The Experts below are selected from a list of 552 Experts worldwide ranked by ideXlab platform
Abhaya V Kulkarni - One of the best experts on this subject based on the ideXlab platform.
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comparative effectiveness of flexible versus rigid Neuroendoscopy for endoscopic third ventriculostomy and choroid plexus cauterization a propensity score matched cohort and survival analysis
Journal of Neurosurgery, 2017Co-Authors: Shelly Wang, Scellig S D Stone, Alexander G Weil, Aria Fallah, Benjamin C Warf, John Ragheb, Sanjiv Bhatia, Abhaya V KulkarniAbstract:OBJECTIVEEndoscopic third ventriculostomy (ETV)/choroid plexus cauterization (CPC) has become an increasingly common technique for the treatment of infant hydrocephalus. Both flexible and rigid Neuroendoscopy can be used, with little empirical evidence directly comparing the two. Therefore, the authors used a propensity score–matched cohort and survival analysis to assess the comparative efficacy of flexible and rigid Neuroendoscopy.METHODSIndividual data were collected through retrospective review of infants younger than 2 years of age, treated at 1 of 2 hospitals: 1) Boston Children's Hospital, exclusively utilizing flexible Neuroendoscopy, and 2) Nicklaus Children's Hospital-Jackson Memorial Hospital, exclusively utilizing rigid Neuroendoscopy. Patient characteristics and postoperative outcomes were assessed. A propensity score model was developed to balance patient characteristics in the case mix.RESULTSA propensity score model for neuroendoscope type was developed with 5 independent variables: chrono...
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comparative effectiveness of flexible versus rigid Neuroendoscopy for endoscopic third ventriculostomy and choroid plexus cauterization a propensity score matched cohort and survival analysis
Journal of Neurosurgery, 2017Co-Authors: Shelly Wang, Scellig S D Stone, Alexander G Weil, Aria Fallah, Benjamin C Warf, John Ragheb, Sanjiv Bhatia, Abhaya V KulkarniAbstract:OBJECTIVE Endoscopic third ventriculostomy (ETV)/choroid plexus cauterization (CPC) has become an increasingly common technique for the treatment of infant hydrocephalus. Both flexible and rigid Neuroendoscopy can be used, with little empirical evidence directly comparing the two. Therefore, the authors used a propensity score-matched cohort and survival analysis to assess the comparative efficacy of flexible and rigid Neuroendoscopy. METHODS Individual data were collected through retrospective review of infants younger than 2 years of age, treated at 1 of 2 hospitals: 1) Boston Children's Hospital, exclusively utilizing flexible Neuroendoscopy, and 2) Nicklaus Children's Hospital-Jackson Memorial Hospital, exclusively utilizing rigid Neuroendoscopy. Patient characteristics and postoperative outcomes were assessed. A propensity score model was developed to balance patient characteristics in the case mix. RESULTS A propensity score model for neuroendoscope type was developed with 5 independent variables: chronological age, sex, hydrocephalus etiology, prior CSF diversion, and prepontine scarring. Propensity score decile-adjusted and 1-to-1 nearest-neighbor matching analysis revealed that compared with flexible Neuroendoscopy, rigid Neuroendoscopy had an ETV/CPC failure odds ratio (OR) of 1.43 (p = 0.31) and 1.31 (p = 0.47), respectively, compared with an unadjusted OR of 2.40 (p = 0.034). Furthermore, in a Cox regression analysis controlled by propensity score, rigid Neuroendoscopy had a hazard ratio (HR) of 1.10 (p = 0.70), compared with an unadjusted HR of 1.61 (p = 0.031). CONCLUSIONS Although unadjusted analysis suggested worse ETV/CPC outcomes for infants treated by rigid Neuroendoscopy, much of the difference could be attributed to the case mix and other predictors of outcome. A larger sample observational study or randomized controlled trials are required to provide evidence-based guidelines on ETV/CPC technique.
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Neuroendoscopy in the youngest age group
World Neurosurgery, 2013Co-Authors: Shlomi Constantini, Spyros Sgouros, Abhaya V KulkarniAbstract:Objectives The aim of this report is to review current data on the role of Neuroendoscopy in infants. Specific emphasis will be given to the International Infant Hydrocephalus Study (IIHS). Previous studies, available information, and future directions are discussed. Methods The IIHS is a major international endeavor comparing the results of endoscopic third ventriculostomy (ETV) to ventriculoperitoneal shunting in infants younger than 2 years of age. It is a prospective, randomized study, with a “parental preference” option, that recruits infants with aqueductal stenosis without a history of prematurity or other associated brain anomalies. The primary outcome measure is neurocognitive outcome at 5 years of age. In addition to IIHS data, we also looked at results of Neuroendoscopy in infants with other indications, such as fourth ventricular outlet obstruction, Dandy Walker syndrome, etc. Results The IIHS study includes more than 40 centers on all continents. To date, we have recruited more than 150 infants to the study. At this point we can only release limited data, namely that the complication rates are similar between the two arms. More patients are needed to finalize the study, with an endpoint of 250 children. Conclusions Neuroendoscopy in infants can be performed with reasonable morbidity. The preferred indications in infants are still not totally refined, especially vis-a-vis shunting procedures. More international, multicenter efforts are required to clarify these points.
Shelly Wang - One of the best experts on this subject based on the ideXlab platform.
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comparative effectiveness of flexible versus rigid Neuroendoscopy for endoscopic third ventriculostomy and choroid plexus cauterization a propensity score matched cohort and survival analysis
Journal of Neurosurgery, 2017Co-Authors: Shelly Wang, Scellig S D Stone, Alexander G Weil, Aria Fallah, Benjamin C Warf, John Ragheb, Sanjiv Bhatia, Abhaya V KulkarniAbstract:OBJECTIVEEndoscopic third ventriculostomy (ETV)/choroid plexus cauterization (CPC) has become an increasingly common technique for the treatment of infant hydrocephalus. Both flexible and rigid Neuroendoscopy can be used, with little empirical evidence directly comparing the two. Therefore, the authors used a propensity score–matched cohort and survival analysis to assess the comparative efficacy of flexible and rigid Neuroendoscopy.METHODSIndividual data were collected through retrospective review of infants younger than 2 years of age, treated at 1 of 2 hospitals: 1) Boston Children's Hospital, exclusively utilizing flexible Neuroendoscopy, and 2) Nicklaus Children's Hospital-Jackson Memorial Hospital, exclusively utilizing rigid Neuroendoscopy. Patient characteristics and postoperative outcomes were assessed. A propensity score model was developed to balance patient characteristics in the case mix.RESULTSA propensity score model for neuroendoscope type was developed with 5 independent variables: chrono...
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comparative effectiveness of flexible versus rigid Neuroendoscopy for endoscopic third ventriculostomy and choroid plexus cauterization a propensity score matched cohort and survival analysis
Journal of Neurosurgery, 2017Co-Authors: Shelly Wang, Scellig S D Stone, Alexander G Weil, Aria Fallah, Benjamin C Warf, John Ragheb, Sanjiv Bhatia, Abhaya V KulkarniAbstract:OBJECTIVE Endoscopic third ventriculostomy (ETV)/choroid plexus cauterization (CPC) has become an increasingly common technique for the treatment of infant hydrocephalus. Both flexible and rigid Neuroendoscopy can be used, with little empirical evidence directly comparing the two. Therefore, the authors used a propensity score-matched cohort and survival analysis to assess the comparative efficacy of flexible and rigid Neuroendoscopy. METHODS Individual data were collected through retrospective review of infants younger than 2 years of age, treated at 1 of 2 hospitals: 1) Boston Children's Hospital, exclusively utilizing flexible Neuroendoscopy, and 2) Nicklaus Children's Hospital-Jackson Memorial Hospital, exclusively utilizing rigid Neuroendoscopy. Patient characteristics and postoperative outcomes were assessed. A propensity score model was developed to balance patient characteristics in the case mix. RESULTS A propensity score model for neuroendoscope type was developed with 5 independent variables: chronological age, sex, hydrocephalus etiology, prior CSF diversion, and prepontine scarring. Propensity score decile-adjusted and 1-to-1 nearest-neighbor matching analysis revealed that compared with flexible Neuroendoscopy, rigid Neuroendoscopy had an ETV/CPC failure odds ratio (OR) of 1.43 (p = 0.31) and 1.31 (p = 0.47), respectively, compared with an unadjusted OR of 2.40 (p = 0.034). Furthermore, in a Cox regression analysis controlled by propensity score, rigid Neuroendoscopy had a hazard ratio (HR) of 1.10 (p = 0.70), compared with an unadjusted HR of 1.61 (p = 0.031). CONCLUSIONS Although unadjusted analysis suggested worse ETV/CPC outcomes for infants treated by rigid Neuroendoscopy, much of the difference could be attributed to the case mix and other predictors of outcome. A larger sample observational study or randomized controlled trials are required to provide evidence-based guidelines on ETV/CPC technique.
Scellig S D Stone - One of the best experts on this subject based on the ideXlab platform.
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comparative effectiveness of flexible versus rigid Neuroendoscopy for endoscopic third ventriculostomy and choroid plexus cauterization a propensity score matched cohort and survival analysis
Journal of Neurosurgery, 2017Co-Authors: Shelly Wang, Scellig S D Stone, Alexander G Weil, Aria Fallah, Benjamin C Warf, John Ragheb, Sanjiv Bhatia, Abhaya V KulkarniAbstract:OBJECTIVEEndoscopic third ventriculostomy (ETV)/choroid plexus cauterization (CPC) has become an increasingly common technique for the treatment of infant hydrocephalus. Both flexible and rigid Neuroendoscopy can be used, with little empirical evidence directly comparing the two. Therefore, the authors used a propensity score–matched cohort and survival analysis to assess the comparative efficacy of flexible and rigid Neuroendoscopy.METHODSIndividual data were collected through retrospective review of infants younger than 2 years of age, treated at 1 of 2 hospitals: 1) Boston Children's Hospital, exclusively utilizing flexible Neuroendoscopy, and 2) Nicklaus Children's Hospital-Jackson Memorial Hospital, exclusively utilizing rigid Neuroendoscopy. Patient characteristics and postoperative outcomes were assessed. A propensity score model was developed to balance patient characteristics in the case mix.RESULTSA propensity score model for neuroendoscope type was developed with 5 independent variables: chrono...
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comparative effectiveness of flexible versus rigid Neuroendoscopy for endoscopic third ventriculostomy and choroid plexus cauterization a propensity score matched cohort and survival analysis
Journal of Neurosurgery, 2017Co-Authors: Shelly Wang, Scellig S D Stone, Alexander G Weil, Aria Fallah, Benjamin C Warf, John Ragheb, Sanjiv Bhatia, Abhaya V KulkarniAbstract:OBJECTIVE Endoscopic third ventriculostomy (ETV)/choroid plexus cauterization (CPC) has become an increasingly common technique for the treatment of infant hydrocephalus. Both flexible and rigid Neuroendoscopy can be used, with little empirical evidence directly comparing the two. Therefore, the authors used a propensity score-matched cohort and survival analysis to assess the comparative efficacy of flexible and rigid Neuroendoscopy. METHODS Individual data were collected through retrospective review of infants younger than 2 years of age, treated at 1 of 2 hospitals: 1) Boston Children's Hospital, exclusively utilizing flexible Neuroendoscopy, and 2) Nicklaus Children's Hospital-Jackson Memorial Hospital, exclusively utilizing rigid Neuroendoscopy. Patient characteristics and postoperative outcomes were assessed. A propensity score model was developed to balance patient characteristics in the case mix. RESULTS A propensity score model for neuroendoscope type was developed with 5 independent variables: chronological age, sex, hydrocephalus etiology, prior CSF diversion, and prepontine scarring. Propensity score decile-adjusted and 1-to-1 nearest-neighbor matching analysis revealed that compared with flexible Neuroendoscopy, rigid Neuroendoscopy had an ETV/CPC failure odds ratio (OR) of 1.43 (p = 0.31) and 1.31 (p = 0.47), respectively, compared with an unadjusted OR of 2.40 (p = 0.034). Furthermore, in a Cox regression analysis controlled by propensity score, rigid Neuroendoscopy had a hazard ratio (HR) of 1.10 (p = 0.70), compared with an unadjusted HR of 1.61 (p = 0.031). CONCLUSIONS Although unadjusted analysis suggested worse ETV/CPC outcomes for infants treated by rigid Neuroendoscopy, much of the difference could be attributed to the case mix and other predictors of outcome. A larger sample observational study or randomized controlled trials are required to provide evidence-based guidelines on ETV/CPC technique.
Alexander G Weil - One of the best experts on this subject based on the ideXlab platform.
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comparative effectiveness of flexible versus rigid Neuroendoscopy for endoscopic third ventriculostomy and choroid plexus cauterization a propensity score matched cohort and survival analysis
Journal of Neurosurgery, 2017Co-Authors: Shelly Wang, Scellig S D Stone, Alexander G Weil, Aria Fallah, Benjamin C Warf, John Ragheb, Sanjiv Bhatia, Abhaya V KulkarniAbstract:OBJECTIVEEndoscopic third ventriculostomy (ETV)/choroid plexus cauterization (CPC) has become an increasingly common technique for the treatment of infant hydrocephalus. Both flexible and rigid Neuroendoscopy can be used, with little empirical evidence directly comparing the two. Therefore, the authors used a propensity score–matched cohort and survival analysis to assess the comparative efficacy of flexible and rigid Neuroendoscopy.METHODSIndividual data were collected through retrospective review of infants younger than 2 years of age, treated at 1 of 2 hospitals: 1) Boston Children's Hospital, exclusively utilizing flexible Neuroendoscopy, and 2) Nicklaus Children's Hospital-Jackson Memorial Hospital, exclusively utilizing rigid Neuroendoscopy. Patient characteristics and postoperative outcomes were assessed. A propensity score model was developed to balance patient characteristics in the case mix.RESULTSA propensity score model for neuroendoscope type was developed with 5 independent variables: chrono...
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comparative effectiveness of flexible versus rigid Neuroendoscopy for endoscopic third ventriculostomy and choroid plexus cauterization a propensity score matched cohort and survival analysis
Journal of Neurosurgery, 2017Co-Authors: Shelly Wang, Scellig S D Stone, Alexander G Weil, Aria Fallah, Benjamin C Warf, John Ragheb, Sanjiv Bhatia, Abhaya V KulkarniAbstract:OBJECTIVE Endoscopic third ventriculostomy (ETV)/choroid plexus cauterization (CPC) has become an increasingly common technique for the treatment of infant hydrocephalus. Both flexible and rigid Neuroendoscopy can be used, with little empirical evidence directly comparing the two. Therefore, the authors used a propensity score-matched cohort and survival analysis to assess the comparative efficacy of flexible and rigid Neuroendoscopy. METHODS Individual data were collected through retrospective review of infants younger than 2 years of age, treated at 1 of 2 hospitals: 1) Boston Children's Hospital, exclusively utilizing flexible Neuroendoscopy, and 2) Nicklaus Children's Hospital-Jackson Memorial Hospital, exclusively utilizing rigid Neuroendoscopy. Patient characteristics and postoperative outcomes were assessed. A propensity score model was developed to balance patient characteristics in the case mix. RESULTS A propensity score model for neuroendoscope type was developed with 5 independent variables: chronological age, sex, hydrocephalus etiology, prior CSF diversion, and prepontine scarring. Propensity score decile-adjusted and 1-to-1 nearest-neighbor matching analysis revealed that compared with flexible Neuroendoscopy, rigid Neuroendoscopy had an ETV/CPC failure odds ratio (OR) of 1.43 (p = 0.31) and 1.31 (p = 0.47), respectively, compared with an unadjusted OR of 2.40 (p = 0.034). Furthermore, in a Cox regression analysis controlled by propensity score, rigid Neuroendoscopy had a hazard ratio (HR) of 1.10 (p = 0.70), compared with an unadjusted HR of 1.61 (p = 0.031). CONCLUSIONS Although unadjusted analysis suggested worse ETV/CPC outcomes for infants treated by rigid Neuroendoscopy, much of the difference could be attributed to the case mix and other predictors of outcome. A larger sample observational study or randomized controlled trials are required to provide evidence-based guidelines on ETV/CPC technique.
Aria Fallah - One of the best experts on this subject based on the ideXlab platform.
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comparative effectiveness of flexible versus rigid Neuroendoscopy for endoscopic third ventriculostomy and choroid plexus cauterization a propensity score matched cohort and survival analysis
Journal of Neurosurgery, 2017Co-Authors: Shelly Wang, Scellig S D Stone, Alexander G Weil, Aria Fallah, Benjamin C Warf, John Ragheb, Sanjiv Bhatia, Abhaya V KulkarniAbstract:OBJECTIVEEndoscopic third ventriculostomy (ETV)/choroid plexus cauterization (CPC) has become an increasingly common technique for the treatment of infant hydrocephalus. Both flexible and rigid Neuroendoscopy can be used, with little empirical evidence directly comparing the two. Therefore, the authors used a propensity score–matched cohort and survival analysis to assess the comparative efficacy of flexible and rigid Neuroendoscopy.METHODSIndividual data were collected through retrospective review of infants younger than 2 years of age, treated at 1 of 2 hospitals: 1) Boston Children's Hospital, exclusively utilizing flexible Neuroendoscopy, and 2) Nicklaus Children's Hospital-Jackson Memorial Hospital, exclusively utilizing rigid Neuroendoscopy. Patient characteristics and postoperative outcomes were assessed. A propensity score model was developed to balance patient characteristics in the case mix.RESULTSA propensity score model for neuroendoscope type was developed with 5 independent variables: chrono...
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comparative effectiveness of flexible versus rigid Neuroendoscopy for endoscopic third ventriculostomy and choroid plexus cauterization a propensity score matched cohort and survival analysis
Journal of Neurosurgery, 2017Co-Authors: Shelly Wang, Scellig S D Stone, Alexander G Weil, Aria Fallah, Benjamin C Warf, John Ragheb, Sanjiv Bhatia, Abhaya V KulkarniAbstract:OBJECTIVE Endoscopic third ventriculostomy (ETV)/choroid plexus cauterization (CPC) has become an increasingly common technique for the treatment of infant hydrocephalus. Both flexible and rigid Neuroendoscopy can be used, with little empirical evidence directly comparing the two. Therefore, the authors used a propensity score-matched cohort and survival analysis to assess the comparative efficacy of flexible and rigid Neuroendoscopy. METHODS Individual data were collected through retrospective review of infants younger than 2 years of age, treated at 1 of 2 hospitals: 1) Boston Children's Hospital, exclusively utilizing flexible Neuroendoscopy, and 2) Nicklaus Children's Hospital-Jackson Memorial Hospital, exclusively utilizing rigid Neuroendoscopy. Patient characteristics and postoperative outcomes were assessed. A propensity score model was developed to balance patient characteristics in the case mix. RESULTS A propensity score model for neuroendoscope type was developed with 5 independent variables: chronological age, sex, hydrocephalus etiology, prior CSF diversion, and prepontine scarring. Propensity score decile-adjusted and 1-to-1 nearest-neighbor matching analysis revealed that compared with flexible Neuroendoscopy, rigid Neuroendoscopy had an ETV/CPC failure odds ratio (OR) of 1.43 (p = 0.31) and 1.31 (p = 0.47), respectively, compared with an unadjusted OR of 2.40 (p = 0.034). Furthermore, in a Cox regression analysis controlled by propensity score, rigid Neuroendoscopy had a hazard ratio (HR) of 1.10 (p = 0.70), compared with an unadjusted HR of 1.61 (p = 0.031). CONCLUSIONS Although unadjusted analysis suggested worse ETV/CPC outcomes for infants treated by rigid Neuroendoscopy, much of the difference could be attributed to the case mix and other predictors of outcome. A larger sample observational study or randomized controlled trials are required to provide evidence-based guidelines on ETV/CPC technique.