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Maulidya, Atiza Fajrin - One of the best experts on this subject based on the ideXlab platform.
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Pengaruh peningkatan konsentrasi surfaktan Span 20 terhadap karakteristik sistem Niosom Kuersetin dengan metode Reverse Phase Evaporation (RPE)
2017Co-Authors: Maulidya, Atiza FajrinAbstract:INDONESIA: Kuersetin (3,4-dihidroksiflavonol) merupakan suatu senyawa flavonoid golongan flavonol yang memberikan banyak manfaat diantaranya sebagai antioksidan, antiinflamasi dan antibakteri. Banyaknya manfaat yang terkandung dalam kuersetin merupakan bentuk tanda-tanda kekuasaan Allah SWT. Kuersetin merupakan senyawa golongan BCS kelas II yang mempunyai sifat kelarutan dalam air rendah dan permeabilitas yang tinggi, sehingga perlu adanya suatu formulasi yang dapat meningkatkan bioavailibilitasnya yaitu dibuat dengan sistem pembawa niosom. Allah telah memberikan isyarat kepada manusia untuk berusaha mengembangkan, mengkaji, dan mempelajari kemampuan ilmiahnya. Komponen niosom yaitu surfaktan non ionik dan kolesterol. Penelitian ini bertujuan untuk mengetahui pengaruh peningkatan konsentrasi surfaktan yang digunakan dalam formula niosom terhadap karakteristik niosom yang meliputi uji organoleptis, uji pH, uji morfologi dan ukuran partikel, serta uji efisiensi penjebakan. Niosom dibuat dengan menggunakan metode Reverse Phase Evaporation (RPE). Formula niosom dibuat dengan peningkatan konsentrasi berturut-turut yaitu 7,74%; 8,74%; 9,74%. Karakteristik organoleptik yang dihasilkan yaitu warna kuning, bau khas kuersetin, dan konsistensi yang semakin kental dengan bertambahnya konsentrasi Span 20. Nilai pH pada tiap formula yang dihasilkan rata-rata sebesar 6,1; 6,13 dan 6,16. Hasil pengamatan morfologi niosom dengan menggunakan Scanning Electron Microscopy (SEM) yang diketahui yaitu berbentuk mendekati bulat (sferis) sedangkan hasil ukuran partikel berturut-turut sebesar 2,131 µm, 2,994 µm dan 3,311 µm dan efisiensi penjebakan dengan hasil berturut-turut sebesar 81,86%; 84,02% dan 88,24%. Hasil penelitian yang dilakukan menunjukkan bahwa peningkatan konsentrasi surfaktan Span 20 yang digunakan dalam formulasi sistem niosom kuersetin berpengaruh terhadap konsistensi sediaan sistem niosom kuersetin, ukuran partikel, dan efisiensi penjebakan namun tidak berpengaruh terhadap warna, bau dan pH sedian sistem niosom kuersetin. ENGLISH: Quercetin (3,4-dihidrociflavonol) is a flavonoid compound owning many benefits such as antioxidants, anti-inflammatory, and antibacterial. The huge benefits containing at quercetin are the sign of Allah SWT’s power. Quercetin is classified as BCS II owing low solubility character in the water and high permeability, thus it is important to have formulation that can increase it’s bioavailability made by the carriage of Niosome. Allah has signaled to humans to try to develop, study, and learn their scientific abilities. The component of Niosome are surfactant non-ionic and cholesterol. The purpose of this research is to acknowledge the influence of the increasing of surfactant concentration used in the Niosome formula to the character of Niosome including organoleptic test, pH test, morphology and particle size test, and entrapment efficiency test. Niosom is made of three formula using Reverse Phase Evaporation (RPE) method. Niosome formula is made by increasing concentration in F1, F2, and F3 respectively which are 7,74%; 8,74%; 9,74%. The character of organoleptic result is having light yellow colour, with quercetin smell, and the thick of consistency as the result of the increasing of Span 20. The value of pH in each formula results is in the average 6,1; 6,13 and 6,16. The result of morphology observation of niosom by using Scanning Electron Microscopy (SEM) is circle shape (sferis) while the result of particle size respectively are 2,131 µm, 2,994 µm and 3,311 µm and the entrapment efficiency with respective result are 81,86%; 84,02% and 88,24%. The result of this research shows that the increasing of surfactant concentration span 20 used in the niosom system formula influence the substance of noisome quercetin system, the size of particles, and entrapment efficiency but it does not influence the color, smell and pH in the Niosome quercetin system
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Pengaruh peningkatan konsentrasi surfaktan span 20 terhadap karakteristik sistem niosom kuersetindengan metode Reverse Phase Evaporation (RPE)
2017Co-Authors: Maulidya, Atiza FajrinAbstract:INDONESIA : Kuersetin (3,4-dihidroksiflavonol) merupakan suatu senyawa flavonoid golongan flavonol yang memberikan banyak manfaat diantaranya sebagai antioksidan, antiinflamasi dan antibakteri. Banyaknya manfaat yang terkandung dalam kuersetin merupakan bentuk tanda-tanda kekuasaan Allah SWT. Kuersetin merupakan senyawa golongan BCS kelas II yang mempunyai sifat kelarutan dalam air rendah dan permeabilitas yang tinggi, sehingga perlu adanya suatu formulasi yang dapat meningkatkan bioavailibilitasnya yaitu dibuat dengan sistem pembawa niosom. Allah telah memberikan isyarat kepada manusia untuk berusaha mengembangkan, mengkaji, dan mempelajari kemampuan ilmiahnya. Komponen niosom yaitu surfaktan non ionik dan kolesterol. Penelitian ini bertujuan untuk mengetahui pengaruh peningkatan konsentrasi surfaktan yang digunakan dalam formula niosom terhadap karakteristik niosom yang meliputi uji organoleptis, uji pH, uji morfologi dan ukuran partikel, serta uji efisiensi penjebakan. Niosom dibuat dengan menggunakan metode Reverse Phase Evaporation (RPE). Formula niosom dibuat dengan peningkatan konsentrasi berturut-turut yaitu 7,74%; 8,74%; 9,74%. Karakteristik organoleptik yang dihasilkan yaitu warna kuning, bau khas kuersetin, dan konsistensi yang semakin kental dengan bertambahnya konsentrasi Span 20. Nilai pH pada tiap formula yang dihasilkan rata-rata sebesar 6,1; 6,13 dan 6,16. Hasil pengamatan morfologi niosom dengan menggunakan Scanning Electron Microscopy (SEM) yang diketahui yaitu berbentuk mendekati bulat (sferis) sedangkan hasil ukuran partikel berturut-turut sebesar 2,131 µm, 2,994 µm dan 3,311 µm dan efisiensi penjebakan dengan hasil berturut-turut sebesar 81,86%; 84,02% dan 88,24%. Hasil penelitian yang dilakukan menunjukkan bahwa peningkatan konsentrasi surfaktan Span 20 yang digunakan dalam formulasi sistem niosom kuersetin berpengaruh terhadap konsistensi sediaan sistem niosom kuersetin, ukuran partikel, dan efisiensi penjebakan namun tidak berpengaruh terhadap warna, bau dan pH sedian sistem niosom kuersetin. ENGLISH : Quercetin (3,4-dihidrociflavonol) is a flavonoid compound owning many benefits such as antioxidants, anti-inflammatory, and antibacterial. The huge benefits containing at quercetin are the sign of Allah SWT’s power. Quercetin is classified as BCS II owing low solubility character in the water and high permeability, thus it is important to have formulation that can increase it’s bioavailability made by the carriage of Niosome. Allah has signaled to humans to try to develop, study, and learn their scientific abilities. The component of Niosome are surfactant non-ionic and cholesterol. The purpose of this research is to acknowledge the influence of the increasing of surfactant concentration used in the Niosome formula to the character of Niosome including organoleptic test, pH test, morphology and particle size test, and entrapment efficiency test. Niosom is made of three formula using Reverse Phase Evaporation (RPE) method. Niosome formula is made by increasing concentration in F1, F2, and F3 respectively which are 7,74%; 8,74%; 9,74%. The character of organoleptic result is having light yellow colour, with quercetin smell, and the thick of consistency as the result of the increasing of Span 20. The value of pH in each formula results is in the average 6,1; 6,13 and 6,16. The result of morphology observation of niosom by using Scanning Electron Microscopy (SEM) is circle shape (sferis) while the result of particle size respectively are 2,131 µm, 2,994 µm and 3,311 µm and the entrapment efficiency with respective result are 81,86%; 84,02% and 88,24%. The result of this research shows that the increasing of surfactant concentration span 20 used in the niosom system formula influence the substance of noisome quercetin system, the size of particles, and entrapment efficiency but it does not influence the color, smell and pH in the Niosome quercetin system
Massimo Fresta - One of the best experts on this subject based on the ideXlab platform.
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In vitro and in vivo evaluation of Bola-surfactant containing Niosomes for transdermal delivery
Biomedical Microdevices, 2007Co-Authors: Donatella Paolino, Antonio Ricciardi, Nevio Picci, Christian Celia, Rita Muzzalupo, Massimo FrestaAbstract:A novel Niosome formulation is proposed for topical drug delivery of ammonium glycyrrhizinate, a natural compound with an efficacious anti-inflammatory activity. Niosomes were made up of a new non ionic surfactant, α,ω-hexadecyl-bis-(1-aza-18-crown-6) (Bolasurfactant)-Span 80-cholesterol (2:3:1 molar ratio). Niosome vesicles were prepared with the thin layer evaporation method and were physico-chemically characterized. The tolerability of Bola-surfactant both as free molecules or assembled ion Niosome vesicles was evaluated in vitro on cultured of human keratinocyte cells (NCTC2544). Human tolerability was evaluated on volunteers. The ability of Bola-Niosomes to promote intracellular delivery was evaluated by confocal laser scanning microscopy (CLSM) studies. Human stratum corneum and epidermis (SCE) membranes were used in vitro to investigate the percutaneous permeation. The anti-inflammatory activity of ammonium glycyrrhizinate was evaluated in vivo on human volunteers with a chemically induced erythema. Experimental data show that Bola-Niosomes are characterized by amean size of ∼400 nm and are able to provide an encapsulation efficiency of 40% with respect to the drug amount used during preparation. CLSM showed that Bola-Niosomes were able to promote the intracellular uptake of the delivered substances. BolaNiosomes were also able to significantly improve (p
G. K. Pillai - One of the best experts on this subject based on the ideXlab platform.
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Effect of Niosome Encapsulation of Methotrexate, Macrophage Activation on Tissue Distribution of Methotrexate and Tumor Size
Drug Delivery, 2008Co-Authors: K. S. Chandraprakash, Nayanabhirama Udupa, P. Uma Devi, G. K. PillaiAbstract:AbstractMethotrexate was encapsulated in “Niosomes” of sorbitan monostearate (Span 60) by the reverse phase evaporation technique. After i.v. infusion into mice methotrexate concentration was higher in all tissues except kidney with niosomal methotrexate than with methotrexate solution. Niosome encapsulation and macrophage activation enhanced the delivery of methotrexate to the tumor and increased its antitumor activity.
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Niosome encapsulated of vincristine sulfate improved anticancer activity with reduced toxicity in mice
Journal of Drug Targeting, 1994Co-Authors: G Parthasarathi, N Udupa, P Umadevi, G. K. PillaiAbstract:Nonionic surfactant vesicles (Niosomes) are promising drug carriers for anticancer drugs. Niosome encapsulated vincristine sulfate prepared by transmembrane pH gradient drug uptake process (remote loading method) was evaluated for toxicity and antitumour activity after administration to tumour bearing mice. The toxicity of vincristine sulfate was reduced after Niosome encapsulation and anticancer activity improved, which may be due to better delivery of vincristine at the tumour site.
Suresh P Vyas - One of the best experts on this subject based on the ideXlab platform.
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non ionic surfactant based vesicles Niosomes in drug delivery
International Journal of Pharmaceutics, 1998Co-Authors: Ijeoma F Uchegbu, Suresh P VyasAbstract:Abstract The self assembly of non-ionic surfactants into vesicles was first reported in the seventies by researchers in the cosmetic industry. Since then a number of groups world wide have studied non-ionic surfactant vesicles (Niosomes) with a view to evaluating their potential as drug carriers. This article presents a summary of the achievements in the field to date. Niosomes may be formed form a diverse array of amphiphiles bearing sugar, polyoxyethylene, polyglycerol, crown ether and amino acid hydrophilic head groups and these amphiphiles typically possess one to two hydrophobic alkyl, perfluoroalkyl or steroidal groups. The self assembly of surfactants into Niosomes is governed not only by the nature of the surfactant but by the presence of membrane additives, the nature of the drug encapsulated and the actual method of preparation. Methods of Niosome preparation and the number of different morphologies that have been identified are detailed. The influence of formulation factors on Niosome stability is also examined as are methods to optimise drug loading. In vivo these systems have been evaluated as immunological adjuvants, anti-cancer/anti-infective drug targeting agents and carriers of anti-inflammatory drugs. Niosomes have also been used in diagnostic imaging. Efforts to achieve transdermal and ophthalmic drug delivery with some formulations are also discussed.
Sanghwa Han - One of the best experts on this subject based on the ideXlab platform.
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An electron spin resonance study of non-ionic surfactant vesicles (Niosomes).
Chemistry and physics of lipids, 2014Co-Authors: Seongyeol Yeom, Bong Seop Shin, Sanghwa HanAbstract:Abstract Certain non-ionic surfactants form lamellar vesicles called Niosomes. Being elastic and deformable, Niosomes have been used as an efficient vehicle for transdermal drug delivery. However, dynamic properties of Niosomes have not been studied extensively. In this study we used electron spin resonance (ESR) technique to measure the membrane fluidity of Niosomes. In parallel with phospholipid liposomes, the ESR spectra of 5- and 16-doxyl stearate in Niosomes of sorbitan monostearate (Span 60) and sorbitan monooleate (Span 80) showed that motion of the spin label was more restricted at the region near the headgroup than near the bilayer center. Cholesterol increased fluidity of Span 60 Niosomes whereas it decreased fluidity of Span 80 Niosomes. Dicetyl phosphate added at 10 mol% concentration as a stabilizer had a minimal effect on the membrane fluidity throughout the bilayer. We also used ESR technique to monitor the hydration-induced transformation of Span 60 proNiosome gel to Niosome and showed that the Niosome prepared by hydration of proNiosome gel was identical to the Niosome obtained from a thin film hydration method. Finally the ESR spectra of Span Niosomes were compared with those of polysorbate (Tween) Niosomes and polyethoxy fatty ether (Brij) Niosomes. Tween Niosomes had a bulky headgroup and were much less rigid than Span Niosomes. This effect of headgroup size on fluidity was also manifest in Brij Niosomes where fluidity increased with the number of ethoxy units in the polyethoxy headgroup.