The Experts below are selected from a list of 21 Experts worldwide ranked by ideXlab platform
John I. Harper - One of the best experts on this subject based on the ideXlab platform.
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Gene polymorphism in Netherton and common atopic Disease
Nature Genetics, 2001Co-Authors: Andrew J. Walley, Stephane Chavanas, Miriam F. Moffatt, Robert Esnouf, B Ubhi, Robert Lawrence, K Wong, Gonçalo R. Abecasis, E Y Jones, John I. HarperAbstract:Atopic dermatitis (AD) and asthma are characterized by IgE-mediated atopic (allergic) responses to common proteins (allergens), many of which are proteinases. Loci influencing atopy have been localized to a number of chromosomal regions^ 1 , including the chromosome 5q31 cytokine cluster^ 2 , 3 , 4 . Netherton Disease is a rare recessive skin disorder in which atopy is a universal accompaniment^ 5 . The gene underlying Netherton Disease ( SPINK5 )^ 6 encodes a 15-domain serine proteinase inhibitor (LEKTI) which is expressed in epithelial and mucosal surfaces and in the thymus^ 6 , 7 . We have identified six coding polymorphisms in SPINK5 ( Table 1 ) and found that a Glu420→Lys variant shows significant association with atopy and AD in two independent panels of families. Our results implicate a previously unrecognized pathway for the development of common allergic illnesses. Table 1 Single-nucleotide polymorphisms in SPINK5
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Gene polymorphism in Netherton and common atopic Disease.
Nature genetics, 2001Co-Authors: Andrew Walley, Stephane Chavanas, Miriam F. Moffatt, Robert Esnouf, B Ubhi, Robert Lawrence, K Wong, Gonçalo R. Abecasis, E Y Jones, John I. HarperAbstract:Atopic dermatitis (AD) and asthma are characterized by IgE-mediated atopic (allergic) responses to common proteins (allergens), many of which are proteinases. Loci influencing atopy have been localized to a number of chromosomal regions1, including the chromosome 5q31 cytokine cluster2,3,4. Netherton Disease is a rare recessive skin disorder in which atopy is a universal accompaniment5. The gene underlying Netherton Disease (SPINK5)6 encodes a 15-domain serine proteinase inhibitor (LEKTI) which is expressed in epithelial and mucosal surfaces and in the thymus6,7. We have identified six coding polymorphisms in SPINK5 (Table 1) and found that a Glu420→Lys variant shows significant association with atopy and AD in two independent panels of families. Our results implicate a previously unrecognized pathway for the development of common allergic illnesses.
Robert Esnouf - One of the best experts on this subject based on the ideXlab platform.
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Gene polymorphism in Netherton and common atopic Disease
Nature Genetics, 2001Co-Authors: Andrew J. Walley, Stephane Chavanas, Miriam F. Moffatt, Robert Esnouf, B Ubhi, Robert Lawrence, K Wong, Gonçalo R. Abecasis, E Y Jones, John I. HarperAbstract:Atopic dermatitis (AD) and asthma are characterized by IgE-mediated atopic (allergic) responses to common proteins (allergens), many of which are proteinases. Loci influencing atopy have been localized to a number of chromosomal regions^ 1 , including the chromosome 5q31 cytokine cluster^ 2 , 3 , 4 . Netherton Disease is a rare recessive skin disorder in which atopy is a universal accompaniment^ 5 . The gene underlying Netherton Disease ( SPINK5 )^ 6 encodes a 15-domain serine proteinase inhibitor (LEKTI) which is expressed in epithelial and mucosal surfaces and in the thymus^ 6 , 7 . We have identified six coding polymorphisms in SPINK5 ( Table 1 ) and found that a Glu420→Lys variant shows significant association with atopy and AD in two independent panels of families. Our results implicate a previously unrecognized pathway for the development of common allergic illnesses. Table 1 Single-nucleotide polymorphisms in SPINK5
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Gene polymorphism in Netherton and common atopic Disease.
Nature genetics, 2001Co-Authors: Andrew Walley, Stephane Chavanas, Miriam F. Moffatt, Robert Esnouf, B Ubhi, Robert Lawrence, K Wong, Gonçalo R. Abecasis, E Y Jones, John I. HarperAbstract:Atopic dermatitis (AD) and asthma are characterized by IgE-mediated atopic (allergic) responses to common proteins (allergens), many of which are proteinases. Loci influencing atopy have been localized to a number of chromosomal regions1, including the chromosome 5q31 cytokine cluster2,3,4. Netherton Disease is a rare recessive skin disorder in which atopy is a universal accompaniment5. The gene underlying Netherton Disease (SPINK5)6 encodes a 15-domain serine proteinase inhibitor (LEKTI) which is expressed in epithelial and mucosal surfaces and in the thymus6,7. We have identified six coding polymorphisms in SPINK5 (Table 1) and found that a Glu420→Lys variant shows significant association with atopy and AD in two independent panels of families. Our results implicate a previously unrecognized pathway for the development of common allergic illnesses.
E Y Jones - One of the best experts on this subject based on the ideXlab platform.
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Gene polymorphism in Netherton and common atopic Disease
Nature Genetics, 2001Co-Authors: Andrew J. Walley, Stephane Chavanas, Miriam F. Moffatt, Robert Esnouf, B Ubhi, Robert Lawrence, K Wong, Gonçalo R. Abecasis, E Y Jones, John I. HarperAbstract:Atopic dermatitis (AD) and asthma are characterized by IgE-mediated atopic (allergic) responses to common proteins (allergens), many of which are proteinases. Loci influencing atopy have been localized to a number of chromosomal regions^ 1 , including the chromosome 5q31 cytokine cluster^ 2 , 3 , 4 . Netherton Disease is a rare recessive skin disorder in which atopy is a universal accompaniment^ 5 . The gene underlying Netherton Disease ( SPINK5 )^ 6 encodes a 15-domain serine proteinase inhibitor (LEKTI) which is expressed in epithelial and mucosal surfaces and in the thymus^ 6 , 7 . We have identified six coding polymorphisms in SPINK5 ( Table 1 ) and found that a Glu420→Lys variant shows significant association with atopy and AD in two independent panels of families. Our results implicate a previously unrecognized pathway for the development of common allergic illnesses. Table 1 Single-nucleotide polymorphisms in SPINK5
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Gene polymorphism in Netherton and common atopic Disease.
Nature genetics, 2001Co-Authors: Andrew Walley, Stephane Chavanas, Miriam F. Moffatt, Robert Esnouf, B Ubhi, Robert Lawrence, K Wong, Gonçalo R. Abecasis, E Y Jones, John I. HarperAbstract:Atopic dermatitis (AD) and asthma are characterized by IgE-mediated atopic (allergic) responses to common proteins (allergens), many of which are proteinases. Loci influencing atopy have been localized to a number of chromosomal regions1, including the chromosome 5q31 cytokine cluster2,3,4. Netherton Disease is a rare recessive skin disorder in which atopy is a universal accompaniment5. The gene underlying Netherton Disease (SPINK5)6 encodes a 15-domain serine proteinase inhibitor (LEKTI) which is expressed in epithelial and mucosal surfaces and in the thymus6,7. We have identified six coding polymorphisms in SPINK5 (Table 1) and found that a Glu420→Lys variant shows significant association with atopy and AD in two independent panels of families. Our results implicate a previously unrecognized pathway for the development of common allergic illnesses.
Gonçalo R. Abecasis - One of the best experts on this subject based on the ideXlab platform.
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Gene polymorphism in Netherton and common atopic Disease
Nature Genetics, 2001Co-Authors: Andrew J. Walley, Stephane Chavanas, Miriam F. Moffatt, Robert Esnouf, B Ubhi, Robert Lawrence, K Wong, Gonçalo R. Abecasis, E Y Jones, John I. HarperAbstract:Atopic dermatitis (AD) and asthma are characterized by IgE-mediated atopic (allergic) responses to common proteins (allergens), many of which are proteinases. Loci influencing atopy have been localized to a number of chromosomal regions^ 1 , including the chromosome 5q31 cytokine cluster^ 2 , 3 , 4 . Netherton Disease is a rare recessive skin disorder in which atopy is a universal accompaniment^ 5 . The gene underlying Netherton Disease ( SPINK5 )^ 6 encodes a 15-domain serine proteinase inhibitor (LEKTI) which is expressed in epithelial and mucosal surfaces and in the thymus^ 6 , 7 . We have identified six coding polymorphisms in SPINK5 ( Table 1 ) and found that a Glu420→Lys variant shows significant association with atopy and AD in two independent panels of families. Our results implicate a previously unrecognized pathway for the development of common allergic illnesses. Table 1 Single-nucleotide polymorphisms in SPINK5
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Gene polymorphism in Netherton and common atopic Disease.
Nature genetics, 2001Co-Authors: Andrew Walley, Stephane Chavanas, Miriam F. Moffatt, Robert Esnouf, B Ubhi, Robert Lawrence, K Wong, Gonçalo R. Abecasis, E Y Jones, John I. HarperAbstract:Atopic dermatitis (AD) and asthma are characterized by IgE-mediated atopic (allergic) responses to common proteins (allergens), many of which are proteinases. Loci influencing atopy have been localized to a number of chromosomal regions1, including the chromosome 5q31 cytokine cluster2,3,4. Netherton Disease is a rare recessive skin disorder in which atopy is a universal accompaniment5. The gene underlying Netherton Disease (SPINK5)6 encodes a 15-domain serine proteinase inhibitor (LEKTI) which is expressed in epithelial and mucosal surfaces and in the thymus6,7. We have identified six coding polymorphisms in SPINK5 (Table 1) and found that a Glu420→Lys variant shows significant association with atopy and AD in two independent panels of families. Our results implicate a previously unrecognized pathway for the development of common allergic illnesses.
K Wong - One of the best experts on this subject based on the ideXlab platform.
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Gene polymorphism in Netherton and common atopic Disease
Nature Genetics, 2001Co-Authors: Andrew J. Walley, Stephane Chavanas, Miriam F. Moffatt, Robert Esnouf, B Ubhi, Robert Lawrence, K Wong, Gonçalo R. Abecasis, E Y Jones, John I. HarperAbstract:Atopic dermatitis (AD) and asthma are characterized by IgE-mediated atopic (allergic) responses to common proteins (allergens), many of which are proteinases. Loci influencing atopy have been localized to a number of chromosomal regions^ 1 , including the chromosome 5q31 cytokine cluster^ 2 , 3 , 4 . Netherton Disease is a rare recessive skin disorder in which atopy is a universal accompaniment^ 5 . The gene underlying Netherton Disease ( SPINK5 )^ 6 encodes a 15-domain serine proteinase inhibitor (LEKTI) which is expressed in epithelial and mucosal surfaces and in the thymus^ 6 , 7 . We have identified six coding polymorphisms in SPINK5 ( Table 1 ) and found that a Glu420→Lys variant shows significant association with atopy and AD in two independent panels of families. Our results implicate a previously unrecognized pathway for the development of common allergic illnesses. Table 1 Single-nucleotide polymorphisms in SPINK5
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Gene polymorphism in Netherton and common atopic Disease.
Nature genetics, 2001Co-Authors: Andrew Walley, Stephane Chavanas, Miriam F. Moffatt, Robert Esnouf, B Ubhi, Robert Lawrence, K Wong, Gonçalo R. Abecasis, E Y Jones, John I. HarperAbstract:Atopic dermatitis (AD) and asthma are characterized by IgE-mediated atopic (allergic) responses to common proteins (allergens), many of which are proteinases. Loci influencing atopy have been localized to a number of chromosomal regions1, including the chromosome 5q31 cytokine cluster2,3,4. Netherton Disease is a rare recessive skin disorder in which atopy is a universal accompaniment5. The gene underlying Netherton Disease (SPINK5)6 encodes a 15-domain serine proteinase inhibitor (LEKTI) which is expressed in epithelial and mucosal surfaces and in the thymus6,7. We have identified six coding polymorphisms in SPINK5 (Table 1) and found that a Glu420→Lys variant shows significant association with atopy and AD in two independent panels of families. Our results implicate a previously unrecognized pathway for the development of common allergic illnesses.