The Experts below are selected from a list of 6 Experts worldwide ranked by ideXlab platform

Gahan Bose - One of the best experts on this subject based on the ideXlab platform.

  • clinical neuroprotection and secondary Neuronal Injury Mechanisms
    Anaesthesia & Intensive Care Medicine, 2008
    Co-Authors: Katharine Hunt, Gahan Bose
    Abstract:

    Abstract Anaesthetists and intensive care physicians commonly encounter brain injuries in their clinical practice. Cerebral insults may arise from traumatic brain Injury, may follow cardiothoracic, vascular or major orthopaedic surgery, and are seen in medical conditions including subarachnoid haemorrhage, central nervous system infection, epilepsy and stroke. In all cases, Neuronal Injury may lead to severe disability or death; however, aggressive early treatment to prevent the Mechanisms that lead to irreversible ischaemia and Neuronal cell destruction can result in improvements in patient morbidity and mortality. Neuroprotection involves intervention initiated before the onset of an ischaemic event in an attempt to modify the cascade of biological events that follow ischaemia and thus limit permanent cell damage. Neuroresuscitation, on the other hand, refers to treatment aimed at restoring blood flow to cells that have already become exposed to an ischaemic insult.

Katharine Hunt - One of the best experts on this subject based on the ideXlab platform.

  • clinical neuroprotection and secondary Neuronal Injury Mechanisms
    Anaesthesia & Intensive Care Medicine, 2008
    Co-Authors: Katharine Hunt, Gahan Bose
    Abstract:

    Abstract Anaesthetists and intensive care physicians commonly encounter brain injuries in their clinical practice. Cerebral insults may arise from traumatic brain Injury, may follow cardiothoracic, vascular or major orthopaedic surgery, and are seen in medical conditions including subarachnoid haemorrhage, central nervous system infection, epilepsy and stroke. In all cases, Neuronal Injury may lead to severe disability or death; however, aggressive early treatment to prevent the Mechanisms that lead to irreversible ischaemia and Neuronal cell destruction can result in improvements in patient morbidity and mortality. Neuroprotection involves intervention initiated before the onset of an ischaemic event in an attempt to modify the cascade of biological events that follow ischaemia and thus limit permanent cell damage. Neuroresuscitation, on the other hand, refers to treatment aimed at restoring blood flow to cells that have already become exposed to an ischaemic insult.

Nancy J Rothwell - One of the best experts on this subject based on the ideXlab platform.

  • interleukin 1 and Neuronal Injury Mechanisms modification and therapeutic potential
    Brain Behavior and Immunity, 2003
    Co-Authors: Nancy J Rothwell
    Abstract:

    Interleukin-1 (IL-1) expression in the brain increases in response to acute and chronic insults, and IL-1 contributes directly to experimentally induced ischaemic, excitotoxic, and traumatic brain Injury. Release and cleavage of active IL-1 beta may be achieved via purinergic P2X7 receptors and activation of caspase-1. The Mechanisms of action of IL-1 are largely unknown, but may involve effects on glia, endothelia, and neurones, or on physical parameters within the brain such as temperature or acidity. The naturally occurring IL-1 receptor antagonist (IL-1ra) is currently being considered for treatment of stroke and other disorders.