The Experts below are selected from a list of 174 Experts worldwide ranked by ideXlab platform

Felipe Prosper - One of the best experts on this subject based on the ideXlab platform.

  • Cardiotrophin 1 protects beta cells from apoptosis and prevents streptozotocin-induced diabetes in a mouse model
    Diabetologia, 2013
    Co-Authors: M. Jimenez-gonzalez, Fabienne Jaques, Saray Rodriguez, Angelo Porciuncula, R.m. Príncipe, Gloria Abizanda, M Iñiguez, Javier Escalada, Javier Salvador, Felipe Prosper
    Abstract:

    Aims/hypothesis Cardiotrophin 1 (CT-1) is a recently described cytokine originally isolated from the heart where it has been shown to play an important role in apoptotic protection of cardiomyocytes and heart hypertrophy. Its beneficial properties have also been described in other organs such as liver and Neuromuscular Tissue. In the present study, we investigated whether CT-1 can confer protection against pro-apoptotic stimuli in pancreatic beta cells, and its role in insulin secretion and diabetes development. Methods The effects of CT-1 on apoptosis and function were studied using MIN6B1 cells and freshly isolated murine pancreatic islets. The impact on the development of diabetes was evaluated in Ct1 -null ( Ct1 ^−/−) mice (the gene Ct1 is also known as Ctf1 ) using two streptozotocin (STZ)-induced models of diabetes. Results CT-1 has a protective effect in MIN6B1 cells and murine islets under the pro-apoptotic stimulus of serum deprivation, which correlates with the expression of B cell lymphoma-extra large, or following exposure to a mixture of cytokines. In addition, CT-1 enhances glucose-stimulated insulin secretion in MIN6B1 cells and this was repressed by inhibitors of phospholipase C. Furthermore, Ct1 ^−/− mice were more prone to develop diabetes, and their glucose tolerance test showed impaired plasma glucose clearance which correlated with decreased pancreatic insulin secretion. Conclusions/interpretation The results obtained from both in vitro and in vivo experiments show that CT-1 improves beta cell function and survival, and protects mice against STZ-induced diabetes.

  • Cardiotrophin 1 protects beta cells from apoptosis and prevents streptozotocin-induced diabetes in a mouse model
    Diabetologia, 2013
    Co-Authors: M. Jimenez-gonzalez, Fabienne Jaques, Saray Rodriguez, Angelo Porciuncula, R.m. Príncipe, Gloria Abizanda, M Iñiguez, Javier Escalada, Javier Salvador, Felipe Prosper
    Abstract:

    Aims/hypothesis Cardiotrophin 1 (CT-1) is a recently described cytokine originally isolated from the heart where it has been shown to play an important role in apoptotic protection of cardiomyocytes and heart hypertrophy. Its beneficial properties have also been described in other organs such as liver and Neuromuscular Tissue. In the present study, we investigated whether CT-1 can confer protection against pro-apoptotic stimuli in pancreatic beta cells, and its role in insulin secretion and diabetes development.

M. Jimenez-gonzalez - One of the best experts on this subject based on the ideXlab platform.

  • Cardiotrophin 1 protects beta cells from apoptosis and prevents streptozotocin-induced diabetes in a mouse model
    Diabetologia, 2013
    Co-Authors: M. Jimenez-gonzalez, Fabienne Jaques, Saray Rodriguez, Angelo Porciuncula, R.m. Príncipe, Gloria Abizanda, M Iñiguez, Javier Escalada, Javier Salvador, Felipe Prosper
    Abstract:

    Aims/hypothesis Cardiotrophin 1 (CT-1) is a recently described cytokine originally isolated from the heart where it has been shown to play an important role in apoptotic protection of cardiomyocytes and heart hypertrophy. Its beneficial properties have also been described in other organs such as liver and Neuromuscular Tissue. In the present study, we investigated whether CT-1 can confer protection against pro-apoptotic stimuli in pancreatic beta cells, and its role in insulin secretion and diabetes development. Methods The effects of CT-1 on apoptosis and function were studied using MIN6B1 cells and freshly isolated murine pancreatic islets. The impact on the development of diabetes was evaluated in Ct1 -null ( Ct1 ^−/−) mice (the gene Ct1 is also known as Ctf1 ) using two streptozotocin (STZ)-induced models of diabetes. Results CT-1 has a protective effect in MIN6B1 cells and murine islets under the pro-apoptotic stimulus of serum deprivation, which correlates with the expression of B cell lymphoma-extra large, or following exposure to a mixture of cytokines. In addition, CT-1 enhances glucose-stimulated insulin secretion in MIN6B1 cells and this was repressed by inhibitors of phospholipase C. Furthermore, Ct1 ^−/− mice were more prone to develop diabetes, and their glucose tolerance test showed impaired plasma glucose clearance which correlated with decreased pancreatic insulin secretion. Conclusions/interpretation The results obtained from both in vitro and in vivo experiments show that CT-1 improves beta cell function and survival, and protects mice against STZ-induced diabetes.

  • Cardiotrophin 1 protects beta cells from apoptosis and prevents streptozotocin-induced diabetes in a mouse model
    Diabetologia, 2013
    Co-Authors: M. Jimenez-gonzalez, Fabienne Jaques, Saray Rodriguez, Angelo Porciuncula, R.m. Príncipe, Gloria Abizanda, M Iñiguez, Javier Escalada, Javier Salvador, Felipe Prosper
    Abstract:

    Aims/hypothesis Cardiotrophin 1 (CT-1) is a recently described cytokine originally isolated from the heart where it has been shown to play an important role in apoptotic protection of cardiomyocytes and heart hypertrophy. Its beneficial properties have also been described in other organs such as liver and Neuromuscular Tissue. In the present study, we investigated whether CT-1 can confer protection against pro-apoptotic stimuli in pancreatic beta cells, and its role in insulin secretion and diabetes development.

Javier Salvador - One of the best experts on this subject based on the ideXlab platform.

  • Cardiotrophin 1 protects beta cells from apoptosis and prevents streptozotocin-induced diabetes in a mouse model
    Diabetologia, 2013
    Co-Authors: M. Jimenez-gonzalez, Fabienne Jaques, Saray Rodriguez, Angelo Porciuncula, R.m. Príncipe, Gloria Abizanda, M Iñiguez, Javier Escalada, Javier Salvador, Felipe Prosper
    Abstract:

    Aims/hypothesis Cardiotrophin 1 (CT-1) is a recently described cytokine originally isolated from the heart where it has been shown to play an important role in apoptotic protection of cardiomyocytes and heart hypertrophy. Its beneficial properties have also been described in other organs such as liver and Neuromuscular Tissue. In the present study, we investigated whether CT-1 can confer protection against pro-apoptotic stimuli in pancreatic beta cells, and its role in insulin secretion and diabetes development. Methods The effects of CT-1 on apoptosis and function were studied using MIN6B1 cells and freshly isolated murine pancreatic islets. The impact on the development of diabetes was evaluated in Ct1 -null ( Ct1 ^−/−) mice (the gene Ct1 is also known as Ctf1 ) using two streptozotocin (STZ)-induced models of diabetes. Results CT-1 has a protective effect in MIN6B1 cells and murine islets under the pro-apoptotic stimulus of serum deprivation, which correlates with the expression of B cell lymphoma-extra large, or following exposure to a mixture of cytokines. In addition, CT-1 enhances glucose-stimulated insulin secretion in MIN6B1 cells and this was repressed by inhibitors of phospholipase C. Furthermore, Ct1 ^−/− mice were more prone to develop diabetes, and their glucose tolerance test showed impaired plasma glucose clearance which correlated with decreased pancreatic insulin secretion. Conclusions/interpretation The results obtained from both in vitro and in vivo experiments show that CT-1 improves beta cell function and survival, and protects mice against STZ-induced diabetes.

  • Cardiotrophin 1 protects beta cells from apoptosis and prevents streptozotocin-induced diabetes in a mouse model
    Diabetologia, 2013
    Co-Authors: M. Jimenez-gonzalez, Fabienne Jaques, Saray Rodriguez, Angelo Porciuncula, R.m. Príncipe, Gloria Abizanda, M Iñiguez, Javier Escalada, Javier Salvador, Felipe Prosper
    Abstract:

    Aims/hypothesis Cardiotrophin 1 (CT-1) is a recently described cytokine originally isolated from the heart where it has been shown to play an important role in apoptotic protection of cardiomyocytes and heart hypertrophy. Its beneficial properties have also been described in other organs such as liver and Neuromuscular Tissue. In the present study, we investigated whether CT-1 can confer protection against pro-apoptotic stimuli in pancreatic beta cells, and its role in insulin secretion and diabetes development.

Javier Escalada - One of the best experts on this subject based on the ideXlab platform.

  • Cardiotrophin 1 protects beta cells from apoptosis and prevents streptozotocin-induced diabetes in a mouse model
    Diabetologia, 2013
    Co-Authors: M. Jimenez-gonzalez, Fabienne Jaques, Saray Rodriguez, Angelo Porciuncula, R.m. Príncipe, Gloria Abizanda, M Iñiguez, Javier Escalada, Javier Salvador, Felipe Prosper
    Abstract:

    Aims/hypothesis Cardiotrophin 1 (CT-1) is a recently described cytokine originally isolated from the heart where it has been shown to play an important role in apoptotic protection of cardiomyocytes and heart hypertrophy. Its beneficial properties have also been described in other organs such as liver and Neuromuscular Tissue. In the present study, we investigated whether CT-1 can confer protection against pro-apoptotic stimuli in pancreatic beta cells, and its role in insulin secretion and diabetes development. Methods The effects of CT-1 on apoptosis and function were studied using MIN6B1 cells and freshly isolated murine pancreatic islets. The impact on the development of diabetes was evaluated in Ct1 -null ( Ct1 ^−/−) mice (the gene Ct1 is also known as Ctf1 ) using two streptozotocin (STZ)-induced models of diabetes. Results CT-1 has a protective effect in MIN6B1 cells and murine islets under the pro-apoptotic stimulus of serum deprivation, which correlates with the expression of B cell lymphoma-extra large, or following exposure to a mixture of cytokines. In addition, CT-1 enhances glucose-stimulated insulin secretion in MIN6B1 cells and this was repressed by inhibitors of phospholipase C. Furthermore, Ct1 ^−/− mice were more prone to develop diabetes, and their glucose tolerance test showed impaired plasma glucose clearance which correlated with decreased pancreatic insulin secretion. Conclusions/interpretation The results obtained from both in vitro and in vivo experiments show that CT-1 improves beta cell function and survival, and protects mice against STZ-induced diabetes.

  • Cardiotrophin 1 protects beta cells from apoptosis and prevents streptozotocin-induced diabetes in a mouse model
    Diabetologia, 2013
    Co-Authors: M. Jimenez-gonzalez, Fabienne Jaques, Saray Rodriguez, Angelo Porciuncula, R.m. Príncipe, Gloria Abizanda, M Iñiguez, Javier Escalada, Javier Salvador, Felipe Prosper
    Abstract:

    Aims/hypothesis Cardiotrophin 1 (CT-1) is a recently described cytokine originally isolated from the heart where it has been shown to play an important role in apoptotic protection of cardiomyocytes and heart hypertrophy. Its beneficial properties have also been described in other organs such as liver and Neuromuscular Tissue. In the present study, we investigated whether CT-1 can confer protection against pro-apoptotic stimuli in pancreatic beta cells, and its role in insulin secretion and diabetes development.

M Iñiguez - One of the best experts on this subject based on the ideXlab platform.

  • Cardiotrophin 1 protects beta cells from apoptosis and prevents streptozotocin-induced diabetes in a mouse model
    Diabetologia, 2013
    Co-Authors: M. Jimenez-gonzalez, Fabienne Jaques, Saray Rodriguez, Angelo Porciuncula, R.m. Príncipe, Gloria Abizanda, M Iñiguez, Javier Escalada, Javier Salvador, Felipe Prosper
    Abstract:

    Aims/hypothesis Cardiotrophin 1 (CT-1) is a recently described cytokine originally isolated from the heart where it has been shown to play an important role in apoptotic protection of cardiomyocytes and heart hypertrophy. Its beneficial properties have also been described in other organs such as liver and Neuromuscular Tissue. In the present study, we investigated whether CT-1 can confer protection against pro-apoptotic stimuli in pancreatic beta cells, and its role in insulin secretion and diabetes development. Methods The effects of CT-1 on apoptosis and function were studied using MIN6B1 cells and freshly isolated murine pancreatic islets. The impact on the development of diabetes was evaluated in Ct1 -null ( Ct1 ^−/−) mice (the gene Ct1 is also known as Ctf1 ) using two streptozotocin (STZ)-induced models of diabetes. Results CT-1 has a protective effect in MIN6B1 cells and murine islets under the pro-apoptotic stimulus of serum deprivation, which correlates with the expression of B cell lymphoma-extra large, or following exposure to a mixture of cytokines. In addition, CT-1 enhances glucose-stimulated insulin secretion in MIN6B1 cells and this was repressed by inhibitors of phospholipase C. Furthermore, Ct1 ^−/− mice were more prone to develop diabetes, and their glucose tolerance test showed impaired plasma glucose clearance which correlated with decreased pancreatic insulin secretion. Conclusions/interpretation The results obtained from both in vitro and in vivo experiments show that CT-1 improves beta cell function and survival, and protects mice against STZ-induced diabetes.

  • Cardiotrophin 1 protects beta cells from apoptosis and prevents streptozotocin-induced diabetes in a mouse model
    Diabetologia, 2013
    Co-Authors: M. Jimenez-gonzalez, Fabienne Jaques, Saray Rodriguez, Angelo Porciuncula, R.m. Príncipe, Gloria Abizanda, M Iñiguez, Javier Escalada, Javier Salvador, Felipe Prosper
    Abstract:

    Aims/hypothesis Cardiotrophin 1 (CT-1) is a recently described cytokine originally isolated from the heart where it has been shown to play an important role in apoptotic protection of cardiomyocytes and heart hypertrophy. Its beneficial properties have also been described in other organs such as liver and Neuromuscular Tissue. In the present study, we investigated whether CT-1 can confer protection against pro-apoptotic stimuli in pancreatic beta cells, and its role in insulin secretion and diabetes development.