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Masayoshi Inoue - One of the best experts on this subject based on the ideXlab platform.

  • High Neutrophil Count as a Negative Prognostic Factor for Relapse in Patients with Thymic Epithelial Tumor
    Annals of Surgical Oncology, 2020
    Co-Authors: Satoru Okada, Satoshi Teramukai, Masanori Shimomura, Hiroaki Tsunezuka, Shunta Ishihara, Satoshi Ikebe, Tatsuo Furuya, Junichi Shimada, Masayoshi Inoue
    Abstract:

    Purpose Preoperative Neutrophil Count is reportedly associated with poor prognosis in cancer patients. This study aimed to investigate the clinical significance of pre-treatment peripheral blood cell Counts in patients with thymic epithelial tumors (TETs). Methods A retrospective review of 71 patients with completely resected TETs [64 thymoma, 6 thymic carcinoma, and 1 thymic neuroendocrine tumor] between 2000 and 2018 was conducted. Associations between tumor recurrence and pre-treatment peripheral blood cell Counts of leukocytes (WBC), Neutrophils (Neut), lymphocytes (Lymph), monocytes (Mono), and platelets (Plt) were analyzed. Optimal cut-off points were selected using receiver operating characteristic curve analysis to predict tumor recurrence. Results High WBC (≥ 7000), Neut (≥ 4450), and Plt (≥ 226 × 10^3) Counts had significantly poor relapse-free survival (RFS), but high Lymph (≥ 1950) and Mono (≥ 400) did not. High Neut had the strongest correlation with recurrence (area under curve, 0.800); we focused on the analysis between high-Neut and low-Neut groups. High Neut Count significantly correlated with smoking history, pre-treatment C-reactive protein level, and advanced stage; high Neut Count and aggressive histology tended to show correlations. RFS was significantly poorer in the high-Neut group than in the low-Neut group ( p  = 0.003), with 5-year RFS rates of 63.8% and 96.8%, respectively. High Neut Count was a significant adverse predictor for RFS and cumulative incidence of recurrence ( p  = 0.005 and p 

  • high Neutrophil Count as a negative prognostic factor for relapse in patients with thymic epithelial tumor
    Annals of Surgical Oncology, 2020
    Co-Authors: Satoru Okada, Satoshi Teramukai, Masanori Shimomura, Hiroaki Tsunezuka, Shunta Ishihara, Satoshi Ikebe, Tatsuo Furuya, Junichi Shimada, Masayoshi Inoue
    Abstract:

    Preoperative Neutrophil Count is reportedly associated with poor prognosis in cancer patients. This study aimed to investigate the clinical significance of pre-treatment peripheral blood cell Counts in patients with thymic epithelial tumors (TETs). A retrospective review of 71 patients with completely resected TETs [64 thymoma, 6 thymic carcinoma, and 1 thymic neuroendocrine tumor] between 2000 and 2018 was conducted. Associations between tumor recurrence and pre-treatment peripheral blood cell Counts of leukocytes (WBC), Neutrophils (Neut), lymphocytes (Lymph), monocytes (Mono), and platelets (Plt) were analyzed. Optimal cut-off points were selected using receiver operating characteristic curve analysis to predict tumor recurrence. High WBC (≥ 7000), Neut (≥ 4450), and Plt (≥ 226 × 103) Counts had significantly poor relapse-free survival (RFS), but high Lymph (≥ 1950) and Mono (≥ 400) did not. High Neut had the strongest correlation with recurrence (area under curve, 0.800); we focused on the analysis between high-Neut and low-Neut groups. High Neut Count significantly correlated with smoking history, pre-treatment C-reactive protein level, and advanced stage; high Neut Count and aggressive histology tended to show correlations. RFS was significantly poorer in the high-Neut group than in the low-Neut group (p = 0.003), with 5-year RFS rates of 63.8% and 96.8%, respectively. High Neut Count was a significant adverse predictor for RFS and cumulative incidence of recurrence (p = 0.005 and p < 0.001, respectively). The risk scoring system comprising high Neut Count, advanced stage, and aggressive histology demonstrated better prognostic ability than any prognostic factors alone. High Neut Count significantly correlated with TET recurrence, suggesting a negative prognostic effect of latent inflammation in TET patients.

Satoshi Teramukai - One of the best experts on this subject based on the ideXlab platform.

  • High Neutrophil Count as a Negative Prognostic Factor for Relapse in Patients with Thymic Epithelial Tumor
    Annals of Surgical Oncology, 2020
    Co-Authors: Satoru Okada, Satoshi Teramukai, Masanori Shimomura, Hiroaki Tsunezuka, Shunta Ishihara, Satoshi Ikebe, Tatsuo Furuya, Junichi Shimada, Masayoshi Inoue
    Abstract:

    Purpose Preoperative Neutrophil Count is reportedly associated with poor prognosis in cancer patients. This study aimed to investigate the clinical significance of pre-treatment peripheral blood cell Counts in patients with thymic epithelial tumors (TETs). Methods A retrospective review of 71 patients with completely resected TETs [64 thymoma, 6 thymic carcinoma, and 1 thymic neuroendocrine tumor] between 2000 and 2018 was conducted. Associations between tumor recurrence and pre-treatment peripheral blood cell Counts of leukocytes (WBC), Neutrophils (Neut), lymphocytes (Lymph), monocytes (Mono), and platelets (Plt) were analyzed. Optimal cut-off points were selected using receiver operating characteristic curve analysis to predict tumor recurrence. Results High WBC (≥ 7000), Neut (≥ 4450), and Plt (≥ 226 × 10^3) Counts had significantly poor relapse-free survival (RFS), but high Lymph (≥ 1950) and Mono (≥ 400) did not. High Neut had the strongest correlation with recurrence (area under curve, 0.800); we focused on the analysis between high-Neut and low-Neut groups. High Neut Count significantly correlated with smoking history, pre-treatment C-reactive protein level, and advanced stage; high Neut Count and aggressive histology tended to show correlations. RFS was significantly poorer in the high-Neut group than in the low-Neut group ( p  = 0.003), with 5-year RFS rates of 63.8% and 96.8%, respectively. High Neut Count was a significant adverse predictor for RFS and cumulative incidence of recurrence ( p  = 0.005 and p 

  • high Neutrophil Count as a negative prognostic factor for relapse in patients with thymic epithelial tumor
    Annals of Surgical Oncology, 2020
    Co-Authors: Satoru Okada, Satoshi Teramukai, Masanori Shimomura, Hiroaki Tsunezuka, Shunta Ishihara, Satoshi Ikebe, Tatsuo Furuya, Junichi Shimada, Masayoshi Inoue
    Abstract:

    Preoperative Neutrophil Count is reportedly associated with poor prognosis in cancer patients. This study aimed to investigate the clinical significance of pre-treatment peripheral blood cell Counts in patients with thymic epithelial tumors (TETs). A retrospective review of 71 patients with completely resected TETs [64 thymoma, 6 thymic carcinoma, and 1 thymic neuroendocrine tumor] between 2000 and 2018 was conducted. Associations between tumor recurrence and pre-treatment peripheral blood cell Counts of leukocytes (WBC), Neutrophils (Neut), lymphocytes (Lymph), monocytes (Mono), and platelets (Plt) were analyzed. Optimal cut-off points were selected using receiver operating characteristic curve analysis to predict tumor recurrence. High WBC (≥ 7000), Neut (≥ 4450), and Plt (≥ 226 × 103) Counts had significantly poor relapse-free survival (RFS), but high Lymph (≥ 1950) and Mono (≥ 400) did not. High Neut had the strongest correlation with recurrence (area under curve, 0.800); we focused on the analysis between high-Neut and low-Neut groups. High Neut Count significantly correlated with smoking history, pre-treatment C-reactive protein level, and advanced stage; high Neut Count and aggressive histology tended to show correlations. RFS was significantly poorer in the high-Neut group than in the low-Neut group (p = 0.003), with 5-year RFS rates of 63.8% and 96.8%, respectively. High Neut Count was a significant adverse predictor for RFS and cumulative incidence of recurrence (p = 0.005 and p < 0.001, respectively). The risk scoring system comprising high Neut Count, advanced stage, and aggressive histology demonstrated better prognostic ability than any prognostic factors alone. High Neut Count significantly correlated with TET recurrence, suggesting a negative prognostic effect of latent inflammation in TET patients.

  • pretreatment Neutrophil Count as an independent prognostic factor in advanced non small cell lung cancer an analysis of japan multinational trial organisation lc00 03
    European Journal of Cancer, 2009
    Co-Authors: Satoshi Teramukai, Toshiyuki Kitano, Yusuke Kishida, Masaaki Kawahara, Kaoru Kubota, K Komuta, Koichi Minato, T Mio, Yuka Fujita, Toshiro Yonei
    Abstract:

    We examined the impact of pretreatment Neutrophil Count on survival in patients with advanced non-small-cell lung cancer (NSCLC). A total of 388 chemo-naive patients with stage IIIB or IV NSCLC from a randomised controlled trial were evaluated. The effects of pretreatment peripheral blood Neutrophil, lymphocyte and monocyte Counts and Neutrophil-lymphocyte ratio on survival were examined using the proportional hazards regression model to estimate hazard ratios after adjustment for covariates. The optimal cut-off value was determined by proportional hazards regression analysis with the minimum P-value approach and shrinkage procedure. After adjustment for prognostic factors, the pretreatment elevated Neutrophil Count was statistically significantly associated with short overall (P=0.0008) and progression-free survival (P=0.024), whereas no association was found between prognosis and lymphocyte or monocyte Count. The cut-off value selected for Neutrophil Count was 4500 mm(-3) (corrected hazard ratio, 1.67; 95% confidence interval (CI), 1.09-2.54). The median survival time was 19.3 months (95%CI, 16.5-21.4) for the low-Neutrophil group (4500 mm(-3), n=204) and was 10.2 months (95%CI, 8.0-12.3) for the high-Neutrophil group (4500 mm(-3), n=184). We confirmed that pretreatment elevated Neutrophil Count is an independent prognostic factor in patients with advanced NSCLC receiving modern chemotherapy. Neutrophil Count is easily measured at low cost, and it may be a useful indicator of patient prognosis.

Satoru Okada - One of the best experts on this subject based on the ideXlab platform.

  • High Neutrophil Count as a Negative Prognostic Factor for Relapse in Patients with Thymic Epithelial Tumor
    Annals of Surgical Oncology, 2020
    Co-Authors: Satoru Okada, Satoshi Teramukai, Masanori Shimomura, Hiroaki Tsunezuka, Shunta Ishihara, Satoshi Ikebe, Tatsuo Furuya, Junichi Shimada, Masayoshi Inoue
    Abstract:

    Purpose Preoperative Neutrophil Count is reportedly associated with poor prognosis in cancer patients. This study aimed to investigate the clinical significance of pre-treatment peripheral blood cell Counts in patients with thymic epithelial tumors (TETs). Methods A retrospective review of 71 patients with completely resected TETs [64 thymoma, 6 thymic carcinoma, and 1 thymic neuroendocrine tumor] between 2000 and 2018 was conducted. Associations between tumor recurrence and pre-treatment peripheral blood cell Counts of leukocytes (WBC), Neutrophils (Neut), lymphocytes (Lymph), monocytes (Mono), and platelets (Plt) were analyzed. Optimal cut-off points were selected using receiver operating characteristic curve analysis to predict tumor recurrence. Results High WBC (≥ 7000), Neut (≥ 4450), and Plt (≥ 226 × 10^3) Counts had significantly poor relapse-free survival (RFS), but high Lymph (≥ 1950) and Mono (≥ 400) did not. High Neut had the strongest correlation with recurrence (area under curve, 0.800); we focused on the analysis between high-Neut and low-Neut groups. High Neut Count significantly correlated with smoking history, pre-treatment C-reactive protein level, and advanced stage; high Neut Count and aggressive histology tended to show correlations. RFS was significantly poorer in the high-Neut group than in the low-Neut group ( p  = 0.003), with 5-year RFS rates of 63.8% and 96.8%, respectively. High Neut Count was a significant adverse predictor for RFS and cumulative incidence of recurrence ( p  = 0.005 and p 

  • high Neutrophil Count as a negative prognostic factor for relapse in patients with thymic epithelial tumor
    Annals of Surgical Oncology, 2020
    Co-Authors: Satoru Okada, Satoshi Teramukai, Masanori Shimomura, Hiroaki Tsunezuka, Shunta Ishihara, Satoshi Ikebe, Tatsuo Furuya, Junichi Shimada, Masayoshi Inoue
    Abstract:

    Preoperative Neutrophil Count is reportedly associated with poor prognosis in cancer patients. This study aimed to investigate the clinical significance of pre-treatment peripheral blood cell Counts in patients with thymic epithelial tumors (TETs). A retrospective review of 71 patients with completely resected TETs [64 thymoma, 6 thymic carcinoma, and 1 thymic neuroendocrine tumor] between 2000 and 2018 was conducted. Associations between tumor recurrence and pre-treatment peripheral blood cell Counts of leukocytes (WBC), Neutrophils (Neut), lymphocytes (Lymph), monocytes (Mono), and platelets (Plt) were analyzed. Optimal cut-off points were selected using receiver operating characteristic curve analysis to predict tumor recurrence. High WBC (≥ 7000), Neut (≥ 4450), and Plt (≥ 226 × 103) Counts had significantly poor relapse-free survival (RFS), but high Lymph (≥ 1950) and Mono (≥ 400) did not. High Neut had the strongest correlation with recurrence (area under curve, 0.800); we focused on the analysis between high-Neut and low-Neut groups. High Neut Count significantly correlated with smoking history, pre-treatment C-reactive protein level, and advanced stage; high Neut Count and aggressive histology tended to show correlations. RFS was significantly poorer in the high-Neut group than in the low-Neut group (p = 0.003), with 5-year RFS rates of 63.8% and 96.8%, respectively. High Neut Count was a significant adverse predictor for RFS and cumulative incidence of recurrence (p = 0.005 and p < 0.001, respectively). The risk scoring system comprising high Neut Count, advanced stage, and aggressive histology demonstrated better prognostic ability than any prognostic factors alone. High Neut Count significantly correlated with TET recurrence, suggesting a negative prognostic effect of latent inflammation in TET patients.

Paolo Verdecchia - One of the best experts on this subject based on the ideXlab platform.

  • Neutrophil Count and ambulatory pulse pressure as predictors of cardiovascular adverse events in postmenopausal women with hypertension.
    American journal of hypertension, 2011
    Co-Authors: Fabio Angeli, Enrica Angeli, Giuseppe Ambrosio, Giovanni Mazzotta, Gianpaolo Reboldi, Claudio Cavallini, Paolo Verdecchia
    Abstract:

    Background Elevated Neutrophil Count, a marker of systemic inflammation, has been suggested as a prognostic marker of cardiovascular disease in postmenopausal women with hypertension. We tested the hypothesis that an association exists between elevated Neutrophil Count and increased arterial stiffness, as reflected by a wide pulse pressure (PP), in this population of women. We also tested PP as predictor of cardiovascular adverse events in this population.

  • Neutrophil Count for the identification of postmenopausal hypertensive women at increased cardiovascular risk
    Obstetrics & Gynecology, 2010
    Co-Authors: Fabio Angeli, Enrica Angeli, Giuseppe Ambrosio, Giovanni Mazzotta, Gianpaolo Reboldi, Paolo Verdecchia
    Abstract:

    OBJECTIVE High white blood cell and Neutrophil Counts identify patients at increased cardiovascular risk in various clinical settings. However, the prognostic value of white blood cell and Neutrophil Counts in hypertensive postmenopausal women is unknown. We tested the independent prognostic value of total white blood cell and Neutrophil Counts for cardiovascular events in hypertensive postmenopausal women. METHODS We examined 298 initially untreated postmenopausal women with essential hypertension who were part of Progetto Ipertensione Umbria Monitoraggio Ambulatoriale (PIUMA). Mean duration of follow-up was 8 years (range 1-20 years). Treatment was tailored to each individual. RESULTS Mean age at entry was 59 years. Diabetic women comprised 9.1% of the group, and current smokers comprised 17.5% of the group. During follow-up, 31 new major cardiovascular events occurred. In univariable analyses, age, diabetes, serum creatinine, blood pressure, left ventricular hypertrophy, and Neutrophil Count showed an association with the risk of events (all P<.05). In a multivariable Cox analysis, after adjustment for traditional cardiovascular risk factors, for each 1.25x10 (1 standard deviation) increase in Neutrophil Count there was a 67% higher risk of cardiovascular events (hazard ratio 1.67, 95% confidence interval 1.32-2.07; P<.001). Furthermore, Neutrophil Count showed robust incremental predictive value for cardiovascular events, in addition to traditional risk factors. Total white blood cell Count did not show any association with cardiovascular events. CONCLUSION A high peripheral Neutrophil Count identifies postmenopausal hypertensive women at increased risk of cardiovascular disease. Such relation appears to be independent of traditional risk factors. LEVEL OF EVIDENCE III.

  • Neutrophil Count for the identification of postmenopausal hypertensive women at increased cardiovascular risk.
    Obstetrics and gynecology, 2010
    Co-Authors: Fabio Angeli, Enrica Angeli, Giuseppe Ambrosio, Giovanni Mazzotta, Gianpaolo Reboldi, Paolo Verdecchia
    Abstract:

    OBJECTIVE High white blood cell and Neutrophil Counts identify patients at increased cardiovascular risk in various clinical settings. However, the prognostic value of white blood cell and Neutrophil Counts in hypertensive postmenopausal women is unknown. We tested the independent prognostic value of total white blood cell and Neutrophil Counts for cardiovascular events in hypertensive postmenopausal women. METHODS We examined 298 initially untreated postmenopausal women with essential hypertension who were part of Progetto Ipertensione Umbria Monitoraggio Ambulatoriale (PIUMA). Mean duration of follow-up was 8 years (range 1-20 years). Treatment was tailored to each individual. RESULTS Mean age at entry was 59 years. Diabetic women comprised 9.1% of the group, and current smokers comprised 17.5% of the group. During follow-up, 31 new major cardiovascular events occurred. In univariable analyses, age, diabetes, serum creatinine, blood pressure, left ventricular hypertrophy, and Neutrophil Count showed an association with the risk of events (all P

Nobuoki Kohno - One of the best experts on this subject based on the ideXlab platform.