH (26.7%, 95% CI 16.1 to 39.7) and 31, mechanical prophylaxis (64.6%, 95% CI 49.5 to 77.8). The difference between the two groups was highly significant (p < 0.001). Only one patient in the LMWH group had severe bleeding. We conclude that one daily subcutaneous injection of Calcium Nadroparin in a fixed, weight-adjusted dosage scheme is superior to intermittent pneumatic compression of the foot for thromboprophylaxis after TKA. The LMWH scheme was also safe.
-
Prevention of deep-vein thrombosis after total knee replacement
The Journal of Bone and Joint Surgery. British volume, 1999Co-Authors: J. Blanchard, Dominique Didier, Henri Bounameaux, Jean-yves Meuwly, Pierre-françois Leyvraz, Marie-josé Miron, Pierre Hoffmeyer, Pierre-alain SchneiderAbstract:The optimal regime of antithrombotic prophylaxis for patients undergoing total knee arthroplasty (TKA) has not been established. Many surgeons employ intermittent pneumatic compression while others use low-molecular-weight heparins (LMWH) which were primarily developed for total hip arthroplasty. We compared the efficacy and safety of these two techniques in a randomised study with blinded assessment of the endpoint by phlebography.We randomised 130 patients, scheduled for elective TKA, to receive one daily subcutaneous injection of Nadroparin Calcium (dosage adapted to body-weight) or continuous intermittent pneumatic compression of the foot by means of the arteriovenous impulse system.A total of 108 patients (60 in the LMWH group and 48 in the mechanical prophylaxis group) had phlebography eight to 12 days after surgery. Of the 47 with deep-vein thrombosis, 16 had received LMWH (26.7%, 95% CI 16.1 to 39.7) and 31, mechanical prophylaxis (64.6%, 95% CI 49.5 to 77.8). The difference between the two groups...
Bogli F - One of the best experts on this subject based on the ideXlab platform.
-
Comparison of 2 low molecular weight heparins in patients undergoing major abdominal surgery
Minerva Anestesiologica, 1996Co-Authors: Mabilia Ma, Minicucci S, Pettiti G, Tamponi G, Bogli FAbstract:Thromboembolic disease can, in a large number of cases, be prevented in patients undergoing major surgery by using low molecular weight heparin (LMWH). These molecules extracted from standard heparin using a variety of cleavage methods possess different physical and chemical characteristics. The aim of this study was to compare two LMWH in the prevention of thromboembolism and in terms of safety. Thirty patients of both sexes were admitted to the study and underwent major abdominal surgery. Fifteen patients were treated with dalteparin sodium, 2500 IU, and fifteen with Nadroparin Calcium, 3075 IU. Subcutaneous administration was commenced two hours prior to surgery and continued for at least five days after the operation until the complete mobilisation of the patient. Six blood samples were taken from each patient in order to assay: aPTT, heparin, X factor, Quick time, ATIII, platelets and hemoglobin. Intraoperative bleeding and drainage were recorded for each patient. The group treated with Nadroparin showed a significant reduction in hemoglobin, correlated with greater blood loss (p < 0.05) compared to the group treated with dalteparin. Both Nadroparin and dalteparin showed good anti-Xa activity and safety, but although they possess the same pharmacodynamic characteristics, they should not be regarded as equal or interchangeable.
-
Comparison of 2 low molecular weight heparins in patients undergoing major abdominal surgery
Minerva anestesiologica, 1996Co-Authors: Minicucci S, Pettiti G, Tamponi G, Bogli FAbstract:INTRODUCTION AND AIMS Thromboembolic disease can, in a large number of cases, be prevented in patients undergoing major surgery by using low molecular weight heparin (LMWH). These molecules extracted from standard heparin using a variety of cleavage methods possess different physical and chemical characteristics. The aim of this study was to compare two LMWH in the prevention of thromboembolism and in terms of safety. METHODS Thirty patients of both sexes were admitted to the study and underwent major abdominal surgery. Fifteen patients were treated with dalteparin sodium, 2500 IU, and fifteen with Nadroparin Calcium, 3075 IU. Subcutaneous administration was commenced two hours prior to surgery and continued for at least five days after the operation until the complete mobilisation of the patient. Six blood samples were taken from each patient in order to assay: aPTT, heparin, X factor, Quick time, ATIII, platelets and hemoglobin. Intraoperative bleeding and drainage were recorded for each patient. RESULTS The group treated with Nadroparin showed a significant reduction in hemoglobin, correlated with greater blood loss (p < 0.05) compared to the group treated with dalteparin. CONCLUSIONS Both Nadroparin and dalteparin showed good anti-Xa activity and safety, but although they possess the same pharmacodynamic characteristics, they should not be regarded as equal or interchangeable.
Henri Bounameaux - One of the best experts on this subject based on the ideXlab platform.
-
prevention of deep vein thrombosis after total knee replacement randomised comparison between a low molecular weight heparin Nadroparin and mechanical prophylaxis with a foot pump system
Journal of Bone and Joint Surgery-british Volume, 1999Co-Authors: J. Blanchard, Dominique Didier, Henri Bounameaux, Jean-yves Meuwly, Pierre-françois Leyvraz, Marie-josé Miron, Pierre Hoffmeyer, Pierre-alain SchneiderAbstract:The optimal regime of antithrombotic prophylaxis for patients undergoing total knee arthroplasty (TKA) has not been established. Many surgeons employ intermittent pneumatic compression while others use low-molecular-weight heparins (LMWH) which were primarily developed for total hip arthroplasty. We compared the efficacy and safety of these two techniques in a randomised study with blinded assessment of the endpoint by phlebography. We randomised 130 patients, scheduled for elective TKA, to receive one daily subcutaneous injection of Nadroparin Calcium (dosage adapted to body-weight) or continuous intermittent pneumatic compression of the foot by means of the arteriovenous impulse system. A total of 108 patients (60 in the LMWH group and 48 in the mechanical prophylaxis group) had phlebography eight to 12 days after surgery. Of the 47 with deep-vein thrombosis, 16 had received LMWH (26.7%, 95% CI 16.1 to 39.7) and 31, mechanical prophylaxis (64.6%, 95% CI 49.5 to 77.8). The difference between the two groups was highly significant (p < 0.001). Only one patient in the LMWH group had severe bleeding. We conclude that one daily subcutaneous injection of Calcium Nadroparin in a fixed, weight-adjusted dosage scheme is superior to intermittent pneumatic compression of the foot for thromboprophylaxis after TKA. The LMWH scheme was also safe.
-
Prevention of deep-vein thrombosis after total knee replacement
The Journal of Bone and Joint Surgery. British volume, 1999Co-Authors: J. Blanchard, Dominique Didier, Henri Bounameaux, Jean-yves Meuwly, Pierre-françois Leyvraz, Marie-josé Miron, Pierre Hoffmeyer, Pierre-alain SchneiderAbstract:The optimal regime of antithrombotic prophylaxis for patients undergoing total knee arthroplasty (TKA) has not been established. Many surgeons employ intermittent pneumatic compression while others use low-molecular-weight heparins (LMWH) which were primarily developed for total hip arthroplasty. We compared the efficacy and safety of these two techniques in a randomised study with blinded assessment of the endpoint by phlebography.We randomised 130 patients, scheduled for elective TKA, to receive one daily subcutaneous injection of Nadroparin Calcium (dosage adapted to body-weight) or continuous intermittent pneumatic compression of the foot by means of the arteriovenous impulse system.A total of 108 patients (60 in the LMWH group and 48 in the mechanical prophylaxis group) had phlebography eight to 12 days after surgery. Of the 47 with deep-vein thrombosis, 16 had received LMWH (26.7%, 95% CI 16.1 to 39.7) and 31, mechanical prophylaxis (64.6%, 95% CI 49.5 to 77.8). The difference between the two groups...
-
Unexpectedly high rate of phlebographic deep venous thrombosis following elective general abdominal surgery among patients given prophylaxis with low-molecular-weight heparin.
Archives of Surgery, 1993Co-Authors: Henri Bounameaux, Dominique Didier, Olivier Huber, Ebrahim Khabiri, P A Schneider, Adrien RohneiAbstract:• One hundred ninety-four patients undergoing elective general abdominal surgery were randomized in a single-blind study to receive one daily subcutaneous injection of a low-molecular-weight heparin, dalteparin sodium (2500 IU, n=97) or Nadroparin Calcium (3075 IU, n=97), two regimens that are approved in Europe to prevent deep venous thrombosis. On the eighth postoperative day, bilateral ascending leg phlebography (n=185) showed the presence of deep venous thrombosis in 45 cases (24.3%; 95% confidence interval, 18% to 31%), with a significantly higher rate (on intention-to-treat) among the patients who received the lower dosage (30 vs 15 deep venous thromboses). We conclude that the two regimens of low-molecular-weight heparin that were used in this study failed to prevent postoperative phlebographically proved deep venous thrombosis in one of four patients. ( Arch Surg. 1993;128:326-328)
Dominique Didier - One of the best experts on this subject based on the ideXlab platform.
-
prevention of deep vein thrombosis after total knee replacement randomised comparison between a low molecular weight heparin Nadroparin and mechanical prophylaxis with a foot pump system
Journal of Bone and Joint Surgery-british Volume, 1999Co-Authors: J. Blanchard, Dominique Didier, Henri Bounameaux, Jean-yves Meuwly, Pierre-françois Leyvraz, Marie-josé Miron, Pierre Hoffmeyer, Pierre-alain SchneiderAbstract:The optimal regime of antithrombotic prophylaxis for patients undergoing total knee arthroplasty (TKA) has not been established. Many surgeons employ intermittent pneumatic compression while others use low-molecular-weight heparins (LMWH) which were primarily developed for total hip arthroplasty. We compared the efficacy and safety of these two techniques in a randomised study with blinded assessment of the endpoint by phlebography. We randomised 130 patients, scheduled for elective TKA, to receive one daily subcutaneous injection of Nadroparin Calcium (dosage adapted to body-weight) or continuous intermittent pneumatic compression of the foot by means of the arteriovenous impulse system. A total of 108 patients (60 in the LMWH group and 48 in the mechanical prophylaxis group) had phlebography eight to 12 days after surgery. Of the 47 with deep-vein thrombosis, 16 had received LMWH (26.7%, 95% CI 16.1 to 39.7) and 31, mechanical prophylaxis (64.6%, 95% CI 49.5 to 77.8). The difference between the two groups was highly significant (p < 0.001). Only one patient in the LMWH group had severe bleeding. We conclude that one daily subcutaneous injection of Calcium Nadroparin in a fixed, weight-adjusted dosage scheme is superior to intermittent pneumatic compression of the foot for thromboprophylaxis after TKA. The LMWH scheme was also safe.
-
Prevention of deep-vein thrombosis after total knee replacement
The Journal of Bone and Joint Surgery. British volume, 1999Co-Authors: J. Blanchard, Dominique Didier, Henri Bounameaux, Jean-yves Meuwly, Pierre-françois Leyvraz, Marie-josé Miron, Pierre Hoffmeyer, Pierre-alain SchneiderAbstract:The optimal regime of antithrombotic prophylaxis for patients undergoing total knee arthroplasty (TKA) has not been established. Many surgeons employ intermittent pneumatic compression while others use low-molecular-weight heparins (LMWH) which were primarily developed for total hip arthroplasty. We compared the efficacy and safety of these two techniques in a randomised study with blinded assessment of the endpoint by phlebography.We randomised 130 patients, scheduled for elective TKA, to receive one daily subcutaneous injection of Nadroparin Calcium (dosage adapted to body-weight) or continuous intermittent pneumatic compression of the foot by means of the arteriovenous impulse system.A total of 108 patients (60 in the LMWH group and 48 in the mechanical prophylaxis group) had phlebography eight to 12 days after surgery. Of the 47 with deep-vein thrombosis, 16 had received LMWH (26.7%, 95% CI 16.1 to 39.7) and 31, mechanical prophylaxis (64.6%, 95% CI 49.5 to 77.8). The difference between the two groups...
-
Unexpectedly high rate of phlebographic deep venous thrombosis following elective general abdominal surgery among patients given prophylaxis with low-molecular-weight heparin.
Archives of Surgery, 1993Co-Authors: Henri Bounameaux, Dominique Didier, Olivier Huber, Ebrahim Khabiri, P A Schneider, Adrien RohneiAbstract:• One hundred ninety-four patients undergoing elective general abdominal surgery were randomized in a single-blind study to receive one daily subcutaneous injection of a low-molecular-weight heparin, dalteparin sodium (2500 IU, n=97) or Nadroparin Calcium (3075 IU, n=97), two regimens that are approved in Europe to prevent deep venous thrombosis. On the eighth postoperative day, bilateral ascending leg phlebography (n=185) showed the presence of deep venous thrombosis in 45 cases (24.3%; 95% confidence interval, 18% to 31%), with a significantly higher rate (on intention-to-treat) among the patients who received the lower dosage (30 vs 15 deep venous thromboses). We conclude that the two regimens of low-molecular-weight heparin that were used in this study failed to prevent postoperative phlebographically proved deep venous thrombosis in one of four patients. ( Arch Surg. 1993;128:326-328)
J. Blanchard - One of the best experts on this subject based on the ideXlab platform.
-
prevention of deep vein thrombosis after total knee replacement randomised comparison between a low molecular weight heparin Nadroparin and mechanical prophylaxis with a foot pump system
Journal of Bone and Joint Surgery-british Volume, 1999Co-Authors: J. Blanchard, Dominique Didier, Henri Bounameaux, Jean-yves Meuwly, Pierre-françois Leyvraz, Marie-josé Miron, Pierre Hoffmeyer, Pierre-alain SchneiderAbstract:The optimal regime of antithrombotic prophylaxis for patients undergoing total knee arthroplasty (TKA) has not been established. Many surgeons employ intermittent pneumatic compression while others use low-molecular-weight heparins (LMWH) which were primarily developed for total hip arthroplasty. We compared the efficacy and safety of these two techniques in a randomised study with blinded assessment of the endpoint by phlebography. We randomised 130 patients, scheduled for elective TKA, to receive one daily subcutaneous injection of Nadroparin Calcium (dosage adapted to body-weight) or continuous intermittent pneumatic compression of the foot by means of the arteriovenous impulse system. A total of 108 patients (60 in the LMWH group and 48 in the mechanical prophylaxis group) had phlebography eight to 12 days after surgery. Of the 47 with deep-vein thrombosis, 16 had received LMWH (26.7%, 95% CI 16.1 to 39.7) and 31, mechanical prophylaxis (64.6%, 95% CI 49.5 to 77.8). The difference between the two groups was highly significant (p < 0.001). Only one patient in the LMWH group had severe bleeding. We conclude that one daily subcutaneous injection of Calcium Nadroparin in a fixed, weight-adjusted dosage scheme is superior to intermittent pneumatic compression of the foot for thromboprophylaxis after TKA. The LMWH scheme was also safe.
-
Prevention of deep-vein thrombosis after total knee replacement
The Journal of Bone and Joint Surgery. British volume, 1999Co-Authors: J. Blanchard, Dominique Didier, Henri Bounameaux, Jean-yves Meuwly, Pierre-françois Leyvraz, Marie-josé Miron, Pierre Hoffmeyer, Pierre-alain SchneiderAbstract:The optimal regime of antithrombotic prophylaxis for patients undergoing total knee arthroplasty (TKA) has not been established. Many surgeons employ intermittent pneumatic compression while others use low-molecular-weight heparins (LMWH) which were primarily developed for total hip arthroplasty. We compared the efficacy and safety of these two techniques in a randomised study with blinded assessment of the endpoint by phlebography.We randomised 130 patients, scheduled for elective TKA, to receive one daily subcutaneous injection of Nadroparin Calcium (dosage adapted to body-weight) or continuous intermittent pneumatic compression of the foot by means of the arteriovenous impulse system.A total of 108 patients (60 in the LMWH group and 48 in the mechanical prophylaxis group) had phlebography eight to 12 days after surgery. Of the 47 with deep-vein thrombosis, 16 had received LMWH (26.7%, 95% CI 16.1 to 39.7) and 31, mechanical prophylaxis (64.6%, 95% CI 49.5 to 77.8). The difference between the two groups...
