The Experts below are selected from a list of 4830 Experts worldwide ranked by ideXlab platform
S.h. Pai - One of the best experts on this subject based on the ideXlab platform.
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A study of process optimization using the combined submerged arc Nanoparticle synthesis system for preparing TiO2 Nanoparticle suspension
Journal of Alloys and Compounds, 2006Co-Authors: Ho Chang, Ching-song Jwo, Mu-jung Kao, S.h. PaiAbstract:Abstract Using ultrasonic-aided submerged arc Nanoparticle synthesis system, which is an innovative Nanoparticle Preparation Method, this paper employs some major parameters together with robust design to investigate the optimized parameters, such as peak current, pulse duration, open voltage and amplitude of ultrasonic vibration, for producing TiO 2 Nanoparticle suspension by using the least number of experiments. The experimental results indicate that evenly distributed TiO 2 Nanoparticles can be manufactured. The pH value of isoelectric point (IEP) of the produced particle suspension is pH 5. The suspension is dispersed when the potential value of the suspension is distant from the IEP, or it would be aggregated when the potential value is close to the IEP. The produced TiO 2 Nanoparticle suspension would absorb UV when the wavelength is 300–380 nm.
Ho Chang - One of the best experts on this subject based on the ideXlab platform.
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A study of process optimization using the combined submerged arc Nanoparticle synthesis system for preparing TiO2 Nanoparticle suspension
Journal of Alloys and Compounds, 2006Co-Authors: Ho Chang, Ching-song Jwo, Mu-jung Kao, S.h. PaiAbstract:Abstract Using ultrasonic-aided submerged arc Nanoparticle synthesis system, which is an innovative Nanoparticle Preparation Method, this paper employs some major parameters together with robust design to investigate the optimized parameters, such as peak current, pulse duration, open voltage and amplitude of ultrasonic vibration, for producing TiO 2 Nanoparticle suspension by using the least number of experiments. The experimental results indicate that evenly distributed TiO 2 Nanoparticles can be manufactured. The pH value of isoelectric point (IEP) of the produced particle suspension is pH 5. The suspension is dispersed when the potential value of the suspension is distant from the IEP, or it would be aggregated when the potential value is close to the IEP. The produced TiO 2 Nanoparticle suspension would absorb UV when the wavelength is 300–380 nm.
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Nanoparticle suspension Preparation using the arc spray Nanoparticle synthesis system combined with ultrasonic vibration and rotating electrode
The International Journal of Advanced Manufacturing Technology, 2005Co-Authors: Ho Chang, T.t. Tsung, Y.c. Yang, L.c. Chen, H.m. Lin, C.k. Lin, Ching-song JwoAbstract:This study aims to investigate the use of a new Nanoparticle Preparation Method, i.e., the arc spray Nanoparticle synthesis system (ASNSS) combined with ultrasonic vibration and rotating electrode, to prepare TiO_2 Nanoparticle suspension. For the proposed new Method of Nanoparticle suspension Preparation, this study has designed four different process modes of experimentation for comparison, in order to obtain suspended Nanoparticles with smaller particle size and relatively good dispersion. This study discusses the process modes with different settings of variables including peak current, pulse duration, breakdown voltage, temperature of the dielectric fluid and amplitude of ultrasonic vibration, in order to determine the better conditions for the Preparation of TiO_2 Nanoparticles suspension. The Transition Electron Microscope (TEM) image of the experiment result shows that TiO_2 Nanoparticles prepared by the ultrasonic vibration assisted vacuum arc spray process has an average particle size of less than 10 nm.
Soliman Mohammadi-samani - One of the best experts on this subject based on the ideXlab platform.
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Preparation, optimization, and in-vitro/in-vivo/ex-vivo characterization of chitosan-heparin Nanoparticles: drug-induced gelation.
The Journal of pharmacy and pharmacology, 2013Co-Authors: Mohammad-ali Shahbazi, Mehrdad Hamidi, Soliman Mohammadi-samaniAbstract:Objectives Management of blood coagulation-related diseases is currently limited by the inability to provide an adequate drug concentration in blood circulation for a long term. As a promising way to overcome this problem, the long-acting forms of these drugs have attracted many interests in recent years. Methods In this study, chitosan-heparin Nanoparticles were prepared as a polymeric delivery system intended for the prolonged intravenous delivery of heparin where the drug was used as both the therapeutic agent and a gel-forming counter-ion. The Nanoparticle Preparation Method was optimized using a Taguchi orthogonal array. Critical formulation variables were optimized in this study in terms of their corresponding effects on the target response of particle size. Nanoparticles were characterized by the Fourier transform infrared spectroscopy, transmission electron microscopy and zeta potential. Key findings The size, polydispersity index, zeta potential and encapsulation efficiency for the optimized formulation were found to be 61.33 ± 1.53 nm, 0.06, +15.7 mv and 74.16 ± 1.27%, respectively. The sizes of the prepared drug-loaded Nanoparticles were stable at least 1 week at room temperature and 3 months in refrigerator. Conclusions The ex-vivo and in-vivo tests on the heparin-chitosan Nanoparticles using activated partial thromboplastin time (aPTT) as the biological index were indicative of a smoother and longer elevation in aPTT in the presence of nanoparticulate drug.
S. K. Sahu - One of the best experts on this subject based on the ideXlab platform.
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Biodegradable Nanoparticles - A Novel Approach for Oral Administration of Biological Products
International Journal of Pharmaceutical Sciences and Nanotechnology, 2009Co-Authors: Amiya Kumar Prusty, S. K. SahuAbstract:Recent developments in science and technology lead towards miniaturization, touching all the spheres of life starting from automobile industry to pharmaceutical industry. The advances in nanotechnology, helps in preparing Nanoparticles containing biologically active proteins, that have all the benefits of nanoparticulate system as well as maintain the stability and activity of the biological Preparations against low pH of gastric fluid and action of proteolytic enzymes. The Nanoparticle Preparation Method discussed is ionic gelation between a polycationic and a polyanionic polymer under magnetic stirring. The polymers used for Preparation of Nanoparticles are biodegradable and hydrophilic. Nanoparticles due to their small size can penetrate through smaller capillaries and are easily taken up by cells that allow efficient drug accumulation at the target sites. Nanoparticles maintained sustained drug release over a period of days or even weeks decreasing the frequency of injection in case of parenteral Preparations. By preparing Nanoparticles using polycations like chitosan, the tight junctions between epithelial cells are opened making paracellular diffusion feasible. Therefore, the nanosized biological products are much more efficient in reaching the target site than the original proteins or peptides.
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Review Article Biodegradable Nanoparticles - A Novel Approach for Oral Administration of Biological Products
2009Co-Authors: Amiya Kumar Prusty, S. K. SahuAbstract:Recent developments in science and technology lead towards miniaturization, touching all the spheres of life starting from automobile industry to pharmaceutical industry. The advances in nanotechnology, helps in preparing Nanoparticles containing biologically active proteins, that have all the benefits of nanoparticulate system as well as maintain the stability and activity of the biological Preparations against low pH of gastric fluid and action of proteolytic enzymes. The Nanoparticle Preparation Method discussed is ionic gelation between a polycationic and a polyanionic polymer under magnetic stirring. The polymers used for Preparation of Nanoparticles are biodegradable and hydrophilic. Nanoparticles due to their small size can penetrate through smaller capillaries and are easily taken up by cells that allow efficient drug accumulation at the target sites. Nanoparticles maintained sustained drug release over a period of days or even weeks decreasing the frequency of injection in case of parenteral Preparations. By preparing Nanoparticles using polycations like chitosan, the tight junctions between epithelial cells are opened making paracellular diffusion feasible. Therefore, the nanosized biological products are much more efficient in reaching the target site than the original proteins or peptides.
M. Mičušík - One of the best experts on this subject based on the ideXlab platform.
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Characterization and magnetic properties of nickel and nickel-iron Nanoparticle colloidal suspensions in imidazolium-based ionic liquids prepared by magnetron sputtering
Journal of Alloys and Compounds, 2018Co-Authors: A. Cigáň, P. Lobotka, A. Dvurečenskij, M. Škrátek, György Radnóczi, M. Majerová, Z. Czigany, J. Maňka, Ivo Vávra, M. MičušíkAbstract:Abstract Colloids of Ni and Ni-Fe Nanoparticles in two imidazolium-based ionic liquids were prepared by magnetron sputtering of nickel and co-sputtering of nickel and iron, respectively, on the surface of the ionic liquids. The liquids consist of the same cation 1-butyl-3-methylimidazolium [BMIM] and two different anions: hexafluorophosphate [PF6] or bis(trifluoromethylsulfonyl)imide [Tf2N]. The Nanoparticle Preparation Method was based on extremely low vapour pressures of the ionic liquids, which allowed them to be used in vacuum. Magnetic properties of the metal nanocolloids (NCs) and the pure ionic liquids were analysed in detail, including the effect of ageing over a period of more than 30 months. The NCs were studied by TEM microscopy, UV–Vis spectroscopy and SQUID magnetometry. They were stable in time. No sedimentation or agglomeration of Nanoparticles was observed after more than 24 months. The ionic liquid ions play more than the role of a surfactant, e.g. magnetic data gave evidence of a strong interaction between the ionic liquids and metal Nanoparticles.
