The Experts below are selected from a list of 168 Experts worldwide ranked by ideXlab platform
Alison F Hinckley - One of the best experts on this subject based on the ideXlab platform.
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willingness to pay for select tick borne disease prevention measures in endemic areas
Journal of Public Health Management and Practice, 2021Co-Authors: Sara Niesobecki, Heather Rutz, Katherine A Feldman, Linda M Niccolai, Sarah A Hook, Alison F HinckleyAbstract:Tick-borne diseases (TBDs) are increasing despite prevention recommendations. We explored whether cost is a barrier to prevention use in Connecticut and Maryland, using a cross-sectional survey. Respondents were queried regarding their willingness to pay for chemical, Natural, and rodent-targeted yard Pesticide treatments and permethrin-treated clothing. We evaluated associations between demographics, TBD knowledge and attitudes, and willingness to pay for prevention methods. Most respondents would pay for yard treatments (85%); 95% preferring Natural Pesticide, and 82% would pay for permethrin-treated clothing. Most did not want to pay more than $99 for any of the yard treatments. Having a household income of $100 000 was associated with willingness to pay $100 or more for chemical, Natural, or rodent-targeted treatments and $25 or more for permethrin self-treated and pretreated clothing. Yard treatments, especially Natural Pesticides, were acceptable for TBD prevention; however, current pricing may be cost-prohibitive. Permethrin-treated clothing may be an affordable and acceptable prevention method.
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knowledge attitudes and behaviors regarding tick borne disease prevention in endemic areas
Ticks and Tick-borne Diseases, 2019Co-Authors: Sara Niesobecki, Amberjean Hansen, Heather Rutz, Shaylee P Mehta, Katherine A Feldman, James I Meek, Linda M Niccolai, Sarah A Hook, Alison F HinckleyAbstract:Abstract As part of a TickNET collaboration we evaluated the knowledge, attitudes, and behaviors related to tick-borne disease (TBD) prevention among persons living in endemic areas of Connecticut (CT) and Maryland (MD). Up-to-date information on the use of various prevention methods, as well as attitudes toward available and potential prevention options, is critical for effective promotion of recommended behaviors. During 2016–2017, printed invitations were mailed via the post office to 27,029 households requesting participation in an online survey regarding knowledge of TBD, risk perceptions, and prevention behaviors. Prevention behaviors included tick checks, showering/bathing, insect repellents, pet tick control, and chemical or Natural Pesticide use on residential properties. Associations of sociodemographic characteristics and knowledge and attitude variables with prevention behaviors were assessed in unadjusted analyses and multivariable models to calculate adjusted odds ratios (aOR). Participants were also asked if they would be willing to get a Lyme disease (LD) vaccine, if one becomes available. Overall, 1883 (7%) persons completed the survey. Participants reported using preventive behaviors most of the time or always as follows: pet tick control (83%), tick checks (58%), showering/bathing (42%), insect repellent (31%), and chemical (23%) or Natural (15%) Pesticides on property. Self-rated knowledge of LD, perceived prevalence of LD, perceived severity of LD, and perceived likelihood of contracting LD or another TBD were significantly (p > $100,000 was significantly associated with applying a chemical or Natural Pesticide to one’s property [aOR 1.29, aOR 1.40, respectively]. A majority of respondents (84%) reported that they were very likely or somewhat likely to get a LD vaccine if one were available. Few behaviors (tick checks and pet tick control) were reported to be practiced by more than half of the respondents living in LD endemic areas. Perceived prevalence of LD was the only factor associated with performing most of the prevention behaviors (tick checks, showering/bathing, use of insect repellents, and pet tick control). Use of chemical or Natural Pesticides appears to be driven by income. Greater efforts are needed to encourage use of prevention behaviors in endemic areas, and this may be facilitated by increasing awareness of local prevalence.
Sara Niesobecki - One of the best experts on this subject based on the ideXlab platform.
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willingness to pay for select tick borne disease prevention measures in endemic areas
Journal of Public Health Management and Practice, 2021Co-Authors: Sara Niesobecki, Heather Rutz, Katherine A Feldman, Linda M Niccolai, Sarah A Hook, Alison F HinckleyAbstract:Tick-borne diseases (TBDs) are increasing despite prevention recommendations. We explored whether cost is a barrier to prevention use in Connecticut and Maryland, using a cross-sectional survey. Respondents were queried regarding their willingness to pay for chemical, Natural, and rodent-targeted yard Pesticide treatments and permethrin-treated clothing. We evaluated associations between demographics, TBD knowledge and attitudes, and willingness to pay for prevention methods. Most respondents would pay for yard treatments (85%); 95% preferring Natural Pesticide, and 82% would pay for permethrin-treated clothing. Most did not want to pay more than $99 for any of the yard treatments. Having a household income of $100 000 was associated with willingness to pay $100 or more for chemical, Natural, or rodent-targeted treatments and $25 or more for permethrin self-treated and pretreated clothing. Yard treatments, especially Natural Pesticides, were acceptable for TBD prevention; however, current pricing may be cost-prohibitive. Permethrin-treated clothing may be an affordable and acceptable prevention method.
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knowledge attitudes and behaviors regarding tick borne disease prevention in endemic areas
Ticks and Tick-borne Diseases, 2019Co-Authors: Sara Niesobecki, Amberjean Hansen, Heather Rutz, Shaylee P Mehta, Katherine A Feldman, James I Meek, Linda M Niccolai, Sarah A Hook, Alison F HinckleyAbstract:Abstract As part of a TickNET collaboration we evaluated the knowledge, attitudes, and behaviors related to tick-borne disease (TBD) prevention among persons living in endemic areas of Connecticut (CT) and Maryland (MD). Up-to-date information on the use of various prevention methods, as well as attitudes toward available and potential prevention options, is critical for effective promotion of recommended behaviors. During 2016–2017, printed invitations were mailed via the post office to 27,029 households requesting participation in an online survey regarding knowledge of TBD, risk perceptions, and prevention behaviors. Prevention behaviors included tick checks, showering/bathing, insect repellents, pet tick control, and chemical or Natural Pesticide use on residential properties. Associations of sociodemographic characteristics and knowledge and attitude variables with prevention behaviors were assessed in unadjusted analyses and multivariable models to calculate adjusted odds ratios (aOR). Participants were also asked if they would be willing to get a Lyme disease (LD) vaccine, if one becomes available. Overall, 1883 (7%) persons completed the survey. Participants reported using preventive behaviors most of the time or always as follows: pet tick control (83%), tick checks (58%), showering/bathing (42%), insect repellent (31%), and chemical (23%) or Natural (15%) Pesticides on property. Self-rated knowledge of LD, perceived prevalence of LD, perceived severity of LD, and perceived likelihood of contracting LD or another TBD were significantly (p > $100,000 was significantly associated with applying a chemical or Natural Pesticide to one’s property [aOR 1.29, aOR 1.40, respectively]. A majority of respondents (84%) reported that they were very likely or somewhat likely to get a LD vaccine if one were available. Few behaviors (tick checks and pet tick control) were reported to be practiced by more than half of the respondents living in LD endemic areas. Perceived prevalence of LD was the only factor associated with performing most of the prevention behaviors (tick checks, showering/bathing, use of insect repellents, and pet tick control). Use of chemical or Natural Pesticides appears to be driven by income. Greater efforts are needed to encourage use of prevention behaviors in endemic areas, and this may be facilitated by increasing awareness of local prevalence.
Jieyu Zhang - One of the best experts on this subject based on the ideXlab platform.
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Natural Pesticide dihydrorotenone arrests human plasma cancer cells at the g0 g1 phase of the cell cycle
Journal of Biochemical and Molecular Toxicology, 2014Co-Authors: Jieyu Zhang, Kunkun Han, Zubin Zhang, Guodong Chen, Jinping Zhang, Xinliang Mao, Biyin CaoAbstract:Dihydrorotenone (DHR) is a Natural Pesticide used for farming including organic produces. We recently found that DHR induces human plasma cell apoptosis by provoking endoplasmic reticulum stress. In the present study, we found that DHR arrested human plasma cancer cells at the G0/G1 phase of the cell cycle. Mechanistical studies demonstrated that cell cycle arrest was associated with downregulated cell cycle promotors including cyclin D2, cyclin D3, cyclin-dependent kinases (CDK4, CKD6), and phosphorylated-Rb. DHR inhibited cyclin D2 transactivation, thus inhibiting its mRNA expression. In addition, DHR upregulated the cell cycle repressors p21 and p53. DHR also increased the phosphorylation level of p53, suggesting the upregulated transactivation function of p53, which was confirmed by the induction of p21, a substrate of activated p53. Moreover, DHR downregulated AKT and ERK phosphorylation, an incentive of cell cycle progression. Therefore, these results collectively demonstrated that DHR disrupts the cell cycle progress, which suggests that DHR is toxic to human plasma cells. Caution is thus suggested when handling with this agent.
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the Natural Pesticide dihydrorotenone induces human plasma cell apoptosis by triggering endoplasmic reticulum stress and activating p38 signaling pathway
PLOS ONE, 2013Co-Authors: Jieyu Zhang, Zubin Zhang, Biyin Cao, Juan Tang, Aaron D Schimmer, Xinliang MaoAbstract:Dihydrorotenone (DHR) is a Natural Pesticide widely used in farming industry, such as organic produces. DHR is a potent mitochondrial inhibitor and probably induces Parkinsonian syndrome, however, it is not known whether DHR is toxic to other systems. In the present study, we evaluated the cytotoxicity of DHR on human plasma cells. As predicted, DHR impaired mitochondrial function by decreasing mitochondrial membrane potential in plasma cells. Because mito-dysfunction leads to unfolded protein response (UPR) and endoplasmic reticulum (ER) stress, we examined the signature proteins in ER stress, including GRP78, ATF4, and CHOP. After DHR treatment, these proteins were significantly upregulated. It is reported that activation of the mitogen-activated protein kinases p38 and JNK are involved in endoplasmic reticulum stress. However, in the subsequent study, DHR was found to activate p38 but not the JNK signaling. When pre-treated with p38 inhibitor SB203580, activation of p38 and cell apoptosis induced by DHR was partially blocked. Thus, we found that DHR induced human plasma cell death by activating the p38 but not the JNK signaling pathway. Because plasma cells are very important in the immune system, this study provided a new insight in the safety evaluation of DHR application.
Vikas V Gite - One of the best experts on this subject based on the ideXlab platform.
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Renewable resource-based polymeric microencapsulation of Natural Pesticide and its release study: An alternative green approach
RSC Advances, 2014Co-Authors: Rahul Kishore Hedaoo, Vikas V GiteAbstract:Recently, the use of renewable sources in synthesizing polymers has been remarkably increased due to numerous reasons, such as finite as well as unreliable petroleum sources and increasing environmental awareness. Considering the need of the day, we are reporting the preparation of polymeric microcapsules based on cardanol as a renewable source by an in situ polymerization technique to encapsulate the biobased core. Comparative study for successful encapsulation of karanja oil by cardanol formaldehyde and conventional phenol formaldehyde-based microcapsules is made. The success of polymerization is characterized by structure and thermal analysis using FTIR and TGA, respectively. Distinctive surface morphologies of the prepared microcapsules are examined by SEM, which confirmed formation of wrinkle-free and globular-shaped microcapsules. The size of prepared microcapsules is determined by a particle-size analyzer. The amount of encapsulated core material released is estimated quantitatively by solvent extraction, and gravimetric and UV spectrophotometric methods. Thus, the current research is oriented towards the exploration of biobased, renewable shell material for the microencapsulation of biobased cores for the structural design of a new generation of Pesticide formulations. Therefore, the most recent advancements include an interdisciplinary combination of biobased polymers and agrochemicals, which is a significant requirement for attaining a cleaner global environment.
Sarah A Hook - One of the best experts on this subject based on the ideXlab platform.
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willingness to pay for select tick borne disease prevention measures in endemic areas
Journal of Public Health Management and Practice, 2021Co-Authors: Sara Niesobecki, Heather Rutz, Katherine A Feldman, Linda M Niccolai, Sarah A Hook, Alison F HinckleyAbstract:Tick-borne diseases (TBDs) are increasing despite prevention recommendations. We explored whether cost is a barrier to prevention use in Connecticut and Maryland, using a cross-sectional survey. Respondents were queried regarding their willingness to pay for chemical, Natural, and rodent-targeted yard Pesticide treatments and permethrin-treated clothing. We evaluated associations between demographics, TBD knowledge and attitudes, and willingness to pay for prevention methods. Most respondents would pay for yard treatments (85%); 95% preferring Natural Pesticide, and 82% would pay for permethrin-treated clothing. Most did not want to pay more than $99 for any of the yard treatments. Having a household income of $100 000 was associated with willingness to pay $100 or more for chemical, Natural, or rodent-targeted treatments and $25 or more for permethrin self-treated and pretreated clothing. Yard treatments, especially Natural Pesticides, were acceptable for TBD prevention; however, current pricing may be cost-prohibitive. Permethrin-treated clothing may be an affordable and acceptable prevention method.
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knowledge attitudes and behaviors regarding tick borne disease prevention in endemic areas
Ticks and Tick-borne Diseases, 2019Co-Authors: Sara Niesobecki, Amberjean Hansen, Heather Rutz, Shaylee P Mehta, Katherine A Feldman, James I Meek, Linda M Niccolai, Sarah A Hook, Alison F HinckleyAbstract:Abstract As part of a TickNET collaboration we evaluated the knowledge, attitudes, and behaviors related to tick-borne disease (TBD) prevention among persons living in endemic areas of Connecticut (CT) and Maryland (MD). Up-to-date information on the use of various prevention methods, as well as attitudes toward available and potential prevention options, is critical for effective promotion of recommended behaviors. During 2016–2017, printed invitations were mailed via the post office to 27,029 households requesting participation in an online survey regarding knowledge of TBD, risk perceptions, and prevention behaviors. Prevention behaviors included tick checks, showering/bathing, insect repellents, pet tick control, and chemical or Natural Pesticide use on residential properties. Associations of sociodemographic characteristics and knowledge and attitude variables with prevention behaviors were assessed in unadjusted analyses and multivariable models to calculate adjusted odds ratios (aOR). Participants were also asked if they would be willing to get a Lyme disease (LD) vaccine, if one becomes available. Overall, 1883 (7%) persons completed the survey. Participants reported using preventive behaviors most of the time or always as follows: pet tick control (83%), tick checks (58%), showering/bathing (42%), insect repellent (31%), and chemical (23%) or Natural (15%) Pesticides on property. Self-rated knowledge of LD, perceived prevalence of LD, perceived severity of LD, and perceived likelihood of contracting LD or another TBD were significantly (p > $100,000 was significantly associated with applying a chemical or Natural Pesticide to one’s property [aOR 1.29, aOR 1.40, respectively]. A majority of respondents (84%) reported that they were very likely or somewhat likely to get a LD vaccine if one were available. Few behaviors (tick checks and pet tick control) were reported to be practiced by more than half of the respondents living in LD endemic areas. Perceived prevalence of LD was the only factor associated with performing most of the prevention behaviors (tick checks, showering/bathing, use of insect repellents, and pet tick control). Use of chemical or Natural Pesticides appears to be driven by income. Greater efforts are needed to encourage use of prevention behaviors in endemic areas, and this may be facilitated by increasing awareness of local prevalence.
