The Experts below are selected from a list of 51 Experts worldwide ranked by ideXlab platform

Sarnoff A. Mednick - One of the best experts on this subject based on the ideXlab platform.

  • Rhesus incompatibility as a risk factor for schizophrenia in male adults.
    Archives of General Psychiatry, 1996
    Co-Authors: J. Megginson Hollister, Peter Laing, Sarnoff A. Mednick
    Abstract:

    Background: Rhesus (Rh) incompatibility is a cause of Hemolytic Disease of the fetus and Newborn. Hemolytic Disease results from the transplacentally transmitted maternal antibodies against Rh factor D and can cause permanent neurological damage in the affected Newborn. This study examines the hypothesis that Rh incompatibility may be a risk factor for schizophrenia. Methods: A sample of 1867 male subjects was divided into two groups, 535 Rh incompatible and 1332 Rh compatible, and compared on rate of schizophrenia. Results: The rate of schizophrenia was significantly higher in the Rh-incompatible group (2.1%) compared with the Rh-compatible group (0.8%) ( P P Conclusion: Rh incompatibility may be a risk factor for schizophrenia.

Richard W O'shaughnessy - One of the best experts on this subject based on the ideXlab platform.

  • Management of pregnancies complicated by anti-c isoimmunization.
    Obstetrics and gynecology, 2004
    Co-Authors: David N Hackney, Eric J Knudtson, Karen Q Rossi, Dave Krugh, Richard W O'shaughnessy
    Abstract:

    To review cases of anti-c isoimmunization and determine the most appropriate management strategies. We performed a review of 102 pregnancies managed at The Ohio State University from 1967 to 2001 for anti-c isoimmunization. Of these, 55 had complete data and are included in this report. Information collected included serum titers, deltaOD450 values, Liley zones, fetal and neonatal hemoglobin levels and antigen typing, neonatal direct antiglobulin test, and neonatal outcomes. The appropriateness of traditional management was then evaluated. Of the 55 pregnancies, 46 had fetuses with positive direct antiglobulin test, and nine pregnancies had unaffected fetuses. Of the affected neonates, 12 (26%) had serious Hemolytic Disease of the Newborn. Of these 12, 8 required fetal transfusion, and the remaining 4 Newborns had hemoglobin levels of less than 10 g/dL at the time of delivery. A titer of 1:32 or greater or the presence of hydrops fetalis identified all such fetuses. There were 58 amniocenteses performed for deltaOD450 When plotted on modified Liley graphs, deltaOD450 values corresponded to Disease severity. There were no perinatal deaths attributable to anti-c Hemolytic Disease of the Newborn. Anti-c isoimmunization might cause significant fetal and Newborn Hemolytic Disease. A titer of 1:32 or greater or evidence of hydrops fetalis identified all the serious Hemolytic Disease at our institution. The significance of antibody titers and deltaOD450 values was similar to Rh-D sensitized pregnancies, and management by the same modalities is appropriate.

J. Megginson Hollister - One of the best experts on this subject based on the ideXlab platform.

  • Rhesus incompatibility as a risk factor for schizophrenia in male adults.
    Archives of General Psychiatry, 1996
    Co-Authors: J. Megginson Hollister, Peter Laing, Sarnoff A. Mednick
    Abstract:

    Background: Rhesus (Rh) incompatibility is a cause of Hemolytic Disease of the fetus and Newborn. Hemolytic Disease results from the transplacentally transmitted maternal antibodies against Rh factor D and can cause permanent neurological damage in the affected Newborn. This study examines the hypothesis that Rh incompatibility may be a risk factor for schizophrenia. Methods: A sample of 1867 male subjects was divided into two groups, 535 Rh incompatible and 1332 Rh compatible, and compared on rate of schizophrenia. Results: The rate of schizophrenia was significantly higher in the Rh-incompatible group (2.1%) compared with the Rh-compatible group (0.8%) ( P P Conclusion: Rh incompatibility may be a risk factor for schizophrenia.

David N Hackney - One of the best experts on this subject based on the ideXlab platform.

  • Management of pregnancies complicated by anti-c isoimmunization.
    Obstetrics and gynecology, 2004
    Co-Authors: David N Hackney, Eric J Knudtson, Karen Q Rossi, Dave Krugh, Richard W O'shaughnessy
    Abstract:

    To review cases of anti-c isoimmunization and determine the most appropriate management strategies. We performed a review of 102 pregnancies managed at The Ohio State University from 1967 to 2001 for anti-c isoimmunization. Of these, 55 had complete data and are included in this report. Information collected included serum titers, deltaOD450 values, Liley zones, fetal and neonatal hemoglobin levels and antigen typing, neonatal direct antiglobulin test, and neonatal outcomes. The appropriateness of traditional management was then evaluated. Of the 55 pregnancies, 46 had fetuses with positive direct antiglobulin test, and nine pregnancies had unaffected fetuses. Of the affected neonates, 12 (26%) had serious Hemolytic Disease of the Newborn. Of these 12, 8 required fetal transfusion, and the remaining 4 Newborns had hemoglobin levels of less than 10 g/dL at the time of delivery. A titer of 1:32 or greater or the presence of hydrops fetalis identified all such fetuses. There were 58 amniocenteses performed for deltaOD450 When plotted on modified Liley graphs, deltaOD450 values corresponded to Disease severity. There were no perinatal deaths attributable to anti-c Hemolytic Disease of the Newborn. Anti-c isoimmunization might cause significant fetal and Newborn Hemolytic Disease. A titer of 1:32 or greater or evidence of hydrops fetalis identified all the serious Hemolytic Disease at our institution. The significance of antibody titers and deltaOD450 values was similar to Rh-D sensitized pregnancies, and management by the same modalities is appropriate.

Peter Laing - One of the best experts on this subject based on the ideXlab platform.

  • Rhesus incompatibility as a risk factor for schizophrenia in male adults.
    Archives of General Psychiatry, 1996
    Co-Authors: J. Megginson Hollister, Peter Laing, Sarnoff A. Mednick
    Abstract:

    Background: Rhesus (Rh) incompatibility is a cause of Hemolytic Disease of the fetus and Newborn. Hemolytic Disease results from the transplacentally transmitted maternal antibodies against Rh factor D and can cause permanent neurological damage in the affected Newborn. This study examines the hypothesis that Rh incompatibility may be a risk factor for schizophrenia. Methods: A sample of 1867 male subjects was divided into two groups, 535 Rh incompatible and 1332 Rh compatible, and compared on rate of schizophrenia. Results: The rate of schizophrenia was significantly higher in the Rh-incompatible group (2.1%) compared with the Rh-compatible group (0.8%) ( P P Conclusion: Rh incompatibility may be a risk factor for schizophrenia.