The Experts below are selected from a list of 720 Experts worldwide ranked by ideXlab platform
Paul B Googe - One of the best experts on this subject based on the ideXlab platform.
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microphthalmia transcription factor and nki c3 expression in cellular Neurothekeoma
Modern Pathology, 2004Co-Authors: Robert N Page, Roy King, Martin C Mihm, Paul B GoogeAbstract:While the usual or myxoid-type Neurothekeoma has been reasonably well established as being a tumor of neural origin, the cellular Neurothekeoma remains in disputed histogenesis. We studied a series of 11 cellular Neurothekeomas using paraffin immunoperoxidase staining with microphthalmia transcription factor (Mitf), NKI/C3, and S-100. The majority of the tumors in our series stained with NKI/C3 (9/11) and Mitf (9/11). All failed to stain with S-100. Furthermore, we divided our series of cellular Neurothekeomas according to cytomorphology; tumors demonstrating predominantly spindled morphology, predominantly epithelioid morphology, and mixed spindle and epithelioid morphology. The two tumors that failed to stain with NKI/C3 both demonstrated predominantly spindled morphology. One of the tumors that failed to stain with Mitf showed exclusive spindled morphology, while the other showed mixed morphology (spindle and epithelioid). Two of the tumors, which stained strongly with Mitf, however, showed exclusive epithelioid morphology. This current study furthers the concept that cellular Neurothekeoma is a tumor of neuroectodermal origin, and further suggests that it may express some component of melanocytic differentiation.
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Microphthalmia transcription factor and NKI/C3 expression in cellular Neurothekeoma
Modern Pathology, 2004Co-Authors: Robert N Page, Roy King, Martin C Mihm, Paul B GoogeAbstract:While the usual or myxoid-type Neurothekeoma has been reasonably well established as being a tumor of neural origin, the cellular Neurothekeoma remains in disputed histogenesis. We studied a series of 11 cellular Neurothekeomas using paraffin immunoperoxidase staining with microphthalmia transcription factor (Mitf), NKI/C3, and S-100. The majority of the tumors in our series stained with NKI/C3 (9/11) and Mitf (9/11). All failed to stain with S-100. Furthermore, we divided our series of cellular Neurothekeomas according to cytomorphology; tumors demonstrating predominantly spindled morphology, predominantly epithelioid morphology, and mixed spindle and epithelioid morphology. The two tumors that failed to stain with NKI/C3 both demonstrated predominantly spindled morphology. One of the tumors that failed to stain with Mitf showed exclusive spindled morphology, while the other showed mixed morphology (spindle and epithelioid). Two of the tumors, which stained strongly with Mitf, however, showed exclusive epithelioid morphology. This current study furthers the concept that cellular Neurothekeoma is a tumor of neuroectodermal origin, and further suggests that it may express some component of melanocytic differentiation.
Martin C Mihm - One of the best experts on this subject based on the ideXlab platform.
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microphthalmia transcription factor and nki c3 expression in cellular Neurothekeoma
Modern Pathology, 2004Co-Authors: Robert N Page, Roy King, Martin C Mihm, Paul B GoogeAbstract:While the usual or myxoid-type Neurothekeoma has been reasonably well established as being a tumor of neural origin, the cellular Neurothekeoma remains in disputed histogenesis. We studied a series of 11 cellular Neurothekeomas using paraffin immunoperoxidase staining with microphthalmia transcription factor (Mitf), NKI/C3, and S-100. The majority of the tumors in our series stained with NKI/C3 (9/11) and Mitf (9/11). All failed to stain with S-100. Furthermore, we divided our series of cellular Neurothekeomas according to cytomorphology; tumors demonstrating predominantly spindled morphology, predominantly epithelioid morphology, and mixed spindle and epithelioid morphology. The two tumors that failed to stain with NKI/C3 both demonstrated predominantly spindled morphology. One of the tumors that failed to stain with Mitf showed exclusive spindled morphology, while the other showed mixed morphology (spindle and epithelioid). Two of the tumors, which stained strongly with Mitf, however, showed exclusive epithelioid morphology. This current study furthers the concept that cellular Neurothekeoma is a tumor of neuroectodermal origin, and further suggests that it may express some component of melanocytic differentiation.
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Microphthalmia transcription factor and NKI/C3 expression in cellular Neurothekeoma
Modern Pathology, 2004Co-Authors: Robert N Page, Roy King, Martin C Mihm, Paul B GoogeAbstract:While the usual or myxoid-type Neurothekeoma has been reasonably well established as being a tumor of neural origin, the cellular Neurothekeoma remains in disputed histogenesis. We studied a series of 11 cellular Neurothekeomas using paraffin immunoperoxidase staining with microphthalmia transcription factor (Mitf), NKI/C3, and S-100. The majority of the tumors in our series stained with NKI/C3 (9/11) and Mitf (9/11). All failed to stain with S-100. Furthermore, we divided our series of cellular Neurothekeomas according to cytomorphology; tumors demonstrating predominantly spindled morphology, predominantly epithelioid morphology, and mixed spindle and epithelioid morphology. The two tumors that failed to stain with NKI/C3 both demonstrated predominantly spindled morphology. One of the tumors that failed to stain with Mitf showed exclusive spindled morphology, while the other showed mixed morphology (spindle and epithelioid). Two of the tumors, which stained strongly with Mitf, however, showed exclusive epithelioid morphology. This current study furthers the concept that cellular Neurothekeoma is a tumor of neuroectodermal origin, and further suggests that it may express some component of melanocytic differentiation.
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Studies on the cellular origin of Neurothekeoma: clinical, light microscopic, immunohistochemical, and ultrastructural observations.
Journal of the American Academy of Dermatology, 1991Co-Authors: Raymond L. Barnhill, G. Richard Dickersin, Volker Nickeleit, Atul K. Bhan, Jan E. Muhlbauer, Mildred E. Phillips, Martin C MihmAbstract:The clinical, histopathologic, and immunohistochernical features of 11 cases of Neurothekeoma are reported. One case was examined by electron microscopy. The mean age of the patients was 27.1 years; the study comprised eight female and three male patients. Most lesions were nondescript papules and located on the upper part of the body, seven cases of Neurothekeoma on the head. Eight cases were classified as cellular Neurothekeoma on the basis of a striking fascicular pattern and three cases as myxomatous Neurothekeoma because of prominent myxoid stromal change. All cellular Neurothekeomas failed to express S-100 protein, whereas the three myxomatous types were strongly positive for this marker. Other than vimentin, there was no significant immunoreactivity with other immunohistochemical markers. Ultrastructural study of one case of cellular Neurothekeoma was inconclusive for cell type although a perineurial origin could not be excluded. On the basis of these results, we conclude that cellular Neurothekeoma differs from myxomatous Neurothekeoma not only by clinical and histologic findings but also by immunoreactivity with S-100 protein. These findings also suggest the existence of two distinct subtypes of Neurothekeoma and possible origin of the two variants of Neurothekeoma from different cell types or at least variation in phenotypic expression of a common cell type. On the other hand, it cannot be excluded that these two variants are different stages in the natural history of Neurothekeoma.
Robert N Page - One of the best experts on this subject based on the ideXlab platform.
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microphthalmia transcription factor and nki c3 expression in cellular Neurothekeoma
Modern Pathology, 2004Co-Authors: Robert N Page, Roy King, Martin C Mihm, Paul B GoogeAbstract:While the usual or myxoid-type Neurothekeoma has been reasonably well established as being a tumor of neural origin, the cellular Neurothekeoma remains in disputed histogenesis. We studied a series of 11 cellular Neurothekeomas using paraffin immunoperoxidase staining with microphthalmia transcription factor (Mitf), NKI/C3, and S-100. The majority of the tumors in our series stained with NKI/C3 (9/11) and Mitf (9/11). All failed to stain with S-100. Furthermore, we divided our series of cellular Neurothekeomas according to cytomorphology; tumors demonstrating predominantly spindled morphology, predominantly epithelioid morphology, and mixed spindle and epithelioid morphology. The two tumors that failed to stain with NKI/C3 both demonstrated predominantly spindled morphology. One of the tumors that failed to stain with Mitf showed exclusive spindled morphology, while the other showed mixed morphology (spindle and epithelioid). Two of the tumors, which stained strongly with Mitf, however, showed exclusive epithelioid morphology. This current study furthers the concept that cellular Neurothekeoma is a tumor of neuroectodermal origin, and further suggests that it may express some component of melanocytic differentiation.
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Microphthalmia transcription factor and NKI/C3 expression in cellular Neurothekeoma
Modern Pathology, 2004Co-Authors: Robert N Page, Roy King, Martin C Mihm, Paul B GoogeAbstract:While the usual or myxoid-type Neurothekeoma has been reasonably well established as being a tumor of neural origin, the cellular Neurothekeoma remains in disputed histogenesis. We studied a series of 11 cellular Neurothekeomas using paraffin immunoperoxidase staining with microphthalmia transcription factor (Mitf), NKI/C3, and S-100. The majority of the tumors in our series stained with NKI/C3 (9/11) and Mitf (9/11). All failed to stain with S-100. Furthermore, we divided our series of cellular Neurothekeomas according to cytomorphology; tumors demonstrating predominantly spindled morphology, predominantly epithelioid morphology, and mixed spindle and epithelioid morphology. The two tumors that failed to stain with NKI/C3 both demonstrated predominantly spindled morphology. One of the tumors that failed to stain with Mitf showed exclusive spindled morphology, while the other showed mixed morphology (spindle and epithelioid). Two of the tumors, which stained strongly with Mitf, however, showed exclusive epithelioid morphology. This current study furthers the concept that cellular Neurothekeoma is a tumor of neuroectodermal origin, and further suggests that it may express some component of melanocytic differentiation.
Raymond L. Barnhill - One of the best experts on this subject based on the ideXlab platform.
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Cellular Neurothekeoma in a Female with Guillain-Barré Syndrome: A Case Report and Review of the Literature.
Dermatopathology (Basel Switzerland), 2014Co-Authors: Divya Sachdev, Raymond L. Barnhill, Emma Taylor, Scott WorswickAbstract:Cellular Neurothekeoma is a rare cutaneous tumor that occurs more frequently in women. A 68-year-old female with a history of left nasal alar basal cell carcinoma and Guillain-Barre syndrome presented to the clinic with a 3-mm firm skin-colored papule with scattered telangiectasias. Histopathologic examination with immunochemistry of the lesion was consistent with cellular Neurothekeoma. It stained positive for microphthalmia transcription factor and NKI-C3 and negative for HMB-45 and S-100. The lesion was excised with 3-mm margins, and no recurrence was noted within 1 year of follow-up. We present a case of cellular Neurothekeoma in a patient with a history of Guillain-Barre syndrome as well as a review of the literature. Our case report is unique in that no prior association has been found in the literature between cellular Neurothekeoma and Guillain-Barre syndrome.
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Cellular Neurothekeoma in a Female with Guillain-Barré Syndrome: A Case Report and Review of the Literature
Karger Publishers, 2014Co-Authors: Divya Sachdev, Raymond L. Barnhill, Emma Taylor, Scott WorswickAbstract:Cellular Neurothekeoma is a rare cutaneous tumor that occurs more frequently in women. A 68-year-old female with a history of left nasal alar basal cell carcinoma and Guillain-Barré syndrome presented to the clinic with a 3-mm firm skin-colored papule with scattered telangiectasias. Histopathologic examination with immunochemistry of the lesion was consistent with cellular Neurothekeoma. It stained positive for microphthalmia transcription factor and NKI-C3 and negative for HMB-45 and S-100. The lesion was excised with 3-mm margins, and no recurrence was noted within 1 year of follow-up. We present a case of cellular Neurothekeoma in a patient with a history of Guillain-Barré syndrome as well as a review of the literature. Our case report is unique in that no prior association has been found in the literature between cellular Neurothekeoma and Guillain-Barré syndrome. © 2014 S. Karger AG, Base
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Studies on the cellular origin of Neurothekeoma: clinical, light microscopic, immunohistochemical, and ultrastructural observations.
Journal of the American Academy of Dermatology, 1991Co-Authors: Raymond L. Barnhill, G. Richard Dickersin, Volker Nickeleit, Atul K. Bhan, Jan E. Muhlbauer, Mildred E. Phillips, Martin C MihmAbstract:The clinical, histopathologic, and immunohistochernical features of 11 cases of Neurothekeoma are reported. One case was examined by electron microscopy. The mean age of the patients was 27.1 years; the study comprised eight female and three male patients. Most lesions were nondescript papules and located on the upper part of the body, seven cases of Neurothekeoma on the head. Eight cases were classified as cellular Neurothekeoma on the basis of a striking fascicular pattern and three cases as myxomatous Neurothekeoma because of prominent myxoid stromal change. All cellular Neurothekeomas failed to express S-100 protein, whereas the three myxomatous types were strongly positive for this marker. Other than vimentin, there was no significant immunoreactivity with other immunohistochemical markers. Ultrastructural study of one case of cellular Neurothekeoma was inconclusive for cell type although a perineurial origin could not be excluded. On the basis of these results, we conclude that cellular Neurothekeoma differs from myxomatous Neurothekeoma not only by clinical and histologic findings but also by immunoreactivity with S-100 protein. These findings also suggest the existence of two distinct subtypes of Neurothekeoma and possible origin of the two variants of Neurothekeoma from different cell types or at least variation in phenotypic expression of a common cell type. On the other hand, it cannot be excluded that these two variants are different stages in the natural history of Neurothekeoma.
Roy King - One of the best experts on this subject based on the ideXlab platform.
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microphthalmia transcription factor and nki c3 expression in cellular Neurothekeoma
Modern Pathology, 2004Co-Authors: Robert N Page, Roy King, Martin C Mihm, Paul B GoogeAbstract:While the usual or myxoid-type Neurothekeoma has been reasonably well established as being a tumor of neural origin, the cellular Neurothekeoma remains in disputed histogenesis. We studied a series of 11 cellular Neurothekeomas using paraffin immunoperoxidase staining with microphthalmia transcription factor (Mitf), NKI/C3, and S-100. The majority of the tumors in our series stained with NKI/C3 (9/11) and Mitf (9/11). All failed to stain with S-100. Furthermore, we divided our series of cellular Neurothekeomas according to cytomorphology; tumors demonstrating predominantly spindled morphology, predominantly epithelioid morphology, and mixed spindle and epithelioid morphology. The two tumors that failed to stain with NKI/C3 both demonstrated predominantly spindled morphology. One of the tumors that failed to stain with Mitf showed exclusive spindled morphology, while the other showed mixed morphology (spindle and epithelioid). Two of the tumors, which stained strongly with Mitf, however, showed exclusive epithelioid morphology. This current study furthers the concept that cellular Neurothekeoma is a tumor of neuroectodermal origin, and further suggests that it may express some component of melanocytic differentiation.
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Microphthalmia transcription factor and NKI/C3 expression in cellular Neurothekeoma
Modern Pathology, 2004Co-Authors: Robert N Page, Roy King, Martin C Mihm, Paul B GoogeAbstract:While the usual or myxoid-type Neurothekeoma has been reasonably well established as being a tumor of neural origin, the cellular Neurothekeoma remains in disputed histogenesis. We studied a series of 11 cellular Neurothekeomas using paraffin immunoperoxidase staining with microphthalmia transcription factor (Mitf), NKI/C3, and S-100. The majority of the tumors in our series stained with NKI/C3 (9/11) and Mitf (9/11). All failed to stain with S-100. Furthermore, we divided our series of cellular Neurothekeomas according to cytomorphology; tumors demonstrating predominantly spindled morphology, predominantly epithelioid morphology, and mixed spindle and epithelioid morphology. The two tumors that failed to stain with NKI/C3 both demonstrated predominantly spindled morphology. One of the tumors that failed to stain with Mitf showed exclusive spindled morphology, while the other showed mixed morphology (spindle and epithelioid). Two of the tumors, which stained strongly with Mitf, however, showed exclusive epithelioid morphology. This current study furthers the concept that cellular Neurothekeoma is a tumor of neuroectodermal origin, and further suggests that it may express some component of melanocytic differentiation.