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David Ropartz - One of the best experts on this subject based on the ideXlab platform.
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Negative Polarity Helium Charge Transfer Dissociation Tandem Mass Spectrometry: Radical-Initiated Fragmentation of Complex Polysulfated Anions.
Analytical chemistry, 2017Co-Authors: David Ropartz, Glen P. Jackson, Hélène RogniauxAbstract:This work provides the first use of helium charge transfer dissociation (He-CTD) tandem mass spectrometry (MS/MS) in Negative Polarity mode. Three sulfated oligosaccharides of natural origin were chosen as representative structures that are difficult to solve by conventional MS/MS approaches. Negative Polarity He-CTD provided a full set of structurally informative fragments, which permitted the unambiguous determination of the complete structures of these molecules, including the characterization of labile sulfated functional groups. Despite close structural features, the three molecules led to distinct fragmentation patterns depending on the position of the sulfate group in the heterocycle. The observed fragments showed a consistent radical-initiated mechanism of dissociation, which shares similarities with fragment types produced in electron detachment dissociation (EDD), Negative electron transfer dissociation (NETD), or extreme UV photodissociation (XUV-PD). Short times of data collection and the fact...
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Negative Polarity Helium Charge Transfer Dissociation Tandem Mass Spectrometry: Radical-Initiated Fragmentation of Complex Polysulfated Anions
Analytical Chemistry, 2017Co-Authors: David Ropartz, Glen P. Jackson, Hélène Rogniaux-bonaventureAbstract:This work provides the first use of helium charge transfer dissociation (He-CTD) tandem mass spectrometry (MS/MS) in Negative Polarity mode. Three sulfated oligosaccharides of natural origin were chosen as representative structures that are difficult to solve by conventional MS/MS approaches. Negative Polarity He-CTD provided a full set of structurally informative fragments, which permitted the unambiguous determination of the complete structures of these molecules, including the characterization of labile sulfated functional groups. Despite close structural features, the three molecules led to distinct fragmentation patterns depending on the position of the sulfate group in the heterocycle. The observed fragments showed a consistent radical-initiated mechanism of dissociation, which shares similarities with fragment types produced in electron detachment dissociation (EDD), Negative electron transfer dissociation (NETD), or extreme UV photodissociation (XUV-PD). Short times of data collection and the fact that the technique can be affordably implementable in any standard laboratory and with a classical ion trap mass spectrometer were other remarkable characteristics of Negative Polarity He-CTD.
Hélène Rogniaux-bonaventure - One of the best experts on this subject based on the ideXlab platform.
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Negative Polarity Helium Charge Transfer Dissociation Tandem Mass Spectrometry: Radical-Initiated Fragmentation of Complex Polysulfated Anions
Analytical Chemistry, 2017Co-Authors: David Ropartz, Glen P. Jackson, Hélène Rogniaux-bonaventureAbstract:This work provides the first use of helium charge transfer dissociation (He-CTD) tandem mass spectrometry (MS/MS) in Negative Polarity mode. Three sulfated oligosaccharides of natural origin were chosen as representative structures that are difficult to solve by conventional MS/MS approaches. Negative Polarity He-CTD provided a full set of structurally informative fragments, which permitted the unambiguous determination of the complete structures of these molecules, including the characterization of labile sulfated functional groups. Despite close structural features, the three molecules led to distinct fragmentation patterns depending on the position of the sulfate group in the heterocycle. The observed fragments showed a consistent radical-initiated mechanism of dissociation, which shares similarities with fragment types produced in electron detachment dissociation (EDD), Negative electron transfer dissociation (NETD), or extreme UV photodissociation (XUV-PD). Short times of data collection and the fact that the technique can be affordably implementable in any standard laboratory and with a classical ion trap mass spectrometer were other remarkable characteristics of Negative Polarity He-CTD.
Hélène Rogniaux - One of the best experts on this subject based on the ideXlab platform.
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Negative Polarity Helium Charge Transfer Dissociation Tandem Mass Spectrometry: Radical-Initiated Fragmentation of Complex Polysulfated Anions.
Analytical chemistry, 2017Co-Authors: David Ropartz, Glen P. Jackson, Hélène RogniauxAbstract:This work provides the first use of helium charge transfer dissociation (He-CTD) tandem mass spectrometry (MS/MS) in Negative Polarity mode. Three sulfated oligosaccharides of natural origin were chosen as representative structures that are difficult to solve by conventional MS/MS approaches. Negative Polarity He-CTD provided a full set of structurally informative fragments, which permitted the unambiguous determination of the complete structures of these molecules, including the characterization of labile sulfated functional groups. Despite close structural features, the three molecules led to distinct fragmentation patterns depending on the position of the sulfate group in the heterocycle. The observed fragments showed a consistent radical-initiated mechanism of dissociation, which shares similarities with fragment types produced in electron detachment dissociation (EDD), Negative electron transfer dissociation (NETD), or extreme UV photodissociation (XUV-PD). Short times of data collection and the fact...
Glen P. Jackson - One of the best experts on this subject based on the ideXlab platform.
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Negative Polarity Helium Charge Transfer Dissociation Tandem Mass Spectrometry: Radical-Initiated Fragmentation of Complex Polysulfated Anions.
Analytical chemistry, 2017Co-Authors: David Ropartz, Glen P. Jackson, Hélène RogniauxAbstract:This work provides the first use of helium charge transfer dissociation (He-CTD) tandem mass spectrometry (MS/MS) in Negative Polarity mode. Three sulfated oligosaccharides of natural origin were chosen as representative structures that are difficult to solve by conventional MS/MS approaches. Negative Polarity He-CTD provided a full set of structurally informative fragments, which permitted the unambiguous determination of the complete structures of these molecules, including the characterization of labile sulfated functional groups. Despite close structural features, the three molecules led to distinct fragmentation patterns depending on the position of the sulfate group in the heterocycle. The observed fragments showed a consistent radical-initiated mechanism of dissociation, which shares similarities with fragment types produced in electron detachment dissociation (EDD), Negative electron transfer dissociation (NETD), or extreme UV photodissociation (XUV-PD). Short times of data collection and the fact...
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Negative Polarity Helium Charge Transfer Dissociation Tandem Mass Spectrometry: Radical-Initiated Fragmentation of Complex Polysulfated Anions
Analytical Chemistry, 2017Co-Authors: David Ropartz, Glen P. Jackson, Hélène Rogniaux-bonaventureAbstract:This work provides the first use of helium charge transfer dissociation (He-CTD) tandem mass spectrometry (MS/MS) in Negative Polarity mode. Three sulfated oligosaccharides of natural origin were chosen as representative structures that are difficult to solve by conventional MS/MS approaches. Negative Polarity He-CTD provided a full set of structurally informative fragments, which permitted the unambiguous determination of the complete structures of these molecules, including the characterization of labile sulfated functional groups. Despite close structural features, the three molecules led to distinct fragmentation patterns depending on the position of the sulfate group in the heterocycle. The observed fragments showed a consistent radical-initiated mechanism of dissociation, which shares similarities with fragment types produced in electron detachment dissociation (EDD), Negative electron transfer dissociation (NETD), or extreme UV photodissociation (XUV-PD). Short times of data collection and the fact that the technique can be affordably implementable in any standard laboratory and with a classical ion trap mass spectrometer were other remarkable characteristics of Negative Polarity He-CTD.
Rodolphe Rosol - One of the best experts on this subject based on the ideXlab platform.
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Study and optimization of Negative Polarity rod pinch diode as flash radiography source at 4.5 MV
Physics of Plasmas, 2012Co-Authors: Bertrand Etchessahar, Michel Caron, Virgile Bernigaud, Rémi Nicolas, Frédéric Cartier, Stéphanie Cartier, Laurent Hourdin, Laurent Magnin, Frédéric Poulet, Rodolphe RosolAbstract:The Negative Polarity rod pinch diode (NPRPD) is a potential millimeter spot size radiography source for high voltage generators (4 to 8 MV) [Cooperstein et al., “Considerations of rod-pinch diode operation in Negative Polarity for radiography,” in Proceedings of the 14th IEEE Pulsed Power Conference, 2003, pp. 975–978]. The NPRPD consists of a small diameter (few mm) cylindrical anode extending from the front end of the vacuum cell through a thin annular cathode, held by a central conductor. The Polarity has been inverted when compared to the original rod pinch diode [Cooperstein et al., “Theoretical modeling and experimental characterization of a rod-pinch diode,” Phys. Plasmas 8(10), 4618–4636 (2001)] in order to take advantage from the maximal x-ray emission toward the anode holder at such a voltage [Swanekamp et al., “Evaluation of self-magnetically pinched diodes up to 10 MV as high resolution flash X-ray sources,” IEEE Trans. Plasma Sci. 32(5), 2004–2016 (2004). We have studied this diode at 4.5 MV...
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Negative Polarity rod pinch diode experiments on the astertx generator
2010 Abstracts IEEE International Conference on Plasma Science, 2010Co-Authors: Bertrand Etchessahar, Rodolphe Rosol, Michel Caron, Martial Toury, Frédéric Carrier, Yaël Tailleur, Virgile Bernigaud, Rémi Nicolas, David Pierre, Michel WuattierAbstract:ASTERTX is a 6MV Marx+Blumlein X-ray generaton, dedicated to the testing of electrical components. For our experiments, the vacuum diode has been modified in order to set up a flash radiographic diode. The Negative Polarity rod pinch diode (NPRPD) has been tested on this generator since 2004. The Polarity has been reversed from previous experiments, in order to take advantage from the maximal X-ray emission toward the anode holder at such a voltage. The main goals of these new experiments are a better understanding of the physical phenomena, by the use of new diagnostics as a 4 images high speed camera, a streak camera and vacuum voltage probes.
