The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Yang Luo - One of the best experts on this subject based on the ideXlab platform.
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Negligible Effect of sodium chloride on the development and function of tgf β induced cd4 foxp3 regulatory t cells
Cell Reports, 2019Co-Authors: Yang Luo, Youqiu Xue, Julie Wang, Junlong Dang, Qiannan Fang, Gonghua Huang, Nancy J Olsen, Song Guo ZhengAbstract:Summary High-salt diets inhibit the suppressive function of thymus-derived natural regulatory T cells (tTreg). Transforming growth factor β (TGF-β)-induced ex vivo regulatory T cells (iTreg) comprise another Treg subset that exhibits similarities and differences with tTreg. Here, we demonstrate that iTregs are completely stable and fully functional under high salt conditions. High salt does not influence the development, differentiation, and functional activities of iTreg but affects Foxp3 stability and function of tTreg in vitro and in vivo. In addition, high salt does not significantly change the transcription profiles of the iTreg signature or pro-inflammatory genes. Therefore, we conclude that iTreg, unlike tTreg, are stable and functional in the presence of high salt. Our findings provide additional evidence that iTreg may have different biological features from tTreg and suggest a greater potential for clinical utility in patients with autoimmune diseases, in which the complicated role of environmental factors, including diet, must be considered.
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Negligible Effect of Sodium Chloride on the Development and Function of TGF-β-Induced CD4+ Foxp3+ Regulatory T Cells
Elsevier, 2019Co-Authors: Yang Luo, Youqiu Xue, Julie Wang, Junlong Dang, Qiannan Fang, Gonghua Huang, Nancy Olsen, Song Guo ZhengAbstract:Summary: High-salt diets inhibit the suppressive function of thymus-derived natural regulatory T cells (tTreg). Transforming growth factor β (TGF-β)-induced ex vivo regulatory T cells (iTreg) comprise another Treg subset that exhibits similarities and differences with tTreg. Here, we demonstrate that iTregs are completely stable and fully functional under high salt conditions. High salt does not influence the development, differentiation, and functional activities of iTreg but affects Foxp3 stability and function of tTreg in vitro and in vivo. In addition, high salt does not significantly change the transcription profiles of the iTreg signature or pro-inflammatory genes. Therefore, we conclude that iTreg, unlike tTreg, are stable and functional in the presence of high salt. Our findings provide additional evidence that iTreg may have different biological features from tTreg and suggest a greater potential for clinical utility in patients with autoimmune diseases, in which the complicated role of environmental factors, including diet, must be considered. : Luo et al. show that high salt does not affect the characteristics of TGF-β-induced regulatory T cells (iTregs). iTregs are stable and functional in the presence of high salt during autoimmune responses. Keywords: TGF-β-induced regulatory T cells, iTreg, thymus-derived natural regulatory T cells, tTreg, induced regulatory T cells in the periphery, pTreg, sodium chloride, Th1, Th17, coliti
Song Guo Zheng - One of the best experts on this subject based on the ideXlab platform.
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Negligible Effect of sodium chloride on the development and function of tgf β induced cd4 foxp3 regulatory t cells
Cell Reports, 2019Co-Authors: Yang Luo, Youqiu Xue, Julie Wang, Junlong Dang, Qiannan Fang, Gonghua Huang, Nancy J Olsen, Song Guo ZhengAbstract:Summary High-salt diets inhibit the suppressive function of thymus-derived natural regulatory T cells (tTreg). Transforming growth factor β (TGF-β)-induced ex vivo regulatory T cells (iTreg) comprise another Treg subset that exhibits similarities and differences with tTreg. Here, we demonstrate that iTregs are completely stable and fully functional under high salt conditions. High salt does not influence the development, differentiation, and functional activities of iTreg but affects Foxp3 stability and function of tTreg in vitro and in vivo. In addition, high salt does not significantly change the transcription profiles of the iTreg signature or pro-inflammatory genes. Therefore, we conclude that iTreg, unlike tTreg, are stable and functional in the presence of high salt. Our findings provide additional evidence that iTreg may have different biological features from tTreg and suggest a greater potential for clinical utility in patients with autoimmune diseases, in which the complicated role of environmental factors, including diet, must be considered.
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Negligible Effect of Sodium Chloride on the Development and Function of TGF-β-Induced CD4+ Foxp3+ Regulatory T Cells
Elsevier, 2019Co-Authors: Yang Luo, Youqiu Xue, Julie Wang, Junlong Dang, Qiannan Fang, Gonghua Huang, Nancy Olsen, Song Guo ZhengAbstract:Summary: High-salt diets inhibit the suppressive function of thymus-derived natural regulatory T cells (tTreg). Transforming growth factor β (TGF-β)-induced ex vivo regulatory T cells (iTreg) comprise another Treg subset that exhibits similarities and differences with tTreg. Here, we demonstrate that iTregs are completely stable and fully functional under high salt conditions. High salt does not influence the development, differentiation, and functional activities of iTreg but affects Foxp3 stability and function of tTreg in vitro and in vivo. In addition, high salt does not significantly change the transcription profiles of the iTreg signature or pro-inflammatory genes. Therefore, we conclude that iTreg, unlike tTreg, are stable and functional in the presence of high salt. Our findings provide additional evidence that iTreg may have different biological features from tTreg and suggest a greater potential for clinical utility in patients with autoimmune diseases, in which the complicated role of environmental factors, including diet, must be considered. : Luo et al. show that high salt does not affect the characteristics of TGF-β-induced regulatory T cells (iTregs). iTregs are stable and functional in the presence of high salt during autoimmune responses. Keywords: TGF-β-induced regulatory T cells, iTreg, thymus-derived natural regulatory T cells, tTreg, induced regulatory T cells in the periphery, pTreg, sodium chloride, Th1, Th17, coliti
Youqiu Xue - One of the best experts on this subject based on the ideXlab platform.
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Negligible Effect of sodium chloride on the development and function of tgf β induced cd4 foxp3 regulatory t cells
Cell Reports, 2019Co-Authors: Yang Luo, Youqiu Xue, Julie Wang, Junlong Dang, Qiannan Fang, Gonghua Huang, Nancy J Olsen, Song Guo ZhengAbstract:Summary High-salt diets inhibit the suppressive function of thymus-derived natural regulatory T cells (tTreg). Transforming growth factor β (TGF-β)-induced ex vivo regulatory T cells (iTreg) comprise another Treg subset that exhibits similarities and differences with tTreg. Here, we demonstrate that iTregs are completely stable and fully functional under high salt conditions. High salt does not influence the development, differentiation, and functional activities of iTreg but affects Foxp3 stability and function of tTreg in vitro and in vivo. In addition, high salt does not significantly change the transcription profiles of the iTreg signature or pro-inflammatory genes. Therefore, we conclude that iTreg, unlike tTreg, are stable and functional in the presence of high salt. Our findings provide additional evidence that iTreg may have different biological features from tTreg and suggest a greater potential for clinical utility in patients with autoimmune diseases, in which the complicated role of environmental factors, including diet, must be considered.
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Negligible Effect of Sodium Chloride on the Development and Function of TGF-β-Induced CD4+ Foxp3+ Regulatory T Cells
Elsevier, 2019Co-Authors: Yang Luo, Youqiu Xue, Julie Wang, Junlong Dang, Qiannan Fang, Gonghua Huang, Nancy Olsen, Song Guo ZhengAbstract:Summary: High-salt diets inhibit the suppressive function of thymus-derived natural regulatory T cells (tTreg). Transforming growth factor β (TGF-β)-induced ex vivo regulatory T cells (iTreg) comprise another Treg subset that exhibits similarities and differences with tTreg. Here, we demonstrate that iTregs are completely stable and fully functional under high salt conditions. High salt does not influence the development, differentiation, and functional activities of iTreg but affects Foxp3 stability and function of tTreg in vitro and in vivo. In addition, high salt does not significantly change the transcription profiles of the iTreg signature or pro-inflammatory genes. Therefore, we conclude that iTreg, unlike tTreg, are stable and functional in the presence of high salt. Our findings provide additional evidence that iTreg may have different biological features from tTreg and suggest a greater potential for clinical utility in patients with autoimmune diseases, in which the complicated role of environmental factors, including diet, must be considered. : Luo et al. show that high salt does not affect the characteristics of TGF-β-induced regulatory T cells (iTregs). iTregs are stable and functional in the presence of high salt during autoimmune responses. Keywords: TGF-β-induced regulatory T cells, iTreg, thymus-derived natural regulatory T cells, tTreg, induced regulatory T cells in the periphery, pTreg, sodium chloride, Th1, Th17, coliti
Julie Wang - One of the best experts on this subject based on the ideXlab platform.
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Negligible Effect of sodium chloride on the development and function of tgf β induced cd4 foxp3 regulatory t cells
Cell Reports, 2019Co-Authors: Yang Luo, Youqiu Xue, Julie Wang, Junlong Dang, Qiannan Fang, Gonghua Huang, Nancy J Olsen, Song Guo ZhengAbstract:Summary High-salt diets inhibit the suppressive function of thymus-derived natural regulatory T cells (tTreg). Transforming growth factor β (TGF-β)-induced ex vivo regulatory T cells (iTreg) comprise another Treg subset that exhibits similarities and differences with tTreg. Here, we demonstrate that iTregs are completely stable and fully functional under high salt conditions. High salt does not influence the development, differentiation, and functional activities of iTreg but affects Foxp3 stability and function of tTreg in vitro and in vivo. In addition, high salt does not significantly change the transcription profiles of the iTreg signature or pro-inflammatory genes. Therefore, we conclude that iTreg, unlike tTreg, are stable and functional in the presence of high salt. Our findings provide additional evidence that iTreg may have different biological features from tTreg and suggest a greater potential for clinical utility in patients with autoimmune diseases, in which the complicated role of environmental factors, including diet, must be considered.
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Negligible Effect of Sodium Chloride on the Development and Function of TGF-β-Induced CD4+ Foxp3+ Regulatory T Cells
Elsevier, 2019Co-Authors: Yang Luo, Youqiu Xue, Julie Wang, Junlong Dang, Qiannan Fang, Gonghua Huang, Nancy Olsen, Song Guo ZhengAbstract:Summary: High-salt diets inhibit the suppressive function of thymus-derived natural regulatory T cells (tTreg). Transforming growth factor β (TGF-β)-induced ex vivo regulatory T cells (iTreg) comprise another Treg subset that exhibits similarities and differences with tTreg. Here, we demonstrate that iTregs are completely stable and fully functional under high salt conditions. High salt does not influence the development, differentiation, and functional activities of iTreg but affects Foxp3 stability and function of tTreg in vitro and in vivo. In addition, high salt does not significantly change the transcription profiles of the iTreg signature or pro-inflammatory genes. Therefore, we conclude that iTreg, unlike tTreg, are stable and functional in the presence of high salt. Our findings provide additional evidence that iTreg may have different biological features from tTreg and suggest a greater potential for clinical utility in patients with autoimmune diseases, in which the complicated role of environmental factors, including diet, must be considered. : Luo et al. show that high salt does not affect the characteristics of TGF-β-induced regulatory T cells (iTregs). iTregs are stable and functional in the presence of high salt during autoimmune responses. Keywords: TGF-β-induced regulatory T cells, iTreg, thymus-derived natural regulatory T cells, tTreg, induced regulatory T cells in the periphery, pTreg, sodium chloride, Th1, Th17, coliti
Junlong Dang - One of the best experts on this subject based on the ideXlab platform.
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Negligible Effect of sodium chloride on the development and function of tgf β induced cd4 foxp3 regulatory t cells
Cell Reports, 2019Co-Authors: Yang Luo, Youqiu Xue, Julie Wang, Junlong Dang, Qiannan Fang, Gonghua Huang, Nancy J Olsen, Song Guo ZhengAbstract:Summary High-salt diets inhibit the suppressive function of thymus-derived natural regulatory T cells (tTreg). Transforming growth factor β (TGF-β)-induced ex vivo regulatory T cells (iTreg) comprise another Treg subset that exhibits similarities and differences with tTreg. Here, we demonstrate that iTregs are completely stable and fully functional under high salt conditions. High salt does not influence the development, differentiation, and functional activities of iTreg but affects Foxp3 stability and function of tTreg in vitro and in vivo. In addition, high salt does not significantly change the transcription profiles of the iTreg signature or pro-inflammatory genes. Therefore, we conclude that iTreg, unlike tTreg, are stable and functional in the presence of high salt. Our findings provide additional evidence that iTreg may have different biological features from tTreg and suggest a greater potential for clinical utility in patients with autoimmune diseases, in which the complicated role of environmental factors, including diet, must be considered.
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Negligible Effect of Sodium Chloride on the Development and Function of TGF-β-Induced CD4+ Foxp3+ Regulatory T Cells
Elsevier, 2019Co-Authors: Yang Luo, Youqiu Xue, Julie Wang, Junlong Dang, Qiannan Fang, Gonghua Huang, Nancy Olsen, Song Guo ZhengAbstract:Summary: High-salt diets inhibit the suppressive function of thymus-derived natural regulatory T cells (tTreg). Transforming growth factor β (TGF-β)-induced ex vivo regulatory T cells (iTreg) comprise another Treg subset that exhibits similarities and differences with tTreg. Here, we demonstrate that iTregs are completely stable and fully functional under high salt conditions. High salt does not influence the development, differentiation, and functional activities of iTreg but affects Foxp3 stability and function of tTreg in vitro and in vivo. In addition, high salt does not significantly change the transcription profiles of the iTreg signature or pro-inflammatory genes. Therefore, we conclude that iTreg, unlike tTreg, are stable and functional in the presence of high salt. Our findings provide additional evidence that iTreg may have different biological features from tTreg and suggest a greater potential for clinical utility in patients with autoimmune diseases, in which the complicated role of environmental factors, including diet, must be considered. : Luo et al. show that high salt does not affect the characteristics of TGF-β-induced regulatory T cells (iTregs). iTregs are stable and functional in the presence of high salt during autoimmune responses. Keywords: TGF-β-induced regulatory T cells, iTreg, thymus-derived natural regulatory T cells, tTreg, induced regulatory T cells in the periphery, pTreg, sodium chloride, Th1, Th17, coliti
