The Experts below are selected from a list of 7317 Experts worldwide ranked by ideXlab platform
Kent G. Benner - One of the best experts on this subject based on the ideXlab platform.
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milk thistle silybum marianum for the therapy of liver disease
The American Journal of Gastroenterology, 1998Co-Authors: Kenneth Flora, Martin Hahn, Hugo R. Rosen, Kent G. BennerAbstract:Silymarin, derived from the milk thistle plant, Silybum marianum, has been used for centuries as a Natural Remedy for diseases of the liver and biliary tract. As interest in alternative therapy has emerged in the United States, gastroenterologists have encountered increasing numbers of patients taking silymarin with little understanding of its purported properties. Silymarin and its active constituent, silybin, have been reported to work as antioxidants scavenging free radicals and inhibiting lipid peroxidation. Studies also suggest that they protect against genomic injury, increase hepatocyte protein synthesis, decrease the activity of tumor promoters, stabilize mast cells, chelate iron, and slow calcium metabolism. In this article we review silymarin's history, pharmacology, and properties, and the clinical trials pertaining to patients with acute and chronic liver disease.
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Clinical reviewMilk thistle (Silybum marianum) for the therapy of liver disease
The American Journal of Gastroenterology, 1998Co-Authors: Kenneth D. Flora, Martin Hahn, Hugo R. Rosen, Kent G. BennerAbstract:Silymarin, derived from the milk thistle plant, Silybum marianum, has been used for centuries as a Natural Remedy for diseases of the liver and biliary tract. As interest in alternative therapy has emerged in the United States, gastroenterologists have encountered increasing numbers of patients taking silymarin with little understanding of its purported properties. Silymarin and its active constituent, silybin, have been reported to work as antioxidants scavenging free radicals and inhibiting lipid peroxidation. Studies also suggest that they protect against genomic injury, increase hepatocyte protein synthesis, decrease the activity of tumor promoters, stabilize mast cells, chelate iron, and slow calcium metabolism. In this article we review silymarin's history, pharmacology, and properties, and the clinical trials pertaining to patients with acute and chronic liver disease.
Helena Jernström - One of the best experts on this subject based on the ideXlab platform.
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Natural Remedy use in a prospective cohort of breast cancer patients in southern sweden
Acta Oncologica, 2011Co-Authors: Maria Hietala, Maria Henningson, Christian Ingvar, Per-ebbe Jönsson, Carsten Rose, Helena JernströmAbstract:Abstract Background. Complementary and alternative medicine (CAM) use is common among breast cancer patients. Several CAM therapies may have negative side effects or interact with conventional therapies. We studied biologically based CAM use with and without vitamins/minerals in relation to patient and tumor characteristics as well as treatment in an ongoing prospective cohort of 855 primary breast cancer patients. Methods. Patients from two hospitals in southern Sweden were included. Pre-operative and follow-up questionnaires containing questions on food intake, lifestyle, and concomitant medications, including Natural remedies, were completed up to five years postoperatively. Clinical information was obtained from clinical records and tumor characteristics from pathology reports. Results. CAM and/or vitamins/minerals were used by 34.2% pre-operatively and by 57.9% during at least one visit. Over 100 different preparations were reported. At least eight of the commonly used preparations may interact with conventional breast cancer therapies. CAM users more often had a BMI <25 kg/m(2) (OR 1.76; 95%CI 1.33-2.33), were more often nulliparous (OR 1.59; 1.08-2.34), alcohol (OR 2.13; 1.44-3.14), antidepressants (OR 1.48; 1.02-2.15), and hormone therapy users (OR 1.57; 1.18-2.07), less often smokers (OR 0.71; 0.50-0.99), and consumed less coffee (OR 0.88; 0.82-0.95) than non CAM users. Tumor characteristics were not associated with CAM use. CAM use was more common among tamoxifen (OR 1.32; 1.00-1.75) and less common among chemotherapy (OR 0.63; 0.42-0.92) treated patients. Vitamins/minerals use was more common in aromatase inhibitor treated patients (OR 1.84; 1.33-2.53). There was no significant association between short-term disease-free survival and CAM use. Conclusion. CAM use was common and associated with certain patient characteristics. CAM use may cause clinically significant drug interactions and it is therefore of clinical interest to identify potential CAM users.
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Natural Remedy use in a prospective cohort of breast cancer patients in southern Sweden
Acta oncologica (Stockholm Sweden), 2010Co-Authors: Maria Hietala, Maria Henningson, Christian Ingvar, Per-ebbe Jönsson, Carsten Rose, Helena JernströmAbstract:Abstract Background. Complementary and alternative medicine (CAM) use is common among breast cancer patients. Several CAM therapies may have negative side effects or interact with conventional therapies. We studied biologically based CAM use with and without vitamins/minerals in relation to patient and tumor characteristics as well as treatment in an ongoing prospective cohort of 855 primary breast cancer patients. Methods. Patients from two hospitals in southern Sweden were included. Pre-operative and follow-up questionnaires containing questions on food intake, lifestyle, and concomitant medications, including Natural remedies, were completed up to five years postoperatively. Clinical information was obtained from clinical records and tumor characteristics from pathology reports. Results. CAM and/or vitamins/minerals were used by 34.2% pre-operatively and by 57.9% during at least one visit. Over 100 different preparations were reported. At least eight of the commonly used preparations may interact with conventional breast cancer therapies. CAM users more often had a BMI
Hugo R. Rosen - One of the best experts on this subject based on the ideXlab platform.
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milk thistle silybum marianum for the therapy of liver disease
The American Journal of Gastroenterology, 1998Co-Authors: Kenneth Flora, Martin Hahn, Hugo R. Rosen, Kent G. BennerAbstract:Silymarin, derived from the milk thistle plant, Silybum marianum, has been used for centuries as a Natural Remedy for diseases of the liver and biliary tract. As interest in alternative therapy has emerged in the United States, gastroenterologists have encountered increasing numbers of patients taking silymarin with little understanding of its purported properties. Silymarin and its active constituent, silybin, have been reported to work as antioxidants scavenging free radicals and inhibiting lipid peroxidation. Studies also suggest that they protect against genomic injury, increase hepatocyte protein synthesis, decrease the activity of tumor promoters, stabilize mast cells, chelate iron, and slow calcium metabolism. In this article we review silymarin's history, pharmacology, and properties, and the clinical trials pertaining to patients with acute and chronic liver disease.
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Clinical reviewMilk thistle (Silybum marianum) for the therapy of liver disease
The American Journal of Gastroenterology, 1998Co-Authors: Kenneth D. Flora, Martin Hahn, Hugo R. Rosen, Kent G. BennerAbstract:Silymarin, derived from the milk thistle plant, Silybum marianum, has been used for centuries as a Natural Remedy for diseases of the liver and biliary tract. As interest in alternative therapy has emerged in the United States, gastroenterologists have encountered increasing numbers of patients taking silymarin with little understanding of its purported properties. Silymarin and its active constituent, silybin, have been reported to work as antioxidants scavenging free radicals and inhibiting lipid peroxidation. Studies also suggest that they protect against genomic injury, increase hepatocyte protein synthesis, decrease the activity of tumor promoters, stabilize mast cells, chelate iron, and slow calcium metabolism. In this article we review silymarin's history, pharmacology, and properties, and the clinical trials pertaining to patients with acute and chronic liver disease.
Martin Hahn - One of the best experts on this subject based on the ideXlab platform.
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milk thistle silybum marianum for the therapy of liver disease
The American Journal of Gastroenterology, 1998Co-Authors: Kenneth Flora, Martin Hahn, Hugo R. Rosen, Kent G. BennerAbstract:Silymarin, derived from the milk thistle plant, Silybum marianum, has been used for centuries as a Natural Remedy for diseases of the liver and biliary tract. As interest in alternative therapy has emerged in the United States, gastroenterologists have encountered increasing numbers of patients taking silymarin with little understanding of its purported properties. Silymarin and its active constituent, silybin, have been reported to work as antioxidants scavenging free radicals and inhibiting lipid peroxidation. Studies also suggest that they protect against genomic injury, increase hepatocyte protein synthesis, decrease the activity of tumor promoters, stabilize mast cells, chelate iron, and slow calcium metabolism. In this article we review silymarin's history, pharmacology, and properties, and the clinical trials pertaining to patients with acute and chronic liver disease.
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Clinical reviewMilk thistle (Silybum marianum) for the therapy of liver disease
The American Journal of Gastroenterology, 1998Co-Authors: Kenneth D. Flora, Martin Hahn, Hugo R. Rosen, Kent G. BennerAbstract:Silymarin, derived from the milk thistle plant, Silybum marianum, has been used for centuries as a Natural Remedy for diseases of the liver and biliary tract. As interest in alternative therapy has emerged in the United States, gastroenterologists have encountered increasing numbers of patients taking silymarin with little understanding of its purported properties. Silymarin and its active constituent, silybin, have been reported to work as antioxidants scavenging free radicals and inhibiting lipid peroxidation. Studies also suggest that they protect against genomic injury, increase hepatocyte protein synthesis, decrease the activity of tumor promoters, stabilize mast cells, chelate iron, and slow calcium metabolism. In this article we review silymarin's history, pharmacology, and properties, and the clinical trials pertaining to patients with acute and chronic liver disease.
Mirko Congiu - One of the best experts on this subject based on the ideXlab platform.
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Prenatal THC exposure produces a hyperdopaminergic phenotype rescued by pregnenolone
Nature Neuroscience, 2019Co-Authors: Roberto Frau, Vivien Miczán, Francesco Traccis, Sonia Aroni, Silvia Fanni, Claudia Sagheddu, Valeria Serra, Csaba István Pongor, Pierluigi Saba, Mirko CongiuAbstract:The increased legal availability of cannabis has led to a common misconception that it is a safe Natural Remedy for, among others, pregnancy-related ailments such as morning sickness. Emerging clinical evidence, however, indicates that prenatal cannabis exposure (PCE) predisposes offspring to various neuropsychiatric disorders linked to aberrant dopaminergic function. Yet, our knowledge of how cannabis exposure affects the maturation of this neuromodulatory system remains limited. Here, we show that male, but not female, offspring of Δ^9-tetrahydrocannabinol (THC)-exposed dams, a rat PCE model, exhibit extensive molecular and synaptic changes in dopaminergic neurons of the ventral tegmental area, including altered excitatory-to-inhibitory balance and switched polarity of long-term synaptic plasticity. The resulting hyperdopaminergic state leads to increased behavioral sensitivity to acute THC exposure during pre-adolescence. The neurosteroid pregnenolone, a US Food and Drug Administration (FDA) approved drug, rescues synaptic defects and normalizes dopaminergic activity and behavior in PCE offspring, thus suggesting a therapeutic approach for offspring exposed to cannabis during pregnancy.In offspring exposed to THC in utero, molecular, synaptic and circuit reorganizations lead to a hyperdopaminergic phenotype and behavioral susceptibility. The neurosteroid pregnenolone restores both dopamine function and abnormal behavior.
