The Experts below are selected from a list of 9336 Experts worldwide ranked by ideXlab platform
Jiri Sonek - One of the best experts on this subject based on the ideXlab platform.
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Nasal Bone assessment in prenatal screening for trisomy 21
American Journal of Obstetrics and Gynecology, 2006Co-Authors: Jiri Sonek, Sergio Cicero, Ran NeigerAbstract:A small nose is a common facial feature of individuals with trisomy 21. Evidence based on radiologic, histomorphologic, and sonographic studies shows that Nasal Bone abnormalities are significantly more common in trisomy 21 fetuses than in euploid fetuses. These abnormalities, which include both Nasal Bone absence and short Nasal Bone length, can be detected by prenatal ultrasound. In this article we review the evidence and discuss the potential value of assessment of the fetal Nasal Bone in screening for trisomy 21.
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Nasal Bone assessment in prenatal screening for trisomy 21
American Journal of Obstetrics and Gynecology, 2006Co-Authors: Jiri Sonek, Ran Neiger, Sergio Cicero, K H NicolaidesAbstract:A small nose is a common facial feature of individuals with trisomy 21. Evidence based on radiologic, histomorphologic, and sonographic studies shows that Nasal Bone abnormalities are significantly more common in trisomy 21 fetuses than in euploid fetuses. These abnormalities, which include both Nasal Bone absence and short Nasal Bone length, can be detected by prenatal ultrasound. In this article we review the evidence and discuss the potential value of assessment of the fetal Nasal Bone in screening for trisomy 21.
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Nasal Bone hypoplasia in trisomy 21 at 15 22 weeks gestation
Ultrasound in Obstetrics & Gynecology, 2003Co-Authors: Sergio Cicero, Jiri Sonek, David S Mckenna, Christopher S Croom, L. JohnsonAbstract:Objective To investigate the potential value of ultrasound examination of the fetal profile for present/hypoplastic fetal Nasal Bone at 15-22 weeks' gestation as a marker for trisomy 21. Methods This was an observational ultrasound study in 1046 singleton pregnancies undergoing amniocentesis for fetal karyotyping at 15-22 (median, 17) weeks' gestation. Immediately before amniocentesis the fetal profile was examined to determine if the Nasal Bone was present or hypoplastic (absent or shorter than 2.5 mm). The incidence of Nasal hypoplasia in the trisomy 21 and the chromosomally normal fetuses was determined and the likelihood ratio for trisomy 21 for Nasal hypoplasia was calculated. Results All fetuses were successfully examined for the presence of the Nasal Bone. The Nasal Bone was hypoplastic in 21/34 (61.8%) fetuses with trisomy 21, in 12/982 (1.2%) chromosomally normal fetuses and in 1/30 (3.3%) fetuses with other chromosomal defects. In 3/21 (14.3%) trisomy 21 fetuses with Nasal hypoplasia there were no other abnormal ultrasound findings. In the chromosomally normal group hypoplastic Nasal Bone was found in 0.5% of Caucasians and in 8.8% of Afro-Caribbeans. The likelihood ratio for trisomy 21 for hypoplastic Nasal Bone was 50.5 (95% CI 27.1-92.7) and for present Nasal Bone it was 0.38 (95% CI 0.24-0.56). Conclusion Nasal Bone hypoplasia at the 15-22-week scan is associated with a high risk for trisomy 21 and it is a highly sensitive and specific marker for this chromosomal abnormality.
Sergio Cicero - One of the best experts on this subject based on the ideXlab platform.
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Nasal Bone assessment in prenatal screening for trisomy 21
American Journal of Obstetrics and Gynecology, 2006Co-Authors: Jiri Sonek, Sergio Cicero, Ran NeigerAbstract:A small nose is a common facial feature of individuals with trisomy 21. Evidence based on radiologic, histomorphologic, and sonographic studies shows that Nasal Bone abnormalities are significantly more common in trisomy 21 fetuses than in euploid fetuses. These abnormalities, which include both Nasal Bone absence and short Nasal Bone length, can be detected by prenatal ultrasound. In this article we review the evidence and discuss the potential value of assessment of the fetal Nasal Bone in screening for trisomy 21.
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Nasal Bone assessment in prenatal screening for trisomy 21
American Journal of Obstetrics and Gynecology, 2006Co-Authors: Jiri Sonek, Ran Neiger, Sergio Cicero, K H NicolaidesAbstract:A small nose is a common facial feature of individuals with trisomy 21. Evidence based on radiologic, histomorphologic, and sonographic studies shows that Nasal Bone abnormalities are significantly more common in trisomy 21 fetuses than in euploid fetuses. These abnormalities, which include both Nasal Bone absence and short Nasal Bone length, can be detected by prenatal ultrasound. In this article we review the evidence and discuss the potential value of assessment of the fetal Nasal Bone in screening for trisomy 21.
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Nasal Bone in first trimester screening for trisomy 21
American Journal of Obstetrics and Gynecology, 2006Co-Authors: Sergio Cicero, Kyriaki Avgidou, G Rembouskos, K O Kagan, K H NicolaidesAbstract:Objective This study was undertaken to investigate the impact of incorporating assessment of the Nasal Bone into first-trimester combined screening by fetal nuchal translucency (NT) thickness and maternal serum biochemistry. Study design In this prospective combined screening study for trisomy 21, the fetal Nasal Bone was also examined and classified as present or absent. A multivariate approach was used to calculate patient-specific risks for trisomy 21 and the detection rate (DR) and false-positive rate (FPR) were estimated. We examined 2 screening strategies; first, integrated first-trimester screening in all patients and second, first-stage screening of all patients using fetal NT and maternal serum free s-hCG and PAPP-A, followed by second-stage assessment of Nasal Bone only in those with an intermediate risk of 1 in 101 to 1 in 1000 after the first-stage. Results The Nasal Bone was absent in 113 (0.6%) of the 20,165 chromosomally or phenotypically normal fetuses and in 87 (62.1%) of the 140 fetuses with trisomy 21. With combined first-trimester NT and serum screening, the DR of 90% was achieved at a FPR of 5%. Inclusion of the Nasal Bone, either in all cases or in about 10% of the total in the 2-stage approach, halved the FPR to 2.5%. Conclusion Inclusion of the Nasal Bone in first-trimester combined screening for trisomy 21 achieves a DR of 90% for a FPR of 2.5%.
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Nasal Bone hypoplasia in trisomy 21 at 15 22 weeks gestation
Ultrasound in Obstetrics & Gynecology, 2003Co-Authors: Sergio Cicero, Jiri Sonek, David S Mckenna, Christopher S Croom, L. JohnsonAbstract:Objective To investigate the potential value of ultrasound examination of the fetal profile for present/hypoplastic fetal Nasal Bone at 15-22 weeks' gestation as a marker for trisomy 21. Methods This was an observational ultrasound study in 1046 singleton pregnancies undergoing amniocentesis for fetal karyotyping at 15-22 (median, 17) weeks' gestation. Immediately before amniocentesis the fetal profile was examined to determine if the Nasal Bone was present or hypoplastic (absent or shorter than 2.5 mm). The incidence of Nasal hypoplasia in the trisomy 21 and the chromosomally normal fetuses was determined and the likelihood ratio for trisomy 21 for Nasal hypoplasia was calculated. Results All fetuses were successfully examined for the presence of the Nasal Bone. The Nasal Bone was hypoplastic in 21/34 (61.8%) fetuses with trisomy 21, in 12/982 (1.2%) chromosomally normal fetuses and in 1/30 (3.3%) fetuses with other chromosomal defects. In 3/21 (14.3%) trisomy 21 fetuses with Nasal hypoplasia there were no other abnormal ultrasound findings. In the chromosomally normal group hypoplastic Nasal Bone was found in 0.5% of Caucasians and in 8.8% of Afro-Caribbeans. The likelihood ratio for trisomy 21 for hypoplastic Nasal Bone was 50.5 (95% CI 27.1-92.7) and for present Nasal Bone it was 0.38 (95% CI 0.24-0.56). Conclusion Nasal Bone hypoplasia at the 15-22-week scan is associated with a high risk for trisomy 21 and it is a highly sensitive and specific marker for this chromosomal abnormality.
K H Nicolaides - One of the best experts on this subject based on the ideXlab platform.
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Nasal Bone assessment in prenatal screening for trisomy 21
American Journal of Obstetrics and Gynecology, 2006Co-Authors: Jiri Sonek, Ran Neiger, Sergio Cicero, K H NicolaidesAbstract:A small nose is a common facial feature of individuals with trisomy 21. Evidence based on radiologic, histomorphologic, and sonographic studies shows that Nasal Bone abnormalities are significantly more common in trisomy 21 fetuses than in euploid fetuses. These abnormalities, which include both Nasal Bone absence and short Nasal Bone length, can be detected by prenatal ultrasound. In this article we review the evidence and discuss the potential value of assessment of the fetal Nasal Bone in screening for trisomy 21.
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Nasal Bone in first trimester screening for trisomy 21
American Journal of Obstetrics and Gynecology, 2006Co-Authors: Sergio Cicero, Kyriaki Avgidou, G Rembouskos, K O Kagan, K H NicolaidesAbstract:Objective This study was undertaken to investigate the impact of incorporating assessment of the Nasal Bone into first-trimester combined screening by fetal nuchal translucency (NT) thickness and maternal serum biochemistry. Study design In this prospective combined screening study for trisomy 21, the fetal Nasal Bone was also examined and classified as present or absent. A multivariate approach was used to calculate patient-specific risks for trisomy 21 and the detection rate (DR) and false-positive rate (FPR) were estimated. We examined 2 screening strategies; first, integrated first-trimester screening in all patients and second, first-stage screening of all patients using fetal NT and maternal serum free s-hCG and PAPP-A, followed by second-stage assessment of Nasal Bone only in those with an intermediate risk of 1 in 101 to 1 in 1000 after the first-stage. Results The Nasal Bone was absent in 113 (0.6%) of the 20,165 chromosomally or phenotypically normal fetuses and in 87 (62.1%) of the 140 fetuses with trisomy 21. With combined first-trimester NT and serum screening, the DR of 90% was achieved at a FPR of 5%. Inclusion of the Nasal Bone, either in all cases or in about 10% of the total in the 2-stage approach, halved the FPR to 2.5%. Conclusion Inclusion of the Nasal Bone in first-trimester combined screening for trisomy 21 achieves a DR of 90% for a FPR of 2.5%.
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fetal Nasal Bone length in chromosomally normal and abnormal fetuses at 11 14 weeks of gestation
Journal of Maternal-fetal & Neonatal Medicine, 2002Co-Authors: S Cicero, G Rembouskos, R Bindra, C Tripsanas, K H NicolaidesAbstract:Objective: To determine the value of measuring fetal Nasal Bone length at 11-14 weeks of gestation in screening for chromosomal defects. Methods: The fetal profile was examined and the Nasal Bone length was measured in 1092 fetuses immediately before chorionic villous sampling for karyotyping at 11-14 weeks of gestation. Results: The median gestation was 12 (11-14) weeks. The fetal profile was successfully examined in all cases. The fetal karyotype was normal in 955 pregnancies and abnormal in 137, including 79 cases of trisomy 21. In the chromosomally normal group, the fetal Nasal Bone length increased significantly with crown-rump length (CRL) from a mean of 1.3 mm at a CRL of 45 mm to 2.1 mm at a CRL of 84 mm. In 54 of the 79 (68.4%) cases of trisomy 21, the Nasal Bone was absent. In the 25 cases with present Nasal Bone, the Nasal Bone length for the CRL was not significantly different from normal. Similarly, there were no significant differences from normal in the Nasal Bone length of fetuses with oth...
Ran Neiger - One of the best experts on this subject based on the ideXlab platform.
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Nasal Bone assessment in prenatal screening for trisomy 21
American Journal of Obstetrics and Gynecology, 2006Co-Authors: Jiri Sonek, Sergio Cicero, Ran NeigerAbstract:A small nose is a common facial feature of individuals with trisomy 21. Evidence based on radiologic, histomorphologic, and sonographic studies shows that Nasal Bone abnormalities are significantly more common in trisomy 21 fetuses than in euploid fetuses. These abnormalities, which include both Nasal Bone absence and short Nasal Bone length, can be detected by prenatal ultrasound. In this article we review the evidence and discuss the potential value of assessment of the fetal Nasal Bone in screening for trisomy 21.
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Nasal Bone assessment in prenatal screening for trisomy 21
American Journal of Obstetrics and Gynecology, 2006Co-Authors: Jiri Sonek, Ran Neiger, Sergio Cicero, K H NicolaidesAbstract:A small nose is a common facial feature of individuals with trisomy 21. Evidence based on radiologic, histomorphologic, and sonographic studies shows that Nasal Bone abnormalities are significantly more common in trisomy 21 fetuses than in euploid fetuses. These abnormalities, which include both Nasal Bone absence and short Nasal Bone length, can be detected by prenatal ultrasound. In this article we review the evidence and discuss the potential value of assessment of the fetal Nasal Bone in screening for trisomy 21.
Min-suk Kook - One of the best experts on this subject based on the ideXlab platform.
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A retrospective clinical investigation for the effectiveness of closed reduction on Nasal Bone fracture
Maxillofacial Plastic and Reconstructive Surgery, 2019Co-Authors: Byung-hun Kang, Hyo-sun Kang, Jeong Joon Han, Seunggon Jung, Hong-ju Park, Min-suk KookAbstract:Background The Nasal Bone is the most protruding bony structure of the facial Bones. Nasal Bone fracture is the most common facial Bone fracture. The high rate of incidence of Nasal Bone fracture emphasizes the need for systematical investigation of epidemiology, surgical techniques, and complications after surgery. The objective of this study is to investigate the current trends in the treatment of Nasal Bone fractures and the effectiveness of closed reduction depending on the severity of the Nasal Bone fracture. Patients and methods A total of 179 patients with a Nasal Bone fracture from 2009 to 2017 were enrolled. Their clinical examination, patient’s records, and radiographic images of Nasal Bone fractures were evaluated. Results Patients ranged from children to elderly. There were 156 (87.2%) males and 23 (12.8%) females. Traffic accident (36.9%) was the most common cause of Nasal fracture. Orbit fracture (44 patients, 24.6%) was the most common fracture associated with a Nasal Bone fracture. Complications after surgery included postoperative deformity in 20 (11.2%) patients, Nasal obstruction in 11 (6.1%) patients, and olfactory disturbances in 2 (1.1%) patients and patients with more severe Nasal Bone fractures had higher rates of these complications. Conclusion Closed reduction could be performed successfully within 2 weeks after injury.
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A retrospective clinical investigation for the effectiveness of closed reduction on Nasal Bone fracture
Maxillofacial plastic and reconstructive surgery, 2019Co-Authors: Byung-hun Kang, Hyo-sun Kang, Jeong Joon Han, Seunggon Jung, Hong-ju Park, Min-suk KookAbstract:The Nasal Bone is the most protruding bony structure of the facial Bones. Nasal Bone fracture is the most common facial Bone fracture. The high rate of incidence of Nasal Bone fracture emphasizes the need for systematical investigation of epidemiology, surgical techniques, and complications after surgery. The objective of this study is to investigate the current trends in the treatment of Nasal Bone fractures and the effectiveness of closed reduction depending on the severity of the Nasal Bone fracture. A total of 179 patients with a Nasal Bone fracture from 2009 to 2017 were enrolled. Their clinical examination, patient’s records, and radiographic images of Nasal Bone fractures were evaluated. Patients ranged from children to elderly. There were 156 (87.2%) males and 23 (12.8%) females. Traffic accident (36.9%) was the most common cause of Nasal fracture. Orbit fracture (44 patients, 24.6%) was the most common fracture associated with a Nasal Bone fracture. Complications after surgery included postoperative deformity in 20 (11.2%) patients, Nasal obstruction in 11 (6.1%) patients, and olfactory disturbances in 2 (1.1%) patients and patients with more severe Nasal Bone fractures had higher rates of these complications. Closed reduction could be performed successfully within 2 weeks after injury.
