The Experts below are selected from a list of 3687 Experts worldwide ranked by ideXlab platform
Keigo Hikishima - One of the best experts on this subject based on the ideXlab platform.
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parkinson disease diffusion mr imaging to detect Nigrostriatal Pathway loss in a marmoset model treated with 1 methyl 4 phenyl 1 2 3 6 tetrahydropyridine
Radiology, 2015Co-Authors: Keigo Hikishima, Kiyoshi Ando, Ryutaro Yano, Kenji Kawai, Yuji Komaki, Takashi Inoue, Toshio ItohAbstract:Longitudinal voxel-based analysis of diffusion-tensor imaging and ex vivo microscopic tractography showed microstructural changes with denervation of the Nigrostriatal Pathway in the marmoset model of Parkinson disease treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
Toshio Itoh - One of the best experts on this subject based on the ideXlab platform.
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parkinson disease diffusion mr imaging to detect Nigrostriatal Pathway loss in a marmoset model treated with 1 methyl 4 phenyl 1 2 3 6 tetrahydropyridine
Radiology, 2015Co-Authors: Keigo Hikishima, Kiyoshi Ando, Ryutaro Yano, Kenji Kawai, Yuji Komaki, Takashi Inoue, Toshio ItohAbstract:Longitudinal voxel-based analysis of diffusion-tensor imaging and ex vivo microscopic tractography showed microstructural changes with denervation of the Nigrostriatal Pathway in the marmoset model of Parkinson disease treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
Ryutaro Yano - One of the best experts on this subject based on the ideXlab platform.
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parkinson disease diffusion mr imaging to detect Nigrostriatal Pathway loss in a marmoset model treated with 1 methyl 4 phenyl 1 2 3 6 tetrahydropyridine
Radiology, 2015Co-Authors: Keigo Hikishima, Kiyoshi Ando, Ryutaro Yano, Kenji Kawai, Yuji Komaki, Takashi Inoue, Toshio ItohAbstract:Longitudinal voxel-based analysis of diffusion-tensor imaging and ex vivo microscopic tractography showed microstructural changes with denervation of the Nigrostriatal Pathway in the marmoset model of Parkinson disease treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
Yuji Komaki - One of the best experts on this subject based on the ideXlab platform.
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parkinson disease diffusion mr imaging to detect Nigrostriatal Pathway loss in a marmoset model treated with 1 methyl 4 phenyl 1 2 3 6 tetrahydropyridine
Radiology, 2015Co-Authors: Keigo Hikishima, Kiyoshi Ando, Ryutaro Yano, Kenji Kawai, Yuji Komaki, Takashi Inoue, Toshio ItohAbstract:Longitudinal voxel-based analysis of diffusion-tensor imaging and ex vivo microscopic tractography showed microstructural changes with denervation of the Nigrostriatal Pathway in the marmoset model of Parkinson disease treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
John R Sladek - One of the best experts on this subject based on the ideXlab platform.
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embryonic substantia nigra grafts in the mesencephalon send neurites to the host striatum in non human primate after overexpression of gdnf
The Journal of Comparative Neurology, 2009Co-Authors: D E Redmond, Robert H. Roth, Kimberly B Bjugstad, John D Elsworth, C Leranth, Timothy J Collier, Barbara C Blanchard, Richard J Samulski, Patrick Aebischer, John R SladekAbstract:In spite of partial success in treating Parkinson's disease by using ectopically placed grafts of dopamine-producing cells, restoration of the original neuroanatomical circuits, if possible, might work better. Previous evidence of normal anatomic projections from ventral mesencephalic (VM) grafts placed in the substantia nigra (SN) has been limited to neonatal rodents and double grafting or bridging procedures. This study attempted to determine whether injection of a potent growth-promoting factor, glial cell line-derived neurotrophic factor (GDNF), into the target regions or placement of fetal striatal co-grafts in the Nigrostriatal Pathway might elicit neuritic outgrowth to the caudate nucleus. Four adult St. Kitts green monkeys received embryonic VM grafts into the rostral mesencephalon near the host SN, and injections of adeno-associated virus 2 (AAV2)/GDNF or equine infectious anemia virus (EIAV)/GDNF into the caudate. Three adult monkeys were co-grafted with fetal VM tissue near the SN and fetal striatal grafts (STR) 2.5 mm rostral in the Nigrostriatal Pathway. Before sacrifice, the striatal target regions were injected with the retrograde tracer Fluoro-Gold (FG). FG label was found in tyrosine hydroxylase-labeled neurons in VM grafts in the SN of only those monkeys that received AAV2/GDNF vector injections into the ipsilateral striatum. All monkeys showed FG labeling in the host SN when FG labeling was injected on the same side. These data show that grafted dopaminergic neurons can extend neurites to a distant target releasing an elevated concentration of GDNF, and suggest that grafted neurons can be placed into appropriate loci for potential tract reconstruction. Copyright 2009 Wiley-Liss, Inc.
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human neural stem cells migrate along the Nigrostriatal Pathway in a primate model of parkinson s disease
Experimental Neurology, 2008Co-Authors: Kimberly B Bjugstad, Robert H. Roth, Yang D Teng, Eugene D Redmond, John D Elsworth, Shannon K Cornelius, Evan Y Snyder, John R SladekAbstract:Abstract Although evidence of damage-directed neural stem cell (NSC) migration has been well-documented in the rodent, to our knowledge it has never been confirmed or quantified using human NSC (hNSC) in an adult non-human primate modeling a human neurodegenerative disease state. In this report, we attempt to provide that confirmation, potentially advancing basic stem cell concepts toward clinical relevance. hNSCs were implanted into the caudate nucleus (bilaterally) and substantia nigra (unilaterally) of 7, adult St. Kitts African green monkeys ( Chlorocebus sabaeus ) with previous exposure to systemic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), a neurotoxin that disrupts the dopaminergic Nigrostriatal Pathway. A detailed quantitative analysis of hNSC migration patterns at two time points (4 and 7 months) following transplantation was performed. Density contour mapping of hNSCs along the dorsal–ventral and medial–lateral axes of the brain suggested that > 80% of hNSCs migrated from the point of implantation to and along the impaired Nigrostriatal Pathway. Although 2/3 of hNSCs were transplanted within the caudate, 6 total injected donor cells were identified at this site. The migrating hNSC did not appear to be pursuing a neuronal lineage. In the striatum and Nigrostriatal Pathway, but not in the substantia nigra, some hNSCs were found to have taken a glial lineage. The property of neural stem cells to align themselves along a neural Pathway rendered dysfunctional by a given disease is potentially a valuable clinical tool.