The Experts below are selected from a list of 77445 Experts worldwide ranked by ideXlab platform
Fan Wang - One of the best experts on this subject based on the ideXlab platform.
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activatable near infrared dye conjugated hyaluronic acid based Nanoparticles as a targeted theranostic agent for enhanced fluorescence ct photoacoustic imaging guided photothermal therapy
Biomaterials, 2017Co-Authors: Xiaolong Liang, Lei Fang, Xiaoda Li, Xu Zhang, Fan WangAbstract:Targeted theranostic Nano-System integrating functions of both diagnosis and therapy shows great potential for improving diagnosis and therapeutic efficacy. Herein, multifunctional Nanoparticle based on activatable hyaluronic acid (HA) conjugating two near-infrared (NIR) dyes of Cy5.5 and IR825 was successfully designed and fabricated, and simultaneously used as a carrier for encapsulating perfluorooctylbromide (PFOB). In this System, PFOB showed good capability to absorb the X-rays, Cy5.5 on the outer surface acted as a fluorescent dye activatable by hyaluronidases (Hyals) in the tumor, and IR825 in the core as a photothermal agent. The obtained Nanoparticles (NPs) of PFOB@IR825-HA-Cy5.5 can be utilized for triple X-ray computed tomography (CT), fluorescence and photoacoustic imaging. When PFOB@IR825-HA-Cy5.5 NPs were intravenously injected into the mice bearing HT-29 tumor, efficient tumor accumulation was clearly observed, as revealed by the triple modal imaging. An in vivo tumor treatment experiment was conducted by combination of PFOB@IR825-HA-Cy5.5 and near-infrared laser irradiation, achieving effective tumor ablation in mice. Therefore, PFOB@IR825-HA-Cy5.5 NPs is a safe, efficient, imageable photothermal Nanoprobe, showing great potential for cancer theranostics.
Wang Fan - One of the best experts on this subject based on the ideXlab platform.
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Activatable near infrared dye conjugated hyaluronic acid based Nanoparticles as a targeted theranostic agent for enhanced fluorescence/CT/photoacoustic imaging guided photothermal therapy
BIOMATERIALS, 2017Co-Authors: Liang Xiaolong, Xu Zhang, Fang Lei, Li Xiaoda, Wang FanAbstract:Targeted theranostic Nano-System integrating functions of both diagnosis and therapy shows great potential for improving diagnosis and therapeutic efficacy. Herein, multifunctional Nanoparticle based on activatable hyaluronic acid (HA) conjugating two near-infrared (NIR) dyes of Cy5.5 and IR825 was successfully designed and fabricated, and simultaneously used as a carrier for encapsulating perfluorooctylbromide (PFOB). In this System, PFOB showed good capability to absorb the X-rays, Cy5.5 on the outer surface acted as a fluorescent dye activatable by hyaluronidases (Hyals) in the tumor, and IR825 in the core as a photothermal agent. The obtained Nanoparticles (NPs) of PFOB@IR825-HA-Cy5.5 can be utilized for triple X-ray computed tomography (CT), fluorescence and photoacoustic imaging. When PFOB@IR825-HA-Cy5.5 NPs were intravenously injected into the mice bearing HT-29 tumor, efficient tumor accumulation was clearly observed, as revealed by the triple modal imaging. An in vivo tumor treatment experiment was conducted by combination of PFOB@IR825-HA-Cy5.5 and near-infrared laser irradiation, achieving effective tumor ablation in mice. Therefore, PFOB@IR825-HA-Cy5.5 NPs is a safe, efficient, imageable photothermal Nanoprobe, showing great potential for cancer theranostics. (C) 2017 Elsevier Ltd. All rights reserved.National Key Research and Development Program of China [2016YFA0201400]; National Natural Science Foundation of China [81571810, 81201186, 81125011, 81321003, 81427802, 81420108019]; Ministry of Science and Technology of China [2012ZX09102301-018, 2011YQ030114]; Beijing Ministry of Science and Technology [Z141100000214004]; Peking University Third Hospital [BYSY2015023]; China Postdoctoral Science Foundation [2013M530014]SCI(E)ARTICLE72-8413
Xu Zhang - One of the best experts on this subject based on the ideXlab platform.
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activatable near infrared dye conjugated hyaluronic acid based Nanoparticles as a targeted theranostic agent for enhanced fluorescence ct photoacoustic imaging guided photothermal therapy
Biomaterials, 2017Co-Authors: Xiaolong Liang, Lei Fang, Xiaoda Li, Xu Zhang, Fan WangAbstract:Targeted theranostic Nano-System integrating functions of both diagnosis and therapy shows great potential for improving diagnosis and therapeutic efficacy. Herein, multifunctional Nanoparticle based on activatable hyaluronic acid (HA) conjugating two near-infrared (NIR) dyes of Cy5.5 and IR825 was successfully designed and fabricated, and simultaneously used as a carrier for encapsulating perfluorooctylbromide (PFOB). In this System, PFOB showed good capability to absorb the X-rays, Cy5.5 on the outer surface acted as a fluorescent dye activatable by hyaluronidases (Hyals) in the tumor, and IR825 in the core as a photothermal agent. The obtained Nanoparticles (NPs) of PFOB@IR825-HA-Cy5.5 can be utilized for triple X-ray computed tomography (CT), fluorescence and photoacoustic imaging. When PFOB@IR825-HA-Cy5.5 NPs were intravenously injected into the mice bearing HT-29 tumor, efficient tumor accumulation was clearly observed, as revealed by the triple modal imaging. An in vivo tumor treatment experiment was conducted by combination of PFOB@IR825-HA-Cy5.5 and near-infrared laser irradiation, achieving effective tumor ablation in mice. Therefore, PFOB@IR825-HA-Cy5.5 NPs is a safe, efficient, imageable photothermal Nanoprobe, showing great potential for cancer theranostics.
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Activatable near infrared dye conjugated hyaluronic acid based Nanoparticles as a targeted theranostic agent for enhanced fluorescence/CT/photoacoustic imaging guided photothermal therapy
BIOMATERIALS, 2017Co-Authors: Liang Xiaolong, Xu Zhang, Fang Lei, Li Xiaoda, Wang FanAbstract:Targeted theranostic Nano-System integrating functions of both diagnosis and therapy shows great potential for improving diagnosis and therapeutic efficacy. Herein, multifunctional Nanoparticle based on activatable hyaluronic acid (HA) conjugating two near-infrared (NIR) dyes of Cy5.5 and IR825 was successfully designed and fabricated, and simultaneously used as a carrier for encapsulating perfluorooctylbromide (PFOB). In this System, PFOB showed good capability to absorb the X-rays, Cy5.5 on the outer surface acted as a fluorescent dye activatable by hyaluronidases (Hyals) in the tumor, and IR825 in the core as a photothermal agent. The obtained Nanoparticles (NPs) of PFOB@IR825-HA-Cy5.5 can be utilized for triple X-ray computed tomography (CT), fluorescence and photoacoustic imaging. When PFOB@IR825-HA-Cy5.5 NPs were intravenously injected into the mice bearing HT-29 tumor, efficient tumor accumulation was clearly observed, as revealed by the triple modal imaging. An in vivo tumor treatment experiment was conducted by combination of PFOB@IR825-HA-Cy5.5 and near-infrared laser irradiation, achieving effective tumor ablation in mice. Therefore, PFOB@IR825-HA-Cy5.5 NPs is a safe, efficient, imageable photothermal Nanoprobe, showing great potential for cancer theranostics. (C) 2017 Elsevier Ltd. All rights reserved.National Key Research and Development Program of China [2016YFA0201400]; National Natural Science Foundation of China [81571810, 81201186, 81125011, 81321003, 81427802, 81420108019]; Ministry of Science and Technology of China [2012ZX09102301-018, 2011YQ030114]; Beijing Ministry of Science and Technology [Z141100000214004]; Peking University Third Hospital [BYSY2015023]; China Postdoctoral Science Foundation [2013M530014]SCI(E)ARTICLE72-8413
Xiaolong Liang - One of the best experts on this subject based on the ideXlab platform.
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activatable near infrared dye conjugated hyaluronic acid based Nanoparticles as a targeted theranostic agent for enhanced fluorescence ct photoacoustic imaging guided photothermal therapy
Biomaterials, 2017Co-Authors: Xiaolong Liang, Lei Fang, Xiaoda Li, Xu Zhang, Fan WangAbstract:Targeted theranostic Nano-System integrating functions of both diagnosis and therapy shows great potential for improving diagnosis and therapeutic efficacy. Herein, multifunctional Nanoparticle based on activatable hyaluronic acid (HA) conjugating two near-infrared (NIR) dyes of Cy5.5 and IR825 was successfully designed and fabricated, and simultaneously used as a carrier for encapsulating perfluorooctylbromide (PFOB). In this System, PFOB showed good capability to absorb the X-rays, Cy5.5 on the outer surface acted as a fluorescent dye activatable by hyaluronidases (Hyals) in the tumor, and IR825 in the core as a photothermal agent. The obtained Nanoparticles (NPs) of PFOB@IR825-HA-Cy5.5 can be utilized for triple X-ray computed tomography (CT), fluorescence and photoacoustic imaging. When PFOB@IR825-HA-Cy5.5 NPs were intravenously injected into the mice bearing HT-29 tumor, efficient tumor accumulation was clearly observed, as revealed by the triple modal imaging. An in vivo tumor treatment experiment was conducted by combination of PFOB@IR825-HA-Cy5.5 and near-infrared laser irradiation, achieving effective tumor ablation in mice. Therefore, PFOB@IR825-HA-Cy5.5 NPs is a safe, efficient, imageable photothermal Nanoprobe, showing great potential for cancer theranostics.
Liang Xiaolong - One of the best experts on this subject based on the ideXlab platform.
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Activatable near infrared dye conjugated hyaluronic acid based Nanoparticles as a targeted theranostic agent for enhanced fluorescence/CT/photoacoustic imaging guided photothermal therapy
BIOMATERIALS, 2017Co-Authors: Liang Xiaolong, Xu Zhang, Fang Lei, Li Xiaoda, Wang FanAbstract:Targeted theranostic Nano-System integrating functions of both diagnosis and therapy shows great potential for improving diagnosis and therapeutic efficacy. Herein, multifunctional Nanoparticle based on activatable hyaluronic acid (HA) conjugating two near-infrared (NIR) dyes of Cy5.5 and IR825 was successfully designed and fabricated, and simultaneously used as a carrier for encapsulating perfluorooctylbromide (PFOB). In this System, PFOB showed good capability to absorb the X-rays, Cy5.5 on the outer surface acted as a fluorescent dye activatable by hyaluronidases (Hyals) in the tumor, and IR825 in the core as a photothermal agent. The obtained Nanoparticles (NPs) of PFOB@IR825-HA-Cy5.5 can be utilized for triple X-ray computed tomography (CT), fluorescence and photoacoustic imaging. When PFOB@IR825-HA-Cy5.5 NPs were intravenously injected into the mice bearing HT-29 tumor, efficient tumor accumulation was clearly observed, as revealed by the triple modal imaging. An in vivo tumor treatment experiment was conducted by combination of PFOB@IR825-HA-Cy5.5 and near-infrared laser irradiation, achieving effective tumor ablation in mice. Therefore, PFOB@IR825-HA-Cy5.5 NPs is a safe, efficient, imageable photothermal Nanoprobe, showing great potential for cancer theranostics. (C) 2017 Elsevier Ltd. All rights reserved.National Key Research and Development Program of China [2016YFA0201400]; National Natural Science Foundation of China [81571810, 81201186, 81125011, 81321003, 81427802, 81420108019]; Ministry of Science and Technology of China [2012ZX09102301-018, 2011YQ030114]; Beijing Ministry of Science and Technology [Z141100000214004]; Peking University Third Hospital [BYSY2015023]; China Postdoctoral Science Foundation [2013M530014]SCI(E)ARTICLE72-8413
