Nerve Transection

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Nirmal Singh - One of the best experts on this subject based on the ideXlab platform.

  • Ameliorative Potential of Pralidoxime in Tibial and Sural Nerve Transection-Induced Neuropathic Pain in Rats
    Biological & Pharmaceutical Bulletin, 2010
    Co-Authors: Gurpreet Kaur, Amteshwar Singh Jaggi, Nirmal Singh
    Abstract:

    The present study was designed to investigate the ameliorative potential of pralidoxime in tibial and sural Nerve Transection-induced neuropathy in rats. Tibial and sural Nerve Transection was performed by sectioning tibial and sural Nerve portions (2 mm) of the sciatic Nerve, and leaving the common peroneal Nerve intact. The pinprick, acetone, hot and cold tail immersion tests were performed to assess the degree of motor functions, mechanical hyperalgesia, cold allodynia, heat and cold hyperalgesia respectively. Biochemically, the tissue thio-barbituric acid reactive species (TBARS), super-oxide anion contents (the markers of oxidative stress) and total calcium levels were measured. Tibial sural Nerve Transection resulted in the development of mechanical hyperalgesia, cold allodynia, heat and cold hyperalgesia along with the rise in oxidative stress and calcium levels. However, administration of pralidoxime (10, 20 mg/kg intraperitoneally (i.p.)) for 14 d attenuated tibial and sural Nerve Transection-induced cold allodynia, mechanical, hot and cold hyperalgesia. Furthermore, pralidoxime also attenuated tibial and sural Nerve Transection induced increase in oxidative stress and calcium levels. It may be concluded that pralidoxime has ameliorative potential in attenuating the painful neuropathic state associated with tibial and sural Nerve Transection, which may possibly be attributed to decrease in oxidative stress and calcium levels.

  • Ameliorative potential of rosiglitazone in tibial and sural Nerve Transection-induced painful neuropathy in rats
    Pharmacological Research, 2009
    Co-Authors: Vivek Jain, Amteshwar Singh Jaggi, Nirmal Singh
    Abstract:

    Abstract The present study was designed to investigate the ameliorative potential of rosiglitazone, a peroxisome proliferator-activated receptor gamma (PPAR γ) agonist, in tibial and sural Nerve Transection-induced neuropathic pain in rats. The pinprick, cold immersion, hot plate and hot immersion tests were performed to assess the degree of mechanical and cold hyperalgesia; heat hyperalgesia and allodynia, respectively. The tissue thio-barbituric acid reactive species and reduced glutathione were measured as the markers of oxidative stress. Furthermore, the myeloperoxidase activity (a specific marker of inflammation) was also measured along with the determination of the calcium levels. Rosiglitazone (2.5, 5 and 10 mg/kg p.o. ), was administered for 28 days after tibial and sural Nerve Transection. Administration of rosiglitazone (5 and 10 mg/kg p.o. ) attenuated tibial and sural Nerve Transection-induced mechanical and cold hyperalgesia without modulating heat hyperalgesia. Rosiglitazone also attenuated tibial and sural Nerve Transection-induced increase in oxidative stress, myeloperoxidase activity and calcium levels. It may be concluded that rosiglitazone has ameliorative potential in attenuating the painful state associated with tibial and sural Nerve Transection, which may further be attributed to anti-inflammatory actions with subsequent decrease in oxidative stress and calcium levels.

  • Ameliorative effects of Ocimum sanctum in sciatic Nerve Transection-induced neuropathy in rats.
    Journal of ethnopharmacology, 2008
    Co-Authors: Arunachalam Muthuraman, Amteshwar Singh Jaggi, Nirmal Singh, Vishal Diwan, Dhandeep Singh
    Abstract:

    Abstract Objectives The present study was aimed at investigating the ameliorative effect of Ocimum sanctum in sciatic Nerve Transection (axotomy)-induced peripheral neuropathy in rats. Materials and methods Sciatic Nerve Transection-induced axonal degeneration was assessed histopathologically. Paw pressure, Von Frey Hair, tail cold-hyperalgesia, motor in-coordination tests were performed to assess the extent of neuropathy. Biochemical estimations of thiobarbituric acid reactive species (TBARS), reduced glutathione (GSH), and total calcium levels were also performed. Methanolic extract of Ocimum sanctum at different doses (50, 100 and 200 mg/kg p.o.) was administered for 10 consecutive days starting from the day of surgery. Results Administration of Ocimum sanctum attenuated sciatic Nerve Transection-induced axonal degeneration, reduction of nociceptive threshold and motor in-coordination. Moreover, it also attenuated axotomy-induced rise in TBARS, total calcium and decrease in GSH levels in a dose-dependent manner. Conclusion Anti-oxidant and calcium attenuating actions may be responsible for observed ameliorative effects of Ocimum sanctum in axotomy-induced neuropathy.

Amteshwar Singh Jaggi - One of the best experts on this subject based on the ideXlab platform.

  • Ameliorative Potential of Pralidoxime in Tibial and Sural Nerve Transection-Induced Neuropathic Pain in Rats
    Biological & Pharmaceutical Bulletin, 2010
    Co-Authors: Gurpreet Kaur, Amteshwar Singh Jaggi, Nirmal Singh
    Abstract:

    The present study was designed to investigate the ameliorative potential of pralidoxime in tibial and sural Nerve Transection-induced neuropathy in rats. Tibial and sural Nerve Transection was performed by sectioning tibial and sural Nerve portions (2 mm) of the sciatic Nerve, and leaving the common peroneal Nerve intact. The pinprick, acetone, hot and cold tail immersion tests were performed to assess the degree of motor functions, mechanical hyperalgesia, cold allodynia, heat and cold hyperalgesia respectively. Biochemically, the tissue thio-barbituric acid reactive species (TBARS), super-oxide anion contents (the markers of oxidative stress) and total calcium levels were measured. Tibial sural Nerve Transection resulted in the development of mechanical hyperalgesia, cold allodynia, heat and cold hyperalgesia along with the rise in oxidative stress and calcium levels. However, administration of pralidoxime (10, 20 mg/kg intraperitoneally (i.p.)) for 14 d attenuated tibial and sural Nerve Transection-induced cold allodynia, mechanical, hot and cold hyperalgesia. Furthermore, pralidoxime also attenuated tibial and sural Nerve Transection induced increase in oxidative stress and calcium levels. It may be concluded that pralidoxime has ameliorative potential in attenuating the painful neuropathic state associated with tibial and sural Nerve Transection, which may possibly be attributed to decrease in oxidative stress and calcium levels.

  • Ameliorative potential of rosiglitazone in tibial and sural Nerve Transection-induced painful neuropathy in rats
    Pharmacological Research, 2009
    Co-Authors: Vivek Jain, Amteshwar Singh Jaggi, Nirmal Singh
    Abstract:

    Abstract The present study was designed to investigate the ameliorative potential of rosiglitazone, a peroxisome proliferator-activated receptor gamma (PPAR γ) agonist, in tibial and sural Nerve Transection-induced neuropathic pain in rats. The pinprick, cold immersion, hot plate and hot immersion tests were performed to assess the degree of mechanical and cold hyperalgesia; heat hyperalgesia and allodynia, respectively. The tissue thio-barbituric acid reactive species and reduced glutathione were measured as the markers of oxidative stress. Furthermore, the myeloperoxidase activity (a specific marker of inflammation) was also measured along with the determination of the calcium levels. Rosiglitazone (2.5, 5 and 10 mg/kg p.o. ), was administered for 28 days after tibial and sural Nerve Transection. Administration of rosiglitazone (5 and 10 mg/kg p.o. ) attenuated tibial and sural Nerve Transection-induced mechanical and cold hyperalgesia without modulating heat hyperalgesia. Rosiglitazone also attenuated tibial and sural Nerve Transection-induced increase in oxidative stress, myeloperoxidase activity and calcium levels. It may be concluded that rosiglitazone has ameliorative potential in attenuating the painful state associated with tibial and sural Nerve Transection, which may further be attributed to anti-inflammatory actions with subsequent decrease in oxidative stress and calcium levels.

  • Ameliorative effects of Ocimum sanctum in sciatic Nerve Transection-induced neuropathy in rats.
    Journal of ethnopharmacology, 2008
    Co-Authors: Arunachalam Muthuraman, Amteshwar Singh Jaggi, Nirmal Singh, Vishal Diwan, Dhandeep Singh
    Abstract:

    Abstract Objectives The present study was aimed at investigating the ameliorative effect of Ocimum sanctum in sciatic Nerve Transection (axotomy)-induced peripheral neuropathy in rats. Materials and methods Sciatic Nerve Transection-induced axonal degeneration was assessed histopathologically. Paw pressure, Von Frey Hair, tail cold-hyperalgesia, motor in-coordination tests were performed to assess the extent of neuropathy. Biochemical estimations of thiobarbituric acid reactive species (TBARS), reduced glutathione (GSH), and total calcium levels were also performed. Methanolic extract of Ocimum sanctum at different doses (50, 100 and 200 mg/kg p.o.) was administered for 10 consecutive days starting from the day of surgery. Results Administration of Ocimum sanctum attenuated sciatic Nerve Transection-induced axonal degeneration, reduction of nociceptive threshold and motor in-coordination. Moreover, it also attenuated axotomy-induced rise in TBARS, total calcium and decrease in GSH levels in a dose-dependent manner. Conclusion Anti-oxidant and calcium attenuating actions may be responsible for observed ameliorative effects of Ocimum sanctum in axotomy-induced neuropathy.

David L Hill - One of the best experts on this subject based on the ideXlab platform.

  • fungiform taste bud degeneration in c57bl 6j mice following chorda lingual Nerve Transection
    The Journal of Comparative Neurology, 2007
    Co-Authors: Nick A Guagliardo, David L Hill
    Abstract:

    Taste buds are dependent on innervation for normal morphology and function. Fungiform taste bud degeneration after chorda tympani Nerve injury has been well documented in rats, hamsters, and gerbils. The current study examines fungiform taste bud distribution and structure in adult C57BL/6J mice from both intact taste systems and after unilateral chorda-lingual Nerve Transection. Fungiform taste buds were visualized and measured with the aid of cytokeratin 8. In control mice, taste buds were smaller and more abundant on the anterior tip (<1 mm) of the tongue. By 5 days after Nerve Transection taste buds were smaller and fewer on the side of the tongue ipsilateral to the Transection and continued to decrease in both size and number until 15 days postTransection. Degenerating fungiform taste buds were smaller due to a loss of taste bud cells rather than changes in taste bud morphology. While almost all taste buds disappeared in more posterior fungiform papillae by 15 days postTransection, the anterior tip of the tongue retained nearly half of its taste buds compared to intact mice. Surviving taste buds could not be explained by an apparent innervation from the remaining intact Nerves. Contralateral effects of Nerve Transection were also observed; taste buds were larger due to an increase in the number of taste bud cells. These data are the first to characterize adult mouse fungiform taste buds and subsequent degeneration after unilateral Nerve Transection. They provide the basis for more mechanistic studies in which genetically engineered mice can be used.

  • Fungiform taste bud degeneration in C57BL/6J mice following chorda-lingual Nerve Transection.
    The Journal of comparative neurology, 2007
    Co-Authors: Nick A Guagliardo, David L Hill
    Abstract:

    Taste buds are dependent on innervation for normal morphology and function. Fungiform taste bud degeneration after chorda tympani Nerve injury has been well documented in rats, hamsters, and gerbils. The current study examines fungiform taste bud distribution and structure in adult C57BL/6J mice from both intact taste systems and after unilateral chorda-lingual Nerve Transection. Fungiform taste buds were visualized and measured with the aid of cytokeratin 8. In control mice, taste buds were smaller and more abundant on the anterior tip (

Dhandeep Singh - One of the best experts on this subject based on the ideXlab platform.

  • Ameliorative effects of Ocimum sanctum in sciatic Nerve Transection-induced neuropathy in rats.
    Journal of ethnopharmacology, 2008
    Co-Authors: Arunachalam Muthuraman, Amteshwar Singh Jaggi, Nirmal Singh, Vishal Diwan, Dhandeep Singh
    Abstract:

    Abstract Objectives The present study was aimed at investigating the ameliorative effect of Ocimum sanctum in sciatic Nerve Transection (axotomy)-induced peripheral neuropathy in rats. Materials and methods Sciatic Nerve Transection-induced axonal degeneration was assessed histopathologically. Paw pressure, Von Frey Hair, tail cold-hyperalgesia, motor in-coordination tests were performed to assess the extent of neuropathy. Biochemical estimations of thiobarbituric acid reactive species (TBARS), reduced glutathione (GSH), and total calcium levels were also performed. Methanolic extract of Ocimum sanctum at different doses (50, 100 and 200 mg/kg p.o.) was administered for 10 consecutive days starting from the day of surgery. Results Administration of Ocimum sanctum attenuated sciatic Nerve Transection-induced axonal degeneration, reduction of nociceptive threshold and motor in-coordination. Moreover, it also attenuated axotomy-induced rise in TBARS, total calcium and decrease in GSH levels in a dose-dependent manner. Conclusion Anti-oxidant and calcium attenuating actions may be responsible for observed ameliorative effects of Ocimum sanctum in axotomy-induced neuropathy.

Nick A Guagliardo - One of the best experts on this subject based on the ideXlab platform.

  • fungiform taste bud degeneration in c57bl 6j mice following chorda lingual Nerve Transection
    The Journal of Comparative Neurology, 2007
    Co-Authors: Nick A Guagliardo, David L Hill
    Abstract:

    Taste buds are dependent on innervation for normal morphology and function. Fungiform taste bud degeneration after chorda tympani Nerve injury has been well documented in rats, hamsters, and gerbils. The current study examines fungiform taste bud distribution and structure in adult C57BL/6J mice from both intact taste systems and after unilateral chorda-lingual Nerve Transection. Fungiform taste buds were visualized and measured with the aid of cytokeratin 8. In control mice, taste buds were smaller and more abundant on the anterior tip (<1 mm) of the tongue. By 5 days after Nerve Transection taste buds were smaller and fewer on the side of the tongue ipsilateral to the Transection and continued to decrease in both size and number until 15 days postTransection. Degenerating fungiform taste buds were smaller due to a loss of taste bud cells rather than changes in taste bud morphology. While almost all taste buds disappeared in more posterior fungiform papillae by 15 days postTransection, the anterior tip of the tongue retained nearly half of its taste buds compared to intact mice. Surviving taste buds could not be explained by an apparent innervation from the remaining intact Nerves. Contralateral effects of Nerve Transection were also observed; taste buds were larger due to an increase in the number of taste bud cells. These data are the first to characterize adult mouse fungiform taste buds and subsequent degeneration after unilateral Nerve Transection. They provide the basis for more mechanistic studies in which genetically engineered mice can be used.

  • Fungiform taste bud degeneration in C57BL/6J mice following chorda-lingual Nerve Transection.
    The Journal of comparative neurology, 2007
    Co-Authors: Nick A Guagliardo, David L Hill
    Abstract:

    Taste buds are dependent on innervation for normal morphology and function. Fungiform taste bud degeneration after chorda tympani Nerve injury has been well documented in rats, hamsters, and gerbils. The current study examines fungiform taste bud distribution and structure in adult C57BL/6J mice from both intact taste systems and after unilateral chorda-lingual Nerve Transection. Fungiform taste buds were visualized and measured with the aid of cytokeratin 8. In control mice, taste buds were smaller and more abundant on the anterior tip (