The Experts below are selected from a list of 6 Experts worldwide ranked by ideXlab platform
Steven L Carroll - One of the best experts on this subject based on the ideXlab platform.
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comparative oncogenomics for peripheral Nerve Sheath Cancer gene discovery
2015Co-Authors: Steven L CarrollAbstract:Abstract : We have developed a robust transgenic mouse model (P0-GGF 3 mice) in which overexpression of the growth factor neuregulin-1 (NRG1) results in the reproducible development of plexiform neurofibromas which subsequently progress to become MPNSTs. We hypothesized that comprehensively characterizing alterations in the genomes and gene expression profiles of peripheral Nerve Sheath tumors arising in our P0- GGF 3 mouse model will identify candidate driver genes mediating plexiform neurofibroma pathogenesis and neurofibroma-MPNST progression, thereby identifying new therapeutic targets in the equivalent human tumors. To test this overarching hypothesis, we are using a comprehensive multi-tiered process to identify candidate driver mutations in P0-GGF 3 neurofibromas and MPNSTs, establish gene signatures defining distinct tumor subtypes and functionally test the role of selected driver mutations characteristic of specific subtypes. Potential driver mutations within relatively large regions of chromosomal gain or loss will be identified using high density array comparative genomic hybridization (aCGH) and cross-species comparisons of this data with aCGH findings from human neurofibromas and MPNSTs. Smaller mutations (missense mutations, nonsense mutations, small indels and fusion events) will be identified using a combination of transcriptome (RNA-Seq) and exome sequencing in these same murine tumors. The contribution of selected candidate driver mutations characteristic of specific tumor subtypes will be validated by manipulating the function of these genes and examining the effect this has in vivo, using orthotopically allografted tumor cells, and a variety of in vitro functional assays. We will validate the relevance of these mutated mouse genes in human neurofibromas and MPNSTs by determining whether these same genes are mutated in human tumors.
Lisa A. Cannon-albright - One of the best experts on this subject based on the ideXlab platform.
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Increased risk for other Cancers in individuals with Ewing sarcoma and their relatives.
Cancer Medicine, 2019Co-Authors: Diana Abbott, Schuyler O'brien, James M. Farnham, Erin L. Young, Kevin B. Jones, Stephen L. Lessnick, R. Lor Randall, Joshua D. Schiffman, Lisa A. Cannon-albrightAbstract:Author(s): Abbott, Diana; O'Brien, Schuyler; Farnham, James M; Young, Erin L; Yap, Jeffrey; Jones, Kevin; Lessnick, Stephen L; Randall, R Lor; Schiffman, Joshua D; Cannon-Albright, Lisa A | Abstract: BACKGROUND:There are few reports of the association of other Cancers with Ewing sarcoma in patients and their relatives. We use a resource combining statewide genealogy and Cancer reporting to provide unbiased risks. METHODS:Using a combined genealogy of 2.3 million Utah individuals and the Utah Cancer Registry (UCR), relative risks (RRs) for Cancers of other sites were estimated in 143 Ewing sarcoma patients using a Cox proportional hazards model with matched controls; however, risks in relatives were estimated using internal cohort-specific Cancer rates in first-, second-, and third-degree relatives. RESULTS:Cancers of three sites (breast, brain, complex genotype/karyotype sarcoma) were observed in excess in Ewing sarcoma patients. No Ewing sarcoma patients were identified among first-, second-, or third-degree relatives of Ewing sarcoma patients. Significantly increased risk for brain, lung/bronchus, female genital, and prostate Cancer was observed in first-degree relatives. Significantly increased risks were observed in second-degree relatives for breast Cancer, nonmelanoma eye Cancer, malignant peripheral Nerve Sheath Cancer, non-Hodgkin lymphoma, and translocation sarcomas. Significantly increased risks for stomach Cancer, prostate Cancer, and acute lymphocytic leukemia were observed in third-degree relatives. CONCLUSIONS:This analysis of risk for Cancer among Ewing sarcoma patients and their relatives indicates evidence for some increased Cancer predisposition in this population which can be used to individualize consideration of potential treatment of patients and screening of patients and relatives.
Diana Abbott - One of the best experts on this subject based on the ideXlab platform.
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Increased risk for other Cancers in individuals with Ewing sarcoma and their relatives.
Cancer Medicine, 2019Co-Authors: Diana Abbott, Schuyler O'brien, James M. Farnham, Erin L. Young, Kevin B. Jones, Stephen L. Lessnick, R. Lor Randall, Joshua D. Schiffman, Lisa A. Cannon-albrightAbstract:Author(s): Abbott, Diana; O'Brien, Schuyler; Farnham, James M; Young, Erin L; Yap, Jeffrey; Jones, Kevin; Lessnick, Stephen L; Randall, R Lor; Schiffman, Joshua D; Cannon-Albright, Lisa A | Abstract: BACKGROUND:There are few reports of the association of other Cancers with Ewing sarcoma in patients and their relatives. We use a resource combining statewide genealogy and Cancer reporting to provide unbiased risks. METHODS:Using a combined genealogy of 2.3 million Utah individuals and the Utah Cancer Registry (UCR), relative risks (RRs) for Cancers of other sites were estimated in 143 Ewing sarcoma patients using a Cox proportional hazards model with matched controls; however, risks in relatives were estimated using internal cohort-specific Cancer rates in first-, second-, and third-degree relatives. RESULTS:Cancers of three sites (breast, brain, complex genotype/karyotype sarcoma) were observed in excess in Ewing sarcoma patients. No Ewing sarcoma patients were identified among first-, second-, or third-degree relatives of Ewing sarcoma patients. Significantly increased risk for brain, lung/bronchus, female genital, and prostate Cancer was observed in first-degree relatives. Significantly increased risks were observed in second-degree relatives for breast Cancer, nonmelanoma eye Cancer, malignant peripheral Nerve Sheath Cancer, non-Hodgkin lymphoma, and translocation sarcomas. Significantly increased risks for stomach Cancer, prostate Cancer, and acute lymphocytic leukemia were observed in third-degree relatives. CONCLUSIONS:This analysis of risk for Cancer among Ewing sarcoma patients and their relatives indicates evidence for some increased Cancer predisposition in this population which can be used to individualize consideration of potential treatment of patients and screening of patients and relatives.
Schuyler O'brien - One of the best experts on this subject based on the ideXlab platform.
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Increased risk for other Cancers in individuals with Ewing sarcoma and their relatives.
Cancer Medicine, 2019Co-Authors: Diana Abbott, Schuyler O'brien, James M. Farnham, Erin L. Young, Kevin B. Jones, Stephen L. Lessnick, R. Lor Randall, Joshua D. Schiffman, Lisa A. Cannon-albrightAbstract:Author(s): Abbott, Diana; O'Brien, Schuyler; Farnham, James M; Young, Erin L; Yap, Jeffrey; Jones, Kevin; Lessnick, Stephen L; Randall, R Lor; Schiffman, Joshua D; Cannon-Albright, Lisa A | Abstract: BACKGROUND:There are few reports of the association of other Cancers with Ewing sarcoma in patients and their relatives. We use a resource combining statewide genealogy and Cancer reporting to provide unbiased risks. METHODS:Using a combined genealogy of 2.3 million Utah individuals and the Utah Cancer Registry (UCR), relative risks (RRs) for Cancers of other sites were estimated in 143 Ewing sarcoma patients using a Cox proportional hazards model with matched controls; however, risks in relatives were estimated using internal cohort-specific Cancer rates in first-, second-, and third-degree relatives. RESULTS:Cancers of three sites (breast, brain, complex genotype/karyotype sarcoma) were observed in excess in Ewing sarcoma patients. No Ewing sarcoma patients were identified among first-, second-, or third-degree relatives of Ewing sarcoma patients. Significantly increased risk for brain, lung/bronchus, female genital, and prostate Cancer was observed in first-degree relatives. Significantly increased risks were observed in second-degree relatives for breast Cancer, nonmelanoma eye Cancer, malignant peripheral Nerve Sheath Cancer, non-Hodgkin lymphoma, and translocation sarcomas. Significantly increased risks for stomach Cancer, prostate Cancer, and acute lymphocytic leukemia were observed in third-degree relatives. CONCLUSIONS:This analysis of risk for Cancer among Ewing sarcoma patients and their relatives indicates evidence for some increased Cancer predisposition in this population which can be used to individualize consideration of potential treatment of patients and screening of patients and relatives.
James M. Farnham - One of the best experts on this subject based on the ideXlab platform.
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Increased risk for other Cancers in individuals with Ewing sarcoma and their relatives.
Cancer Medicine, 2019Co-Authors: Diana Abbott, Schuyler O'brien, James M. Farnham, Erin L. Young, Kevin B. Jones, Stephen L. Lessnick, R. Lor Randall, Joshua D. Schiffman, Lisa A. Cannon-albrightAbstract:Author(s): Abbott, Diana; O'Brien, Schuyler; Farnham, James M; Young, Erin L; Yap, Jeffrey; Jones, Kevin; Lessnick, Stephen L; Randall, R Lor; Schiffman, Joshua D; Cannon-Albright, Lisa A | Abstract: BACKGROUND:There are few reports of the association of other Cancers with Ewing sarcoma in patients and their relatives. We use a resource combining statewide genealogy and Cancer reporting to provide unbiased risks. METHODS:Using a combined genealogy of 2.3 million Utah individuals and the Utah Cancer Registry (UCR), relative risks (RRs) for Cancers of other sites were estimated in 143 Ewing sarcoma patients using a Cox proportional hazards model with matched controls; however, risks in relatives were estimated using internal cohort-specific Cancer rates in first-, second-, and third-degree relatives. RESULTS:Cancers of three sites (breast, brain, complex genotype/karyotype sarcoma) were observed in excess in Ewing sarcoma patients. No Ewing sarcoma patients were identified among first-, second-, or third-degree relatives of Ewing sarcoma patients. Significantly increased risk for brain, lung/bronchus, female genital, and prostate Cancer was observed in first-degree relatives. Significantly increased risks were observed in second-degree relatives for breast Cancer, nonmelanoma eye Cancer, malignant peripheral Nerve Sheath Cancer, non-Hodgkin lymphoma, and translocation sarcomas. Significantly increased risks for stomach Cancer, prostate Cancer, and acute lymphocytic leukemia were observed in third-degree relatives. CONCLUSIONS:This analysis of risk for Cancer among Ewing sarcoma patients and their relatives indicates evidence for some increased Cancer predisposition in this population which can be used to individualize consideration of potential treatment of patients and screening of patients and relatives.