The Experts below are selected from a list of 43767 Experts worldwide ranked by ideXlab platform
Frederic Skoczylas - One of the best experts on this subject based on the ideXlab platform.
-
gas migration through water saturated bentonite sand mixtures cox argillite and their interfaces
Canadian Geotechnical Journal, 2016Co-Authors: Yang Song, Frederic SkoczylasAbstract:France’s deep-seated nuclear waste repository consists of a Natural Barrier located at a depth of 500 m in a Callovo-Oxfordian clayey formation. This repository has artificial Barriers that include plugs of swelling clay (MX80 bentonite – sand mixtures) for sealing purposes. This paper focuses on the gas migration properties of water-saturated bentonite–sand mixtures and their interfaces with COx argillite. The main contribution of our study is the identification of a preferential gas migration pathway by measuring the downstream gas breakthrough pressures and gas flow rates. The water permeabilities of the bentonite–sand mixtures and their interfaces with COx argillite or COx argillite itself are the same order of magnitude (10−20–10−21 m2). Thus, water tightness can be obtained for these materials when they become completely saturated. The results obtained from the gas breakthrough tests suggest that both the COx argillite and its interface with the bentonite–sand mixture can act as preferential pathway...
-
Gas migration through water-saturated bentonite–sand mixtures, COx argillite, and their interfaces
Canadian Geotechnical Journal, 2016Co-Authors: Jiang-feng Liu, Frederic Skoczylas, Yang Song, Jian LiuAbstract:France’s deep-seated nuclear waste repository consists of a Natural Barrier located at a depth of 500 m in a Callovo-Oxfordian clayey formation. This repository has artificial Barriers that include...
Yang Song - One of the best experts on this subject based on the ideXlab platform.
-
gas migration through water saturated bentonite sand mixtures cox argillite and their interfaces
Canadian Geotechnical Journal, 2016Co-Authors: Yang Song, Frederic SkoczylasAbstract:France’s deep-seated nuclear waste repository consists of a Natural Barrier located at a depth of 500 m in a Callovo-Oxfordian clayey formation. This repository has artificial Barriers that include plugs of swelling clay (MX80 bentonite – sand mixtures) for sealing purposes. This paper focuses on the gas migration properties of water-saturated bentonite–sand mixtures and their interfaces with COx argillite. The main contribution of our study is the identification of a preferential gas migration pathway by measuring the downstream gas breakthrough pressures and gas flow rates. The water permeabilities of the bentonite–sand mixtures and their interfaces with COx argillite or COx argillite itself are the same order of magnitude (10−20–10−21 m2). Thus, water tightness can be obtained for these materials when they become completely saturated. The results obtained from the gas breakthrough tests suggest that both the COx argillite and its interface with the bentonite–sand mixture can act as preferential pathway...
-
Gas migration through water-saturated bentonite–sand mixtures, COx argillite, and their interfaces
Canadian Geotechnical Journal, 2016Co-Authors: Jiang-feng Liu, Frederic Skoczylas, Yang Song, Jian LiuAbstract:France’s deep-seated nuclear waste repository consists of a Natural Barrier located at a depth of 500 m in a Callovo-Oxfordian clayey formation. This repository has artificial Barriers that include...
Jesus Angulo - One of the best experts on this subject based on the ideXlab platform.
-
langerin heparin interaction two binding sites for small and large ligands as revealed by a combination of nmr spectroscopy and cross linking mapping experiments
Journal of the American Chemical Society, 2015Co-Authors: Juan C Munozgarcia, Eric Chabrol, Franck Fieschi, Javier Rojo, Pedro M. Nieto, Aline Thomas, Romain R Vives, Anne Imberty, Jesus AnguloAbstract:Langerin is a C-type lectin present on Langerhans cells that mediates capture of pathogens in a carbohydrate-dependent manner, leading to subsequent internalization and elimination in the cellular organelles called Birbeck granules. This mechanism mediated by langerin was shown to constitute a Natural Barrier for HIV-1 particle transmission. Besides interacting specifically with high mannose and fucosylated neutral carbohydrate structures, langerin has the ability to bind sulfated carbohydrate ligands as 6-sulfated galactosides in the Ca2+-dependent binding site. Very recently langerin was demonstrated to interact with sulfated glycosaminoglycans (GAGs), in a Ca2+-independent way, resulting in the proposal of a new binding site for GAGs. On the basis of those results, we have conducted a structural study of the interactions of small heparin (HEP)-like oligosaccharides with langerin in solution. Heparin bead cross-linking experiments, an approach specifically designed to identify HEP/heparan sulfate bindin...
-
Langerin–Heparin Interaction: Two Binding Sites for Small and Large Ligands As Revealed by a Combination of NMR Spectroscopy and Cross-Linking Mapping Experiments
Journal of the American Chemical Society, 2015Co-Authors: Juan C. Muñoz-garcía, Eric Chabrol, Franck Fieschi, Javier Rojo, Pedro M. Nieto, Aline Thomas, Romain R Vives, Anne Imberty, Jesus AnguloAbstract:Langerin is a C-type lectin present on Langerhans cells that mediates capture of pathogens in a carbohydrate-dependent manner, leading to subsequent internalization and elimination in the cellular organelles called Birbeck granules. This mechanism mediated by langerin was shown to constitute a Natural Barrier for HIV-1 particle transmission. Besides interacting specifically with high mannose and fucosylated neutral carbohydrate structures, langerin has the ability to bind sulfated carbohydrate ligands as 6-sulfated galactosides in the Ca2+-dependent binding site. Very recently langerin was demonstrated to interact with sulfated glycosaminoglycans (GAGs), in a Ca2+-independent way, resulting in the proposal of a new binding site for GAGs. On the basis of those results, we have conducted a structural study of the interactions of small heparin (HEP)-like oligosaccharides with langerin in solution. Heparin bead cross-linking experiments, an approach specifically designed to identify HEP/heparan sulfate bindin...
-
langerin heparin interaction two binding sites for small and large ligands as revealed by a combination of nmr spectroscopy and cross linking mapping experiments
Journal of the American Chemical Society, 2015Co-Authors: Juan C Munozgarcia, Eric Chabrol, Franck Fieschi, Javier Rojo, Pedro M. Nieto, Aline Thomas, Romain R Vives, Anne Imberty, Jesus AnguloAbstract:Langerin is a C-type lectin present on Langerhans cells that mediates capture of pathogens in a carbohydrate-dependent manner, leading to subsequent internalization and elimination in the cellular organelles called Birbeck granules. This mechanism mediated by langerin was shown to constitute a Natural Barrier for HIV-1 particle transmission. Besides interacting specifically with high mannose and fucosylated neutral carbohydrate structures, langerin has the ability to bind sulfated carbohydrate ligands as 6-sulfated galactosides in the Ca2+-dependent binding site. Very recently langerin was demonstrated to interact with sulfated glycosaminoglycans (GAGs), in a Ca2+-independent way, resulting in the proposal of a new binding site for GAGs. On the basis of those results, we have conducted a structural study of the interactions of small heparin (HEP)-like oligosaccharides with langerin in solution. Heparin bead cross-linking experiments, an approach specifically designed to identify HEP/heparan sulfate bindin...
Richa Saraogi - One of the best experts on this subject based on the ideXlab platform.
-
Natural products as potential drug permeation enhancer in transdermal drug delivery system
Archives of Dermatological Research, 2014Co-Authors: Umesh K. Patil, Richa SaraogiAbstract:Permeation enhancers are defined as substances that are capable of promoting penetration of drugs into skin and transdermal therapeutic systems offers a more reliable mean of administering drug through the skin. Skin is a Natural Barrier so it is necessary to employ enhancement strategies to improve topical bioavailability. This review explores that Natural products have got potential to enhance the permeation of the drug through skin by reversibly reducing the skin Barrier resistance. The use of Natural products is the most reliable means of permeation enhancement of transdermally administered drugs and permits the delivery of broader classes of drugs through the stratum corneum. They are safe, non-toxic, pharmacologically inert, non-irritating, and non-allergenic to use as permeation enhancers. The present review initially highlights the current status of Natural products on the basis of SAR studies which have shown significant enhancer activities.
Suresh P Vyas - One of the best experts on this subject based on the ideXlab platform.
-
nanocarrier based topical drug delivery for the treatment of skin diseases
Expert Opinion on Drug Delivery, 2012Co-Authors: Madhu Gupta, Udita Agrawal, Suresh P VyasAbstract:Introduction: Skin disorders will continue to cause complications in patients. At present, there is an expansion of research into dermatologic treatment due to a critical need for new treatment options to treat skin diseases. Areas covered: The skin itself provides a Natural Barrier against particle penetration for topical delivery. However, it also offers a potential approach for the delivery of therapeutics, especially in diseased skin and via the openings of hair follicles. Recent innovation might be achieved in the field of dermatological treatment with improvement in the dermal localization of bioactives into the affected skin region, via novel nanocarriers that deliver the drugs directly to the target cells. After application, these nanocarriers can penetrate through the stratum corneum into viable skin and accumulate at the target site. However, noteworthy uptake does occur after damage and in certain diseased skin. Expert opinion: Skin-targeted topical delivery by means of nanosystems, in order to...