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Amin Suria - One of the best experts on this subject based on the ideXlab platform.

  • bio active cardenolides from the leaves of Nerium Oleander
    Phytochemistry, 1999
    Co-Authors: Sabira Begum, Bina S Siddiqui, Razia Sultana, Atiya Zia, Amin Suria
    Abstract:

    A bioactivity directed isolation of the methanolic extract of the fresh, uncrushed leaves of Nerium Oleander showing a central nervous system (CNS) depressant eAect in mice has been undertaken. As a result, four CNS depressant cardenolides including a new cardenolide, neridiginoside and three known constituents, nerizoside, neritaloside and odoroside-H, have been isolated which exhibited CNS depressant activity in mice at a dose of 25 mg/kg. The structure of neridiginoside was elucidated as 3b-O(D-diginosyl)-5b,14b-dihydroxy-card-20(22)-enolide, using spectroscopic methods including one-dimensional and two-dimensional NMR (COSY-45, NOESY, J-resolved, HMQC and HMBC). The known compounds have been indentified through spectral studies and comparison of data with those reported in the literature. # 1998 Elsevier Science Ltd. All rights reserved.

  • cardenolides from the methanolic extract of Nerium Oleander leaves possessing central nervous system depressant activity in mice
    Journal of Natural Products, 1997
    Co-Authors: Bina S Siddiqui, Sabira Begum, Razia Sultana, And Atiya Zia, Amin Suria
    Abstract:

    Two new cardenolides, 3β-O-(d-2-O-methyldigitalosyl)-14β-hydroxy-5β-carda-16,20(22)-dienolide (1) and 3β-hydroxy-8,14-epoxy-5β-carda-16,20(22)-dienolide (2), and two known cardenolides, 3β-O-(d-digitalosyl)-14β-hydroxy-16β-acetoxy-5β-card-20(22)-enolide (3) and 3β-O-(d-digitalosyl)-14β-hydroxy-5β-card-20(22)-enolide (4), have been isolated from the leaves of Nerium Oleander following a bioactivity-directed isolation of the MeOH extract, which showed central nervous system (CNS) depressant activity in mice at a dosage of 50 mg/kg ip. Their structures were established on the basis of chemical and spectral data. Compounds 1, 3, and 4 were found to exhibit sedation in mice at a dosage of 25 mg/kg, although 2 had no effect on the CNS of mice at a dosage of up to 50 mg/kg.

  • cardenolides from the methanolic extract of Nerium Oleander leaves possessing central nervous system depressant activity in mice
    Journal of Natural Products, 1997
    Co-Authors: Bina S Siddiqui, Sabira Begum, Razia Sultana, And Atiya Zia, Amin Suria
    Abstract:

    Two new cardenolides, 3 beta-O-(D-2-O-methyldigitalosyl)-14 beta-hydroxy-5 beta-carda-16,20(22)-dienolide (1) and 3 beta-hydroxy-8,14-epoxy-5 beta-carda-16,20(22)-dienolide (2), and two known cardenolides, 3 beta-O-(D-digitalosyl)-14 beta-hydroxy-16 beta-acetoxy-5 beta-card-20(22)-enolide (3) and 3 beta-O-(D-digitalosyl)-14 beta-hydroxy-5 beta-card-20(22)-enolide (4), have been isolated from the leaves of Nerium Oleander following a bioactivity-directed isolation of the MeOH extract, which showed central nervous system (CNS) depressant activity in mice at a dosage of 50 mg/kg i.p. Their structures were established on the basis of chemical and spectral data. Compounds 1, 3, and 4 were found to exhibit sedation in mice at a dosage of 25 mg/kg, although 2 had no effect on the CNS of mice at a dosage of up to 50 mg/kg.

  • studies on the constituents of the leaves of Nerium Oleander on behavior pattern in mice
    Journal of Ethnopharmacology, 1995
    Co-Authors: Atiya Zia, Bina S Siddiqui, Sabira Begum, Salimuzzaman Siddiqui, Amin Suria
    Abstract:

    Fresh, undried and uncrushed leaves of Nerium Oleander were subjected to methanol extraction and bioassay directed fractionation. This led to the isolation of two purified fractions namely, B-1 and B-3. Fractions B-1 and B-3 were studied with respect to their actions on the central nervous system and behavior pattern in mice. Both fractions were found to produce reduction in locomotor activity, rota rod performance and potentiation of hexobarbital sleeping time. These fractions also showed analgesic activity. When tested against picrotoxin induced convulsions fraction B-1 showed 40% protection, while fraction B-3 exhibited 60% protection against bicuculline induced convulsions. These findings suggest that both fractions possess a CNS depressant action.

Bina S Siddiqui - One of the best experts on this subject based on the ideXlab platform.

  • flavonoid and cardenolide glycosides and a pentacyclic triterpene from the leaves of Nerium Oleander and evaluation of cytotoxicity
    Phytochemistry, 2012
    Co-Authors: Bina S Siddiqui, Nasima Khatoon, Sabira Begum, Ahsana Dar Farooq, Kehkashan Arshad Qamar, Huma Aslam Bhatti, Syed Kashif Ali
    Abstract:

    Abstract A pentacyclic triterpene, Oleanderocioic acid, two flavonoidal glycosides, quercetin-5- O -[α- l -rhamnopyranosyl-(1 → 6)]-β- d -glucopyranoside and kaempferol-5- O -[α- l -rhamnopyranosyl-(1 → 6)-β- d -glucopyranoside, and a cardenolide, oleandigoside, together with 11 known compounds, were isolated from the leaves of Nerium Oleander . Their structures were elucidated on the basis of spectroscopic analysis. The growth inhibitory and cytotoxic activities of eight compounds were evaluated against the MCF-7 human breast cancer cell line using a sulforhodamine B assay. Three compounds, oleandrin, odoroside A and B were further assayed using a panel of 57 human cancer cell lines.

  • bio active cardenolides from the leaves of Nerium Oleander
    Phytochemistry, 1999
    Co-Authors: Sabira Begum, Bina S Siddiqui, Razia Sultana, Atiya Zia, Amin Suria
    Abstract:

    A bioactivity directed isolation of the methanolic extract of the fresh, uncrushed leaves of Nerium Oleander showing a central nervous system (CNS) depressant eAect in mice has been undertaken. As a result, four CNS depressant cardenolides including a new cardenolide, neridiginoside and three known constituents, nerizoside, neritaloside and odoroside-H, have been isolated which exhibited CNS depressant activity in mice at a dose of 25 mg/kg. The structure of neridiginoside was elucidated as 3b-O(D-diginosyl)-5b,14b-dihydroxy-card-20(22)-enolide, using spectroscopic methods including one-dimensional and two-dimensional NMR (COSY-45, NOESY, J-resolved, HMQC and HMBC). The known compounds have been indentified through spectral studies and comparison of data with those reported in the literature. # 1998 Elsevier Science Ltd. All rights reserved.

  • cardenolides from the methanolic extract of Nerium Oleander leaves possessing central nervous system depressant activity in mice
    Journal of Natural Products, 1997
    Co-Authors: Bina S Siddiqui, Sabira Begum, Razia Sultana, And Atiya Zia, Amin Suria
    Abstract:

    Two new cardenolides, 3β-O-(d-2-O-methyldigitalosyl)-14β-hydroxy-5β-carda-16,20(22)-dienolide (1) and 3β-hydroxy-8,14-epoxy-5β-carda-16,20(22)-dienolide (2), and two known cardenolides, 3β-O-(d-digitalosyl)-14β-hydroxy-16β-acetoxy-5β-card-20(22)-enolide (3) and 3β-O-(d-digitalosyl)-14β-hydroxy-5β-card-20(22)-enolide (4), have been isolated from the leaves of Nerium Oleander following a bioactivity-directed isolation of the MeOH extract, which showed central nervous system (CNS) depressant activity in mice at a dosage of 50 mg/kg ip. Their structures were established on the basis of chemical and spectral data. Compounds 1, 3, and 4 were found to exhibit sedation in mice at a dosage of 25 mg/kg, although 2 had no effect on the CNS of mice at a dosage of up to 50 mg/kg.

  • cardenolides from the methanolic extract of Nerium Oleander leaves possessing central nervous system depressant activity in mice
    Journal of Natural Products, 1997
    Co-Authors: Bina S Siddiqui, Sabira Begum, Razia Sultana, And Atiya Zia, Amin Suria
    Abstract:

    Two new cardenolides, 3 beta-O-(D-2-O-methyldigitalosyl)-14 beta-hydroxy-5 beta-carda-16,20(22)-dienolide (1) and 3 beta-hydroxy-8,14-epoxy-5 beta-carda-16,20(22)-dienolide (2), and two known cardenolides, 3 beta-O-(D-digitalosyl)-14 beta-hydroxy-16 beta-acetoxy-5 beta-card-20(22)-enolide (3) and 3 beta-O-(D-digitalosyl)-14 beta-hydroxy-5 beta-card-20(22)-enolide (4), have been isolated from the leaves of Nerium Oleander following a bioactivity-directed isolation of the MeOH extract, which showed central nervous system (CNS) depressant activity in mice at a dosage of 50 mg/kg i.p. Their structures were established on the basis of chemical and spectral data. Compounds 1, 3, and 4 were found to exhibit sedation in mice at a dosage of 25 mg/kg, although 2 had no effect on the CNS of mice at a dosage of up to 50 mg/kg.

  • studies on the constituents of the leaves of Nerium Oleander on behavior pattern in mice
    Journal of Ethnopharmacology, 1995
    Co-Authors: Atiya Zia, Bina S Siddiqui, Sabira Begum, Salimuzzaman Siddiqui, Amin Suria
    Abstract:

    Fresh, undried and uncrushed leaves of Nerium Oleander were subjected to methanol extraction and bioassay directed fractionation. This led to the isolation of two purified fractions namely, B-1 and B-3. Fractions B-1 and B-3 were studied with respect to their actions on the central nervous system and behavior pattern in mice. Both fractions were found to produce reduction in locomotor activity, rota rod performance and potentiation of hexobarbital sleeping time. These fractions also showed analgesic activity. When tested against picrotoxin induced convulsions fraction B-1 showed 40% protection, while fraction B-3 exhibited 60% protection against bicuculline induced convulsions. These findings suggest that both fractions possess a CNS depressant action.

Sabira Begum - One of the best experts on this subject based on the ideXlab platform.

  • flavonoid and cardenolide glycosides and a pentacyclic triterpene from the leaves of Nerium Oleander and evaluation of cytotoxicity
    Phytochemistry, 2012
    Co-Authors: Bina S Siddiqui, Nasima Khatoon, Sabira Begum, Ahsana Dar Farooq, Kehkashan Arshad Qamar, Huma Aslam Bhatti, Syed Kashif Ali
    Abstract:

    Abstract A pentacyclic triterpene, Oleanderocioic acid, two flavonoidal glycosides, quercetin-5- O -[α- l -rhamnopyranosyl-(1 → 6)]-β- d -glucopyranoside and kaempferol-5- O -[α- l -rhamnopyranosyl-(1 → 6)-β- d -glucopyranoside, and a cardenolide, oleandigoside, together with 11 known compounds, were isolated from the leaves of Nerium Oleander . Their structures were elucidated on the basis of spectroscopic analysis. The growth inhibitory and cytotoxic activities of eight compounds were evaluated against the MCF-7 human breast cancer cell line using a sulforhodamine B assay. Three compounds, oleandrin, odoroside A and B were further assayed using a panel of 57 human cancer cell lines.

  • two new steroids dehydroadynerizoside and neristigmol from Nerium Oleander leaves
    Polish Journal of Chemistry, 2006
    Co-Authors: B S Siddiqui, Sabira Begum, N Khatoon, Razia Sultana, S A Durrani
    Abstract:

    Two new steroids dehydroadynerizoside (1) and neristigmol (2) have been isolated from the fresh, uncrushed leaves of Nerium Oleander and their structures elucidated as 3 β-O-(β-D-2-deoxy-rhamnosyl)-8,14β-epoxy-5β-carda-16,20(22)-dienolide and hexyl p-stigmasteryloxy-benzoate, respectively. The structure elucidation is based on spectroscopic methods including ID NMR ( 1 H NMR, 13 C NMR) and 2D NMR ('H-'H COSY, NOESY, HMQC, HMBC and J-resolved) and chemical transformation.

  • bio active cardenolides from the leaves of Nerium Oleander
    Phytochemistry, 1999
    Co-Authors: Sabira Begum, Bina S Siddiqui, Razia Sultana, Atiya Zia, Amin Suria
    Abstract:

    A bioactivity directed isolation of the methanolic extract of the fresh, uncrushed leaves of Nerium Oleander showing a central nervous system (CNS) depressant eAect in mice has been undertaken. As a result, four CNS depressant cardenolides including a new cardenolide, neridiginoside and three known constituents, nerizoside, neritaloside and odoroside-H, have been isolated which exhibited CNS depressant activity in mice at a dose of 25 mg/kg. The structure of neridiginoside was elucidated as 3b-O(D-diginosyl)-5b,14b-dihydroxy-card-20(22)-enolide, using spectroscopic methods including one-dimensional and two-dimensional NMR (COSY-45, NOESY, J-resolved, HMQC and HMBC). The known compounds have been indentified through spectral studies and comparison of data with those reported in the literature. # 1998 Elsevier Science Ltd. All rights reserved.

  • cardenolides from the methanolic extract of Nerium Oleander leaves possessing central nervous system depressant activity in mice
    Journal of Natural Products, 1997
    Co-Authors: Bina S Siddiqui, Sabira Begum, Razia Sultana, And Atiya Zia, Amin Suria
    Abstract:

    Two new cardenolides, 3β-O-(d-2-O-methyldigitalosyl)-14β-hydroxy-5β-carda-16,20(22)-dienolide (1) and 3β-hydroxy-8,14-epoxy-5β-carda-16,20(22)-dienolide (2), and two known cardenolides, 3β-O-(d-digitalosyl)-14β-hydroxy-16β-acetoxy-5β-card-20(22)-enolide (3) and 3β-O-(d-digitalosyl)-14β-hydroxy-5β-card-20(22)-enolide (4), have been isolated from the leaves of Nerium Oleander following a bioactivity-directed isolation of the MeOH extract, which showed central nervous system (CNS) depressant activity in mice at a dosage of 50 mg/kg ip. Their structures were established on the basis of chemical and spectral data. Compounds 1, 3, and 4 were found to exhibit sedation in mice at a dosage of 25 mg/kg, although 2 had no effect on the CNS of mice at a dosage of up to 50 mg/kg.

  • cardenolides from the methanolic extract of Nerium Oleander leaves possessing central nervous system depressant activity in mice
    Journal of Natural Products, 1997
    Co-Authors: Bina S Siddiqui, Sabira Begum, Razia Sultana, And Atiya Zia, Amin Suria
    Abstract:

    Two new cardenolides, 3 beta-O-(D-2-O-methyldigitalosyl)-14 beta-hydroxy-5 beta-carda-16,20(22)-dienolide (1) and 3 beta-hydroxy-8,14-epoxy-5 beta-carda-16,20(22)-dienolide (2), and two known cardenolides, 3 beta-O-(D-digitalosyl)-14 beta-hydroxy-16 beta-acetoxy-5 beta-card-20(22)-enolide (3) and 3 beta-O-(D-digitalosyl)-14 beta-hydroxy-5 beta-card-20(22)-enolide (4), have been isolated from the leaves of Nerium Oleander following a bioactivity-directed isolation of the MeOH extract, which showed central nervous system (CNS) depressant activity in mice at a dosage of 50 mg/kg i.p. Their structures were established on the basis of chemical and spectral data. Compounds 1, 3, and 4 were found to exhibit sedation in mice at a dosage of 25 mg/kg, although 2 had no effect on the CNS of mice at a dosage of up to 50 mg/kg.

Luay Rashan - One of the best experts on this subject based on the ideXlab platform.

Razia Sultana - One of the best experts on this subject based on the ideXlab platform.

  • two new steroids dehydroadynerizoside and neristigmol from Nerium Oleander leaves
    Polish Journal of Chemistry, 2006
    Co-Authors: B S Siddiqui, Sabira Begum, N Khatoon, Razia Sultana, S A Durrani
    Abstract:

    Two new steroids dehydroadynerizoside (1) and neristigmol (2) have been isolated from the fresh, uncrushed leaves of Nerium Oleander and their structures elucidated as 3 β-O-(β-D-2-deoxy-rhamnosyl)-8,14β-epoxy-5β-carda-16,20(22)-dienolide and hexyl p-stigmasteryloxy-benzoate, respectively. The structure elucidation is based on spectroscopic methods including ID NMR ( 1 H NMR, 13 C NMR) and 2D NMR ('H-'H COSY, NOESY, HMQC, HMBC and J-resolved) and chemical transformation.

  • bio active cardenolides from the leaves of Nerium Oleander
    Phytochemistry, 1999
    Co-Authors: Sabira Begum, Bina S Siddiqui, Razia Sultana, Atiya Zia, Amin Suria
    Abstract:

    A bioactivity directed isolation of the methanolic extract of the fresh, uncrushed leaves of Nerium Oleander showing a central nervous system (CNS) depressant eAect in mice has been undertaken. As a result, four CNS depressant cardenolides including a new cardenolide, neridiginoside and three known constituents, nerizoside, neritaloside and odoroside-H, have been isolated which exhibited CNS depressant activity in mice at a dose of 25 mg/kg. The structure of neridiginoside was elucidated as 3b-O(D-diginosyl)-5b,14b-dihydroxy-card-20(22)-enolide, using spectroscopic methods including one-dimensional and two-dimensional NMR (COSY-45, NOESY, J-resolved, HMQC and HMBC). The known compounds have been indentified through spectral studies and comparison of data with those reported in the literature. # 1998 Elsevier Science Ltd. All rights reserved.

  • cardenolides from the methanolic extract of Nerium Oleander leaves possessing central nervous system depressant activity in mice
    Journal of Natural Products, 1997
    Co-Authors: Bina S Siddiqui, Sabira Begum, Razia Sultana, And Atiya Zia, Amin Suria
    Abstract:

    Two new cardenolides, 3β-O-(d-2-O-methyldigitalosyl)-14β-hydroxy-5β-carda-16,20(22)-dienolide (1) and 3β-hydroxy-8,14-epoxy-5β-carda-16,20(22)-dienolide (2), and two known cardenolides, 3β-O-(d-digitalosyl)-14β-hydroxy-16β-acetoxy-5β-card-20(22)-enolide (3) and 3β-O-(d-digitalosyl)-14β-hydroxy-5β-card-20(22)-enolide (4), have been isolated from the leaves of Nerium Oleander following a bioactivity-directed isolation of the MeOH extract, which showed central nervous system (CNS) depressant activity in mice at a dosage of 50 mg/kg ip. Their structures were established on the basis of chemical and spectral data. Compounds 1, 3, and 4 were found to exhibit sedation in mice at a dosage of 25 mg/kg, although 2 had no effect on the CNS of mice at a dosage of up to 50 mg/kg.

  • cardenolides from the methanolic extract of Nerium Oleander leaves possessing central nervous system depressant activity in mice
    Journal of Natural Products, 1997
    Co-Authors: Bina S Siddiqui, Sabira Begum, Razia Sultana, And Atiya Zia, Amin Suria
    Abstract:

    Two new cardenolides, 3 beta-O-(D-2-O-methyldigitalosyl)-14 beta-hydroxy-5 beta-carda-16,20(22)-dienolide (1) and 3 beta-hydroxy-8,14-epoxy-5 beta-carda-16,20(22)-dienolide (2), and two known cardenolides, 3 beta-O-(D-digitalosyl)-14 beta-hydroxy-16 beta-acetoxy-5 beta-card-20(22)-enolide (3) and 3 beta-O-(D-digitalosyl)-14 beta-hydroxy-5 beta-card-20(22)-enolide (4), have been isolated from the leaves of Nerium Oleander following a bioactivity-directed isolation of the MeOH extract, which showed central nervous system (CNS) depressant activity in mice at a dosage of 50 mg/kg i.p. Their structures were established on the basis of chemical and spectral data. Compounds 1, 3, and 4 were found to exhibit sedation in mice at a dosage of 25 mg/kg, although 2 had no effect on the CNS of mice at a dosage of up to 50 mg/kg.