The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
J A Chayvialle - One of the best experts on this subject based on the ideXlab platform.
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Necrolytic Migratory Erythema first symptom of a malignant glucagonoma treatment by long acting somatostatin and surgical resection report of three cases
Ejso, 1998Co-Authors: El Z Rassi, Christian Partensky, Pierrejean Valette, Francoise Berger, J A ChayvialleAbstract:We report three cases of malignant glucanoma with Necrolytic Migratory Erythema as the first clinical symptom. Long-acting somatostatin analogue was the first step of a multimodal therapeutic strategy which included surgical resection of the primary tumour in every case. Liver metastases which were present in two patients were treated by hepatic arterial chemoembolization and systemic chemotherapy in one case and by liver resection for cytoreduction and hepatic arterial chemoembolization in another case. Skin lesions resolved in all three patients.
Robert G Dluhy - One of the best experts on this subject based on the ideXlab platform.
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peripheral amino acid and fatty acid infusion for the treatment of Necrolytic Migratory Erythema in the glucagonoma syndrome
Clinical Endocrinology, 2002Co-Authors: Erik K Alexander, Malcolm K Robinson, Maryjane Staniec, Robert G DluhyAbstract:Summary Necrolytic Migratory Erythema (NME), the characteristic rash associated with the glucagonoma syndrome, is a cause of substantial morbidity among patients with this rare malignancy. Treatment options are suboptimal, and often useful for only short or moderate durations. We report the effective, long-term (> 1 year) use of intermittent infusions of amino acids (AA) and fatty acids (FA) administered via peripheral intravenous access for the treatment of NME in the glucagonoma syndrome. Despite resolution of the NME, serum amino acid (initially subnormal) and fatty acid (initially normal) levels remained unchanged. Tumour growth and other symptoms related to the glucagonoma syndrome appear unaffected by such infusions.
Sanches Jr., José Antonio - One of the best experts on this subject based on the ideXlab platform.
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Eritema necrolítico migratório associado à síndrome glucagonoma: descrição de um caso
Faculdade de Medicina Universidade de São Paulo - FM USP, 2001Co-Authors: Dal Coleto, Cassio C., Ana Paula F. De Mello, Piquero-casals Jaime, Lima, Fábio R., Vilela, Maria Aparecida Constantino, Festa-neto Cyro, Sanches Jr., José AntonioAbstract:Necrolytic Migratory Erythema is a rare skin condition that consists of migrating areas of Erythema with blisters that heal with hyperpigmentation. It usually occurs in patients with an alpha islet cell tumor of the pancreas-or glucagonoma-and when associated with glucose intolerance, anemia, hyperglucagonemia, and weight loss defines the glucagonoma syndrome. We describe a 52-year-old female patient with Necrolytic Migratory Erythema associated with glucagonoma syndrome who had metastatic disease at presentation and passed away one week after her admission. The autopsy showed a tumor in the body of the pancreas, which was diagnosed as a neuroendocrine tumor and confirmed by immunohistochemistry. The diagnosis of Necrolytic Migratory Erythema is a matter of great importance, since it might be an auxiliary tool for the early detection of glucagonoma.O eritema necrolítico migratório é uma rara condição cutânea que se apresenta como lesões eritematosas, migratórias, com vesículas e bolhas na superfície, evoluindo para cura com hiperpigmentação. É freqüentemente observado em doentes com tumor de células alfa do pâncreas, ou glucagonoma, e quando associado com intolerância a glicose, anemia, hiperglucagonemia, e perda de peso definem a síndrome do glucagonoma. É descrito o caso de uma paciente do sexo feminino, 52 anos, branca, com eritema necrolítico migratório associado à síndrome do glucagonoma com doença metastática na apresentação, vindo a falecer uma semana após sua admissão. A autópsia mostrou um tumor no corpo do pâncreas diagnosticado como tumor neuroendócrino e confirmado pela imuno-histoquímica. O reconhecimento do eritema necrolítico migratório é de grande importância para a possibilidade de diagnóstico precoce do glucagonoma
José Antonio Sanches - One of the best experts on this subject based on the ideXlab platform.
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Necrolytic Migratory Erythema associated with glucagonoma syndrome: a case report Eritema necrolítico migratório associado à síndrome glucagonoma: descrição de um caso
Universidade de São Paulo - FM USP, 2001Co-Authors: Cassio Dal C. Coleto, Ana Paula F. De Mello, Jaime Piquero-casals, Fábio R. Lima, Maria Aparecida Constantino Vilela, Cyro Festa-neto, José Antonio SanchesAbstract:Necrolytic Migratory Erythema is a rare skin condition that consists of migrating areas of Erythema with blisters that heal with hyperpigmentation. It usually occurs in patients with an alpha islet cell tumor of the pancreas-or glucagonoma-and when associated with glucose intolerance, anemia, hyperglucagonemia, and weight loss defines the glucagonoma syndrome. We describe a 52-year-old female patient with Necrolytic Migratory Erythema associated with glucagonoma syndrome who had metastatic disease at presentation and passed away one week after her admission. The autopsy showed a tumor in the body of the pancreas, which was diagnosed as a neuroendocrine tumor and confirmed by immunohistochemistry. The diagnosis of Necrolytic Migratory Erythema is a matter of great importance, since it might be an auxiliary tool for the early detection of glucagonoma.O eritema necrolítico migratório é uma rara condição cutânea que se apresenta como lesões eritematosas, migratórias, com vesículas e bolhas na superfície, evoluindo para cura com hiperpigmentação. É freqüentemente observado em doentes com tumor de células alfa do pâncreas, ou glucagonoma, e quando associado com intolerância a glicose, anemia, hiperglucagonemia, e perda de peso definem a síndrome do glucagonoma. É descrito o caso de uma paciente do sexo feminino, 52 anos, branca, com eritema necrolítico migratório associado à síndrome do glucagonoma com doença metastática na apresentação, vindo a falecer uma semana após sua admissão. A autópsia mostrou um tumor no corpo do pâncreas diagnosticado como tumor neuroendócrino e confirmado pela imuno-histoquímica. O reconhecimento do eritema necrolítico migratório é de grande importância para a possibilidade de diagnóstico precoce do glucagonoma
El Z Rassi - One of the best experts on this subject based on the ideXlab platform.
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Necrolytic Migratory Erythema first symptom of a malignant glucagonoma treatment by long acting somatostatin and surgical resection report of three cases
Ejso, 1998Co-Authors: El Z Rassi, Christian Partensky, Pierrejean Valette, Francoise Berger, J A ChayvialleAbstract:We report three cases of malignant glucanoma with Necrolytic Migratory Erythema as the first clinical symptom. Long-acting somatostatin analogue was the first step of a multimodal therapeutic strategy which included surgical resection of the primary tumour in every case. Liver metastases which were present in two patients were treated by hepatic arterial chemoembolization and systemic chemotherapy in one case and by liver resection for cytoreduction and hepatic arterial chemoembolization in another case. Skin lesions resolved in all three patients.
