The Experts below are selected from a list of 1663596 Experts worldwide ranked by ideXlab platform
Xiaowei Zhang - One of the best experts on this subject based on the ideXlab platform.
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Experimental evaluation of the lubrication performance of MoS2/CNT nanofluid for minimal quantity lubrication in Ni-based alloy grinding
International Journal of Machine Tools & Manufacture, 2015Co-Authors: Yanbin Zhang, Changhe Li, Dongkun Zhang, Xiaowei ZhangAbstract:Abstract A nanofluid minimum quantity lubrication with addition of one kind of Nanoparticle has several limitations, such as grinding of difficult-to-cutting materials. Hybrid Nanoparticles integrate the properties of two or more kinds of Nanoparticles, thus having better lubrication and heat transfer performances than single Nanoparticle additives. However, the use of hybrid Nanoparticles in nanofluid minimum quantity lubrication grinding has not been reported. This study aims to determine whether hybrid Nanoparticles have better lubrication performance than pure Nanoparticle. A hybrid nanofluid consisting of MoS2 Nanoparticles with good lubrication effect and CNTs with high heat conductivity coefficient is investigated. The effects of the hybrid nanofluid on grinding force, coefficient of friction, and workpiece surface quality for Ni-based alloy grinding are analyzed. Results show that the MoS2/CNT hybrid Nanoparticles achieve better lubrication effect than single Nanoparticles. The optimal MoS2/CNT mixing ratio and nanofluid concentration are 2:1 and 6 wt%, respectively.
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experimental evaluation of the lubrication performance of mos2 cnt nanofluid for minimal quantity lubrication in ni based alloy grinding
International Journal of Machine Tools & Manufacture, 2015Co-Authors: Yanbin Zhang, Changhe Li, Dongkun Zhang, Xiaowei ZhangAbstract:Abstract A nanofluid minimum quantity lubrication with addition of one kind of Nanoparticle has several limitations, such as grinding of difficult-to-cutting materials. Hybrid Nanoparticles integrate the properties of two or more kinds of Nanoparticles, thus having better lubrication and heat transfer performances than single Nanoparticle additives. However, the use of hybrid Nanoparticles in nanofluid minimum quantity lubrication grinding has not been reported. This study aims to determine whether hybrid Nanoparticles have better lubrication performance than pure Nanoparticle. A hybrid nanofluid consisting of MoS2 Nanoparticles with good lubrication effect and CNTs with high heat conductivity coefficient is investigated. The effects of the hybrid nanofluid on grinding force, coefficient of friction, and workpiece surface quality for Ni-based alloy grinding are analyzed. Results show that the MoS2/CNT hybrid Nanoparticles achieve better lubrication effect than single Nanoparticles. The optimal MoS2/CNT mixing ratio and nanofluid concentration are 2:1 and 6 wt%, respectively.
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experimental verification of Nanoparticle jet minimum quantity lubrication effectiveness in grinding
Journal of Nanoparticle Research, 2014Co-Authors: Dongzhou Jia, Dongkun Zhang, Yanbin Zhang, Xiaowei ZhangAbstract:In our experiment, K-P36 precision numerical control surface grinder was used for dry grinding, minimum quantity lubrication (MQL) grinding, Nanoparticle jet MQL grinding, and traditional flood grinding of hardened 45 steel. A three-dimensional dynamometer was used to measure grinding force in the experiment. In this research, experiments were conducted to measure and calculate specific tangential grinding force, frictional coefficient, and specific grinding energy, thus verifying the lubrication performance of Nanoparticles in surface grinding. Findings present that compared with dry grinding, the specific tangential grinding force of MQL grinding, Nanoparticle jet MQL grinding, and flood grinding decreased by 45.88, 62.34, and 69.33 %, respectively. Their frictional coefficient was reduced by 11.22, 29.21, and 32.18 %, and the specific grinding energy declined by 45.89, 62.34, and 69.45 %, respectively. Nanoparticle jet MQL presented ideal lubrication effectiveness, which was attributed to the friction oil film with strong antifriction and anti-wear features formed by Nanoparticles on the grinding wheel/workpiece interface. Moreover, lubricating properties of Nanoparticles of the same size (50 nm) but different types were verified through experimentation. In our experiment, ZrO2 Nanoparticles, polycrystal diamond (PCD) Nanoparticles, and MoS2 Nanoparticles were used in the comparison of Nanoparticle jet MQL grinding. The experimental results manifest that MoS2 Nanoparticles exhibited the optimal lubricating effectiveness, followed by PCD Nanoparticles. Our research also integrated the properties of different Nanoparticles to analyze the lubrication mechanisms of different Nanoparticles. The experiment further verified the impact of Nanoparticle concentration on the effectiveness of Nanoparticle jet MQL in grinding. The experimental results demonstrate that when the Nanoparticle mass fraction was 6 %, the minimum specific tangential grinding force, frictional coefficient, and specific grinding energy were 1.285 N/mm, 0.382, and 57.825 J/mm3, respectively. When Nanoparticle mass fraction was smaller than 6 %, lubrication effects of Nanoparticle jet MQL increased with the rising Nanoparticle mass fraction. When Nanoparticle mass fraction was larger than 6 %, lubrication effects of Nanoparticle jet MQL decreased with the rising Nanoparticle mass fraction.
Yanbin Zhang - One of the best experts on this subject based on the ideXlab platform.
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Experimental evaluation of the lubrication performance of MoS2/CNT nanofluid for minimal quantity lubrication in Ni-based alloy grinding
International Journal of Machine Tools & Manufacture, 2015Co-Authors: Yanbin Zhang, Changhe Li, Dongkun Zhang, Xiaowei ZhangAbstract:Abstract A nanofluid minimum quantity lubrication with addition of one kind of Nanoparticle has several limitations, such as grinding of difficult-to-cutting materials. Hybrid Nanoparticles integrate the properties of two or more kinds of Nanoparticles, thus having better lubrication and heat transfer performances than single Nanoparticle additives. However, the use of hybrid Nanoparticles in nanofluid minimum quantity lubrication grinding has not been reported. This study aims to determine whether hybrid Nanoparticles have better lubrication performance than pure Nanoparticle. A hybrid nanofluid consisting of MoS2 Nanoparticles with good lubrication effect and CNTs with high heat conductivity coefficient is investigated. The effects of the hybrid nanofluid on grinding force, coefficient of friction, and workpiece surface quality for Ni-based alloy grinding are analyzed. Results show that the MoS2/CNT hybrid Nanoparticles achieve better lubrication effect than single Nanoparticles. The optimal MoS2/CNT mixing ratio and nanofluid concentration are 2:1 and 6 wt%, respectively.
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experimental evaluation of the lubrication performance of mos2 cnt nanofluid for minimal quantity lubrication in ni based alloy grinding
International Journal of Machine Tools & Manufacture, 2015Co-Authors: Yanbin Zhang, Changhe Li, Dongkun Zhang, Xiaowei ZhangAbstract:Abstract A nanofluid minimum quantity lubrication with addition of one kind of Nanoparticle has several limitations, such as grinding of difficult-to-cutting materials. Hybrid Nanoparticles integrate the properties of two or more kinds of Nanoparticles, thus having better lubrication and heat transfer performances than single Nanoparticle additives. However, the use of hybrid Nanoparticles in nanofluid minimum quantity lubrication grinding has not been reported. This study aims to determine whether hybrid Nanoparticles have better lubrication performance than pure Nanoparticle. A hybrid nanofluid consisting of MoS2 Nanoparticles with good lubrication effect and CNTs with high heat conductivity coefficient is investigated. The effects of the hybrid nanofluid on grinding force, coefficient of friction, and workpiece surface quality for Ni-based alloy grinding are analyzed. Results show that the MoS2/CNT hybrid Nanoparticles achieve better lubrication effect than single Nanoparticles. The optimal MoS2/CNT mixing ratio and nanofluid concentration are 2:1 and 6 wt%, respectively.
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experimental verification of Nanoparticle jet minimum quantity lubrication effectiveness in grinding
Journal of Nanoparticle Research, 2014Co-Authors: Dongzhou Jia, Dongkun Zhang, Yanbin Zhang, Xiaowei ZhangAbstract:In our experiment, K-P36 precision numerical control surface grinder was used for dry grinding, minimum quantity lubrication (MQL) grinding, Nanoparticle jet MQL grinding, and traditional flood grinding of hardened 45 steel. A three-dimensional dynamometer was used to measure grinding force in the experiment. In this research, experiments were conducted to measure and calculate specific tangential grinding force, frictional coefficient, and specific grinding energy, thus verifying the lubrication performance of Nanoparticles in surface grinding. Findings present that compared with dry grinding, the specific tangential grinding force of MQL grinding, Nanoparticle jet MQL grinding, and flood grinding decreased by 45.88, 62.34, and 69.33 %, respectively. Their frictional coefficient was reduced by 11.22, 29.21, and 32.18 %, and the specific grinding energy declined by 45.89, 62.34, and 69.45 %, respectively. Nanoparticle jet MQL presented ideal lubrication effectiveness, which was attributed to the friction oil film with strong antifriction and anti-wear features formed by Nanoparticles on the grinding wheel/workpiece interface. Moreover, lubricating properties of Nanoparticles of the same size (50 nm) but different types were verified through experimentation. In our experiment, ZrO2 Nanoparticles, polycrystal diamond (PCD) Nanoparticles, and MoS2 Nanoparticles were used in the comparison of Nanoparticle jet MQL grinding. The experimental results manifest that MoS2 Nanoparticles exhibited the optimal lubricating effectiveness, followed by PCD Nanoparticles. Our research also integrated the properties of different Nanoparticles to analyze the lubrication mechanisms of different Nanoparticles. The experiment further verified the impact of Nanoparticle concentration on the effectiveness of Nanoparticle jet MQL in grinding. The experimental results demonstrate that when the Nanoparticle mass fraction was 6 %, the minimum specific tangential grinding force, frictional coefficient, and specific grinding energy were 1.285 N/mm, 0.382, and 57.825 J/mm3, respectively. When Nanoparticle mass fraction was smaller than 6 %, lubrication effects of Nanoparticle jet MQL increased with the rising Nanoparticle mass fraction. When Nanoparticle mass fraction was larger than 6 %, lubrication effects of Nanoparticle jet MQL decreased with the rising Nanoparticle mass fraction.
Won Jong Kim - One of the best experts on this subject based on the ideXlab platform.
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programmed Nanoparticle loaded Nanoparticles for deep penetrating 3d cancer therapy
Advanced Materials, 2018Co-Authors: Jinhwan Kim, Won-gwang Lim, Sungjin Jung, Yeong Mi Lee, Jun Lim, Changshin Jo, Jinwoo Lee, Haeshin Lee, Won Jong KimAbstract:Tumors are 3D, composed of cellular agglomerations and blood vessels. Therapies involving Nanoparticles utilize specific accumulations due to the leaky vascular structures. However, systemically injected Nanoparticles are mostly uptaken by cells located on the surfaces of cancer tissues, lacking deep penetration into the core cancer regions. Herein, an unprecedented strategy, described as injecting "Nanoparticle-loaded Nanoparticles" to address the long-lasting problem is reported for effective surface-to-core drug delivery in entire 3D tumors. The "Nanoparticle-loaded Nanoparticle" is a silica Nanoparticle (≈150 nm) with well-developed, interconnected channels (diameter of ≈30 nm), in which small gold Nanoparticles (AuNPs) (≈15 nm) with programmable DNA are located. The Nanoparticle (AuNPs)-loaded Nanoparticles (silica): (1) can accumulate in tumors through leaky vascular structures by protecting the inner therapeutic AuNPs during blood circulation, and then (2) allow diffusion of the AuNPs for penetration into the entire surface-to-core tumor tissues, and finally (3) release a drug triggered by cancer-characteristic pH gradients. The hierarchical "Nanoparticle-loaded Nanoparticle" can be a rational design for cancer therapies because the outer large Nanoparticles are effective in blood circulation and in protection of the therapeutic Nanoparticles inside, allowing the loaded small Nanoparticles to penetrate deeply into 3D tumors with anticancer drugs.
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Programmed Nanoparticle‐Loaded Nanoparticles for Deep‐Penetrating 3D Cancer Therapy
Advanced Materials, 2018Co-Authors: Jinhwan Kim, Won-gwang Lim, Sungjin Jung, Yeong Mi Lee, Jun Lim, Changshin Jo, Jinwoo Lee, Haeshin Lee, Won Jong KimAbstract:Tumors are 3D, composed of cellular agglomerations and blood vessels. Therapies involving Nanoparticles utilize specific accumulations due to the leaky vascular structures. However, systemically injected Nanoparticles are mostly uptaken by cells located on the surfaces of cancer tissues, lacking deep penetration into the core cancer regions. Herein, an unprecedented strategy, described as injecting "Nanoparticle-loaded Nanoparticles" to address the long-lasting problem is reported for effective surface-to-core drug delivery in entire 3D tumors. The "Nanoparticle-loaded Nanoparticle" is a silica Nanoparticle (≈150 nm) with well-developed, interconnected channels (diameter of ≈30 nm), in which small gold Nanoparticles (AuNPs) (≈15 nm) with programmable DNA are located. The Nanoparticle (AuNPs)-loaded Nanoparticles (silica): (1) can accumulate in tumors through leaky vascular structures by protecting the inner therapeutic AuNPs during blood circulation, and then (2) allow diffusion of the AuNPs for penetration into the entire surface-to-core tumor tissues, and finally (3) release a drug triggered by cancer-characteristic pH gradients. The hierarchical "Nanoparticle-loaded Nanoparticle" can be a rational design for cancer therapies because the outer large Nanoparticles are effective in blood circulation and in protection of the therapeutic Nanoparticles inside, allowing the loaded small Nanoparticles to penetrate deeply into 3D tumors with anticancer drugs.
Dongkun Zhang - One of the best experts on this subject based on the ideXlab platform.
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Experimental evaluation of the lubrication performance of MoS2/CNT nanofluid for minimal quantity lubrication in Ni-based alloy grinding
International Journal of Machine Tools & Manufacture, 2015Co-Authors: Yanbin Zhang, Changhe Li, Dongkun Zhang, Xiaowei ZhangAbstract:Abstract A nanofluid minimum quantity lubrication with addition of one kind of Nanoparticle has several limitations, such as grinding of difficult-to-cutting materials. Hybrid Nanoparticles integrate the properties of two or more kinds of Nanoparticles, thus having better lubrication and heat transfer performances than single Nanoparticle additives. However, the use of hybrid Nanoparticles in nanofluid minimum quantity lubrication grinding has not been reported. This study aims to determine whether hybrid Nanoparticles have better lubrication performance than pure Nanoparticle. A hybrid nanofluid consisting of MoS2 Nanoparticles with good lubrication effect and CNTs with high heat conductivity coefficient is investigated. The effects of the hybrid nanofluid on grinding force, coefficient of friction, and workpiece surface quality for Ni-based alloy grinding are analyzed. Results show that the MoS2/CNT hybrid Nanoparticles achieve better lubrication effect than single Nanoparticles. The optimal MoS2/CNT mixing ratio and nanofluid concentration are 2:1 and 6 wt%, respectively.
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experimental evaluation of the lubrication performance of mos2 cnt nanofluid for minimal quantity lubrication in ni based alloy grinding
International Journal of Machine Tools & Manufacture, 2015Co-Authors: Yanbin Zhang, Changhe Li, Dongkun Zhang, Xiaowei ZhangAbstract:Abstract A nanofluid minimum quantity lubrication with addition of one kind of Nanoparticle has several limitations, such as grinding of difficult-to-cutting materials. Hybrid Nanoparticles integrate the properties of two or more kinds of Nanoparticles, thus having better lubrication and heat transfer performances than single Nanoparticle additives. However, the use of hybrid Nanoparticles in nanofluid minimum quantity lubrication grinding has not been reported. This study aims to determine whether hybrid Nanoparticles have better lubrication performance than pure Nanoparticle. A hybrid nanofluid consisting of MoS2 Nanoparticles with good lubrication effect and CNTs with high heat conductivity coefficient is investigated. The effects of the hybrid nanofluid on grinding force, coefficient of friction, and workpiece surface quality for Ni-based alloy grinding are analyzed. Results show that the MoS2/CNT hybrid Nanoparticles achieve better lubrication effect than single Nanoparticles. The optimal MoS2/CNT mixing ratio and nanofluid concentration are 2:1 and 6 wt%, respectively.
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experimental verification of Nanoparticle jet minimum quantity lubrication effectiveness in grinding
Journal of Nanoparticle Research, 2014Co-Authors: Dongzhou Jia, Dongkun Zhang, Yanbin Zhang, Xiaowei ZhangAbstract:In our experiment, K-P36 precision numerical control surface grinder was used for dry grinding, minimum quantity lubrication (MQL) grinding, Nanoparticle jet MQL grinding, and traditional flood grinding of hardened 45 steel. A three-dimensional dynamometer was used to measure grinding force in the experiment. In this research, experiments were conducted to measure and calculate specific tangential grinding force, frictional coefficient, and specific grinding energy, thus verifying the lubrication performance of Nanoparticles in surface grinding. Findings present that compared with dry grinding, the specific tangential grinding force of MQL grinding, Nanoparticle jet MQL grinding, and flood grinding decreased by 45.88, 62.34, and 69.33 %, respectively. Their frictional coefficient was reduced by 11.22, 29.21, and 32.18 %, and the specific grinding energy declined by 45.89, 62.34, and 69.45 %, respectively. Nanoparticle jet MQL presented ideal lubrication effectiveness, which was attributed to the friction oil film with strong antifriction and anti-wear features formed by Nanoparticles on the grinding wheel/workpiece interface. Moreover, lubricating properties of Nanoparticles of the same size (50 nm) but different types were verified through experimentation. In our experiment, ZrO2 Nanoparticles, polycrystal diamond (PCD) Nanoparticles, and MoS2 Nanoparticles were used in the comparison of Nanoparticle jet MQL grinding. The experimental results manifest that MoS2 Nanoparticles exhibited the optimal lubricating effectiveness, followed by PCD Nanoparticles. Our research also integrated the properties of different Nanoparticles to analyze the lubrication mechanisms of different Nanoparticles. The experiment further verified the impact of Nanoparticle concentration on the effectiveness of Nanoparticle jet MQL in grinding. The experimental results demonstrate that when the Nanoparticle mass fraction was 6 %, the minimum specific tangential grinding force, frictional coefficient, and specific grinding energy were 1.285 N/mm, 0.382, and 57.825 J/mm3, respectively. When Nanoparticle mass fraction was smaller than 6 %, lubrication effects of Nanoparticle jet MQL increased with the rising Nanoparticle mass fraction. When Nanoparticle mass fraction was larger than 6 %, lubrication effects of Nanoparticle jet MQL decreased with the rising Nanoparticle mass fraction.
Christine K Payne - One of the best experts on this subject based on the ideXlab platform.
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Cellular binding of anionic Nanoparticles is inhibited by serum proteins independent of Nanoparticle composition
Biomaterials science, 2013Co-Authors: Candace C. Fleischer, Umesh Kumar, Christine K PayneAbstract:Nanoparticles used in biological applications encounter a complex mixture of extracellular proteins. Adsorption of these proteins on the Nanoparticle surface results in the formation of a “protein corona,” which can dominate the interaction of the Nanoparticle with the cellular environment. The goal of this research was to determine how Nanoparticle composition and surface modification affect the cellular binding of protein-Nanoparticle complexes. We examined the cellular binding of a collection of commonly used anionic Nanoparticles: quantum dots, colloidal gold Nanoparticles, and low-density lipoprotein particles, in the presence and absence of extracellular proteins. These experiments have the advantage of comparing different Nanoparticles under identical conditions. Using a combination of fluorescence and dark field microscopy, flow cytometry, and spectroscopy, we find that cellular binding of these anionic Nanoparticles is inhibited by serum proteins independent of Nanoparticle composition or surface modification. We expect these results will aid in the design of Nanoparticles for in vivo applications.
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Nanoparticle Surface Charge Directs the Cellular Binding of Nanoparticle-Protein Complexes
Biophysical Journal, 2013Co-Authors: Candace C. Fleischer, Christine K PayneAbstract:Nanoparticles are commonly utilized in biological systems as imaging probes, drug delivery agents and in vivo sensors. In most biological applications, the Nanoparticle is exposed to a complex mixture of extracellular proteins that adsorb non-specifically to the Nanoparticle surface. The resulting “protein corona” can dominate the interactions of the Nanoparticle with the cellular membrane. We have focused on the role of Nanoparticle surface charge in the cellular binding of Nanoparticles in the presence of extracellular proteins. Cationic, amine-modified polystyrene Nanoparticles and anionic, carboxylate-modified polystyrene Nanoparticles were studied as a model system. The cellular binding of cationic and anionic Nanoparticles is distinctly different, determined from fluorescence microscopy experiments. For cationic Nanoparticles, the cellular binding is increased in the presence of serum proteins. In comparison, anionic Nanoparticle binding is inhibited by the presence of serum proteins. Competition assays performed with flow cytometry allowed us to quantify differences in binding and to identify the cellular receptors used by the Nanoparticle-protein complexes. We have determined that complexes formed with anionic Nanoparticles bind to native protein receptors, while those formed with cationic Nanoparticles bind to scavenger receptors. These results indicate that for Nanoparticles used in biological applications, the initial surface charge of the Nanoparticle mediates cellular binding. Currently, we are extending our studies to Nanoparticles used for drug and gene delivery.
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Nanoparticle surface charge mediates the cellular receptors used by protein-Nanoparticle complexes.
The journal of physical chemistry. B, 2012Co-Authors: Candace C. Fleischer, Christine K PayneAbstract:Nanoparticles are increasingly important for biological applications ranging from drug delivery to cellular imaging. In the course of these applications, Nanoparticles are exposed to a complex environment of extracellular proteins that can be adsorbed onto the surface of the Nanoparticle, altering Nanoparticle–cell interactions. We have investigated how proteins found in blood serum affect the binding of Nanoparticles to the surface of cells. Using fluorescence microscopy, we find that the cellular binding of cationic Nanoparticles is enhanced by the presence of serum proteins, while the binding of anionic Nanoparticles is inhibited. We have determined that this difference in cellular binding is due to the use of distinct cellular receptors. Competition assays, quantified with flow cytometry, show that the protein–Nanoparticle complex formed from the cationic Nanoparticles binds to scavenger receptors on the cell surface. Interestingly, the protein–Nanoparticle complex formed from anionic Nanoparticles bi...
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Nanoparticle Surface Charge Mediates the Cellular Receptors Used by Protein–Nanoparticle Complexes
The Journal of Physical Chemistry, 2012Co-Authors: Candace C. Fleischer, Christine K PayneAbstract:Nanoparticles are increasingly important for biological applications ranging from drug delivery to cellular imaging. In the course of these applications, Nanoparticles are exposed to a complex environment of extracellular proteins that can be adsorbed onto the surface of the Nanoparticle, altering Nanoparticle–cell interactions. We have investigated how proteins found in blood serum affect the binding of Nanoparticles to the surface of cells. Using fluorescence microscopy, we find that the cellular binding of cationic Nanoparticles is enhanced by the presence of serum proteins, while the binding of anionic Nanoparticles is inhibited. We have determined that this difference in cellular binding is due to the use of distinct cellular receptors. Competition assays, quantified with flow cytometry, show that the protein–Nanoparticle complex formed from the cationic Nanoparticles binds to scavenger receptors on the cell surface. Interestingly, the protein–Nanoparticle complex formed from anionic Nanoparticles binds to native protein receptors. As Nanoparticles become increasingly important for in vivo applications, we expect these results will inform the design of Nanoparticles with improved cellular binding.
