The Experts below are selected from a list of 4125 Experts worldwide ranked by ideXlab platform
Richard A Pollak - One of the best experts on this subject based on the ideXlab platform.
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efficacy and safety of tavaborole topical solution 5 a novel boron based antifungal agent for the treatment of toeNail onychomycosis results from 2 randomized phase iii studies
Journal of The American Academy of Dermatology, 2015Co-Authors: Raza Aly, Sheryl L Baldwin, Remigio Gonzalez Soto, Phoebe Rich, Max Weisfeld, Hector Wiltz, Lee T Zane, Richard A PollakAbstract:Background Onychomycosis, a fungal Nail Infection, can impact quality of life. Objective We sought to evaluate the efficacy and safety of tavaborole topical solution, 5% for treatment of toeNail onychomycosis. Methods In 2 phase-III trials, adults with distal subungual onychomycosis affecting 20% to 60% of a target great toeNail were randomized 2:1 to tavaborole or vehicle once daily for 48 weeks. The primary end point was complete cure of the target great toeNail (completely clear Nail with negative mycology) at week 52. Secondary end points included completely or almost clear Nail, negative mycology, completely or almost clear Nail plus negative mycology, and safety. Results Rates of negative mycology (31.1%-35.9% vs 7.2%-12.2%) and complete cure (6.5% and 9.1% vs 0.5% and 1.5%) significantly favored tavaborole versus vehicle ( P ≤ .001). Completely or almost clear Nail rates also significantly favored tavaborole versus vehicle (26.1%-27.5% vs 9.3%-14.6%; P P Limitations Duration of follow-up is a limitation. Conclusion Tavaborole demonstrates a favorable benefit-risk profile in treatment of toeNail onychomycosis.
S. Krajden - One of the best experts on this subject based on the ideXlab platform.
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onychomycosis tinea pedis and tinea manuum caused by non dermatophytic filamentous fungi nicht dermatophyten fadenpilze als erreger von onychomykosen tinea pedis und tinea manuum
Mycoses, 2009Co-Authors: Richard C. Summerbell, J. Kane, S. KrajdenAbstract:Over 4000 cases of fungal Nail, sole and palm Infection recorded during a three-year study period were investigated to determine the prevalence and significance of etiologic agents other than dermatophytes and yeasts. Littman's oxgall agar, which permitted isolation of cycloheximide-sensitive species but restricted overgrowth by fast growing contaminants, was used to promote isolation of these disease agents. Non-dermatophytic filamentous fungi made up 2.3% of the confirmed etiologic agents obtained overall, and constituted 3.3% of the agents obtained from Nail Infections. The most common species were Scopulariopsis brevicaulis, Hendersonula toruloidea, and Aspergillus sydowii. Scytalidium hyalinum was recorded for the first time from Canada, and an instance of Nail Infection by Gymnascella dankaliensis was recorded. Only H. toruloidea and Sc. hyalinum caused palm and sole Infections.
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onychomycosis tinea pedis and tinea manuum caused by non dermatophytic filamentous fungi
Mycoses, 2009Co-Authors: Richard C. Summerbell, J. Kane, S. KrajdenAbstract:Over 4000 cases of fungal Nail, sole and palm Infection recorded during a three-year study period were investigated to determine the prevalence and significance of etiologic agents other than dermatophytes and yeasts. Littman's oxgall agar, which permitted isolation of cycloheximide-sensitive species but restricted overgrowth by fast growing contaminants, was used to promote isolation of these disease agents. Non-dermatophytic filamentous fungi made up 2.3% of the confirmed etiologic agents obtained overall, and constituted 3.3% of the agents obtained from Nail Infections. The most common species were Scopulariopsis brevicaulis, Hendersonula toruloidea, and Aspergillus sydowii. Scytalidium hyalinum was recorded for the first time from Canada, and an instance of Nail Infection by Gymnascella dankaliensis was recorded. Only H. toruloidea and Sc. hyalinum caused palm and sole Infections.
Raza Aly - One of the best experts on this subject based on the ideXlab platform.
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efficacy and safety of tavaborole topical solution 5 a novel boron based antifungal agent for the treatment of toeNail onychomycosis results from 2 randomized phase iii studies
Journal of The American Academy of Dermatology, 2015Co-Authors: Raza Aly, Sheryl L Baldwin, Remigio Gonzalez Soto, Phoebe Rich, Max Weisfeld, Hector Wiltz, Lee T Zane, Richard A PollakAbstract:Background Onychomycosis, a fungal Nail Infection, can impact quality of life. Objective We sought to evaluate the efficacy and safety of tavaborole topical solution, 5% for treatment of toeNail onychomycosis. Methods In 2 phase-III trials, adults with distal subungual onychomycosis affecting 20% to 60% of a target great toeNail were randomized 2:1 to tavaborole or vehicle once daily for 48 weeks. The primary end point was complete cure of the target great toeNail (completely clear Nail with negative mycology) at week 52. Secondary end points included completely or almost clear Nail, negative mycology, completely or almost clear Nail plus negative mycology, and safety. Results Rates of negative mycology (31.1%-35.9% vs 7.2%-12.2%) and complete cure (6.5% and 9.1% vs 0.5% and 1.5%) significantly favored tavaborole versus vehicle ( P ≤ .001). Completely or almost clear Nail rates also significantly favored tavaborole versus vehicle (26.1%-27.5% vs 9.3%-14.6%; P P Limitations Duration of follow-up is a limitation. Conclusion Tavaborole demonstrates a favorable benefit-risk profile in treatment of toeNail onychomycosis.
Richard C. Summerbell - One of the best experts on this subject based on the ideXlab platform.
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onychomycosis tinea pedis and tinea manuum caused by non dermatophytic filamentous fungi nicht dermatophyten fadenpilze als erreger von onychomykosen tinea pedis und tinea manuum
Mycoses, 2009Co-Authors: Richard C. Summerbell, J. Kane, S. KrajdenAbstract:Over 4000 cases of fungal Nail, sole and palm Infection recorded during a three-year study period were investigated to determine the prevalence and significance of etiologic agents other than dermatophytes and yeasts. Littman's oxgall agar, which permitted isolation of cycloheximide-sensitive species but restricted overgrowth by fast growing contaminants, was used to promote isolation of these disease agents. Non-dermatophytic filamentous fungi made up 2.3% of the confirmed etiologic agents obtained overall, and constituted 3.3% of the agents obtained from Nail Infections. The most common species were Scopulariopsis brevicaulis, Hendersonula toruloidea, and Aspergillus sydowii. Scytalidium hyalinum was recorded for the first time from Canada, and an instance of Nail Infection by Gymnascella dankaliensis was recorded. Only H. toruloidea and Sc. hyalinum caused palm and sole Infections.
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onychomycosis tinea pedis and tinea manuum caused by non dermatophytic filamentous fungi
Mycoses, 2009Co-Authors: Richard C. Summerbell, J. Kane, S. KrajdenAbstract:Over 4000 cases of fungal Nail, sole and palm Infection recorded during a three-year study period were investigated to determine the prevalence and significance of etiologic agents other than dermatophytes and yeasts. Littman's oxgall agar, which permitted isolation of cycloheximide-sensitive species but restricted overgrowth by fast growing contaminants, was used to promote isolation of these disease agents. Non-dermatophytic filamentous fungi made up 2.3% of the confirmed etiologic agents obtained overall, and constituted 3.3% of the agents obtained from Nail Infections. The most common species were Scopulariopsis brevicaulis, Hendersonula toruloidea, and Aspergillus sydowii. Scytalidium hyalinum was recorded for the first time from Canada, and an instance of Nail Infection by Gymnascella dankaliensis was recorded. Only H. toruloidea and Sc. hyalinum caused palm and sole Infections.
D W Warnock - One of the best experts on this subject based on the ideXlab platform.
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Nail Infection caused by onychocola canadensis report of the first four british cases
Medical Mycology, 1997Co-Authors: Colin K Campbell, Elizabeth M Johnson, D W WarnockAbstract:Onychocola canadensis is a recently recognized cause of human Nail Infection. We present the first four cases of onychomycosis caused by this organism among patients resident in the UK.
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fungal Nail disease a guide to good practice report of a working group of the british society for medical mycology
BMJ, 1995Co-Authors: David W Denning, E G V Evans, C C Kibbler, M D Richardson, M M Roberts, T R Rogers, D W Warnock, R E WarrenAbstract:#### Summary points The term onychomycosis refers to fungal Infection of the Nails whether this is a primary event or a secondary Infection of a previously diseased or traumatised Nail. Infection may be due to dermatophyte (ringworm, tinea unguium), yeast, or other non-dermatophyte (mould) species, and the clinical appearance may indicate the nature of the infecting organism. In paronychia chronic Infection of the Nail fold is most often caused by Candida species, but bacterial Infection with Gram negative species such as Pseudomonas may coexist. Acute paronychia (whitlow) due to staphylococcal Infection may also occur, and the presence of these bacterial Infections will influence management. Invasion of the Nail plate by Candida species may occur in the presence of paronychia, immune deficiency states (including chronic mucocutaneous candidiasis), Raynaud's disease, or endocrine disorders. This paper reviews the clinical features of onychomycosis and the differential diagnosis of Nail dystrophy, gives the reasons for appropriate mycological investigation, and discusses guidelines for appropriate treatment on the basis of laboratory findings and particular clinical situations. Treating onychomycoses is difficult but is important because they do not resolve spontaneously. About 30% of all superficial fungal Infections affect the Nail.1 2 A recent population survey of dermatophyte onychomycosis has suggested a prevalence of 2.8% for men and 2.6% for women in the United Kingdom.3 …
