The Experts below are selected from a list of 96 Experts worldwide ranked by ideXlab platform
Takeshi Yagi - One of the best experts on this subject based on the ideXlab platform.
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neuropilin semaphorin iii d mediated chemorepulsive signals play a crucial role in peripheral Nerve Projection in mice
Neuron, 1997Co-Authors: Takashi Kitsukawa, Masahiko Taniguchi, Takeshi Yagi, Masayuki Shimizu, Makoto Sanbo, Tatsumi Hirata, Yoko Bekku, Hajime FujisawaAbstract:Neuropilin is a neuronal cell surface protein and has been shown to function as a receptor for a secreted protein, semaphorin III/D, that can induce neuronal growth cone collapse and repulsion of neurites in vitro. The roles of neuropilin in vivo, however, are unknown. Here, we report that neuropilin-deficient mutant mice produced by targeted disruption of the neuropilin gene show severe abnormalities in the trajectory of efferent fibers of the PNS. We also describe that neuropilin-deprived dorsal root ganglion neurons are perfectly protected from growth cone collapse elicited by semaphorin III/D. Our results indicate that neuropilin-semaphorin III/D-mediated chemorepulsive signals play a major role in guidance of PNS efferents.
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disruption of semaphorin iii d gene causes severe abnormality in peripheral Nerve Projection
Neuron, 1997Co-Authors: Masahiko Taniguchi, Shigeki Yuasa, Hajime Fujisawa, Ichiro Naruse, Shinsuke Saga, Masayoshi Mishina, Takeshi YagiAbstract:The molecules of the collapsin/semaphorin gene family have been thought to play an essential role in axon guidance during development. Semaphorin III/D is a member of this family, has been shown to repel dorsal root ganglion (DRG) axons in vitro, and has been implicated in the patterning of sensory afferents in the spinal cord. Although semaphorin III/D mRNA is expressed in a wide variety of neural and nonneural tissues in vivo, the role played by semaphorin III/D in regions other than the spinal cord is not known. Here, we show that mice homozygous for a targeted mutation in semaphorin III/D show severe abnormality in peripheral Nerve Projection. This abnormality is seen in the trigeminal, facial, vagus, accessory, and glossopharyngeal Nerves but not in the oculomotor Nerve. These results suggest that semaphorin III/D functions as a selective repellent in vivo.
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Disruption of semaphorin III/D gene causes severe abnormality in peripheral Nerve Projection.
Neuron, 1997Co-Authors: Masahiko Taniguchi, Shigeki Yuasa, Hajime Fujisawa, Ichiro Naruse, Shinsuke Saga, Masayoshi Mishina, Takeshi YagiAbstract:The molecules of the collapsin/semaphorin gene family have been thought to play an essential role in axon guidance during development. Semaphorin III/D is a member of this family, has been shown to repel dorsal root ganglion (DRG) axons in vitro, and has been implicated in the patterning of sensory afferents in the spinal cord. Although semaphorin III/D mRNA is expressed in a wide variety of neural and nonneural tissues in vivo, the role played by semaphorin III/D in regions other than the spinal cord is not known. Here, we show that mice homozygous for a targeted mutation in semaphorin III/D show severe abnormality in peripheral Nerve Projection. This abnormality is seen in the trigeminal, facial, vagus, accessory, and glossopharyngeal Nerves but not in the oculomotor Nerve. These results suggest that semaphorin III/D functions as a selective repellent in vivo.
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Neuropilin-semaphorin III/D-mediated chemorepulsive signals play a crucial role in peripheral Nerve Projection in mice.
Neuron, 1997Co-Authors: Takashi Kitsukawa, Masahiko Taniguchi, Takeshi Yagi, Masayuki Shimizu, Makoto Sanbo, Tatsumi Hirata, Yoko Bekku, Hajime FujisawaAbstract:Neuropilin is a neuronal cell surface protein and has been shown to function as a receptor for a secreted protein, semaphorin III/D, that can induce neuronal growth cone collapse and repulsion of neurites in vitro. The roles of neuropilin in vivo, however, are unknown. Here, we report that neuropilin-deficient mutant mice produced by targeted disruption of the neuropilin gene show severe abnormalities in the trajectory of efferent fibers of the PNS. We also describe that neuropilin-deprived dorsal root ganglion neurons are perfectly protected from growth cone collapse elicited by semaphorin III/D. Our results indicate that neuropilin-semaphorin III/D-mediated chemorepulsive signals play a major role in guidance of PNS efferents.
Hajime Fujisawa - One of the best experts on this subject based on the ideXlab platform.
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neuropilin semaphorin iii d mediated chemorepulsive signals play a crucial role in peripheral Nerve Projection in mice
Neuron, 1997Co-Authors: Takashi Kitsukawa, Masahiko Taniguchi, Takeshi Yagi, Masayuki Shimizu, Makoto Sanbo, Tatsumi Hirata, Yoko Bekku, Hajime FujisawaAbstract:Neuropilin is a neuronal cell surface protein and has been shown to function as a receptor for a secreted protein, semaphorin III/D, that can induce neuronal growth cone collapse and repulsion of neurites in vitro. The roles of neuropilin in vivo, however, are unknown. Here, we report that neuropilin-deficient mutant mice produced by targeted disruption of the neuropilin gene show severe abnormalities in the trajectory of efferent fibers of the PNS. We also describe that neuropilin-deprived dorsal root ganglion neurons are perfectly protected from growth cone collapse elicited by semaphorin III/D. Our results indicate that neuropilin-semaphorin III/D-mediated chemorepulsive signals play a major role in guidance of PNS efferents.
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disruption of semaphorin iii d gene causes severe abnormality in peripheral Nerve Projection
Neuron, 1997Co-Authors: Masahiko Taniguchi, Shigeki Yuasa, Hajime Fujisawa, Ichiro Naruse, Shinsuke Saga, Masayoshi Mishina, Takeshi YagiAbstract:The molecules of the collapsin/semaphorin gene family have been thought to play an essential role in axon guidance during development. Semaphorin III/D is a member of this family, has been shown to repel dorsal root ganglion (DRG) axons in vitro, and has been implicated in the patterning of sensory afferents in the spinal cord. Although semaphorin III/D mRNA is expressed in a wide variety of neural and nonneural tissues in vivo, the role played by semaphorin III/D in regions other than the spinal cord is not known. Here, we show that mice homozygous for a targeted mutation in semaphorin III/D show severe abnormality in peripheral Nerve Projection. This abnormality is seen in the trigeminal, facial, vagus, accessory, and glossopharyngeal Nerves but not in the oculomotor Nerve. These results suggest that semaphorin III/D functions as a selective repellent in vivo.
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Disruption of semaphorin III/D gene causes severe abnormality in peripheral Nerve Projection.
Neuron, 1997Co-Authors: Masahiko Taniguchi, Shigeki Yuasa, Hajime Fujisawa, Ichiro Naruse, Shinsuke Saga, Masayoshi Mishina, Takeshi YagiAbstract:The molecules of the collapsin/semaphorin gene family have been thought to play an essential role in axon guidance during development. Semaphorin III/D is a member of this family, has been shown to repel dorsal root ganglion (DRG) axons in vitro, and has been implicated in the patterning of sensory afferents in the spinal cord. Although semaphorin III/D mRNA is expressed in a wide variety of neural and nonneural tissues in vivo, the role played by semaphorin III/D in regions other than the spinal cord is not known. Here, we show that mice homozygous for a targeted mutation in semaphorin III/D show severe abnormality in peripheral Nerve Projection. This abnormality is seen in the trigeminal, facial, vagus, accessory, and glossopharyngeal Nerves but not in the oculomotor Nerve. These results suggest that semaphorin III/D functions as a selective repellent in vivo.
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Neuropilin-semaphorin III/D-mediated chemorepulsive signals play a crucial role in peripheral Nerve Projection in mice.
Neuron, 1997Co-Authors: Takashi Kitsukawa, Masahiko Taniguchi, Takeshi Yagi, Masayuki Shimizu, Makoto Sanbo, Tatsumi Hirata, Yoko Bekku, Hajime FujisawaAbstract:Neuropilin is a neuronal cell surface protein and has been shown to function as a receptor for a secreted protein, semaphorin III/D, that can induce neuronal growth cone collapse and repulsion of neurites in vitro. The roles of neuropilin in vivo, however, are unknown. Here, we report that neuropilin-deficient mutant mice produced by targeted disruption of the neuropilin gene show severe abnormalities in the trajectory of efferent fibers of the PNS. We also describe that neuropilin-deprived dorsal root ganglion neurons are perfectly protected from growth cone collapse elicited by semaphorin III/D. Our results indicate that neuropilin-semaphorin III/D-mediated chemorepulsive signals play a major role in guidance of PNS efferents.
Masahiko Taniguchi - One of the best experts on this subject based on the ideXlab platform.
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neuropilin semaphorin iii d mediated chemorepulsive signals play a crucial role in peripheral Nerve Projection in mice
Neuron, 1997Co-Authors: Takashi Kitsukawa, Masahiko Taniguchi, Takeshi Yagi, Masayuki Shimizu, Makoto Sanbo, Tatsumi Hirata, Yoko Bekku, Hajime FujisawaAbstract:Neuropilin is a neuronal cell surface protein and has been shown to function as a receptor for a secreted protein, semaphorin III/D, that can induce neuronal growth cone collapse and repulsion of neurites in vitro. The roles of neuropilin in vivo, however, are unknown. Here, we report that neuropilin-deficient mutant mice produced by targeted disruption of the neuropilin gene show severe abnormalities in the trajectory of efferent fibers of the PNS. We also describe that neuropilin-deprived dorsal root ganglion neurons are perfectly protected from growth cone collapse elicited by semaphorin III/D. Our results indicate that neuropilin-semaphorin III/D-mediated chemorepulsive signals play a major role in guidance of PNS efferents.
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disruption of semaphorin iii d gene causes severe abnormality in peripheral Nerve Projection
Neuron, 1997Co-Authors: Masahiko Taniguchi, Shigeki Yuasa, Hajime Fujisawa, Ichiro Naruse, Shinsuke Saga, Masayoshi Mishina, Takeshi YagiAbstract:The molecules of the collapsin/semaphorin gene family have been thought to play an essential role in axon guidance during development. Semaphorin III/D is a member of this family, has been shown to repel dorsal root ganglion (DRG) axons in vitro, and has been implicated in the patterning of sensory afferents in the spinal cord. Although semaphorin III/D mRNA is expressed in a wide variety of neural and nonneural tissues in vivo, the role played by semaphorin III/D in regions other than the spinal cord is not known. Here, we show that mice homozygous for a targeted mutation in semaphorin III/D show severe abnormality in peripheral Nerve Projection. This abnormality is seen in the trigeminal, facial, vagus, accessory, and glossopharyngeal Nerves but not in the oculomotor Nerve. These results suggest that semaphorin III/D functions as a selective repellent in vivo.
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Disruption of semaphorin III/D gene causes severe abnormality in peripheral Nerve Projection.
Neuron, 1997Co-Authors: Masahiko Taniguchi, Shigeki Yuasa, Hajime Fujisawa, Ichiro Naruse, Shinsuke Saga, Masayoshi Mishina, Takeshi YagiAbstract:The molecules of the collapsin/semaphorin gene family have been thought to play an essential role in axon guidance during development. Semaphorin III/D is a member of this family, has been shown to repel dorsal root ganglion (DRG) axons in vitro, and has been implicated in the patterning of sensory afferents in the spinal cord. Although semaphorin III/D mRNA is expressed in a wide variety of neural and nonneural tissues in vivo, the role played by semaphorin III/D in regions other than the spinal cord is not known. Here, we show that mice homozygous for a targeted mutation in semaphorin III/D show severe abnormality in peripheral Nerve Projection. This abnormality is seen in the trigeminal, facial, vagus, accessory, and glossopharyngeal Nerves but not in the oculomotor Nerve. These results suggest that semaphorin III/D functions as a selective repellent in vivo.
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Neuropilin-semaphorin III/D-mediated chemorepulsive signals play a crucial role in peripheral Nerve Projection in mice.
Neuron, 1997Co-Authors: Takashi Kitsukawa, Masahiko Taniguchi, Takeshi Yagi, Masayuki Shimizu, Makoto Sanbo, Tatsumi Hirata, Yoko Bekku, Hajime FujisawaAbstract:Neuropilin is a neuronal cell surface protein and has been shown to function as a receptor for a secreted protein, semaphorin III/D, that can induce neuronal growth cone collapse and repulsion of neurites in vitro. The roles of neuropilin in vivo, however, are unknown. Here, we report that neuropilin-deficient mutant mice produced by targeted disruption of the neuropilin gene show severe abnormalities in the trajectory of efferent fibers of the PNS. We also describe that neuropilin-deprived dorsal root ganglion neurons are perfectly protected from growth cone collapse elicited by semaphorin III/D. Our results indicate that neuropilin-semaphorin III/D-mediated chemorepulsive signals play a major role in guidance of PNS efferents.
Masayoshi Mishina - One of the best experts on this subject based on the ideXlab platform.
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disruption of semaphorin iii d gene causes severe abnormality in peripheral Nerve Projection
Neuron, 1997Co-Authors: Masahiko Taniguchi, Shigeki Yuasa, Hajime Fujisawa, Ichiro Naruse, Shinsuke Saga, Masayoshi Mishina, Takeshi YagiAbstract:The molecules of the collapsin/semaphorin gene family have been thought to play an essential role in axon guidance during development. Semaphorin III/D is a member of this family, has been shown to repel dorsal root ganglion (DRG) axons in vitro, and has been implicated in the patterning of sensory afferents in the spinal cord. Although semaphorin III/D mRNA is expressed in a wide variety of neural and nonneural tissues in vivo, the role played by semaphorin III/D in regions other than the spinal cord is not known. Here, we show that mice homozygous for a targeted mutation in semaphorin III/D show severe abnormality in peripheral Nerve Projection. This abnormality is seen in the trigeminal, facial, vagus, accessory, and glossopharyngeal Nerves but not in the oculomotor Nerve. These results suggest that semaphorin III/D functions as a selective repellent in vivo.
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Disruption of semaphorin III/D gene causes severe abnormality in peripheral Nerve Projection.
Neuron, 1997Co-Authors: Masahiko Taniguchi, Shigeki Yuasa, Hajime Fujisawa, Ichiro Naruse, Shinsuke Saga, Masayoshi Mishina, Takeshi YagiAbstract:The molecules of the collapsin/semaphorin gene family have been thought to play an essential role in axon guidance during development. Semaphorin III/D is a member of this family, has been shown to repel dorsal root ganglion (DRG) axons in vitro, and has been implicated in the patterning of sensory afferents in the spinal cord. Although semaphorin III/D mRNA is expressed in a wide variety of neural and nonneural tissues in vivo, the role played by semaphorin III/D in regions other than the spinal cord is not known. Here, we show that mice homozygous for a targeted mutation in semaphorin III/D show severe abnormality in peripheral Nerve Projection. This abnormality is seen in the trigeminal, facial, vagus, accessory, and glossopharyngeal Nerves but not in the oculomotor Nerve. These results suggest that semaphorin III/D functions as a selective repellent in vivo.
Shinsuke Saga - One of the best experts on this subject based on the ideXlab platform.
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disruption of semaphorin iii d gene causes severe abnormality in peripheral Nerve Projection
Neuron, 1997Co-Authors: Masahiko Taniguchi, Shigeki Yuasa, Hajime Fujisawa, Ichiro Naruse, Shinsuke Saga, Masayoshi Mishina, Takeshi YagiAbstract:The molecules of the collapsin/semaphorin gene family have been thought to play an essential role in axon guidance during development. Semaphorin III/D is a member of this family, has been shown to repel dorsal root ganglion (DRG) axons in vitro, and has been implicated in the patterning of sensory afferents in the spinal cord. Although semaphorin III/D mRNA is expressed in a wide variety of neural and nonneural tissues in vivo, the role played by semaphorin III/D in regions other than the spinal cord is not known. Here, we show that mice homozygous for a targeted mutation in semaphorin III/D show severe abnormality in peripheral Nerve Projection. This abnormality is seen in the trigeminal, facial, vagus, accessory, and glossopharyngeal Nerves but not in the oculomotor Nerve. These results suggest that semaphorin III/D functions as a selective repellent in vivo.
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Disruption of semaphorin III/D gene causes severe abnormality in peripheral Nerve Projection.
Neuron, 1997Co-Authors: Masahiko Taniguchi, Shigeki Yuasa, Hajime Fujisawa, Ichiro Naruse, Shinsuke Saga, Masayoshi Mishina, Takeshi YagiAbstract:The molecules of the collapsin/semaphorin gene family have been thought to play an essential role in axon guidance during development. Semaphorin III/D is a member of this family, has been shown to repel dorsal root ganglion (DRG) axons in vitro, and has been implicated in the patterning of sensory afferents in the spinal cord. Although semaphorin III/D mRNA is expressed in a wide variety of neural and nonneural tissues in vivo, the role played by semaphorin III/D in regions other than the spinal cord is not known. Here, we show that mice homozygous for a targeted mutation in semaphorin III/D show severe abnormality in peripheral Nerve Projection. This abnormality is seen in the trigeminal, facial, vagus, accessory, and glossopharyngeal Nerves but not in the oculomotor Nerve. These results suggest that semaphorin III/D functions as a selective repellent in vivo.