The Experts below are selected from a list of 19551 Experts worldwide ranked by ideXlab platform
Joseph B Schwartz - One of the best experts on this subject based on the ideXlab platform.
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drug polymer interaction and its significance on the physical stability of Nifedipine amorphous dispersion in microparticles of an ammonio methacrylate copolymer and ethylcellulose binary blend
Journal of Pharmaceutical Sciences, 2008Co-Authors: Jingjun Huang, Rodney J Wigent, Joseph B SchwartzAbstract:Using spectroscopic and thermal analysis, this study investigated drug-polymer interaction and its significance on the physical stability of drug amorphous dispersion in microparticles of an ammonio polymethacrylate copolymer (Eudragit RL) (RL) and ethylcellulose (EC) binary blend (RL/EC = 2:1 w/w) prepared for use in controlled release of poorly water-soluble drugs. Solid dispersion of the model drug, Nifedipine in the microparticles could be described as an ideal amorphous mixture for drug loadings up to 11% w/w. The antiplasticizing effect of the polymer blend was indicated by a significant increase in the glass transition point from approximately 50 degrees C for the amorphous Nifedipine to approximately 115 degrees C for its solid solution. Moreover, shifts in infrared vibration wavenumber of Nifedipine carbonyl and amine groups suggested that the hydrogen bonds (H-bonds) originally formed among Nifedipine molecules were broken and replaced by those formed between Nifedipine and polymers in the microparticles. Further infrared analysis on Nifedipine amorphous dispersions with a single polymer, namely RL or EC, confirmed the proposed hydrogen-bonding interactions; and their stability study results suggested that both antiplasticizing effects and hydrogen bonding of EC and RL with Nifedipine might be responsible for the physical stability of the microparticles of Nifedipine amorphous dispersion with a RL/EC binary blend.
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drug polymer interaction and its significance on the physical stability of Nifedipine amorphous dispersion in microparticles of an ammonio methacrylate copolymer and ethylcellulose binary blend
Journal of Pharmaceutical Sciences, 2008Co-Authors: Jingjun Huang, Rodney J Wigent, Joseph B SchwartzAbstract:ABSTRACT Using spectroscopic and thermal analysis, this study investigated drug–polymer interaction and its significance on the physical stability of drug amorphous dispersion in microparticles of an ammonio polymethacrylate copolymer (Eudragit RL®) (RL) and ethylcellulose (EC) binary blend (RL/EC = 2:1 w/w) prepared for use in controlled release of poorly water‐soluble drugs. Solid dispersion of the model drug, Nifedipine in the microparticles could be described as an ideal amorphous mixture for drug loadings up to 11% w/w. The antiplasticizing effect of the polymer blend was indicated by a significant increase in the glass transition point from ∼50°C for the amorphous Nifedipine to ∼115°C for its solid solution. Moreover, shifts in infrared vibration wavenumber of Nifedipine carbonyl and amine groups suggested that the hydrogen bonds (H‐bonds) originally formed among Nifedipine molecules were broken and replaced by those formed between Nifedipine and polymers in the microparticles. Further infrared analysis on Nifedipine amorphous dispersions with a single polymer, namely RL or EC, confirmed the proposed hydrogen‐bonding interactions; and their stability study results suggested that both antiplasticizing effects and hydrogen bonding of EC and RL with Nifedipine might be responsible for the physical stability of the microparticles of Nifedipine amorphous dispersion with a RL/EC binary blend. © 2007 Wiley‐Liss, Inc. and the American Pharmacists Association J Pharm Sci 97:251–262, 2008
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Nifedipine solid dispersion in microparticles of ammonio methacrylate copolymer and ethylcellulose binary blend for controlled drug delivery effect of drug loading on release kinetics
International Journal of Pharmaceutics, 2006Co-Authors: Jingjun Huang, Rodney J Wigent, Catherine M Bentzley, Joseph B SchwartzAbstract:In order to elucidate the controlled-release mechanism of a poorly water-soluble drug from microparticles of ammonio methacrylate copolymer and ethylcellulose binary blend prepared by a phase-separation method, Nifedipine-loaded microparticles with different levels of drug loading were evaluated by micromeritic properties, drug physical state, matrix internal structure, drug dissolution, and release modeling. Drug release study indicated that Nifedipine release from the microparticles followed the Fickian diffusion mechanism, which supported the study hypothesis that as a result of formation of a Nifedipine molecular dispersion, Nifedipine dissolution inside the matrix was no longer the rate-limiting step for drug release, and the drug diffusion in matrix became the slowest step instead. Moreover, study results indicated that even though drug loading did not significantly affect the microparticle size distribution and morphology, Nifedipine release rate from those microparticles was more or less influenced by the level of drug loading, depending on matrix formulation. At lower levels of drug loading, Nifedipine release was well described by the Baker and Lonsdale's matrix diffusion model for microspheres containing dissolved drug and Nifedipine had a plasticizing effect on the polymers that caused an increase in drug effective diffusion coefficient with increasing drug loading. However, at higher levels of drug loading, probably due to formation of solid Nifedipine domains in microparticles, a change in the release kinetics was observed.
Jingjun Huang - One of the best experts on this subject based on the ideXlab platform.
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drug polymer interaction and its significance on the physical stability of Nifedipine amorphous dispersion in microparticles of an ammonio methacrylate copolymer and ethylcellulose binary blend
Journal of Pharmaceutical Sciences, 2008Co-Authors: Jingjun Huang, Rodney J Wigent, Joseph B SchwartzAbstract:Using spectroscopic and thermal analysis, this study investigated drug-polymer interaction and its significance on the physical stability of drug amorphous dispersion in microparticles of an ammonio polymethacrylate copolymer (Eudragit RL) (RL) and ethylcellulose (EC) binary blend (RL/EC = 2:1 w/w) prepared for use in controlled release of poorly water-soluble drugs. Solid dispersion of the model drug, Nifedipine in the microparticles could be described as an ideal amorphous mixture for drug loadings up to 11% w/w. The antiplasticizing effect of the polymer blend was indicated by a significant increase in the glass transition point from approximately 50 degrees C for the amorphous Nifedipine to approximately 115 degrees C for its solid solution. Moreover, shifts in infrared vibration wavenumber of Nifedipine carbonyl and amine groups suggested that the hydrogen bonds (H-bonds) originally formed among Nifedipine molecules were broken and replaced by those formed between Nifedipine and polymers in the microparticles. Further infrared analysis on Nifedipine amorphous dispersions with a single polymer, namely RL or EC, confirmed the proposed hydrogen-bonding interactions; and their stability study results suggested that both antiplasticizing effects and hydrogen bonding of EC and RL with Nifedipine might be responsible for the physical stability of the microparticles of Nifedipine amorphous dispersion with a RL/EC binary blend.
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drug polymer interaction and its significance on the physical stability of Nifedipine amorphous dispersion in microparticles of an ammonio methacrylate copolymer and ethylcellulose binary blend
Journal of Pharmaceutical Sciences, 2008Co-Authors: Jingjun Huang, Rodney J Wigent, Joseph B SchwartzAbstract:ABSTRACT Using spectroscopic and thermal analysis, this study investigated drug–polymer interaction and its significance on the physical stability of drug amorphous dispersion in microparticles of an ammonio polymethacrylate copolymer (Eudragit RL®) (RL) and ethylcellulose (EC) binary blend (RL/EC = 2:1 w/w) prepared for use in controlled release of poorly water‐soluble drugs. Solid dispersion of the model drug, Nifedipine in the microparticles could be described as an ideal amorphous mixture for drug loadings up to 11% w/w. The antiplasticizing effect of the polymer blend was indicated by a significant increase in the glass transition point from ∼50°C for the amorphous Nifedipine to ∼115°C for its solid solution. Moreover, shifts in infrared vibration wavenumber of Nifedipine carbonyl and amine groups suggested that the hydrogen bonds (H‐bonds) originally formed among Nifedipine molecules were broken and replaced by those formed between Nifedipine and polymers in the microparticles. Further infrared analysis on Nifedipine amorphous dispersions with a single polymer, namely RL or EC, confirmed the proposed hydrogen‐bonding interactions; and their stability study results suggested that both antiplasticizing effects and hydrogen bonding of EC and RL with Nifedipine might be responsible for the physical stability of the microparticles of Nifedipine amorphous dispersion with a RL/EC binary blend. © 2007 Wiley‐Liss, Inc. and the American Pharmacists Association J Pharm Sci 97:251–262, 2008
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Nifedipine solid dispersion in microparticles of ammonio methacrylate copolymer and ethylcellulose binary blend for controlled drug delivery effect of drug loading on release kinetics
International Journal of Pharmaceutics, 2006Co-Authors: Jingjun Huang, Rodney J Wigent, Catherine M Bentzley, Joseph B SchwartzAbstract:In order to elucidate the controlled-release mechanism of a poorly water-soluble drug from microparticles of ammonio methacrylate copolymer and ethylcellulose binary blend prepared by a phase-separation method, Nifedipine-loaded microparticles with different levels of drug loading were evaluated by micromeritic properties, drug physical state, matrix internal structure, drug dissolution, and release modeling. Drug release study indicated that Nifedipine release from the microparticles followed the Fickian diffusion mechanism, which supported the study hypothesis that as a result of formation of a Nifedipine molecular dispersion, Nifedipine dissolution inside the matrix was no longer the rate-limiting step for drug release, and the drug diffusion in matrix became the slowest step instead. Moreover, study results indicated that even though drug loading did not significantly affect the microparticle size distribution and morphology, Nifedipine release rate from those microparticles was more or less influenced by the level of drug loading, depending on matrix formulation. At lower levels of drug loading, Nifedipine release was well described by the Baker and Lonsdale's matrix diffusion model for microspheres containing dissolved drug and Nifedipine had a plasticizing effect on the polymers that caused an increase in drug effective diffusion coefficient with increasing drug loading. However, at higher levels of drug loading, probably due to formation of solid Nifedipine domains in microparticles, a change in the release kinetics was observed.
Rodney J Wigent - One of the best experts on this subject based on the ideXlab platform.
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drug polymer interaction and its significance on the physical stability of Nifedipine amorphous dispersion in microparticles of an ammonio methacrylate copolymer and ethylcellulose binary blend
Journal of Pharmaceutical Sciences, 2008Co-Authors: Jingjun Huang, Rodney J Wigent, Joseph B SchwartzAbstract:Using spectroscopic and thermal analysis, this study investigated drug-polymer interaction and its significance on the physical stability of drug amorphous dispersion in microparticles of an ammonio polymethacrylate copolymer (Eudragit RL) (RL) and ethylcellulose (EC) binary blend (RL/EC = 2:1 w/w) prepared for use in controlled release of poorly water-soluble drugs. Solid dispersion of the model drug, Nifedipine in the microparticles could be described as an ideal amorphous mixture for drug loadings up to 11% w/w. The antiplasticizing effect of the polymer blend was indicated by a significant increase in the glass transition point from approximately 50 degrees C for the amorphous Nifedipine to approximately 115 degrees C for its solid solution. Moreover, shifts in infrared vibration wavenumber of Nifedipine carbonyl and amine groups suggested that the hydrogen bonds (H-bonds) originally formed among Nifedipine molecules were broken and replaced by those formed between Nifedipine and polymers in the microparticles. Further infrared analysis on Nifedipine amorphous dispersions with a single polymer, namely RL or EC, confirmed the proposed hydrogen-bonding interactions; and their stability study results suggested that both antiplasticizing effects and hydrogen bonding of EC and RL with Nifedipine might be responsible for the physical stability of the microparticles of Nifedipine amorphous dispersion with a RL/EC binary blend.
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drug polymer interaction and its significance on the physical stability of Nifedipine amorphous dispersion in microparticles of an ammonio methacrylate copolymer and ethylcellulose binary blend
Journal of Pharmaceutical Sciences, 2008Co-Authors: Jingjun Huang, Rodney J Wigent, Joseph B SchwartzAbstract:ABSTRACT Using spectroscopic and thermal analysis, this study investigated drug–polymer interaction and its significance on the physical stability of drug amorphous dispersion in microparticles of an ammonio polymethacrylate copolymer (Eudragit RL®) (RL) and ethylcellulose (EC) binary blend (RL/EC = 2:1 w/w) prepared for use in controlled release of poorly water‐soluble drugs. Solid dispersion of the model drug, Nifedipine in the microparticles could be described as an ideal amorphous mixture for drug loadings up to 11% w/w. The antiplasticizing effect of the polymer blend was indicated by a significant increase in the glass transition point from ∼50°C for the amorphous Nifedipine to ∼115°C for its solid solution. Moreover, shifts in infrared vibration wavenumber of Nifedipine carbonyl and amine groups suggested that the hydrogen bonds (H‐bonds) originally formed among Nifedipine molecules were broken and replaced by those formed between Nifedipine and polymers in the microparticles. Further infrared analysis on Nifedipine amorphous dispersions with a single polymer, namely RL or EC, confirmed the proposed hydrogen‐bonding interactions; and their stability study results suggested that both antiplasticizing effects and hydrogen bonding of EC and RL with Nifedipine might be responsible for the physical stability of the microparticles of Nifedipine amorphous dispersion with a RL/EC binary blend. © 2007 Wiley‐Liss, Inc. and the American Pharmacists Association J Pharm Sci 97:251–262, 2008
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Nifedipine solid dispersion in microparticles of ammonio methacrylate copolymer and ethylcellulose binary blend for controlled drug delivery effect of drug loading on release kinetics
International Journal of Pharmaceutics, 2006Co-Authors: Jingjun Huang, Rodney J Wigent, Catherine M Bentzley, Joseph B SchwartzAbstract:In order to elucidate the controlled-release mechanism of a poorly water-soluble drug from microparticles of ammonio methacrylate copolymer and ethylcellulose binary blend prepared by a phase-separation method, Nifedipine-loaded microparticles with different levels of drug loading were evaluated by micromeritic properties, drug physical state, matrix internal structure, drug dissolution, and release modeling. Drug release study indicated that Nifedipine release from the microparticles followed the Fickian diffusion mechanism, which supported the study hypothesis that as a result of formation of a Nifedipine molecular dispersion, Nifedipine dissolution inside the matrix was no longer the rate-limiting step for drug release, and the drug diffusion in matrix became the slowest step instead. Moreover, study results indicated that even though drug loading did not significantly affect the microparticle size distribution and morphology, Nifedipine release rate from those microparticles was more or less influenced by the level of drug loading, depending on matrix formulation. At lower levels of drug loading, Nifedipine release was well described by the Baker and Lonsdale's matrix diffusion model for microspheres containing dissolved drug and Nifedipine had a plasticizing effect on the polymers that caused an increase in drug effective diffusion coefficient with increasing drug loading. However, at higher levels of drug loading, probably due to formation of solid Nifedipine domains in microparticles, a change in the release kinetics was observed.
Ghulam Nabi Yattoo - One of the best experts on this subject based on the ideXlab platform.
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efficacy of Nifedipine therapy in patients with sphincter of oddi dysfunction a prospective double blind randomized placebo controlled cross over trial
British Journal of Clinical Pharmacology, 1992Co-Authors: Mohammad Sultan Khuroo, Showakat Ali Zargar, Ghulam Nabi YattooAbstract:1. Twenty-eight patients who fulfilled entry criteria for sphincter of Oddi dysfunction were randomly allocated to receive Nifedipine and placebo in a cross over design with 12 week treatment periods separated by a 2 week wash-out. 2. All patients had episodic pain resembling biliary pain, had previously undergone cholecystectomy, had elevated alkaline phosphatase during episodes of pain and had elevated basal pressure on sphincter of Oddi manometry. 3. Compared with placebo, significant decreases in cumulative pain score, number of pain episodes, oral analgesic tablets consumed and emergency room visits were observed during Nifedipine treatment. 4. Overall 21 patients improved during Nifedipine therapy while seven patients did not. None of the following predicted response to Nifedipine therapy: enzyme levels, morphine-Prostigmine test, fatty meal sonography, common duct diameter and pressure, sphincter of Oddi phasic pressure, frequency and duration of phasic waves and maximal fall in the basal pressure at sphincter of Oddi manometry after sublingual administration of Nifedipine. However patients with predominant antegrade propagation of phasic contractions of sphincter of Oddi did significantly better on Nifedipine than those with abnormal propagation of phasic contractions. 5. Nifedipine therapy orally in maximal tolerated doses relieves pain in patients with sphincter of Oddi dysfunction who have elevated basal pressure and sphincter of Oddi phasic contractions of predominantly antegrade nature.
Estrada Solorio, Maria Ines - One of the best experts on this subject based on the ideXlab platform.
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Eefecto de los uteroinhibidores en la flujometria doppler uteroplacentaria y fetal durante la amenaza de parto pretermino
'Universitat Autonoma de Barcelona', 2012Co-Authors: Estrada Solorio, Maria InesAbstract:INTRODUCCION El parto pretérmino es una de las principales causas de morbi-mortalidad neonatal. En el Hospital Civil de Guadalajara, en el año 2008 de un total de 8,896 nacimientos, se reporta un porcentaje de recién nacidos prematuros del 7.9% Los uteroinhibidores como un mecanismo para evitar los partos pretérmino han sido utilizados ampliamente en Obstetricia. Suelen tener una serie de efectos colaterales conocidos en la madre, sin embargo se ha estudiado poco el efecto de estos fármacos sobre el feto. El estudio Doppler pretende obtener más conocimientos sobre las repercusiones en ambos. Lamentablemente no se cuenta hasta hoy con valoración amplia sobre el uso de la Orciprenalina y Nifedipina y la respuesta en la flujometría Doppler de la arteria uterina, arteria umbilical, arteria cerebral media y en el índice cerebro-placentario, tema que genera un gran interés ya que de esta forma se valorarían mejor sus consecuencias durante el manejo de la amenaza del parto pretérmino, siendo que en nuestro medio estos fármacos son ampliamente utilizados para este fin. OBJETIVO PRINCIPAL Valorar la influencia de distintos fármacos útero-inhibidores sobre la circulación materna y fetal valorada mediante estudio Doppler. MATERIAL Y METODOS Se realizó un estudio tipo quasiexperimental, en la Unidad de Medicina Materno Fetal (UMMF) del Hospital Civil de Guadalajara UdeG México. A 27 pacientes se les aplico Orciprenalina y a otro grupo de 27 pacientes Nifedipina con embarazos de 28-34 semanas. Se utilizo el Protocolo de manejo de la UMMF. En ambos grupos se evaluaron los efectos hemodinámicos que pudieran presentarse en la madre y el feto ante su administración. RESULTADOS De un total de 54 pacientes se encontró que a mayor edad gestacional menor el índice de pulsatilidad (IP) cuando fue utilizada la Nifedipina y la Orciprenalina. Los cambios hemodinámicos en los diferentes vasos sanguíneos estudiados mediante la valoración de flujometría Doppler los índices de pulsatilidad (IP) sufrieron algunas variaciones mostrando valores estadísticamente significativos, pero sin salir de los percentiles de normalidad para cada edad gestacional y sin ninguna repercusión en la respuesta clínica materna o en el resultado perinatal. CONCLUSIONES La respuesta hemodinamica materno-fetal evaluada mediante flujometría Doppler en las arterias uterinas (Aut), arteria umbilical (AU), arteria cerebral media (ACM) y el índice cerebro-placentario (ICP) no fuueron afectadas por la utilización de Orciprenalina y Nifedipina durante la amenaza de parto pretérmino.INTRODUCTION Preterm birth is a major cause of neonatal morbidity and mortality. In the Civil Hospital of Guadalajara, in 2008 a total of 8.896 births, reported a percentage of premature infants of 7.9% The uteroinhibidores as a mechanism to prevent preterm births have been widely used in obstetrics. They usually have a number of known side effects in the mother, but has been little studied the effect of these drugs on the fetus. The Doppler study aims to gain more knowledge on the impact on both. Unfortunately there is no comprehensive assessment to date with the use of metaproterenol and Nifedipine and response Doppler flowmetry of the uterine artery, umbilical artery, middle cerebral artery and cerebro-placental index, a topic that generates a lot of interest and that in this way would be valued best consequences for the management of preterm labor threat, considering that in our midst these drugs are widely used for this purpose. OBJECTIVE To evaluate the influence of different drugs on the uterus-inhibiting maternal and fetal circulation assessed by Doppler study. MATERIAL AND METHODS A study quasiexperimental type in the Maternal Fetal Medicine Unit (UMMF) of the Civil Hospital of Guadalajara Mexico UdeG. A 27 patients received metaproterenol and another group of 27 patients with pregnancy Nifedipine 28-34 weeks. We used the Protocol UMMF management. Both groups evaluated the hemodynamic effects that may occur in the mother and fetus before its administration. RESULTS Of a total of 54 patients found that higher gestational age less pulsatility index (PI) was used as Nifedipine and metaproterenol. Hemodynamic changes in different blood vessels studied by assessing Doppler flowmetry pulsatility indices (PI) were some variations showing statistical significance, but without leaving the normal percentiles for each gestational age and without any impact on clinical response maternal or perinatal outcome. CONCLUSIONS The maternal-fetal hemodynamic response assessed by Doppler flowmetry in the uterine arteries (Aut), umbilical artery (UA), middle cerebral artery (MCA) and cerebro-placental index (PCI) fuueron not affected by the use of metaproterenol and Nifedipine during preterm labor
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Eefecto de los uteroinhibidores en la flujometria doppler uteroplacentaria y fetal durante la amenaza de parto pretermino /
2012Co-Authors: Estrada Solorio, Maria Ines, Universitat Autònoma De Barcelona. Departament De Periodisme I De CièncAbstract:Introducción: el parto pretérmino es una de las principales causas de morbi-mortalidad neonatal. En el Hospital Civil de Guadalajara, en el año 2008, de un total de 8,896 nacimientos, se reporta un porcentaje de recién nacidos prematuros del 7.9%. Los uteroinhibidores, como un mecanismo para evitar los partos pretérmino, han sido utilizados ampliamente en Obstetricia. Suelen tener una serie de efectos colaterales conocidos en la madre, sin embargo se ha estudiado poco el efecto de estos fármacos sobre el feto. El estudio Doppler pretende obtener más conocimientos sobre las repercusiones en ambos. Lamentablemente no se cuenta hasta hoy con valoración amplia sobre el uso de la Orciprenalina y Nifedipina y la respuesta en la flujometría Doppler de la arteria uterina, arteria umbilical, arteria cerebral media y en el índice cerebro-placentario, tema que genera un gran interés ya que de esta forma se valorarían mejor sus consecuencias durante el manejo de la amenaza del parto pretérmino, siendo que en nuestro medio estos fármacos son ampliamente utilizados para este fin. Objetivo principal: valorar la influencia de distintos fármacos útero-inhibidores sobre la circulación materna y fetal valorada mediante estudio Doppler. Material y métodos: se realizó un estudio tipo quasiexperimental, en la Unidad de Medicina Materno Fetal (U03F) del Hospital Civil de Guadalajara UdeG México. A 27 pacientes se les aplicó Orciprenalina y a otro grupo de 27 pacientes Nifedipina con embarazos de 28-34 semanas. Se utilizó el Protocolo de manejo de la U03F. En ambos grupos se evaluaron los efectos hemodinámicos que pudieran presentarse en la madre y el feto ante su administración. Resultados: de un total de 54 pacientes se encontró que a mayor edad gestacional menor el índice de pulsatilidad (IP) cuando fue utilizada la Nifedipina y la Orciprenalina. Los cambios hemodinámicos en los diferentes vasos sanguíneos estudiados mediante la valoración de flujometría Doppler. Los índices de pulsatilidad (IP) sufrieron algunas variaciones mostrando valores estadísticamente significativos, pero sin salir de los percentiles de normalidad para cada edad gestacional y sin ninguna repercusión en la respuesta clínica materna o en el resultado perinatal. Conclusiones: la respuesta hemodinamica materno-fetal evaluada mediante flujometría Doppler en las arterias uterinas (Aut), arteria umbilical (AU), arteria cerebral media (ACM) y el índice cerebro-placentario (ICP) no fueron afectadas por la utilización de Orciprenalina y Nifedipina durante la amenaza de parto pretérminoINTRODUCCION El parto pretérmino es una de las principales causas de morbi-mortalidad neonatal. En el Hospital Civil de Guadalajara, en el año 2008 de un total de 8,896 nacimientos, se reporta un porcentaje de recién nacidos prematuros del 7.9% Los uteroinhibidores como un mecanismo para evitar los partos pretérmino han sido utilizados ampliamente en Obstetricia. Suelen tener una serie de efectos colaterales conocidos en la madre, sin embargo se ha estudiado poco el efecto de estos fármacos sobre el feto. El estudio Doppler pretende obtener más conocimientos sobre las repercusiones en ambos. Lamentablemente no se cuenta hasta hoy con valoración amplia sobre el uso de la Orciprenalina y Nifedipina y la respuesta en la flujometría Doppler de la arteria uterina, arteria umbilical, arteria cerebral media y en el índice cerebro-placentario, tema que genera un gran interés ya que de esta forma se valorarían mejor sus consecuencias durante el manejo de la amenaza del parto pretérmino, siendo que en nuestro medio estos fármacos son ampliamente utilizados para este fin. OBJETIVO PRINCIPAL Valorar la influencia de distintos fármacos útero-inhibidores sobre la circulación materna y fetal valorada mediante estudio Doppler. MATERIAL Y METODOS Se realizó un estudio tipo quasiexperimental, en la Unidad de Medicina Materno Fetal (UMMF) del Hospital Civil de Guadalajara UdeG México. A 27 pacientes se les aplico Orciprenalina y a otro grupo de 27 pacientes Nifedipina con embarazos de 28-34 semanas. Se utilizo el Protocolo de manejo de la UMMF. En ambos grupos se evaluaron los efectos hemodinámicos que pudieran presentarse en la madre y el feto ante su administración. RESULTADOS De un total de 54 pacientes se encontró que a mayor edad gestacional menor el índice de pulsatilidad (IP) cuando fue utilizada la Nifedipina y la Orciprenalina. Los cambios hemodinámicos en los diferentes vasos sanguíneos estudiados mediante la valoración de flujometría Doppler los índices de pulsatilidad (IP) sufrieron algunas variaciones mostrando valores estadísticamente significativos, pero sin salir de los percentiles de normalidad para cada edad gestacional y sin ninguna repercusión en la respuesta clínica materna o en el resultado perinatal. CONCLUSIONES La respuesta hemodinamica materno-fetal evaluada mediante flujometría Doppler en las arterias uterinas (Aut), arteria umbilical (AU), arteria cerebral media (ACM) y el índice cerebro-placentario (ICP) no fuueron afectadas por la utilización de Orciprenalina y Nifedipina durante la amenaza de parto pretérmino.INTRODUCTION Preterm birth is a major cause of neonatal morbidity and mortality. In the Civil Hospital of Guadalajara, in 2008 a total of 8.896 births, reported a percentage of premature infants of 7.9% The uteroinhibidores as a mechanism to prevent preterm births have been widely used in obstetrics. They usually have a number of known side effects in the mother, but has been little studied the effect of these drugs on the fetus. The Doppler study aims to gain more knowledge on the impact on both. Unfortunately there is no comprehensive assessment to date with the use of metaproterenol and Nifedipine and response Doppler flowmetry of the uterine artery, umbilical artery, middle cerebral artery and cerebro-placental index, a topic that generates a lot of interest and that in this way would be valued best consequences for the management of preterm labor threat, considering that in our midst these drugs are widely used for this purpose. OBJECTIVE To evaluate the influence of different drugs on the uterus-inhibiting maternal and fetal circulation assessed by Doppler study. MATERIAL AND METHODS A study quasiexperimental type in the Maternal Fetal Medicine Unit (UMMF) of the Civil Hospital of Guadalajara Mexico UdeG. A 27 patients received metaproterenol and another group of 27 patients with pregnancy Nifedipine 28-34 weeks. We used the Protocol UMMF management. Both groups evaluated the hemodynamic effects that may occur in the mother and fetus before its administration. RESULTS Of a total of 54 patients found that higher gestational age less pulsatility index (PI) was used as Nifedipine and metaproterenol. Hemodynamic changes in different blood vessels studied by assessing Doppler flowmetry pulsatility indices (PI) were some variations showing statistical significance, but without leaving the normal percentiles for each gestational age and without any impact on clinical response maternal or perinatal outcome. CONCLUSIONS The maternal-fetal hemodynamic response assessed by Doppler flowmetry in the uterine arteries (Aut), umbilical artery (UA), middle cerebral artery (MCA) and cerebro-placental index (PCI) fuueron not affected by the use of metaproterenol and Nifedipine during preterm labor
