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Tetsuya Tachibana - One of the best experts on this subject based on the ideXlab platform.

  • central administration of mesotocin inhibits feeding behavior in chicks
    Regulatory Peptides, 2013
    Co-Authors: Kazuya Masunari, Md Sakirul Islam Khan, Mark A Cline, Tetsuya Tachibana
    Abstract:

    Abstract Mesotocin (MT) is a Neurohypophysis Hormone in non-mammalian vertebrates including chickens, and homologous of oxytocin (OT) in mammals. Oxytocin (OT) is a well known reproductive Hormone in mammals, but the physiological roles of MT in chickens have not been clarified well. OT is thought to regulate feeding behavior because central and peripheral injections of OT inhibit feeding behavior in mammals. In avian, on the other hand, the effect of MT on feeding regulation has not yet been clarified. Therefore, the present study was carried out to examine whether MT is related to the regulation of feeding in chicks ( Gallus gallus ). Intracerebroventricular (ICV) injection of MT significantly decreased food intake in chicks while intraperitoneal injection had no effect. Behavioral observations revealed that ICV injection of MT significantly increased wing-flapping and preening, and tended to increase voluntary movement, implying that the anorexigenic effect of MT might be related to the stress response. However, neither plasma corticosterone concentration nor the mRNA expression of corticotrophin-releasing Hormone (CRH) in the diencephalon was affected by ICV injection of MT. Moreover; ICV injection of CRH did not affect MT mRNA expression in the diencephalon. In sum, central injection of MT is associated with an anorexigenic response that does not appear CRH dependent in chicks.

Kazuya Masunari - One of the best experts on this subject based on the ideXlab platform.

  • central administration of mesotocin inhibits feeding behavior in chicks
    Regulatory Peptides, 2013
    Co-Authors: Kazuya Masunari, Md Sakirul Islam Khan, Mark A Cline, Tetsuya Tachibana
    Abstract:

    Abstract Mesotocin (MT) is a Neurohypophysis Hormone in non-mammalian vertebrates including chickens, and homologous of oxytocin (OT) in mammals. Oxytocin (OT) is a well known reproductive Hormone in mammals, but the physiological roles of MT in chickens have not been clarified well. OT is thought to regulate feeding behavior because central and peripheral injections of OT inhibit feeding behavior in mammals. In avian, on the other hand, the effect of MT on feeding regulation has not yet been clarified. Therefore, the present study was carried out to examine whether MT is related to the regulation of feeding in chicks ( Gallus gallus ). Intracerebroventricular (ICV) injection of MT significantly decreased food intake in chicks while intraperitoneal injection had no effect. Behavioral observations revealed that ICV injection of MT significantly increased wing-flapping and preening, and tended to increase voluntary movement, implying that the anorexigenic effect of MT might be related to the stress response. However, neither plasma corticosterone concentration nor the mRNA expression of corticotrophin-releasing Hormone (CRH) in the diencephalon was affected by ICV injection of MT. Moreover; ICV injection of CRH did not affect MT mRNA expression in the diencephalon. In sum, central injection of MT is associated with an anorexigenic response that does not appear CRH dependent in chicks.

Md Sakirul Islam Khan - One of the best experts on this subject based on the ideXlab platform.

  • central administration of mesotocin inhibits feeding behavior in chicks
    Regulatory Peptides, 2013
    Co-Authors: Kazuya Masunari, Md Sakirul Islam Khan, Mark A Cline, Tetsuya Tachibana
    Abstract:

    Abstract Mesotocin (MT) is a Neurohypophysis Hormone in non-mammalian vertebrates including chickens, and homologous of oxytocin (OT) in mammals. Oxytocin (OT) is a well known reproductive Hormone in mammals, but the physiological roles of MT in chickens have not been clarified well. OT is thought to regulate feeding behavior because central and peripheral injections of OT inhibit feeding behavior in mammals. In avian, on the other hand, the effect of MT on feeding regulation has not yet been clarified. Therefore, the present study was carried out to examine whether MT is related to the regulation of feeding in chicks ( Gallus gallus ). Intracerebroventricular (ICV) injection of MT significantly decreased food intake in chicks while intraperitoneal injection had no effect. Behavioral observations revealed that ICV injection of MT significantly increased wing-flapping and preening, and tended to increase voluntary movement, implying that the anorexigenic effect of MT might be related to the stress response. However, neither plasma corticosterone concentration nor the mRNA expression of corticotrophin-releasing Hormone (CRH) in the diencephalon was affected by ICV injection of MT. Moreover; ICV injection of CRH did not affect MT mRNA expression in the diencephalon. In sum, central injection of MT is associated with an anorexigenic response that does not appear CRH dependent in chicks.

Mark A Cline - One of the best experts on this subject based on the ideXlab platform.

  • central administration of mesotocin inhibits feeding behavior in chicks
    Regulatory Peptides, 2013
    Co-Authors: Kazuya Masunari, Md Sakirul Islam Khan, Mark A Cline, Tetsuya Tachibana
    Abstract:

    Abstract Mesotocin (MT) is a Neurohypophysis Hormone in non-mammalian vertebrates including chickens, and homologous of oxytocin (OT) in mammals. Oxytocin (OT) is a well known reproductive Hormone in mammals, but the physiological roles of MT in chickens have not been clarified well. OT is thought to regulate feeding behavior because central and peripheral injections of OT inhibit feeding behavior in mammals. In avian, on the other hand, the effect of MT on feeding regulation has not yet been clarified. Therefore, the present study was carried out to examine whether MT is related to the regulation of feeding in chicks ( Gallus gallus ). Intracerebroventricular (ICV) injection of MT significantly decreased food intake in chicks while intraperitoneal injection had no effect. Behavioral observations revealed that ICV injection of MT significantly increased wing-flapping and preening, and tended to increase voluntary movement, implying that the anorexigenic effect of MT might be related to the stress response. However, neither plasma corticosterone concentration nor the mRNA expression of corticotrophin-releasing Hormone (CRH) in the diencephalon was affected by ICV injection of MT. Moreover; ICV injection of CRH did not affect MT mRNA expression in the diencephalon. In sum, central injection of MT is associated with an anorexigenic response that does not appear CRH dependent in chicks.

Kate Whittington - One of the best experts on this subject based on the ideXlab platform.

  • oxytocin its role in male reproduction and new potential therapeutic uses
    Human Reproduction Update, 2006
    Co-Authors: Hemlata Thackare, Helen D. Nicholson, Kate Whittington
    Abstract:

    Oxytocin (OT) is traditionally thought of as a "female" Neurohypophysis Hormone due to its role in parturition and milk ejection. However, OT is recognized as having endocrine and paracrine roles in male reproduction. At ejaculation, a burst of OT is released from the Neurohypophysis into the systemic circulation and stimulates contractions of the reproductive tract aiding sperm release. There is conclusive evidence that OT is synthesized within the mammalian testis, epididymis and prostate and the presence of OT receptors (OTRs) through the reproductive tract supports a local action for this peptide. OT has a paracrine role in stimulating contractility of the seminiferous tubules, epididymis and the prostate gland. Interestingly, OT has also been shown to modulate androgen levels in these tissues via stimulation of the conversion of testosterone to dihydrotestostone (DHT) by 5alpha-reductase. The elucidation of OT's role in male reproduction has suggested a number of potential therapeutic uses for this Hormone. Exogenous administration of OT has, in some cases, been shown to increase the numbers of ejaculated sperm, possibly by stimulating contractions of the reproductive tract and thus aiding sperm passage. Within the prostate, OT has been shown to affect gland growth both directly and via its interaction with androgen metabolism. Prostate pathologies due to unregulated cell proliferation/growth, such as benign prostatic hyperplasia and cancer, are unfortunately very common and few effective treatments are available. Greater understanding of paracrine growth mediators, such as OT, is likely to provide new mechanisms for treating such pathologies.