The Experts below are selected from a list of 519 Experts worldwide ranked by ideXlab platform
Malcolm A Bagshaw - One of the best experts on this subject based on the ideXlab platform.
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mammalian cell survival studies characterizing multiport Negative Pi Meson irradiation with the stanford medical Pion generator smpg
International Journal of Hyperthermia, 1994Co-Authors: Peter Fessenden, George M Hahn, George A Fisher, G Luxton, Malcolm A BagshawAbstract:Radiobiological measurements have been made under various conditions of muliport Pion irradiation using the Stanford Medical Pion Generator (SMPG). Chinese hamster cells (HA-1) were suspended in a tissue-equivalent 25% gelatin/medium solution. Hypoxic and aerobic HA-1 cells were irradiated simultaneously in a cylindrical water tank at either 4 or 16 degrees C. Irradiation at the focus of 60 converging Pion beams, at a peak dose rate of 6 rads/min, gave relative biological effectiveness (RBEs) of 2.8, 1.8 and 1.4 at 50, 20 and 5% survival, respectively, and an oxygen enhancement ratio (OER) of 1.7. Plateau irradiation with crossing Pion beams, at a peak dose-rate of 3 rads/min, resulted in survival values very close to those obtained with similar doses of 85 kV X-rays. Preliminary studies with large irradiation volumes in broadened Pion stopPing regions indicate RBEs significantly > 1 for survival > 50%. Supporting microdosimetric data with the SMPG are consistent with the radiobiological results.
Peter Fessenden - One of the best experts on this subject based on the ideXlab platform.
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mammalian cell survival studies characterizing multiport Negative Pi Meson irradiation with the stanford medical Pion generator smpg
International Journal of Hyperthermia, 1994Co-Authors: Peter Fessenden, George M Hahn, George A Fisher, G Luxton, Malcolm A BagshawAbstract:Radiobiological measurements have been made under various conditions of muliport Pion irradiation using the Stanford Medical Pion Generator (SMPG). Chinese hamster cells (HA-1) were suspended in a tissue-equivalent 25% gelatin/medium solution. Hypoxic and aerobic HA-1 cells were irradiated simultaneously in a cylindrical water tank at either 4 or 16 degrees C. Irradiation at the focus of 60 converging Pion beams, at a peak dose rate of 6 rads/min, gave relative biological effectiveness (RBEs) of 2.8, 1.8 and 1.4 at 50, 20 and 5% survival, respectively, and an oxygen enhancement ratio (OER) of 1.7. Plateau irradiation with crossing Pion beams, at a peak dose-rate of 3 rads/min, resulted in survival values very close to those obtained with similar doses of 85 kV X-rays. Preliminary studies with large irradiation volumes in broadened Pion stopPing regions indicate RBEs significantly > 1 for survival > 50%. Supporting microdosimetric data with the SMPG are consistent with the radiobiological results.
George M Hahn - One of the best experts on this subject based on the ideXlab platform.
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mammalian cell survival studies characterizing multiport Negative Pi Meson irradiation with the stanford medical Pion generator smpg
International Journal of Hyperthermia, 1994Co-Authors: Peter Fessenden, George M Hahn, George A Fisher, G Luxton, Malcolm A BagshawAbstract:Radiobiological measurements have been made under various conditions of muliport Pion irradiation using the Stanford Medical Pion Generator (SMPG). Chinese hamster cells (HA-1) were suspended in a tissue-equivalent 25% gelatin/medium solution. Hypoxic and aerobic HA-1 cells were irradiated simultaneously in a cylindrical water tank at either 4 or 16 degrees C. Irradiation at the focus of 60 converging Pion beams, at a peak dose rate of 6 rads/min, gave relative biological effectiveness (RBEs) of 2.8, 1.8 and 1.4 at 50, 20 and 5% survival, respectively, and an oxygen enhancement ratio (OER) of 1.7. Plateau irradiation with crossing Pion beams, at a peak dose-rate of 3 rads/min, resulted in survival values very close to those obtained with similar doses of 85 kV X-rays. Preliminary studies with large irradiation volumes in broadened Pion stopPing regions indicate RBEs significantly > 1 for survival > 50%. Supporting microdosimetric data with the SMPG are consistent with the radiobiological results.
George A Fisher - One of the best experts on this subject based on the ideXlab platform.
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mammalian cell survival studies characterizing multiport Negative Pi Meson irradiation with the stanford medical Pion generator smpg
International Journal of Hyperthermia, 1994Co-Authors: Peter Fessenden, George M Hahn, George A Fisher, G Luxton, Malcolm A BagshawAbstract:Radiobiological measurements have been made under various conditions of muliport Pion irradiation using the Stanford Medical Pion Generator (SMPG). Chinese hamster cells (HA-1) were suspended in a tissue-equivalent 25% gelatin/medium solution. Hypoxic and aerobic HA-1 cells were irradiated simultaneously in a cylindrical water tank at either 4 or 16 degrees C. Irradiation at the focus of 60 converging Pion beams, at a peak dose rate of 6 rads/min, gave relative biological effectiveness (RBEs) of 2.8, 1.8 and 1.4 at 50, 20 and 5% survival, respectively, and an oxygen enhancement ratio (OER) of 1.7. Plateau irradiation with crossing Pion beams, at a peak dose-rate of 3 rads/min, resulted in survival values very close to those obtained with similar doses of 85 kV X-rays. Preliminary studies with large irradiation volumes in broadened Pion stopPing regions indicate RBEs significantly > 1 for survival > 50%. Supporting microdosimetric data with the SMPG are consistent with the radiobiological results.
G Luxton - One of the best experts on this subject based on the ideXlab platform.
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mammalian cell survival studies characterizing multiport Negative Pi Meson irradiation with the stanford medical Pion generator smpg
International Journal of Hyperthermia, 1994Co-Authors: Peter Fessenden, George M Hahn, George A Fisher, G Luxton, Malcolm A BagshawAbstract:Radiobiological measurements have been made under various conditions of muliport Pion irradiation using the Stanford Medical Pion Generator (SMPG). Chinese hamster cells (HA-1) were suspended in a tissue-equivalent 25% gelatin/medium solution. Hypoxic and aerobic HA-1 cells were irradiated simultaneously in a cylindrical water tank at either 4 or 16 degrees C. Irradiation at the focus of 60 converging Pion beams, at a peak dose rate of 6 rads/min, gave relative biological effectiveness (RBEs) of 2.8, 1.8 and 1.4 at 50, 20 and 5% survival, respectively, and an oxygen enhancement ratio (OER) of 1.7. Plateau irradiation with crossing Pion beams, at a peak dose-rate of 3 rads/min, resulted in survival values very close to those obtained with similar doses of 85 kV X-rays. Preliminary studies with large irradiation volumes in broadened Pion stopPing regions indicate RBEs significantly > 1 for survival > 50%. Supporting microdosimetric data with the SMPG are consistent with the radiobiological results.