The Experts below are selected from a list of 5877 Experts worldwide ranked by ideXlab platform
Elisa Martí - One of the best experts on this subject based on the ideXlab platform.
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shh mediated centrosomal recruitment of pka promotes symmetric proliferative Neuroepithelial Cell division
Nature Cell Biology, 2017Co-Authors: Murielle Saade, René Escalona, Susana Usieto, Elena Gonzalezgobartt, Elisa MartíAbstract:Saade et al. show that Shh activation promotes symmetric pericentrin-mediated docking of PKA to centrosomes and the expansion of the motor neuron progenitor pool through symmetric proliferative divisions.
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Shh-mediated centrosomal recruitment of PKA promotes symmetric proliferative Neuroepithelial Cell division
Nature Cell Biology, 2017Co-Authors: Murielle Saade, Elena Gonzalez-gobartt, René Escalona, Susana Usieto, Elisa MartíAbstract:Tight control of the balance between self-expanding symmetric and self-renewing asymmetric neural progenitor divisions is crucial to regulate the number of Cells in the developing central nervous system. We recently demonstrated that Sonic hedgehog (Shh) signalling is required for the expansion of motor neuron progenitors by maintaining symmetric divisions. Here we show that activation of Shh/Gli signalling in dividing Neuroepithelial Cells controls the symmetric recruitment of PKA to the centrosomes that nucleate the mitotic spindle, maintaining symmetric proliferative divisions. Notably, Shh signalling upregulates the expression of pericentrin, which is required to dock PKA to the centrosomes, which in turn exerts a positive feedback onto Shh signalling. Thus, by controlling centrosomal protein assembly, we propose that Shh signalling overcomes the intrinsic asymmetry at the centrosome during Neuroepithelial Cell division, thereby promoting self-expanding symmetric divisions and the expansion of the progenitor pool. Saade et al. show that Shh activation promotes symmetric pericentrin-mediated docking of PKA to centrosomes and the expansion of the motor neuron progenitor pool through symmetric proliferative divisions.
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Shh-mediated centrosomal recruitment of PKA promotes symmetric proliferative Neuroepithelial Cell division
Nature cell biology, 2017Co-Authors: Murielle Saade, Elena Gonzalez-gobartt, René Escalona, Susana Usieto, Elisa MartíAbstract:Tight control of the balance between self-expanding symmetric and self-renewing asymmetric neural progenitor divisions is crucial to regulate the number of Cells in the developing central nervous system. We recently demonstrated that Sonic hedgehog (Shh) signalling is required for the expansion of motor neuron progenitors by maintaining symmetric divisions. Here we show that activation of Shh/Gli signalling in dividing Neuroepithelial Cells controls the symmetric recruitment of PKA to the centrosomes that nucleate the mitotic spindle, maintaining symmetric proliferative divisions. Notably, Shh signalling upregulates the expression of pericentrin, which is required to dock PKA to the centrosomes, which in turn exerts a positive feedback onto Shh signalling. Thus, by controlling centrosomal protein assembly, we propose that Shh signalling overcomes the intrinsic asymmetry at the centrosome during Neuroepithelial Cell division, thereby promoting self-expanding symmetric divisions and the expansion of the progenitor pool.
Murielle Saade - One of the best experts on this subject based on the ideXlab platform.
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shh mediated centrosomal recruitment of pka promotes symmetric proliferative Neuroepithelial Cell division
Nature Cell Biology, 2017Co-Authors: Murielle Saade, René Escalona, Susana Usieto, Elena Gonzalezgobartt, Elisa MartíAbstract:Saade et al. show that Shh activation promotes symmetric pericentrin-mediated docking of PKA to centrosomes and the expansion of the motor neuron progenitor pool through symmetric proliferative divisions.
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Shh-mediated centrosomal recruitment of PKA promotes symmetric proliferative Neuroepithelial Cell division
Nature Cell Biology, 2017Co-Authors: Murielle Saade, Elena Gonzalez-gobartt, René Escalona, Susana Usieto, Elisa MartíAbstract:Tight control of the balance between self-expanding symmetric and self-renewing asymmetric neural progenitor divisions is crucial to regulate the number of Cells in the developing central nervous system. We recently demonstrated that Sonic hedgehog (Shh) signalling is required for the expansion of motor neuron progenitors by maintaining symmetric divisions. Here we show that activation of Shh/Gli signalling in dividing Neuroepithelial Cells controls the symmetric recruitment of PKA to the centrosomes that nucleate the mitotic spindle, maintaining symmetric proliferative divisions. Notably, Shh signalling upregulates the expression of pericentrin, which is required to dock PKA to the centrosomes, which in turn exerts a positive feedback onto Shh signalling. Thus, by controlling centrosomal protein assembly, we propose that Shh signalling overcomes the intrinsic asymmetry at the centrosome during Neuroepithelial Cell division, thereby promoting self-expanding symmetric divisions and the expansion of the progenitor pool. Saade et al. show that Shh activation promotes symmetric pericentrin-mediated docking of PKA to centrosomes and the expansion of the motor neuron progenitor pool through symmetric proliferative divisions.
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Shh-mediated centrosomal recruitment of PKA promotes symmetric proliferative Neuroepithelial Cell division
Nature cell biology, 2017Co-Authors: Murielle Saade, Elena Gonzalez-gobartt, René Escalona, Susana Usieto, Elisa MartíAbstract:Tight control of the balance between self-expanding symmetric and self-renewing asymmetric neural progenitor divisions is crucial to regulate the number of Cells in the developing central nervous system. We recently demonstrated that Sonic hedgehog (Shh) signalling is required for the expansion of motor neuron progenitors by maintaining symmetric divisions. Here we show that activation of Shh/Gli signalling in dividing Neuroepithelial Cells controls the symmetric recruitment of PKA to the centrosomes that nucleate the mitotic spindle, maintaining symmetric proliferative divisions. Notably, Shh signalling upregulates the expression of pericentrin, which is required to dock PKA to the centrosomes, which in turn exerts a positive feedback onto Shh signalling. Thus, by controlling centrosomal protein assembly, we propose that Shh signalling overcomes the intrinsic asymmetry at the centrosome during Neuroepithelial Cell division, thereby promoting self-expanding symmetric divisions and the expansion of the progenitor pool.
René Escalona - One of the best experts on this subject based on the ideXlab platform.
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shh mediated centrosomal recruitment of pka promotes symmetric proliferative Neuroepithelial Cell division
Nature Cell Biology, 2017Co-Authors: Murielle Saade, René Escalona, Susana Usieto, Elena Gonzalezgobartt, Elisa MartíAbstract:Saade et al. show that Shh activation promotes symmetric pericentrin-mediated docking of PKA to centrosomes and the expansion of the motor neuron progenitor pool through symmetric proliferative divisions.
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Shh-mediated centrosomal recruitment of PKA promotes symmetric proliferative Neuroepithelial Cell division
Nature Cell Biology, 2017Co-Authors: Murielle Saade, Elena Gonzalez-gobartt, René Escalona, Susana Usieto, Elisa MartíAbstract:Tight control of the balance between self-expanding symmetric and self-renewing asymmetric neural progenitor divisions is crucial to regulate the number of Cells in the developing central nervous system. We recently demonstrated that Sonic hedgehog (Shh) signalling is required for the expansion of motor neuron progenitors by maintaining symmetric divisions. Here we show that activation of Shh/Gli signalling in dividing Neuroepithelial Cells controls the symmetric recruitment of PKA to the centrosomes that nucleate the mitotic spindle, maintaining symmetric proliferative divisions. Notably, Shh signalling upregulates the expression of pericentrin, which is required to dock PKA to the centrosomes, which in turn exerts a positive feedback onto Shh signalling. Thus, by controlling centrosomal protein assembly, we propose that Shh signalling overcomes the intrinsic asymmetry at the centrosome during Neuroepithelial Cell division, thereby promoting self-expanding symmetric divisions and the expansion of the progenitor pool. Saade et al. show that Shh activation promotes symmetric pericentrin-mediated docking of PKA to centrosomes and the expansion of the motor neuron progenitor pool through symmetric proliferative divisions.
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Shh-mediated centrosomal recruitment of PKA promotes symmetric proliferative Neuroepithelial Cell division
Nature cell biology, 2017Co-Authors: Murielle Saade, Elena Gonzalez-gobartt, René Escalona, Susana Usieto, Elisa MartíAbstract:Tight control of the balance between self-expanding symmetric and self-renewing asymmetric neural progenitor divisions is crucial to regulate the number of Cells in the developing central nervous system. We recently demonstrated that Sonic hedgehog (Shh) signalling is required for the expansion of motor neuron progenitors by maintaining symmetric divisions. Here we show that activation of Shh/Gli signalling in dividing Neuroepithelial Cells controls the symmetric recruitment of PKA to the centrosomes that nucleate the mitotic spindle, maintaining symmetric proliferative divisions. Notably, Shh signalling upregulates the expression of pericentrin, which is required to dock PKA to the centrosomes, which in turn exerts a positive feedback onto Shh signalling. Thus, by controlling centrosomal protein assembly, we propose that Shh signalling overcomes the intrinsic asymmetry at the centrosome during Neuroepithelial Cell division, thereby promoting self-expanding symmetric divisions and the expansion of the progenitor pool.
Valérie Castellani - One of the best experts on this subject based on the ideXlab platform.
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cerebrospinal fluid derived semaphorin3b orients Neuroepithelial Cell divisions in the apicobasal axis
Nature Communications, 2015Co-Authors: Elise Arbeille, Florie Reynaud, Isabelle Sanyas, Muriel Bozon, Karine Kindbeiter, Frédéric Causeret, Alessandra Pierani, Julien Falk, Frédéric Moret, Valérie CastellaniAbstract:The spatial orientation of Cell divisions is fundamental for tissue architecture and homeostasis but the extraCellular cues regulating this process are largely unknown. Here, the authors show that Semaphorin3B released from the floor plate and the nascent choroid plexus controls progenitor division orientation in the developing mouse spinal cord.
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Cerebrospinal fluid-derived Semaphorin3B orients Neuroepithelial Cell divisions in the apicobasal axis.
Nature Communications, 2014Co-Authors: Elise Arbeille, Florie Reynaud, Isabelle Sanyas, Muriel Bozon, Karine Kindbeiter, Frédéric Causeret, Alessandra Pierani, Julien Falk, Frédéric Moret, Valérie CastellaniAbstract:The spatial orientation of Cell divisions is fundamental for tissue architecture and homeostasis. Here we analysed Neuroepithelial progenitors in the developing mouse spinal cord to determine whether extraCellular signals orient the mitotic spindle. We report that Semaphorin3B (Sema3B) released from the floor plate and the nascent choroid plexus in the cerebrospinal fluid (CSF) controls progenitor division orientation. Delivery of exogenous Sema3B to neural progenitors after neural tube opening in living embryos promotes planar orientation of their division. Preventing progenitor access to cues present in the CSF by genetically engineered canal obstruction affects the proportion of planar and oblique divisions. Sema3B knockout phenocopies the loss of progenitor access to the CSF. Sema3B binds to the apical surface of mitotic progenitors and exerts its effect via Neuropilin receptors, GSK3 activation and subsequent inhibition of the microtubule stabilizer CRMP2. Thus, extrinsic control mediated by the Semaphorin signalling orients progenitor divisions in neurogenic zones.
Susana Usieto - One of the best experts on this subject based on the ideXlab platform.
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shh mediated centrosomal recruitment of pka promotes symmetric proliferative Neuroepithelial Cell division
Nature Cell Biology, 2017Co-Authors: Murielle Saade, René Escalona, Susana Usieto, Elena Gonzalezgobartt, Elisa MartíAbstract:Saade et al. show that Shh activation promotes symmetric pericentrin-mediated docking of PKA to centrosomes and the expansion of the motor neuron progenitor pool through symmetric proliferative divisions.
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Shh-mediated centrosomal recruitment of PKA promotes symmetric proliferative Neuroepithelial Cell division
Nature Cell Biology, 2017Co-Authors: Murielle Saade, Elena Gonzalez-gobartt, René Escalona, Susana Usieto, Elisa MartíAbstract:Tight control of the balance between self-expanding symmetric and self-renewing asymmetric neural progenitor divisions is crucial to regulate the number of Cells in the developing central nervous system. We recently demonstrated that Sonic hedgehog (Shh) signalling is required for the expansion of motor neuron progenitors by maintaining symmetric divisions. Here we show that activation of Shh/Gli signalling in dividing Neuroepithelial Cells controls the symmetric recruitment of PKA to the centrosomes that nucleate the mitotic spindle, maintaining symmetric proliferative divisions. Notably, Shh signalling upregulates the expression of pericentrin, which is required to dock PKA to the centrosomes, which in turn exerts a positive feedback onto Shh signalling. Thus, by controlling centrosomal protein assembly, we propose that Shh signalling overcomes the intrinsic asymmetry at the centrosome during Neuroepithelial Cell division, thereby promoting self-expanding symmetric divisions and the expansion of the progenitor pool. Saade et al. show that Shh activation promotes symmetric pericentrin-mediated docking of PKA to centrosomes and the expansion of the motor neuron progenitor pool through symmetric proliferative divisions.
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Shh-mediated centrosomal recruitment of PKA promotes symmetric proliferative Neuroepithelial Cell division
Nature cell biology, 2017Co-Authors: Murielle Saade, Elena Gonzalez-gobartt, René Escalona, Susana Usieto, Elisa MartíAbstract:Tight control of the balance between self-expanding symmetric and self-renewing asymmetric neural progenitor divisions is crucial to regulate the number of Cells in the developing central nervous system. We recently demonstrated that Sonic hedgehog (Shh) signalling is required for the expansion of motor neuron progenitors by maintaining symmetric divisions. Here we show that activation of Shh/Gli signalling in dividing Neuroepithelial Cells controls the symmetric recruitment of PKA to the centrosomes that nucleate the mitotic spindle, maintaining symmetric proliferative divisions. Notably, Shh signalling upregulates the expression of pericentrin, which is required to dock PKA to the centrosomes, which in turn exerts a positive feedback onto Shh signalling. Thus, by controlling centrosomal protein assembly, we propose that Shh signalling overcomes the intrinsic asymmetry at the centrosome during Neuroepithelial Cell division, thereby promoting self-expanding symmetric divisions and the expansion of the progenitor pool.