The Experts below are selected from a list of 285 Experts worldwide ranked by ideXlab platform
Alexander F. Pozharskii - One of the best experts on this subject based on the ideXlab platform.
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tandem synthesis of 10 dimethylaminobenzo h quinazolines from 2 ketimino 1 8 bis dimethylamino Naphthalenes via nucleophilic replacement of the unactivated aromatic nme2 group
Organic Letters, 2016Co-Authors: Vladimir Y Mikshiev, Alexander S Antonov, Alexander F. PozharskiiAbstract:It has been found that 2-bromo-1,8-bis(dimethylamino)Naphthalene on sequential treatment with n-BuLi and 2 equiv of the same or different aryl(hetaryl) cyanide as a result of [2 + 2 + 2] nucleophilic cascade annulation produces 10-dimethylaminobenzo[h]quinazolines, as yet unknown NMe2/–N═ analogues of the proton sponge. It is even more convenient to use preliminarily prepared 2-ketimino-1,8-bis(dimethylamino)Naphthalenes as starting material. The substitution of both peri-NMe2 groups furnishing quinazolino[7,8-h]quinazoline derivatives is also possible. The process is remarkable by surprisingly mild nucleophilic displacement of an unactivated aromatic NMe2 group.
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base promoted transformation of 2 c o r 1 8 bis dimethylamino Naphthalenes into benzo g indole derivatives
Mendeleev Communications, 2015Co-Authors: Svetlana G Kachalkina, I. G. Borodkina, Alexander S Antonov, Yuri F Maltsev, Gennadii S Borodkin, E. A. Filatova, Alexander F. Pozharskii, Aleksander Filarowski, Valery A. OzeryanskiiAbstract:1,8-Bis(dimethylamino)Naphthalenes bearing 2-positioned trifluoroacetyl or ethoxycarbonyl group on treatment with 2-lithio-1,8-bis-dimethylamino)Naphthalene undergo base-promoted transformation into benzo[g]indole derivatives in small to moderate yield, representing previously unknown mode of the pyrrole ring closure which proceeds via deprotonation of the NMe group.
Rebecca Symons - One of the best experts on this subject based on the ideXlab platform.
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Polycyclic aromatic hydrocarbons in fuel-oil contaminated soils, Antarctica
Chemosphere, 1999Co-Authors: Jackie Aislabie, Megan Balks, Norma Astori, Gavin Stevenson, Rebecca SymonsAbstract:Where fuel oil spills have occurred on Antarctic soils polycyclic aromatic hydrocarbons (PAH) may accumulate. Surface and subsurface soil samples were collected from fuel spill sites up to 30 years old, and from nearby control sites, and analysed for the 16 PAHs on the USEPA priority pollutants list, as well as for two methyl substituted Naphthalenes, 1-methylNaphthalene and 2-methylNaphthalene. PAH levels ranged from 41-8105 ng g-1 of dried soil in the samples from contaminated sites and were below detection limits in control site samples. PAH were detected in surface soils and had migrated to lower depths in the contaminated soil. The predominant PAH detected were Naphthalene and its methyl derivatives.
Vladimir Gevorgyan - One of the best experts on this subject based on the ideXlab platform.
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gold i catalyzed double migration cascades toward 1e 3e dienes and Naphthalenes
Tetrahedron, 2009Co-Authors: Alexander S Dudnik, Todd Schwier, Vladimir GevorgyanAbstract:Abstract A novel gold(I)-catalyzed cascade cycloisomerization of a variety of propargylic esters leading to unsymmetrically substituted Naphthalenes has been developed. This domino process involves an unprecedented tandem sequence of 1,3- and 1,2-migrations of two substantially different migrating groups. It is believed that this transformation proceeds via formation of 1,3-diene intermediate or its equivalent, which, upon carbocyclization and aromatization steps, transforms into the Naphthalene skeleton. In addition, it was also demonstrated that a variety of 1,3-dienes can be accessed stereoselectively via the 1,3-migration–proton transfer cascade.
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gold catalyzed double migration benzannulation cascade toward Naphthalenes
Organic Letters, 2008Co-Authors: Alexander S Dudnik, Todd Schwier, Vladimir GevorgyanAbstract:A novel gold(I)-catalyzed cycloisomerization of propargylic esters leading to unsymmetrically substituted Naphthalenes has been developed. This cascade reaction involves an unprecedented tandem sequence of 1,3- and 1,2-migration of two different migrating groups. It is believed that this transformation likely proceeds via the formation of 1,3-diene intermediate or its precursor, which upon cyclization and aromatization steps transforms into the Naphthalene core.
Jackie Aislabie - One of the best experts on this subject based on the ideXlab platform.
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Polycyclic aromatic hydrocarbons in fuel-oil contaminated soils, Antarctica
Chemosphere, 1999Co-Authors: Jackie Aislabie, Megan Balks, Norma Astori, Gavin Stevenson, Rebecca SymonsAbstract:Where fuel oil spills have occurred on Antarctic soils polycyclic aromatic hydrocarbons (PAH) may accumulate. Surface and subsurface soil samples were collected from fuel spill sites up to 30 years old, and from nearby control sites, and analysed for the 16 PAHs on the USEPA priority pollutants list, as well as for two methyl substituted Naphthalenes, 1-methylNaphthalene and 2-methylNaphthalene. PAH levels ranged from 41-8105 ng g-1 of dried soil in the samples from contaminated sites and were below detection limits in control site samples. PAH were detected in surface soils and had migrated to lower depths in the contaminated soil. The predominant PAH detected were Naphthalene and its methyl derivatives.
Vladimir Y Mikshiev - One of the best experts on this subject based on the ideXlab platform.
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tandem synthesis of 10 dimethylaminobenzo h quinazolines from 2 ketimino 1 8 bis dimethylamino Naphthalenes via nucleophilic replacement of the unactivated aromatic nme2 group
Organic Letters, 2016Co-Authors: Vladimir Y Mikshiev, Alexander S Antonov, Alexander F. PozharskiiAbstract:It has been found that 2-bromo-1,8-bis(dimethylamino)Naphthalene on sequential treatment with n-BuLi and 2 equiv of the same or different aryl(hetaryl) cyanide as a result of [2 + 2 + 2] nucleophilic cascade annulation produces 10-dimethylaminobenzo[h]quinazolines, as yet unknown NMe2/–N═ analogues of the proton sponge. It is even more convenient to use preliminarily prepared 2-ketimino-1,8-bis(dimethylamino)Naphthalenes as starting material. The substitution of both peri-NMe2 groups furnishing quinazolino[7,8-h]quinazoline derivatives is also possible. The process is remarkable by surprisingly mild nucleophilic displacement of an unactivated aromatic NMe2 group.
