The Experts below are selected from a list of 1056 Experts worldwide ranked by ideXlab platform
John N. Eble - One of the best experts on this subject based on the ideXlab platform.
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Mixed epithelial and stromal tumor of the kidney lacks the genetic alterations of cellular congenital mesoblastic Nephroma.
Human Pathology, 2001Co-Authors: Christopher R. Pierson, Megan S. Schober, Tracie Wallis, Fazlul H. Sarkar, Poul H. Sorensen, John N. Eble, John R. Srigley, Edward C. Jones, David J. Grignon, Volkan AdsayAbstract:Abstract Mixed epithelial and stromal tumor of the kidney is a recently recognized neoplasm that occurs almost exclusively in perimenopausal women. Because it frequently contains areas of smooth muscle in which epithelial structures are embedded, some have concluded that it is the adult form of congenital mesoblastic Nephroma. Others have concluded that the morphology and epidemiology of mixed epithelial and stromal tumor indicate that it is unrelated to congenital mesoblastic Nephroma. Although the genetic alterations of mixed epithelial and stromal tumor have not been previously elucidated, much is known about the genetic alterations of cellular congenital mesoblastic Nephroma. The present study was undertaken to determine if mixed epithelial and stromal tumors have any of the genetic alterations recognized as typical of cellular congenital mesoblastic Nephroma. RNA extraction was performed on formalin-fixed, paraffin-embedded tissue from 7 mixed epithelial and stromal tumors followed by reverse-transcription polymerase chain reaction to detect the ETV6-NTRK3 gene fusion. Fluorescent in situ hybridization with centromere-specific probes for chromosomes 8, 11, and 17 was performed to evaluate polyploidy of these chromosomes in 11 cases of mixed epithelial and stromal tumor. None of the mixed epithelial and stromal tumors showed any of these genetic alterations. We conclude that mixed epithelial and stromal tumor of the kidney lacks the genetic alterations typical of cellular congenital mesoblastic Nephroma, is unrelated to it, and the appellation “adult mesoblastic Nephroma” should not be used for these tumors. H UM P ATHOL 32:513-520. Copyright © 2001 by W.B. Saunders Company
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extensively cystic renal neoplasms cystic Nephroma cystic partially differentiated nephroblastoma multilocular cystic renal cell carcinoma and cystic hamartoma of renal pelvis
Seminars in Diagnostic Pathology, 1998Co-Authors: John N. Eble, Stephen M BonsibAbstract:Predominantly cystic renal neoplasms have been the source of diagnostic confusion and controversy. In this review, the authors analyze the clinical and pathological features of four entities that consistently exhibit a diffusely cystic growth pattern, are strikingly similar in their gross appearances, and are not separable by preoperative imaging studies. Based on the literature, this review concludes that tumors in young children that have been classified as cystic Nephroma and cystic partially differentiated nephroblastoma likely represent a single entity, and all should be considered highly cystic Wilms' tumors with little or no capacity for invasion or metastasis and diagnosed as cystic partially differentiated nephroblastoma. Conversely, cystic Nephroma in adults has no discernible connection with Wilms' tumor or nephrogenic rests and should be considered a benign composite neoplasm of stroma and epithelium of unknown histogenesis, which may rarely become malignant with secondary development of a sarcoma. Multilocular cystic renal cell carcinoma appears to be unrelated to cystic Nephroma and if the following criteria are met, it appears to be a neoplasm with an intrinsically cystic growth pattern, and no, or at most little, malignant potential: (1) an expansile mass is surrounded by a fibrous wall, (2) the interior of the tumor entirely is composed of cysts and septa with no expansile solid nodules, and (3) the septa contain aggregates of epithelial cells with clear cytoplasm. Cystic hamartoma of the renal pelvis is a rare, complex tumor composed of stroma with a prominent smooth muscle component and a variety of epithelial elements.
Murali Chintagumpala - One of the best experts on this subject based on the ideXlab platform.
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Cellular mesoblastic Nephroma (infantile renal fibrosarcoma): institutional review of the clinical, diagnostic imaging, and pathologic features of a distinctive neoplasm of infancy
Pediatric Radiology, 2009Co-Authors: Petek Bayindir, Robert Paul Guillerman, M. John Hicks, Murali ChintagumpalaAbstract:Background Cellular mesoblastic Nephroma has been associated with a more aggressive course than classic mesoblastic Nephroma, including local recurrences and metastases.
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congenital mesoblastic Nephroma in a child with the beckwith wiedemann syndrome
The Journal of Urology, 1997Co-Authors: Richard W Sutherland, John S Wiener, John M Hicks, Edith P Hawkins, Murali ChintagumpalaAbstract:To our knowledge we report the first known case of congenital mesoblastic Nephroma in an infant with the Beckwith-Wiedemann syndrome. The renal tumor classically associated with the Beckwith-Wiedemann syndrome is Wilms tumor with an overall risk of occurrence of 3 to 5%.1 However, congenital mesoblastic Nephroma is the most common renal tumor of infancy, with 60% of cases presenting within the first 3 months of life and 90% presenting during the first year of life.' CASE REPORT M. M. was first seen at 4 weeks of age for a large umbilical hernia with drainage. Abdominal ultrasound revealed a possible urachal cyst and normal kidneys, but no other abnormality. A voiding cystourethrogram was normal. Genetic service evaluation for large body size (more than 90th percentile), left lower limb hemihypertrophy, asymmetrical macroglossia, posterior helical indentations of the ear pinna, umbilical anomaly and hypoglycemia in the first days of life resulted in a clinical diagnosis of Beckwith-Wiedemann syndrome. A followup abdominal ultrasound and subsequent computerized tomography performed at 8 weeks of life showed resolution of the urachal anomaly, but the development of a new 2 x 3 cm. solid mass in the lower pole of the left kidney. Further studies for a possible Wilms tumor included a chest computerized tomography which revealed a 2 mm. nodule in the parenchyma of the right lung. The patient underwent a biopsy of the lung nodule that revealed an unremarkable lymph node. A firm pale mass in the lower pole of the left kidney, a normal contralateral kidney, and no evidence of metastatic disease were found on abdominal exploration. Biopsy of the renal mass showed congenital mesoblastic Nephroma characterized by a proliferation of relatively bland spindled cells lacking pleomorphism, no increase in mitotic figures, absence of necrosis and hemorrhage, and the presence of entrapped typical renal
Stephen M Bonsib - One of the best experts on this subject based on the ideXlab platform.
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extensively cystic renal neoplasms cystic Nephroma cystic partially differentiated nephroblastoma multilocular cystic renal cell carcinoma and cystic hamartoma of renal pelvis
Seminars in Diagnostic Pathology, 1998Co-Authors: John N. Eble, Stephen M BonsibAbstract:Predominantly cystic renal neoplasms have been the source of diagnostic confusion and controversy. In this review, the authors analyze the clinical and pathological features of four entities that consistently exhibit a diffusely cystic growth pattern, are strikingly similar in their gross appearances, and are not separable by preoperative imaging studies. Based on the literature, this review concludes that tumors in young children that have been classified as cystic Nephroma and cystic partially differentiated nephroblastoma likely represent a single entity, and all should be considered highly cystic Wilms' tumors with little or no capacity for invasion or metastasis and diagnosed as cystic partially differentiated nephroblastoma. Conversely, cystic Nephroma in adults has no discernible connection with Wilms' tumor or nephrogenic rests and should be considered a benign composite neoplasm of stroma and epithelium of unknown histogenesis, which may rarely become malignant with secondary development of a sarcoma. Multilocular cystic renal cell carcinoma appears to be unrelated to cystic Nephroma and if the following criteria are met, it appears to be a neoplasm with an intrinsically cystic growth pattern, and no, or at most little, malignant potential: (1) an expansile mass is surrounded by a fibrous wall, (2) the interior of the tumor entirely is composed of cysts and septa with no expansile solid nodules, and (3) the septa contain aggregates of epithelial cells with clear cytoplasm. Cystic hamartoma of the renal pelvis is a rare, complex tumor composed of stroma with a prominent smooth muscle component and a variety of epithelial elements.
Volkan Adsay - One of the best experts on this subject based on the ideXlab platform.
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Mixed epithelial and stromal tumor of the kidney lacks the genetic alterations of cellular congenital mesoblastic Nephroma.
Human Pathology, 2001Co-Authors: Christopher R. Pierson, Megan S. Schober, Tracie Wallis, Fazlul H. Sarkar, Poul H. Sorensen, John N. Eble, John R. Srigley, Edward C. Jones, David J. Grignon, Volkan AdsayAbstract:Abstract Mixed epithelial and stromal tumor of the kidney is a recently recognized neoplasm that occurs almost exclusively in perimenopausal women. Because it frequently contains areas of smooth muscle in which epithelial structures are embedded, some have concluded that it is the adult form of congenital mesoblastic Nephroma. Others have concluded that the morphology and epidemiology of mixed epithelial and stromal tumor indicate that it is unrelated to congenital mesoblastic Nephroma. Although the genetic alterations of mixed epithelial and stromal tumor have not been previously elucidated, much is known about the genetic alterations of cellular congenital mesoblastic Nephroma. The present study was undertaken to determine if mixed epithelial and stromal tumors have any of the genetic alterations recognized as typical of cellular congenital mesoblastic Nephroma. RNA extraction was performed on formalin-fixed, paraffin-embedded tissue from 7 mixed epithelial and stromal tumors followed by reverse-transcription polymerase chain reaction to detect the ETV6-NTRK3 gene fusion. Fluorescent in situ hybridization with centromere-specific probes for chromosomes 8, 11, and 17 was performed to evaluate polyploidy of these chromosomes in 11 cases of mixed epithelial and stromal tumor. None of the mixed epithelial and stromal tumors showed any of these genetic alterations. We conclude that mixed epithelial and stromal tumor of the kidney lacks the genetic alterations typical of cellular congenital mesoblastic Nephroma, is unrelated to it, and the appellation “adult mesoblastic Nephroma” should not be used for these tumors. H UM P ATHOL 32:513-520. Copyright © 2001 by W.B. Saunders Company
Ferran Algaba - One of the best experts on this subject based on the ideXlab platform.
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editorial comment on cystic Nephroma and mixed epithelial and stromal tumour of the kidney opposite ends of the spectrum of the same entity
European Urology, 2008Co-Authors: Ferran AlgabaAbstract:the first two cases with a fatal clinical outcome. Histopathology 2004;44:302–4. [30] Yap YS, Coleman M, Olver I. Aggressive mixed epithelialstromal tumour of the kidney treated with chemotherapy and radiotherapy. Lancet Oncol 2004;5:747–9. [31] Svec A, Hes O, Michal M, Zachoval R. Malignant mixed epithelial and stromal tumor of the kidney. Virchows Arch 2001;439:700–2. [32] Jevremovic D, Lager DJ, Lewin M. Cystic Nephroma (multilocular cyst) and mixed epithelial and stromal tumor of the kidney: a spectrum of the same entity? Ann Diagn Pathol 2006;10:77–82. [33] Omar AM, Khattak AQ, Lee JA. Cystic renal cell carcinoma arising from multilocular cystic Nephroma of the same kidney. Int Braz J Urol 2006;32:187–9. [34] Shen SS, Truong LD, Ayala AG, Ro JY. Recently described and emphasized entities of renal neoplasms. Arch Pathol Lab Med 2007;131:1234–43. [35] Brown JM. Cystic partially differentiated nephroblastoma. J Pathol 1975;115:175–8. [36] Joshi VV, Banerjee AK, Yadav K, Pathak IC. Cystic partially differentiated nephroblastoma: a clinicopathologic entity in the spectrum of infantile renal neoplasia. Cancer 1977; 40:789–95. [37] Joshi VV, Beckwith JB. Pathologic delineation of the papillonodular type of cystic partially differentiated nephroblastoma. A review of 11 cases. Cancer 1990;66:1568–77. [38] Eble JN. Cystic Nephroma and cystic partially differentiated nephroblastoma: two entities or one? Adv Anat Pathol 1994;1:99–102. [39] Kirkali Z, Algaba F, Scarpelli M, Trias I, Selvaggi FP, Van Poppel H. What does the urologist expect from the pathologist (and what can the pathologists give) in reporting on adult kidney tumour specimens? Eur Urol 2007;51: 1194–201. [40] Ljungberg B, Hanbury DC, Kuczyk MA, et al., European Association of Urology Guideline Group for renal cell