The Experts below are selected from a list of 264 Experts worldwide ranked by ideXlab platform
Hailin Tang - One of the best experts on this subject based on the ideXlab platform.
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irgd modified lipid polymer hybrid nanoparticles loaded with isoliquiritigenin to enhance anti breast cancer Effect and tumor targeting ability
International Journal of Nanomedicine, 2017Co-Authors: Fei Gao, Jinming Zhang, Xiaoming Xie, Fu Peng, Jieshu You, Hailin TangAbstract:Isoliquiritigenin (ISL), a natural anti-breast cancer dietary compound, has poor delivery characteristics and low bioavailability. In order to promote the therapeutic outcome of ISL, a tumor-targeting lipid-polymer hybrid nanoparticle (NP) system modified by tumor-homing iRGD peptides has been developed. The hybrid NPs were prepared by a modified single-step nanoprecipitation method to encapsulate ISL. iRGD peptides were anchored on the surface by a postinsertion method (ISL-iRGD NPs). The stable lipid-polymer structure of ISL-iRGD NPs, with high encapsulation and loading efficiency, was confirmed. Compared to free ISL and non-iRGD-modified counterparts, ISL-iRGD NPs showed higher cytotoxicity and cell apoptosis against the different type of breast cancer cells. This was attributable to higher cellular accumulation mediated by the iRGD-integrin recognition and the Nanoscale Effect. More importantly, based on the active tumor-tissue accumulation by iRGD peptides and the prolonged in vivo circulation by the stealth nanostructure, ISL-iRGD NPs displayed higher tumor-growth inhibition efficiency in 4T1-bearing breast-tumor mouse models. Therefore, the constructed iRGD modified lipid-polymer hybrid NPs would provide a promising drug-delivery strategy to improve ISL in anti-breast cancer efficacy.
Jianbin Luo - One of the best experts on this subject based on the ideXlab platform.
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Nanoscale Effect on Ultrathin Gas Film Lubrication in Hard Disk Drive
Journal of Tribology, 2004Co-Authors: Yongqing Peng, Jianbin LuoAbstract:Since the current thickness of the gas film between the slider and the disk in Hard Disk Drive is already only one order of magnitude larger than the diameter of gas molecules, the Nanoscale Effect cannot be neglected any longer In this paper a Nanoscale Effect function, N p is proposed by investigating the unidirectional flow of the rarefied gas between two parallel plates, and four kinds of formerly and currently employed lubrication models are modified. The calculated results using the modified Reynolds equations indicate that the Nanoscale Effect weaken the rarefaction Effect to some extent for ultra-thin gas film lubrication.
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A new lubrication equation for ultra-thin gas film in hard disk drives
Science China-physics Mechanics & Astronomy, 2004Co-Authors: Yongqing Peng, Jianbin LuoAbstract:To overcome the complicated and time-consuming difficulties of current models, a new lubrication equation based on boundary velocity slip model for solving the ultra-thin film gas lubrication in hard disk drives is proposed by adopting the Nanoscale Effect function, N p. The present model is easy to calculate and applicable at Nanoscale. The results of numerical calculations indicate that the present model produces a close approximation to that of the exact Boltzmann model.
Danfeng Pei - One of the best experts on this subject based on the ideXlab platform.
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liquid metal initiator of ring opening polymerization self capsulation into thermal photomoldable powder for multifunctional composites
Advanced Materials, 2020Co-Authors: Qinghui Shou, Li Zhou, Danfeng PeiAbstract:Liquid metal nanodroplets not only share similar metallic properties and Nanoscale Effect with solid metal nanoparticles, but also possess the additional uniqueness in nonvolatile fluidity and ambient sintering ability into continuous conductors. In most cases, liquid metal nanodroplets are encapsulated into ultrathin and fragile shells of oxides and amphiphile monolayers, and may be hindered from incorporating homogeneously into various composites through conventional processing methods. In this study, ring-opening polymerization is found to be initiated by sonicating the liquid metal EGaIn in fluidic lactones. By this in situ polymerization, EGaIn nanodroplets are encapsulated into polylactone shells with tunable thickness, which can further be dried into a solid powder. Besides high chemical stability and dispersibility in organic solvents, the powder of the EGaIn capsules combines the exceptional properties of the EGaIn droplets (e.g., photothermal Effect) and the polylactone shells (e.g., biocompatibility, biodegradability, and compatibility with different polymer matrixes), being capable of being introduced into thermoplastic composites through liquid casting and thermal- or photomolding for the notch-insensitive tearing property, sintering-induced electric conductivity, and photothermal Effect. Thus, the EGaIn initiator of ring-opening polymerization may start a pathway to produce stable andthermal/photomoldable powders of EGaIn capsules and their multifunctionalcomposites, applicable in biomedicines, soft electronics, and smart robots.
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Liquid Metal Initiator of Ring-Opening Polymerization: Self-Capsulation into Thermal/Photomoldable Powder for Multifunctional Composites.
Advanced materials (Deerfield Beach Fla.), 2020Co-Authors: Qinghui Shou, Li Zhou, Danfeng PeiAbstract:Liquid metal nanodroplets not only share similar metallic properties and Nanoscale Effect with solid metal nanoparticles, but also possess the additional uniqueness in nonvolatile fluidity and ambient sintering ability into continuous conductors. In most cases, liquid metal nanodroplets are encapsulated into ultrathin and fragile shells of oxides and amphiphile monolayers, and may be hindered from incorporating homogeneously into various composites through conventional processing methods. In this study, ring-opening polymerization is found to be initiated by sonicating the liquid metal EGaIn in fluidic lactones. By this in situ polymerization, EGaIn nanodroplets are encapsulated into polylactone shells with tunable thickness, which can further be dried into a solid powder. Besides high chemical stability and dispersibility in organic solvents, the powder of the EGaIn capsules combines the exceptional properties of the EGaIn droplets (e.g., photothermal Effect) and the polylactone shells (e.g., biocompatibility, biodegradability, and compatibility with different polymer matrixes), being capable of being introduced into thermoplastic composites through liquid casting and thermal- or photomolding for the notch-insensitive tearing property, sintering-induced electric conductivity, and photothermal Effect. Thus, the EGaIn initiator of ring-opening polymerization may start a pathway to produce stable andthermal/photomoldable powders of EGaIn capsules and their multifunctionalcomposites, applicable in biomedicines, soft electronics, and smart robots.
Li Yang - One of the best experts on this subject based on the ideXlab platform.
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Preparation of a Nanoscale homogeneous energetic lead azides@porous carbon hybrid with high ignition ability by in situ synthesis
RSC Advances, 2020Co-Authors: Zhenzhan Yan, Li Yang, Ji-min Han, Naimeng Song, Jian-chao LiuAbstract:The ever-increasing demand for miniaturized explosive systems urgently calls for better performance studies through the synthesis of novel Nanoscale materials. In this work, lead azide@porous carbon hybrids (LA@PC) are synthesized by in situ carbonization and azidation of a lead-containing cross-linked gel, in which the Nanoscale LA is uniformly distributed on the porous carbon skeleton. The detailed characterization has shown that such outstanding performance stems from the LA Nanoscale Effect and the excellent conductivity and thermal conductivity of carbon cages. Because of the favorable unique structure, the prepared composite material exhibits excellent ignition performance, and its flame sensitivity can reach 42 cm, which solves the problem of poor ignition capacity of LA on all occasions. In addition, the composite has very low electrostatic sensitivity, further improving the safety of practical application. This work makes it possible for LA to be detonated without using lead styphnate, paving a new way for improving the flame sensitivity of primary explosives.
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Nanoscale Effect on Thermal Decomposition of 2,2′,4,4′,6,6′-Hexanitrostilbene by Dynamic Pressure Measuring Thermal Analysis
Journal of Energetic Materials, 2014Co-Authors: Rui Liu, Tonglai Zhang, Zunning Zhou, Li YangAbstract:2,2′,4,4′,6,6′-Hexanitrostilbene (HNS) was prepared into nano- and microscale particles. The thermal decomposition behaviors were investigated using dynamic pressure measuring thermal analysis. The released gas amount and apparent activation energy show that the nanoparticles (NPs) have higher reaction activity and faster reaction rate and experience more drastic autocatalytic reaction than the microparticles (MPs). A reduction in particle size to Nanoscale decreases the energy barrier of thermal decomposition and influences the reaction mechanism. The “trinitrotoluene mechanism,” which is the homolysis via hydrogen transfer to form a six-membered transition state, corresponds to the initial decomposition of HNS. The Nanoscale Effect is attributed to the surface properties of NPs, including high surface energy, rapid mass and heat transfer, and numerous active reaction sites on the reactant interface.
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Nanoscale Effect on thermal decomposition kinetics of organic particles: dynamic vacuum stability test of 1,3,5-triamino-2,4,6-trinitrobenzene
Physical chemistry chemical physics : PCCP, 2013Co-Authors: Rui Liu, Tonglai Zhang, Li Yang, Zunning ZhouAbstract:Despite the extensive research that has been carried out on organic nanoparticles, little explanation has been provided for the reasons behind their exceptional properties. In this work, the Effect of the particles being on the Nanoscale on the thermal decomposition kinetics of organic particles was examined by means of a dynamic vacuum stability test. Nano- and microscale particles of 1,3,5-triamino-2,4,6-trinitrobenzene were measured for comparison. Analysis of the evolved gas revealed that the nanoparticles (NPs) show much higher reaction activity than the microparticles (MPs). Both the non-isothermal and isothermal reaction mechanisms and kinetics were computed. The NPs and MPs exhibit different reaction mechanisms, while similarly sized particles follow different mechanisms for different stages of the reaction. The mechanisms for the NPs are affected by the temperature in the range considered. NPs have larger values for the apparent activation energy (Ea) and pre-exponential factor (A) than MPs and the relationship of Ea to A demonstrates that a kinetic compensation Effect is evident. The Nanoscale Effect shows there to be a significant influence on the apparent performances and kinetics as well as on the intrinsic reaction mechanisms of organic particles. This Effect can be attributed to the surface properties of NPs, where the high surface area contributes to efficient mass transfer and heat transfer, thus leading to numerous activated molecules being involved in the reaction.
Fei Gao - One of the best experts on this subject based on the ideXlab platform.
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irgd modified lipid polymer hybrid nanoparticles loaded with isoliquiritigenin to enhance anti breast cancer Effect and tumor targeting ability
International Journal of Nanomedicine, 2017Co-Authors: Fei Gao, Jinming Zhang, Xiaoming Xie, Fu Peng, Jieshu You, Hailin TangAbstract:Isoliquiritigenin (ISL), a natural anti-breast cancer dietary compound, has poor delivery characteristics and low bioavailability. In order to promote the therapeutic outcome of ISL, a tumor-targeting lipid-polymer hybrid nanoparticle (NP) system modified by tumor-homing iRGD peptides has been developed. The hybrid NPs were prepared by a modified single-step nanoprecipitation method to encapsulate ISL. iRGD peptides were anchored on the surface by a postinsertion method (ISL-iRGD NPs). The stable lipid-polymer structure of ISL-iRGD NPs, with high encapsulation and loading efficiency, was confirmed. Compared to free ISL and non-iRGD-modified counterparts, ISL-iRGD NPs showed higher cytotoxicity and cell apoptosis against the different type of breast cancer cells. This was attributable to higher cellular accumulation mediated by the iRGD-integrin recognition and the Nanoscale Effect. More importantly, based on the active tumor-tissue accumulation by iRGD peptides and the prolonged in vivo circulation by the stealth nanostructure, ISL-iRGD NPs displayed higher tumor-growth inhibition efficiency in 4T1-bearing breast-tumor mouse models. Therefore, the constructed iRGD modified lipid-polymer hybrid NPs would provide a promising drug-delivery strategy to improve ISL in anti-breast cancer efficacy.
