The Experts below are selected from a list of 11553 Experts worldwide ranked by ideXlab platform
Tianfeng Chen - One of the best experts on this subject based on the ideXlab platform.
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sequentially triggered delivery system of black phosphorus quantum dots with surface charge switching ability for precise tumor radiosensitization
ACS Nano, 2018Co-Authors: Leung Chan, Pan Gao, Wenhua Zhou, Chaoming Mei, Yanyu Huang, Paul K Chu, Tianfeng ChenAbstract:Cancer radiotherapy suffers from drawbacks such as radiation resistance of hypoxic cells, excessive radiation that causes damage of adjacent healthy tissues, and concomitant side effects. Hence, radiotherapy sensitizers with improved radiotherapeutic performance and requiring a relatively small radiation dose are highly desirable. In this study, a nanosystem based on poly(lactic- co-glycolic acid) (PLGA) and ultrasmall black phosphorus quantum dots (BPQDs) is designed and prepared to accomplish precise tumor radiosensitization. The PLGA nanoparticles act as carriers to package the BPQDs to avoid off-target release and rapid degradation during blood circulation. The nanosystem that targets the polypeptide peptide motif Arg-Gly-Asp-Gys actively accumulates in tumor tissues. The 2,3-dimethylmaleic anhydride shell decomposes in an acidic microenvironment, and the nanoparticles become positively charged, thereby favoring cellular uptake. Furthermore, glutathione (GSH) deoxidizes the disulfide bond of cystamine and sequentially triggers release of BPQDs, rendering tumor cells sensitive to radiotherapy. The treatment utilizing the PLGA-SS-D@BPQDs nanosystem and X-ray induces cell apoptosis triggered by overproduction of reactive oxygen species. In the in vivo study, the nanosystem shows excellent radiotherapy sensitization efficiency but negligible histological damage of the major organs. This study provides insights into the design and fabrication of surface-charge-switching and pH-responsive Nanosystems as potent radiosensitizers to achieve excellent radiotherapy sensitization efficacy and negligible toxic side effects.
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therapeutic Nanosystems co deliver anticancer drugs and oncogene sirna to achieve synergetic precise cancer chemo gene therapy
Journal of Materials Chemistry B, 2018Co-Authors: Wei Huang, Chaoming Mei, Yuanwei Liang, Chengcheng Sang, Tianfeng ChenAbstract:Co-delivering a chemotherapeutic agent and cancer-specific small interfering RNA (siRNA) as a new therapeutic modality provides a promising strategy for cancer treatment. In this study, we designed and described a cancer-target and pH-sensitivity nanosystem (RGD-SeNPs/siRNA) which has a DOX-loaded SeNPs core and c-myc siRNA-delivered PAMAM-RGD decoration for combination therapy against glioblastoma. The nanosystem exhibited high stability in water and FBS solutions for a long time. PAMAM-RGD surface decoration significantly enhanced the cellular uptake of RGD-SeNPs/siRNA and increased the selectivity between normal and cancer cells. More importantly, the nanosystem expanded to petaloid particles under pH 5.3 circumstance, which prolonged the duration of drugs after ingestion and reduced undesirable side effects. In addition, a blood-brain barrier (BBB) model we established in vitro revealed the nanosystem effectively penetrated BBB and enhanced antitumor activity. Moreover, the nanosystem also exhibited excellent advantages in penetrating ability and inhibitory effects on U251 tumor spheroids, demonstrating its in vivo anticancer potential. Therefore, this study provides a strategy for the design of cancer-targeted nanoplatforms as carriers of oncogene siRNA and chemotherapeutics to achieve synergistic cancer therapy.
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Designing multifunctional cancer-targeted nanosystem for magnetic resonance molecular imaging-guided theranostics of lung cancer
2018Co-Authors: Peng Gao, Leung Chan, Chaoming Mei, Tianfeng Chen, Zeyu Xiao, Dong Zhang, Changzheng Shi, Liangping LuoAbstract:The integration of diagnosis and therapy is an effective way to improve therapeutic effects for cancer patients, which has acquired widely attentions from researchers. Herein, a multifunctional drug-loaded nanosystem (F/A-PLGA@DOX/SPIO) has been designed and synthesized to reduce the side effects of traditional chemotherapy drugs and realize simultaneous tumor diagnosis and treatment. The surface modification of folic acid (FA) and activatable cell-penetrating peptide (ACPP) endows the nanosystem with excellent cancer targeting capabilities, thus reducing toxicity to normal organs. Besides, the F/A-PLGA@DOX/SPIO nanosystem can serve as an excellent magnetic resonance imaging (MRI) T2-negative contrast agent. More importantly, according to in vitro experiments, the F/A-PLGA@DOX/SPIO nanosystem can promote the overproduction of reactive oxygen species (ROS) within A549 lung cancer cells, inducing cell apoptosis, greatly enhancing the antineoplastic effect. Furthermore, with the help of MRI technology, the targeting imaging of the F/A-PLGA@DOX/SPIO nanosystem within tumors and the dynamic monitoring of medicine efficacy can be realized. Therefore, this study provided a multifunctional drug-loaded F/A-PLGA@DOX/SPIO targeted nanosystem for magnetic resonance molecular imaging-guided theranostics, which has excellent potential for the application in tumor diagnosis and therapy.
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a sequentially triggered nanosystem for precise drug delivery and simultaneous inhibition of cancer growth migration and invasion
Advanced Functional Materials, 2016Co-Authors: Ting Liu, Lanhai Lai, Zhenhuan Song, Tianfeng ChenAbstract:The rational design of cancer-targeted and bioresponsive drug delivery vehicles can enhance the anticancer efficacy of conventional chemotherapeutics and reduce their adverse side effects. However, the complexity of precise delivery and the ability to trigger drug release in specific tumor sites remain a challenging puzzle. Here, a sequentially triggered nanosystem composed of HER2 antibody with disulfide linkage as a surface decorator (HER2@NPs) is constructed for precise drug delivery and the simultaneous inhibition of cancer growth, migration, and invasion. The nanosystem actively accumulates in cancer cells, undergoes self-immolative cleavage in response to biological thiols, and is degraded to form small nanoparticles. After internalization by receptor-mediated endocytosis, the nanoparticles further disassemble under acidic conditions in the presence of lysozymes and cell lysates, leading to sequentially triggered drug release. The released payload triggers overproduction of reactive oxygen species and activates p53 and MAPKs pathways to induce cancer cell apoptosis. Moreover, HER2@NPs markedly suppress the migration and invasion of human bladder cancer cells at nontoxic concentrations. HER2@NPs demonstrate potent in vivo anticancer efficacy, but show no obvious histological damage to the major organs. Taken together, this study provides a valid tactic for the rational design of sequentially triggered Nanosystems for precise drug delivery and cancer therapy.
Hao Wang - One of the best experts on this subject based on the ideXlab platform.
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smart supramolecular Nanosystems for bioimaging and drug delivery
ChemInform, 2015Co-Authors: Peipei Yang, Lei Wang, Hao WangAbstract:The application of smart supramolecular Nanosystems in biomedicine increases rapidly and offers promising prospects for disease diagnostics and therapeutics. Supramolecular Nanosystems such as liposomes, micelles, organic nanoaggregates and metallic nanostructures etc. have been widely explored as diagnostic/therapeutic tools. Here, we review the recent advances in supramolecular Nanosystems with different built-in reporters, e.g., fluorescent, magnetic and photoacoustic signals for bioimaging. In addition, the substantial progress of supramolecular Nanosystems as drug delivery carriers for cancer therapy, including chemotherapy, photothermal and photodynamic therapies is also summarized.
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host guest supramolecular Nanosystems for cancer diagnostics and therapeutics
Advanced Materials, 2013Co-Authors: Lei Wang, Yunshan Fan, Hao WangAbstract:Extensive efforts have been devoted to the construction of functional supramolecular Nanosystems for applications in catalysis, energy conversion, sensing and biomedicine. The applications of supramolecular Nanosystems such as liposomes, micelles, inorganic nanoparticles, carbon materials for cancer diagnostics and therapeutics have been reviewed by other groups. Here, we will focus on the recent momentous advances in the implementation of typical supramolecular hosts (i.e., cyclodextrins, calixarenes, cucurbiturils and metallo-hosts) and their Nanosystems in cancer diagnostics and therapeutics. We discuss the evolutive process of supramolecular Nanosystems from the structural control and characterization to their diagnostic and therapeutic function exploitation and even the future potentials for clinical translation.
Weijing Yang - One of the best experts on this subject based on the ideXlab platform.
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functional t cell activation by smart Nanosystems for effective cancer immunotherapy
Nano Today, 2019Co-Authors: Weijing Yang, Zijian Zhou, Joseph Lau, Xiaoyuan ChenAbstract:Abstract Immunotherapy (e.g., checkpoint blockade, adoptive T cell therapy, cancer vaccine) has emerged as one of the most important treatment modalities for cancer in the past two decades. While these approaches are promising, the response rates observed in clinical trials are less than 30% due to tumor heterogeneity and complexity of the tumor microenvironment. Smart Nanosystems have the potential to address some of the limitations associated with immunotherapy. Herein, we review applications of nanosystem-mediated immunotherapy for functional T cell activation, including formation of artificial antigen presenting cells, cancer nanovaccination, tumor microenvironment modulation, and combination therapy. Finally, we propose areas of research for the future development of nanosystem-mediated cancer immunotherapy.
Hak Soo Choi - One of the best experts on this subject based on the ideXlab platform.
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theranostic Nanosystems for targeted cancer therapy
Nano Today, 2018Co-Authors: Homan Kang, Mi Hyeon Cho, Suk Ho Hong, Yongdoo Choi, Hak Soo ChoiAbstract:Abstract Nanomaterials have revolutionized cancer imaging, diagnosis, and treatment. Multifunctional nanoparticles in particular have been designed for targeted cancer therapy by modulating their physicochemical properties to be delivered to the target and activated by internal and/or external stimuli. This review will focus on the fundamental “chemical” design considerations of stimuli-responsive Nanosystems to achieve favorable tumor targeting beyond biological barriers and, furthermore, enhance targeted cancer therapy. In addition, we will summarize innovative smart Nanosystems responsive to external stimuli (e.g., light, magnetic field, ultrasound, and electric field) and internal stimuli in the tumor microenvironment (e.g., pH, enzyme, redox potential, and oxidative stress).
Xiaoyuan Chen - One of the best experts on this subject based on the ideXlab platform.
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functional t cell activation by smart Nanosystems for effective cancer immunotherapy
Nano Today, 2019Co-Authors: Weijing Yang, Zijian Zhou, Joseph Lau, Xiaoyuan ChenAbstract:Abstract Immunotherapy (e.g., checkpoint blockade, adoptive T cell therapy, cancer vaccine) has emerged as one of the most important treatment modalities for cancer in the past two decades. While these approaches are promising, the response rates observed in clinical trials are less than 30% due to tumor heterogeneity and complexity of the tumor microenvironment. Smart Nanosystems have the potential to address some of the limitations associated with immunotherapy. Herein, we review applications of nanosystem-mediated immunotherapy for functional T cell activation, including formation of artificial antigen presenting cells, cancer nanovaccination, tumor microenvironment modulation, and combination therapy. Finally, we propose areas of research for the future development of nanosystem-mediated cancer immunotherapy.
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x ray activated Nanosystems for theranostic applications
Chemical Society Reviews, 2019Co-Authors: Xiaofeng Chen, Xiaoyuan Chen, Jibin Song, Huanghao YangAbstract:X-rays are widely applied in clinical medical facilities for radiotherapy (RT) and biomedical imaging. However, the sole use of X-rays for cancer treatment leads to insufficient radiation energy deposition due to the low X-ray attenuation coefficients of living tissues and organs, producing unavoidable excessive radiation doses with serious side effects to healthy body parts. Over the past decade, developments in materials science and nanotechnology have led to rapid progress in the field of X-ray-activated tumor-targeting Nanosystems, which are able to tackle even systemic tumors and relieve the burden of exposure to large radiation doses. Additionally, novel imaging contrast agents and techniques have also been developed. In comparison with conventional external light sources (e.g., near infrared), the X-ray technique is ideal for the activation of Nanosystems for cancer treatment and biomedical imaging applications due to its nearly unlimited penetration depth in living tissues and organisms. In this review, we systematically describe the interaction mechanisms between X-rays and Nanosystems, and provide an overview of X-ray-sensitive materials and the recent progress on X-ray-activated Nanosystems for cancer-associated theranostic applications.
