The Experts below are selected from a list of 1815 Experts worldwide ranked by ideXlab platform
Sérgio Livraghi - One of the best experts on this subject based on the ideXlab platform.
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A purely extradural lumbar Nerve Root cavernoma mimicking acute myeloid leukemia recurrence: Case report and literature review.
Surgical neurology international, 2016Co-Authors: Edson Oliveira, José Pedro Lavrador, Alexandra Pignatelli, Joaquim Teixeira, Sérgio LivraghiAbstract:Myeloid sarcoma (MS) is a malignant tumor that usually occurs concomitantly with or following acute myeloid leukemia (AML). Cavernomas are benign congenital malformations that are unusual in the spine and exceedingly rare in pure extradural locations. We report a 73-year-old female with a previous medical history of AML in remission for 3 years who presented with symptoms of low back pain and right lower extremity radiculopathy. A magnetic resonance scan showed an extradural, foraminal Lesion centered at the L2 level involving the right L2 Nerve Root. In view of the history of AML, this Lesion was potentially considered MS, a form of AML relapse. Surgery consisting of a right L1 and L2 hemilaminectomy facilitated gross total resection of the purely extradural Lesion the proved histologically to be a cavernoma. In patients with a history of leukemia, MS must be considered in the differential diagnosis for any epidural or Nerve Root Lesion that appears following treatment. Although rare, cavernomas must be considered among the differential diagnoses for epidural Nerve Root Lesions in the setting of AML.
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A purely extradural lumbar Nerve Root cavernoma mimicking acute myeloid leukemia recurrence: Case report and literature review.
Surgical Neurology International, 2016Co-Authors: Edson Oliveira, José Pedro Lavrador, Joaquim Cruz Teixeira, Alexandra Pignatelli, Sérgio LivraghiAbstract:BACKGROUND Myeloid sarcoma (MS) is a malignant tumor that usually occurs concomitantly with or following acute myeloid leukemia (AML). Cavernomas are benign congenital malformations that are unusual in the spine and exceedingly rare in pure extradural locations. CASE DESCRIPTION We report a 73-year-old female with a previous medical history of AML in remission for 3 years who presented with symptoms of low back pain and right lower extremity radiculopathy. A magnetic resonance scan showed an extradural, foraminal Lesion centered at the L2 level involving the right L2 Nerve Root. In view of the history of AML, this Lesion was potentially considered MS, a form of AML relapse. Surgery consisting of a right L1 and L2 hemilaminectomy facilitated gross total resection of the purely extradural Lesion the proved histologically to be a cavernoma. CONCLUSION In patients with a history of leukemia, MS must be considered in the differential diagnosis for any epidural or Nerve Root Lesion that appears following treatment. Although rare, cavernomas must be considered among the differential diagnoses for epidural Nerve Root Lesions in the setting of AML.
Roberta Barbizan - One of the best experts on this subject based on the ideXlab platform.
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Impact of acute inflammation on spinal motoneuron synaptic plasticity following ventral Root avulsion
Journal of neuroinflammation, 2010Co-Authors: Roberta Barbizan, Alexandre Leite Rodrigues De OliveiraAbstract:Background Ventral Root avulsion is a proximal Nerve Root Lesion in which ventral motor Nerve Rootlets are torn from surface of the spinal cord, resulting in extensive death of motoneurons. It has been previously shown that if such Lesioning is performed in an animal with experimental autoimmune encephalomyelitis (EAE), a significant number of motoneurons can be rescued despite an intense inflammatory reaction. This rescue effect has been attributed to production of a number of neurotrophic factors by invading T cells. Synaptological changes may be involved in neuronal degeneration, and a better understanding of the role of these changes may be of importance for developing new strategies to promote neuronal survival. The objective of the present work was to evaluate neuronal survival, astroglial reaction and synaptic input changes in spinal cord anterior horn motor nuclei after ventral Root avulsion in animals with EAE, both during peak disease and after remission.
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Impact of acute inflammation on spinal motoneuron synaptic plasticity following ventral Root avulsion
Journal of Neuroinflammation, 2010Co-Authors: Roberta Barbizan, Alexandre Lr OliveiraAbstract:Background Ventral Root avulsion is a proximal Nerve Root Lesion in which ventral motor Nerve Rootlets are torn from surface of the spinal cord, resulting in extensive death of motoneurons. It has been previously shown that if such Lesioning is performed in an animal with experimental autoimmune encephalomyelitis (EAE), a significant number of motoneurons can be rescued despite an intense inflammatory reaction. This rescue effect has been attributed to production of a number of neurotrophic factors by invading T cells. Synaptological changes may be involved in neuronal degeneration, and a better understanding of the role of these changes may be of importance for developing new strategies to promote neuronal survival. The objective of the present work was to evaluate neuronal survival, astroglial reaction and synaptic input changes in spinal cord anterior horn motor nuclei after ventral Root avulsion in animals with EAE, both during peak disease and after remission. Methods Lewis rats were subjected to unilateral avulsion of lumbar ventral Roots (VRA) and divided into three groups: VRA control, VRA at peak of EAE, and VRA during EAE remission. The animals were sacrificed and their lumbar spinal cords processed for immunohistochemistry, transmission electron microscopy, and motoneuron counting. Results The results indicate a reduction in astroglial reaction, a maintenance of microglial reactivity, and increases in synaptic covering of, and survival of, motoneurons in the VRA+EAE group as compared to VRA alone. Conclusion The present findings indicate that CNS inflammation may directly influence synaptic plasticity as well as the stability of neuronal networks, positively influencing the survival of Lesioned neurons.
Edson Oliveira - One of the best experts on this subject based on the ideXlab platform.
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A purely extradural lumbar Nerve Root cavernoma mimicking acute myeloid leukemia recurrence: Case report and literature review.
Surgical neurology international, 2016Co-Authors: Edson Oliveira, José Pedro Lavrador, Alexandra Pignatelli, Joaquim Teixeira, Sérgio LivraghiAbstract:Myeloid sarcoma (MS) is a malignant tumor that usually occurs concomitantly with or following acute myeloid leukemia (AML). Cavernomas are benign congenital malformations that are unusual in the spine and exceedingly rare in pure extradural locations. We report a 73-year-old female with a previous medical history of AML in remission for 3 years who presented with symptoms of low back pain and right lower extremity radiculopathy. A magnetic resonance scan showed an extradural, foraminal Lesion centered at the L2 level involving the right L2 Nerve Root. In view of the history of AML, this Lesion was potentially considered MS, a form of AML relapse. Surgery consisting of a right L1 and L2 hemilaminectomy facilitated gross total resection of the purely extradural Lesion the proved histologically to be a cavernoma. In patients with a history of leukemia, MS must be considered in the differential diagnosis for any epidural or Nerve Root Lesion that appears following treatment. Although rare, cavernomas must be considered among the differential diagnoses for epidural Nerve Root Lesions in the setting of AML.
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A purely extradural lumbar Nerve Root cavernoma mimicking acute myeloid leukemia recurrence: Case report and literature review.
Surgical Neurology International, 2016Co-Authors: Edson Oliveira, José Pedro Lavrador, Joaquim Cruz Teixeira, Alexandra Pignatelli, Sérgio LivraghiAbstract:BACKGROUND Myeloid sarcoma (MS) is a malignant tumor that usually occurs concomitantly with or following acute myeloid leukemia (AML). Cavernomas are benign congenital malformations that are unusual in the spine and exceedingly rare in pure extradural locations. CASE DESCRIPTION We report a 73-year-old female with a previous medical history of AML in remission for 3 years who presented with symptoms of low back pain and right lower extremity radiculopathy. A magnetic resonance scan showed an extradural, foraminal Lesion centered at the L2 level involving the right L2 Nerve Root. In view of the history of AML, this Lesion was potentially considered MS, a form of AML relapse. Surgery consisting of a right L1 and L2 hemilaminectomy facilitated gross total resection of the purely extradural Lesion the proved histologically to be a cavernoma. CONCLUSION In patients with a history of leukemia, MS must be considered in the differential diagnosis for any epidural or Nerve Root Lesion that appears following treatment. Although rare, cavernomas must be considered among the differential diagnoses for epidural Nerve Root Lesions in the setting of AML.
Alexandre Lr Oliveira - One of the best experts on this subject based on the ideXlab platform.
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Impact of acute inflammation on spinal motoneuron synaptic plasticity following ventral Root avulsion
Journal of Neuroinflammation, 2010Co-Authors: Roberta Barbizan, Alexandre Lr OliveiraAbstract:Background Ventral Root avulsion is a proximal Nerve Root Lesion in which ventral motor Nerve Rootlets are torn from surface of the spinal cord, resulting in extensive death of motoneurons. It has been previously shown that if such Lesioning is performed in an animal with experimental autoimmune encephalomyelitis (EAE), a significant number of motoneurons can be rescued despite an intense inflammatory reaction. This rescue effect has been attributed to production of a number of neurotrophic factors by invading T cells. Synaptological changes may be involved in neuronal degeneration, and a better understanding of the role of these changes may be of importance for developing new strategies to promote neuronal survival. The objective of the present work was to evaluate neuronal survival, astroglial reaction and synaptic input changes in spinal cord anterior horn motor nuclei after ventral Root avulsion in animals with EAE, both during peak disease and after remission. Methods Lewis rats were subjected to unilateral avulsion of lumbar ventral Roots (VRA) and divided into three groups: VRA control, VRA at peak of EAE, and VRA during EAE remission. The animals were sacrificed and their lumbar spinal cords processed for immunohistochemistry, transmission electron microscopy, and motoneuron counting. Results The results indicate a reduction in astroglial reaction, a maintenance of microglial reactivity, and increases in synaptic covering of, and survival of, motoneurons in the VRA+EAE group as compared to VRA alone. Conclusion The present findings indicate that CNS inflammation may directly influence synaptic plasticity as well as the stability of neuronal networks, positively influencing the survival of Lesioned neurons.
Alexandre Leite Rodrigues De Oliveira - One of the best experts on this subject based on the ideXlab platform.
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Impact of acute inflammation on spinal motoneuron synaptic plasticity following ventral Root avulsion
Journal of neuroinflammation, 2010Co-Authors: Roberta Barbizan, Alexandre Leite Rodrigues De OliveiraAbstract:Background Ventral Root avulsion is a proximal Nerve Root Lesion in which ventral motor Nerve Rootlets are torn from surface of the spinal cord, resulting in extensive death of motoneurons. It has been previously shown that if such Lesioning is performed in an animal with experimental autoimmune encephalomyelitis (EAE), a significant number of motoneurons can be rescued despite an intense inflammatory reaction. This rescue effect has been attributed to production of a number of neurotrophic factors by invading T cells. Synaptological changes may be involved in neuronal degeneration, and a better understanding of the role of these changes may be of importance for developing new strategies to promote neuronal survival. The objective of the present work was to evaluate neuronal survival, astroglial reaction and synaptic input changes in spinal cord anterior horn motor nuclei after ventral Root avulsion in animals with EAE, both during peak disease and after remission.