Neonatal Jaundice

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Tina M Slusher - One of the best experts on this subject based on the ideXlab platform.

  • Knowledge & Practices of Mothers related to Neonatal Jaundice in Saravan, Iran
    Pediatrics, 2018
    Co-Authors: Allia A Vaez, Ida L Slusher, Farshad Sadeghi, Tina M Slusher
    Abstract:

    Purpose: Neonatal Jaundice is a serious condition that may result in fatal complications if not treated appropriately and in a timely manner. Prior research studies indicate that there is a high incidence of Neonatal Jaundice in Iran and that the use of herbal or traditional remedies may lead to a delay in the diagnosis and treatment of Neonatal Jaundice in Iran. Further, there is a paucity of research on the knowledge and practices of mothers related …

  • knowledge practices of mothers related to Neonatal Jaundice in saravan iran
    Pediatrics, 2018
    Co-Authors: Allia A Vaez, Ida L Slusher, Farshad Sadeghi, Tina M Slusher
    Abstract:

    Purpose: Neonatal Jaundice is a serious condition that may result in fatal complications if not treated appropriately and in a timely manner. Prior research studies indicate that there is a high incidence of Neonatal Jaundice in Iran and that the use of herbal or traditional remedies may lead to a delay in the diagnosis and treatment of Neonatal Jaundice in Iran. Further, there is a paucity of research on the knowledge and practices of mothers related …

  • a global need for affordable Neonatal Jaundice technologies
    Seminars in Perinatology, 2011
    Co-Authors: Tina M Slusher, Alvin Zipursky, Vinod K Bhutani
    Abstract:

    Globally, health care providers worldwide recognize that severe Neonatal Jaundice is a “silent” cause of significant Neonatal morbidity and mortality. Untreated Neonatal Jaundice can lead to death in the Neonatal period and to kernicterus, a major cause of neurologic disability (choreo-athetoid cerebral palsy, deafness, language difficulty) in children who survive this largely preventable Neonatal tragedy. Appropriate technologies are urgently needed. These include tools to promote and enhance visual assessment of the degree of Jaundice, such as simpler transcutaneous bilirubin measurements and readily available serum bilirubin measurements that could be incorporated into routine treatment and follow-up. Widespread screening for glucose-6-phoshate dehydrogenase deficiency is needed because this is often a major cause of Neonatal Jaundice and kernicterus worldwide. Recognition and treatment of Rh hemolytic disease, another known preventable cause of kernicterus, is critical. In addition, effective phototherapy is crucial if we are to make kernicterus a “never-event.” Finally it is essential that we conduct appropriate population-based studies to accurately elucidate the magnitude of the problem. However, knowledge alone is not sufficient. If we are to implement these and other programs and technologies to relegate severe Neonatal Jaundice and its sequelae to the history books, screening and interventions must be low cost and technologically appropriate for low and middle income nations.

S. A. Olowe - One of the best experts on this subject based on the ideXlab platform.

  • Infants with severe Neonatal Jaundice in Lagos, Nigeria: incidence, correlates and hearing screening outcomes.
    Tropical Medicine & International Health, 2009
    Co-Authors: Bolajoko O. Olusanya, A. A. Akande, Am Emokpae, S. A. Olowe
    Abstract:

    OBJECTIVES: To establish the incidence, correlates and hearing screening outcomes of infants with severe Neonatal Jaundice in Nigeria. METHODS: Community-based study in which all infants attending Bacille Calmette-Guerin immunisation clinics in inner-city Lagos were enrolled into a universal hearing screening programme during which correlates of severe Neonatal Jaundice (requiring phototherapy and/or exchange blood transfusion) were explored with multivariable logistic regression. RESULTS: Of the 5262 infants enrolled, only 48.7% were born in hospitals although almost all mothers (97.9%) attended antenatal clinics. 6.7% had a history of Neonatal Jaundice of whom 5.5% (95% CI:4.9-6.2) received phototherapy and 1.9% (95% CI:1.5-2.3) had an exchange blood transfusion. Factors independently associated with severe Neonatal Jaundice were maternal religion, occupation, use of herbal preparations during pregnancy, infant's gender, weight at screening, multiple gestation and place of birth. All but two infants with severe Neonatal Jaundice were exclusively breast-fed. Of those who failed the hearing tests, 17.3% were treated with phototherapy and 11.3% had an exchange blood transfusion. At least 8.9% of infants requiring phototherapy and 17.3% of those requiring exchange blood transfusion were at risk of sensorineural hearing loss. CONCLUSIONS: Severe Neonatal Jaundice is a significant condition associated with modifiable risk factors in this population. Policy initiatives for prevention, early detection followed by appropriate and timely intervention are urgently needed to reduce the disease burden.

  • Infants with severe Neonatal Jaundice in Lagos, Nigeria: Incidence, correlates and hearing screening outcomes
    Tropical Medicine and International Health, 2009
    Co-Authors: Bolajoko O. Olusanya, A. A. Akande, Am Emokpae, S. A. Olowe
    Abstract:

    OBJECTIVES: To establish the incidence, correlates and hearing screening outcomes of infants with severe Neonatal Jaundice in Nigeria. METHODS: Community-based study in which all infants attending Bacille Calmette-Guérin immunisation clinics in inner-city Lagos were enrolled into a universal hearing screening programme during which correlates of severe Neonatal Jaundice (requiring phototherapy and/or exchange blood transfusion) were explored with multivariable logistic regression. RESULTS: Of the 5262 infants enrolled, only 48.7% were born in hospitals although almost all mothers (97.9%) attended antenatal clinics. 6.7% had a history of Neonatal Jaundice of whom 5.5% (95% CI:4.9-6.2) received phototherapy and 1.9% (95% CI:1.5-2.3) had an exchange blood transfusion. Factors independently associated with severe Neonatal Jaundice were maternal religion, occupation, use of herbal preparations during pregnancy, infant's gender, weight at screening, multiple gestation and place of birth. All but two infants with severe Neonatal Jaundice were exclusively breast-fed. Of those who failed the hearing tests, 17.3% were treated with phototherapy and 11.3% had an exchange blood transfusion. At least 8.9% of infants requiring phototherapy and 17.3% of those requiring exchange blood transfusion were at risk of sensorineural hearing loss. CONCLUSIONS: Severe Neonatal Jaundice is a significant condition associated with modifiable risk factors in this population. Policy initiatives for prevention, early detection followed by appropriate and timely intervention are urgently needed to reduce the disease burden.

Allia A Vaez - One of the best experts on this subject based on the ideXlab platform.

Bolajoko O. Olusanya - One of the best experts on this subject based on the ideXlab platform.

  • Infants with severe Neonatal Jaundice in Lagos, Nigeria: incidence, correlates and hearing screening outcomes.
    Tropical Medicine & International Health, 2009
    Co-Authors: Bolajoko O. Olusanya, A. A. Akande, Am Emokpae, S. A. Olowe
    Abstract:

    OBJECTIVES: To establish the incidence, correlates and hearing screening outcomes of infants with severe Neonatal Jaundice in Nigeria. METHODS: Community-based study in which all infants attending Bacille Calmette-Guerin immunisation clinics in inner-city Lagos were enrolled into a universal hearing screening programme during which correlates of severe Neonatal Jaundice (requiring phototherapy and/or exchange blood transfusion) were explored with multivariable logistic regression. RESULTS: Of the 5262 infants enrolled, only 48.7% were born in hospitals although almost all mothers (97.9%) attended antenatal clinics. 6.7% had a history of Neonatal Jaundice of whom 5.5% (95% CI:4.9-6.2) received phototherapy and 1.9% (95% CI:1.5-2.3) had an exchange blood transfusion. Factors independently associated with severe Neonatal Jaundice were maternal religion, occupation, use of herbal preparations during pregnancy, infant's gender, weight at screening, multiple gestation and place of birth. All but two infants with severe Neonatal Jaundice were exclusively breast-fed. Of those who failed the hearing tests, 17.3% were treated with phototherapy and 11.3% had an exchange blood transfusion. At least 8.9% of infants requiring phototherapy and 17.3% of those requiring exchange blood transfusion were at risk of sensorineural hearing loss. CONCLUSIONS: Severe Neonatal Jaundice is a significant condition associated with modifiable risk factors in this population. Policy initiatives for prevention, early detection followed by appropriate and timely intervention are urgently needed to reduce the disease burden.

  • Infants with severe Neonatal Jaundice in Lagos, Nigeria: Incidence, correlates and hearing screening outcomes
    Tropical Medicine and International Health, 2009
    Co-Authors: Bolajoko O. Olusanya, A. A. Akande, Am Emokpae, S. A. Olowe
    Abstract:

    OBJECTIVES: To establish the incidence, correlates and hearing screening outcomes of infants with severe Neonatal Jaundice in Nigeria. METHODS: Community-based study in which all infants attending Bacille Calmette-Guérin immunisation clinics in inner-city Lagos were enrolled into a universal hearing screening programme during which correlates of severe Neonatal Jaundice (requiring phototherapy and/or exchange blood transfusion) were explored with multivariable logistic regression. RESULTS: Of the 5262 infants enrolled, only 48.7% were born in hospitals although almost all mothers (97.9%) attended antenatal clinics. 6.7% had a history of Neonatal Jaundice of whom 5.5% (95% CI:4.9-6.2) received phototherapy and 1.9% (95% CI:1.5-2.3) had an exchange blood transfusion. Factors independently associated with severe Neonatal Jaundice were maternal religion, occupation, use of herbal preparations during pregnancy, infant's gender, weight at screening, multiple gestation and place of birth. All but two infants with severe Neonatal Jaundice were exclusively breast-fed. Of those who failed the hearing tests, 17.3% were treated with phototherapy and 11.3% had an exchange blood transfusion. At least 8.9% of infants requiring phototherapy and 17.3% of those requiring exchange blood transfusion were at risk of sensorineural hearing loss. CONCLUSIONS: Severe Neonatal Jaundice is a significant condition associated with modifiable risk factors in this population. Policy initiatives for prevention, early detection followed by appropriate and timely intervention are urgently needed to reduce the disease burden.

David K. Stevenson - One of the best experts on this subject based on the ideXlab platform.

  • understanding Neonatal Jaundice a perspective on causation
    Pediatrics and Neonatology, 2010
    Co-Authors: Ronald S. Cohen, Ronald J. Wong, David K. Stevenson
    Abstract:

    Neonatal Jaundice can be best understood as a balance between the production and elimination of bilirubin, with a multitude of factors and conditions affecting each of these processes. When an imbalance results because of an increase in circulating bilirubin (or the bilirubin load) to significantly high levels (severe hyperbilirubinemia), it may cause permanent neurologic sequelae (kernicterus). In most infants, an increase in bilirubin production (e.g., due to hemolysis) is the primary cause of severe hyperbilirubinemia, and thus reducing bilirubin production is a rational approach for its management. The situation can become critical in infants with an associated impaired bilirubin elimination mechanism as a result of a genetic deficiency and/or polymorphism. Combining information about bilirubin production and genetic information about bilirubin elimination with the tracking of bilirubin levels means that a relative assessment of Jaundice risk might be feasible. Information on the level of bilirubin production and its rate of elimination may help to guide the clinical management of Neonatal Jaundice.

  • Understanding Neonatal Jaundice: A perspective on causation
    Pediatrics and Neonatology, 2010
    Co-Authors: Ronald S. Cohen, Ronald J. Wong, David K. Stevenson
    Abstract:

    Neonatal Jaundice can be best understood as a balance between the production and elimination of bilirubin, with a multitude of factors and conditions affecting each of these processes. When an imbalance results because of an increase in circulating bilirubin (or the bilirubin load) to significantly high levels (severe hyperbilirubinemia), it may cause permanent neurologic sequelae (kernicterus). In most infants, an increase in bilirubin production (e.g., due to hemolysis) is the primary cause of severe hyperbilirubinemia, and thus reducing bilirubin production is a rational approach for its management. The situation can become critical in infants with an associated impaired bilirubin elimination mechanism as a result of a genetic deficiency and/or polymorphism. Combining information about bilirubin production and genetic information about bilirubin elimination with the tracking of bilirubin levels means that a relative assessment of Jaundice risk might be feasible. Information on the level of bilirubin production and its rate of elimination may help to guide the clinical management of Neonatal Jaundice. ?? 2010 Taiwan Pediatric Association.

  • Epidemiology of Neonatal Jaundice in the Jerusalem population
    Journal of pediatric gastroenterology and nutrition, 1990
    Co-Authors: RE Gale, Shaul Dollberg, Daniel S. Seidman, David K. Stevenson
    Abstract:

    Of 10,122 singleton babies born from January 1, 1984 to March 31, 1988, we compared 1,154 term infants with high serum bilirubin levels (greater than 12.9 mg/dl) to 1,154 infants with low serum bilirubin levels (less than or equal to 12.9 mg/dl) randomly selected from the remaining 8,968 subjects. We found that a high bilirubin level was significantly associated with male sex; maternal diabetes (chronic and gestational); pregnancy-induced hypertension; previous sibling with Neonatal Jaundice; delivery by cesarean section, vacuum, or forceps; epidural anesthesia; mother with blood type O; first delivery; cephalohematoma; short gestation; lower birth weight; and lower birth order (p less than 0.01); and older maternal age, low percentile for birth weight, and the percentage of weight loss during hospitalization (p less than 0.05). Variables with significantly different frequencies in control and study groups were used in a multivariate analysis, thus further refining the data by the use of logistic regression. Teenage mothers (less than or equal to 19 years old) had the lowest risk, whereas older mothers (greater than 35 years old) had the highest risk of all age groups for having an infant with Neonatal Jaundice. First delivery and previous sibling with Neonatal Jaundice were also risk factors. Male sex, short gestation, and delivery by vacuum extraction were other notable risk factors. Our results suggest that, even among industrialized Western societies, risk factors may interact differently to produce higher Neonatal serum bilirubin levels. The importance of a risk factor may also be dependent upon its relative prevalence in a parturient population.

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