The Experts below are selected from a list of 2349 Experts worldwide ranked by ideXlab platform
Joseph Wang - One of the best experts on this subject based on the ideXlab platform.
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a Nanomotor based active delivery system for intracellular oxygen transport
ACS Nano, 2019Co-Authors: Fangyu Zhang, Berta Esteban-fernández De Ávila, Liangfang Zhang, Jia Zhuang, Songsong Tang, Qiangzhe Zhang, Ronnie H Fang, Joseph WangAbstract:Active transport of gas molecules is critical to preserve the physiological functions of organisms. Oxygen, as the most essential gas molecule, plays significant roles in maintaining the metabolism and viability of cells. Herein, we report a Nanomotor-based delivery system that combines the fast propulsion of acoustically propelled gold nanowire Nanomotors (AuNW) with the high oxygen carrying capacity of red blood cell membrane-cloaked perfluorocarbon nanoemulsions (RBC-PFC) for active intracellular delivery of oxygen. The oxygen delivery capacity and kinetics of the AuNW Nanomotors carrying RBC-PFC (denoted as “Motor-PFC”) are examined under ultrasound field. Specifically, the fast movement of the Motor-PFC under an acoustic field accelerates intracellular delivery of oxygen to J774 macrophage cells. Upon entering the cells, the oxygen loaded in the Motor-PFC is sustainably released, which maintains the cell viability when cultured under hypoxic conditions. The acoustically propelled Motor-PFC leads to s...
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Active Intracellular Delivery of a Cas9/sgRNA Complex Using Ultrasound‐Propelled Nanomotors
Angewandte Chemie, 2018Co-Authors: Malthe Hansen‐bruhn, Berta Esteban-fernández De Ávila, Mara Beltrán-gastélum, Jing Zhao, Doris E. Ramírez-herrera, Pavimol Angsantikul, Kurt V. Gothelf, Liangfang Zhang, Joseph WangAbstract:Direct and rapid intracellular delivery of a functional Cas9/sgRNA complex using ultrasound-powered Nanomotors is reported. The Cas9/sgRNA complex is loaded onto the Nanomotor surface through a reversible disulfide linkage. A 5 min ultrasound treatment enables the Cas9/sgRNA-loaded Nanomotors to directly penetrate through the plasma membrane of GFP-expressing B16F10 cells. The Cas9/sgRNA is released inside the cells to achieve highly effective GFP gene knockout. The acoustic Cas9/sgRNA-loaded Nanomotors display more than 80 % GFP knockout within 2 h of cell incubation compared to 30 % knockout using static nanowires. More impressively, the Nanomotors enable highly efficient knockout with just 0.6 nm of the Cas9/sgRNA complex. This Nanomotor-based intracellular delivery method thus offers an attractive route to overcome physiological barriers for intracellular delivery of functional proteins and RNAs, thus indicating considerable promise for highly efficient therapeutic applications.
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Targeting and isolation of cancer cells using micro/Nanomotors
Advanced Drug Delivery Reviews, 2017Co-Authors: Berta Esteban-fernández De Ávila, Liangfang Zhang, Joseph WangAbstract:Abstract Micro/Nanomotors distinguish themselves with in situ energy conversion capability for autonomous movement, a feature that confers remarkable potential to improve cancer treatment. In this review article, three areas are highlighted where micro/Nanomotors have established themselves with unique contributions, including propelled navigation to promote cancer cell targeting, powered cell membrane penetration to enhance intracellular delivery, and steered isolation of circulating tumor cells for detection. Progress made in these areas has offered promising inspiration and opportunities aimed for enhancing the efficiency and precision of drug targeting to cancer cells, improving the capability of delivering anticancer drug into cytoplasm for bioactivity, and enabling more rapid and sensitive cancer cell detection. Herein, we review each area with highlights of the current and forthcoming micro/Nanomotor techniques in advancing cancer diagnosis and treatment.
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magneto acoustic hybrid Nanomotor
Nano Letters, 2015Co-Authors: Jinxing Li, Tailin Xu, Tianlong Li, Zhiguang Wu, Melek Kiristi, Joseph WangAbstract:Efficient and controlled nanoscale propulsion in harsh environments requires careful design and manufacturing of nanomachines, which can harvest and translate the propelling forces with high spatial and time resolution. Here we report a new class of artificial nanomachine, named magneto–acoustic hybrid Nanomotor, which displays efficient propulsion in the presence of either magnetic or acoustic fields without adding any chemical fuel. These fuel-free hybrid Nanomotors, which comprise a magnetic helical structure and a concave nanorod end, are synthesized using a template-assisted electrochemical deposition process followed by segment-selective chemical etching. Dynamic switching of the propulsion mode with reversal of the movement direction and digital speed regulation are demonstrated on a single nanovehicle. These hybrid Nanomotors exhibit a diverse biomimetic collective behavior, including stable aggregation, swarm motion, and swarm vortex, triggered in response to different field inputs. Such adaptive...
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Magneto−Acoustic Hybrid Nanomotor
Nano Letters, 2015Co-Authors: Jinxing Li, Tailin Xu, Tianlong Li, Zhiguang Wu, Melek Kiristi, Joseph WangAbstract:Efficient and controlled nanoscale propulsion in harsh environments requires careful design and manufacturing of nanomachines, which can harvest and translate the propelling forces with high spatial and time resolution. Here we report a new class of artificial nanomachine, named magneto–acoustic hybrid Nanomotor, which displays efficient propulsion in the presence of either magnetic or acoustic fields without adding any chemical fuel. These fuel-free hybrid Nanomotors, which comprise a magnetic helical structure and a concave nanorod end, are synthesized using a template-assisted electrochemical deposition process followed by segment-selective chemical etching. Dynamic switching of the propulsion mode with reversal of the movement direction and digital speed regulation are demonstrated on a single nanovehicle. These hybrid Nanomotors exhibit a diverse biomimetic collective behavior, including stable aggregation, swarm motion, and swarm vortex, triggered in response to different field inputs. Such adaptive...
Daniela A Wilson - One of the best experts on this subject based on the ideXlab platform.
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Micro-/Nanomotors toward Biomedical Applications: The Recent Progress in Biocompatibility.
Small, 2020Co-Authors: Juanfeng Ou, Yingfeng Tu, Daniela A Wilson, Jiamiao Jiang, Fei Wang, Shuanghu Wang, Fei PengAbstract:Inspired by the highly versatile natural motors, artificial micro-/Nanomotors that can convert surrounding energies into mechanical motion and accomplish multiple tasks are devised. In the past few years, micro-/Nanomotors have demonstrated significant potential in biomedicine. However, the practical biomedical applications of these small-scale devices are still at an infant stage. For successful bench-to-bed translation, biocompatibility of micro-/Nanomotor systems is the central issue to be considered. Herein, the recent progress in micro-/Nanomotors in biocompatibility is reviewed, with a special focus on their biomedical applications. Through close collaboration between researches in the nanoengineering, material chemistry, and biomedical fields, it is expected that a promising real-world application platform based on micro-/Nanomotors will emerge in the near future.
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Spatial control over catalyst positioning on biodegradable polymeric Nanomotors
Nature Communications, 2019Co-Authors: B. Jelle Toebes, Daniela A WilsonAbstract:Scientists over the world are inspired by biological Nanomotors and try to mimic these complex structures. In recent years multiple Nanomotors have been created for various fields, such as biomedical applications or environmental remediation, which require a different design both in terms of size and shape, as well as material properties. So far, only relatively simple designs for synthetic Nanomotors have been reported. Herein, we report an approach to create biodegradable polymeric Nanomotors with a multivalent design. PEG-PDLLA (poly(ethylene glycol)-b-poly(D,L-lactide)) stomatocytes with azide handles were created that were selectively reduced on the outside surface by TCEP (tris(2-carboxyethyl)phosphine) functionalized beads. Thereby, two different functional handles were created, both on the inner and outer surface of the stomatocytes, providing spatial control for catalyst positioning. Enzymes were coupled on the inside of the stomatocyte to induce motion in the presence of fuel, while fluorophores and other molecules can be attached on the outside. Multiple Nanomotors for application in various fields have been fabricated, but so far only relatively simple designs for synthetic Nanomotors are reported. Here, the authors report on a biodegradable polymeric Nanomotor and demonstrate spatial control for catalyst positioning.
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Motion Control of Polymeric Nanomotors Based on Host–Guest Interactions
Angewandte Chemie, 2019Co-Authors: Yingfeng Tu, Fei Peng, Roeland J M Nolte, Josje M. Heuvelmans, Daniela A WilsonAbstract:Controlling the motion of artificial self-propelled micro- and Nanomotors independent of the fuel concentration is still a great challenge. Here we describe the first report of speed manipulation of supramolecular Nanomotors via blue light-responsive valves, which can regulate the access of hydrogen peroxide fuel into the motors. Light-sensitive polymeric Nanomotors are built up via the self-assembly of functional block copolymers, followed by bowl-shaped stomatocyte formation and incorporation of platinum nanoparticles. Subsequent addition of β-cyclodextrin (β-CD) leads to the formation of inclusion complexes with the trans-isomers of the azobenzene derivatives grafted from the surfaces of the stomatocytes. β-CDs attachment decreases the diffusion rate of hydrogen peroxide into the cavities of the motors because of partly blocking of the openings of the stomatocyte. This results in a lowering of the speed of the Nanomotors. Upon blue light irradiation, the trans-azobenzene moieties isomerize to the cis-form, which lead to the detachment of the β-CDs due to their inability to form complexes with the cis-isomer. As a result, the speed of the Nanomotors increases accordingly. Such a conformational change provides us with the unique possibility to control the speed of the supramolecular Nanomotor via light-responsive host-guest complexation. We envision that such artificial responsive nano-systems with controlled motion could have potential applications in drug delivery.
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Fuel-Free Micro-/Nanomotors as Intelligent Therapeutic Agents
Chemistry-an Asian Journal, 2019Co-Authors: Daniela A Wilson, Yingfeng Tu, Fei PengAbstract:Abstract There are many efficient biological motors in Nature that perform complex functions by converting chemical energy into mechanical motion. Inspired by this, the development of their synthetic counterparts has aroused tremendous research interest in the past decade. Among these man-made motor systems, the fuel-free (or light, magnet, ultrasound, or electric field driven) motors are advantageous in terms of controllability, lifespan, and biocompatibility concerning bioapplications, when compared with their chemically powered counterparts. Therefore, this review will highlight the latest biomedical applications in the versatile field of externally propelled micro-/Nanomotors, as well as elucidating their driving mechanisms. A perspective into the future of the micro-/Nanomotors field and a discussion of the challenges we need to face along the road towards practical clinical translation of external-field-propelled micro-/Nanomotors will be provided.
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poly ionic liquid s based brush type Nanomotor
Micromachines, 2018Co-Authors: Yingfeng Tu, Fei Peng, Wei Li, Daniela A WilsonAbstract:A brush type Nanomotor was fabricated via assembly assistant polymerization of poly(ionic liquid) and surface grafting polymerization. The method for large-scale fabrication of brush Nanomotors with soft surfaces is described. These soft locomotive particles are based on core-shell brush nanoparticles assembled from poly(ionic liquid) as core and thermoresponsive PNIPAM as brush shells on which platinum nanoparticle (PtNP) were grown in situ. The particles show non-Brownian motion in H2O2 solution.
Jian Shen - One of the best experts on this subject based on the ideXlab platform.
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author correction bio inspired nitric oxide driven Nanomotor
Nature Communications, 2019Co-Authors: Huan Chen, Qi Wang, Ping Xu, Yueqi Yu, Jian ShenAbstract:The original version of this Article contained an error in the first sentence of the second paragraph of the ‘Influence of HLA10 Nanomotors on the cells (HUVECs and MCF-7)’ section of the Results, which incorrectly read ‘In order to verify the universality of the formation mechanism of HLAn Nanomotors proposed in this case, that is, the positively charged amino-enriched organic substances and the negative carboxyl groups in L-arginine combined through weak electrostatic force to form nanoparticles, three amino-enriched organic compounds (chitosan, (Mw. 5–100 million), polylysine (Mw. 3000–4000), heparin/folic acid (FA) (Mw. 5000–10,000)) were chosen to react with L-arginine, and the morphology/movement behavior of the obtained nanoparticles (named as CLA10 Nanomotors, PLA10 Nanomotors, HFLA10 Nanomotors) were investigated (Fig. 7 and Supplementary Movie 7).’ The correct version states ‘chitosan, (Mw. 3000–6000 Da)’ in place of ‘chitosan, (Mw. 5–100 million)’. This has been corrected in both the PDF and HTML versions of the Article.
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bio inspired nitric oxide driven Nanomotor
Nature Communications, 2019Co-Authors: Huan Chen, Qi Wang, Ping Xu, Yueqi Yu, Jian ShenAbstract:Current chemical-fuel-driven Nanomotors are driven by gas (e.g. H2, O2, NH3) which only provides motion ability, and can produce waste (e.g. Mg(OH)2, Pt). Here, inspired by endogenous biochemical reactions in the human body involving conversion of amino acid L-arginine to nitric oxide (NO) by NO synthase (NOS) or reactive oxygen species (ROS), we report on a Nanomotor made of hyperbranched polyamide/L-arginine (HLA). The Nanomotor utilizes L-arginine as fuel for the production of NO both as driving force and to provide beneficial effects, including promoting endothelialisation and anticancer effects, along with other beneficial by-products. In addition, the HLA Nanomotors are fluorescent and can be used to monitor the movement of Nanomotors in vivo in the future. This work presents a zero-waste, self-destroyed and self-imaging Nanomotor with potential biological application for the treatment of various diseases in different tissues including blood vessels and tumours. Depletion of propellant in chemical-fuel-driven Nanomotors is a limiting factor in device design and application. Here, the authors create a nitric-oxide-generating nanoparticle and explore cellular uptake and application of the Nanomotors in nitric oxide treatments.
Jinyao Tang - One of the best experts on this subject based on the ideXlab platform.
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From Strong Dichroic Nanomotor to Polarotactic Microswimmer
Advanced Materials, 2019Co-Authors: Xiaojun Zhan, Jing Zheng, Yang Zhao, Rui Cheng, Jizhuang Wang, Jiang Tang, Jinyao TangAbstract:Light-driven micro/Nanomotors are promising candidates for long-envisioned next-generation nanorobotics for targeted drug delivery, noninvasive surgery, nanofabrication, and beyond. To achieve these fantastic applications, effective control of the micro/Nanomotor is essential. Light has been proved as the most versatile method for microswimmer manipulation, while the light propagation direction, intensity, and wavelength have been explored as controlling signals for light-responsive Nanomotors. Here, the controlling method is expanded to the polarization state of the light, and a Nanomotor with a significant dichroic ratio is demonstrated. Due to the anisotropic crystal structure, light polarized parallel to the Sb2 Se3 nanowires is preferentially absorbed. The core-shell Sb2 Se3 /ZnO Nanomotor exhibits strong dichroic swimming behavior: the swimming speed is ≈3 times faster when illuminated with parallel polarized light than perpendicular polarized light. Furthermore, by incorporating two cross-aligned dichroic Nanomotors, a polarotactic artificial microswimmer is achieved, which can be navigated by controlling the polarization direction of the incident light. Compared to the well-studied light-driven rotary motors based on optical tweezers, this dichroic microswimmer offers eight orders of magnitude light-intensity reduction, which may enable large-scale nanomanipulation as well as other heat-sensitive applications.
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light driven micro Nanomotor for promising biomedical tools principle challenge and prospect
Accounts of Chemical Research, 2018Co-Authors: Jizhuang Wang, Xiaojun Zhan, Jing Zheng, Ze Xiong, Jinyao TangAbstract:ConspectusA micro/Nanomotor (MNM), as miniaturized machinery, can potentially bridge the application gap between the traditional macroscale motor and the molecular motor to manipulate materials at the cellular scale. The fascinating biomedical potential application for these tiny robots has been long envisioned by science fiction, such as “Fantastic Voyage”, where complicated surgery can be performed at single cell precision without any surgical incision. However, to enter the highly conservative biomedical and healthcare industry in practice, the MNM must provide unique advantages over existing technology without introducing additional health risk, which has not been fully materialized.As an emerging approach, light-driven micro/Nanomotors (LMNMs) have demonstrated several unique advantages over other MNMs, which will be addressed in this Account. As a control signal, light promises additional degrees of freedom to manipulate MNMs by modulating the light intensity, frequency, polarization, and propagatio...
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a silicon nanowire as a spectrally tunable light driven Nanomotor
Advanced Materials, 2017Co-Authors: Jizhuang Wang, Xiaojun Zhan, Jing Zheng, Ze Xiong, Jinyao TangAbstract:Over the last decades, scientists have endeavored to develop nanoscopic machines and envisioned that these tiny machines could be exploited in biomedical applications and novel material fabrication. Here, a visible-/near-infrared light-driven Nanomotor based on a single silicon nanowire is reported. The silicon Nanomotor harvests energy from light and propels itself by the self-electrophoresis mechanism. Due to the high efficiency, the silicon nanowire can be readily driven by visible and near-infrared illumination at ultralow light intensity (≈3 mW cm−2). The experimental study and numerical simulation also show that the detailed structure around the concentrated reaction center determines the migration behavior of the Nanomotor. Importantly, due to the optical resonance inside the silicon nanowire, the spectral response of the nanowire-based Nanomotor can be readily modulated by the nanowire's diameter. Compared to other methods, light controlling potentially offers more freedom and flexibility, as light can be modulated not only with its intensity and direction, but also with the frequency and polarities. This nanowire motor demonstrates a step forward to harness the advantages of light, which opens up new opportunities for the realization of many novel functions such as multiple channels communication to nanorobots and controllable self-assembly.
Huan Chen - One of the best experts on this subject based on the ideXlab platform.
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author correction bio inspired nitric oxide driven Nanomotor
Nature Communications, 2019Co-Authors: Huan Chen, Qi Wang, Ping Xu, Yueqi Yu, Jian ShenAbstract:The original version of this Article contained an error in the first sentence of the second paragraph of the ‘Influence of HLA10 Nanomotors on the cells (HUVECs and MCF-7)’ section of the Results, which incorrectly read ‘In order to verify the universality of the formation mechanism of HLAn Nanomotors proposed in this case, that is, the positively charged amino-enriched organic substances and the negative carboxyl groups in L-arginine combined through weak electrostatic force to form nanoparticles, three amino-enriched organic compounds (chitosan, (Mw. 5–100 million), polylysine (Mw. 3000–4000), heparin/folic acid (FA) (Mw. 5000–10,000)) were chosen to react with L-arginine, and the morphology/movement behavior of the obtained nanoparticles (named as CLA10 Nanomotors, PLA10 Nanomotors, HFLA10 Nanomotors) were investigated (Fig. 7 and Supplementary Movie 7).’ The correct version states ‘chitosan, (Mw. 3000–6000 Da)’ in place of ‘chitosan, (Mw. 5–100 million)’. This has been corrected in both the PDF and HTML versions of the Article.
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bio inspired nitric oxide driven Nanomotor
Nature Communications, 2019Co-Authors: Huan Chen, Qi Wang, Ping Xu, Yueqi Yu, Jian ShenAbstract:Current chemical-fuel-driven Nanomotors are driven by gas (e.g. H2, O2, NH3) which only provides motion ability, and can produce waste (e.g. Mg(OH)2, Pt). Here, inspired by endogenous biochemical reactions in the human body involving conversion of amino acid L-arginine to nitric oxide (NO) by NO synthase (NOS) or reactive oxygen species (ROS), we report on a Nanomotor made of hyperbranched polyamide/L-arginine (HLA). The Nanomotor utilizes L-arginine as fuel for the production of NO both as driving force and to provide beneficial effects, including promoting endothelialisation and anticancer effects, along with other beneficial by-products. In addition, the HLA Nanomotors are fluorescent and can be used to monitor the movement of Nanomotors in vivo in the future. This work presents a zero-waste, self-destroyed and self-imaging Nanomotor with potential biological application for the treatment of various diseases in different tissues including blood vessels and tumours. Depletion of propellant in chemical-fuel-driven Nanomotors is a limiting factor in device design and application. Here, the authors create a nitric-oxide-generating nanoparticle and explore cellular uptake and application of the Nanomotors in nitric oxide treatments.
