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L V Segesser - One of the best experts on this subject based on the ideXlab platform.

  • Regional diastolic dysfunction in postischaemic myocardium in calf: effect of Nisoldipine
    Cardiovascular research, 1993
    Co-Authors: Otto N. Krogmann, L. Tjon-a-meeuw, Otto M. Hess, M Jacob, J Grimm, B Leskosek, M Pasic, L V Segesser
    Abstract:

    OBJECTIVE: The aim was to assess the effect of Nisoldipine on left ventricular systolic and diastolic function during prolonged myocardial ischaemia. METHODS: The left circumflex coronary artery was ligated for 2 h and reperfused for 4 h in 12 calves. The animals were randomised to a control group (n = 6) or to treatment with 1.25 mg.h-1 intravenous Nisoldipine (n = 6) during 2 h of ischaemia. Circulatory support by a ventricular assist device was performed throughout the experiment except for the time of haemodynamic measurements. Regional wall thickening of a normal and an ischaemic left ventricular region was determined using pairs of ultrasonic crystals. Left ventricular pressure was measured by micromanometry. Left ventricular wall thickness and regional wall stiffness at a common preload of 10 mm Hg were calculated using an elastic model with shifting asymptote. RESULTS: Ten animals survived after 6 h. No difference was observed in systolic function between controls and Nisoldipine treated animals. Systolic thickening of the ischaemic wall remained depressed 4 h after reperfusion and showed some recovery after dopamine infusion. Ischaemic wall stiffness at a common preload was lower after Nisoldipine during ischaemia and reperfusion than in controls. Control wall stiffness remained unchanged during the whole experiment with and without Nisoldipine. Diastolic thinning of the ischaemic wall was prevented by Nisoldipine during ischaemia and after reperfusion. CONCLUSIONS: Prolonged myocardial ischaemia is associated with increased myocardial stiffness of the ischaemic wall. Mechanical unloading can help to bridge the acute phase but cannot prevent postischaemic diastolic dysfunction of the ischaemic wall. Nisoldipine has a beneficial effect on regional diastolic function during ischaemia and reperfusion by decreasing regional wall stiffness and preventing diastolic thinning of the ischaemic wall.

Bruno Magnani - One of the best experts on this subject based on the ideXlab platform.

  • Effects of Nisoldipine in coronary artery disease: a radioisotopic approach.
    Journal of Cardiovascular Pharmacology, 1992
    Co-Authors: F. Tartagni, Giovanni Melandri, I. De Tommaso, Fallani F, M. R. Di Niro, P. Antonioli, M. Dondi, Corbelli C, Bruno Magnani
    Abstract:

    The clinical, electrocardiographic, and scintigraphic effects of oral administration of Nisoldipine were investigated using two separate study protocols. In the first, the acute effects of Nisoldipine were evaluated by means of nuclear ventricolography and demonstrated no deleterious effects on global contractility and an amelioration of several hypokinetic segments. In the.second protocol, myocardial perfusion effects were evaluated by means of tomoscintigraphy. An improvement of segmental uptake of thallium was caused by Nisoldipine

  • Effects of Nisoldipine in coronary artery disease: a radioisotopic approach.
    Journal of cardiovascular pharmacology, 1992
    Co-Authors: F. Tartagni, Giovanni Melandri, I. De Tommaso, M. R. Di Niro, P. Antonioli, M. Dondi, F Fallani, C Corbelli, Bruno Magnani
    Abstract:

    The clinical, electrocardiographic, and scintigraphic effects of oral administration of Nisoldipine were investigated using two separate study protocols. In the first, the acute effects of Nisoldipine were evaluated by means of nuclear ventricolography and demonstrated no deleterious effects on global contractility and an amelioration of several hypokinetic segments. In the second protocol, myocardial perfusion effects were evaluated by means of tomoscintigraphy. An improvement of segmental uptake of thallium was caused by Nisoldipine. The addition of atenolol markedly reduced the rate-pressure product and further improved myocardial perfusion.

Basil S Lewis - One of the best experts on this subject based on the ideXlab platform.

  • efficacy and safety of Nisoldipine coat core in the management of angina pectoris systemic hypertension and ischemic ventricular dysfunction
    American Journal of Cardiology, 1995
    Co-Authors: Basil S Lewis
    Abstract:

    Abstract The effects of the long-acting dihydropyridine calcium antagonist Nisoldipine coat core (CC) have been investigated in > 3,500 patients with angina pectoris, hypertension, arid ischemic ventricular dysfunction. In patients with angina pectoris, Nisoldipine CC improved total treadmill exercise duration (p = 0.027), delayed the onset of angina pectoris (p = 0.009), and increased time to exercise-induced ST-segment depression (p = 0.061). In general, Nisoldipine 20–40 mg was effective, and the dose-response curve flattened thereafter. In patients with hypertension, 10–40 mg once daily as monotherapy reduced blood pressure (p 65 years of age. In the Doppler Flow and Echocardiography in Functional Cardiac Insufficiency: Assessment of Nisoldipine Therapy (DEFIANT-I) study of patients recovering from myocardial infarction, Nisoldipine CC had a salutary effect on diastolic ventricular function, with a higher transmitral early filling velocity and shorter isovolumic relaxation time than in patients receiving placebo. Bicycle exercise capacity was greater (by 12 W; 95% confidence interval, 0.8–23.3) and exercise-induced ischemia occurred less frequently. The Nisoldipine CC data pool (3,679 patients) showed that the drug was well tolerated with a low incidence of side effects. Angina pectoris, chest pain, and dyspnea, occurred less frequently with Nisoldipine CC, and mortality was slightly lower in patients taking the drug (0.28% vs 0.37%). The absence or very low incidence of acute vasodilatory effects may indicate that complications associated with sharp peak and trough effects of drug (reflex sympathetic stimulation, catecholamine release, activation of the renin—angiotensin system) may be less frequent with long-acting calcium antagonists.

Otto N. Krogmann - One of the best experts on this subject based on the ideXlab platform.

  • Regional diastolic dysfunction in postischaemic myocardium in calf: effect of Nisoldipine
    Cardiovascular research, 1993
    Co-Authors: Otto N. Krogmann, L. Tjon-a-meeuw, Otto M. Hess, M Jacob, J Grimm, B Leskosek, M Pasic, L V Segesser
    Abstract:

    OBJECTIVE: The aim was to assess the effect of Nisoldipine on left ventricular systolic and diastolic function during prolonged myocardial ischaemia. METHODS: The left circumflex coronary artery was ligated for 2 h and reperfused for 4 h in 12 calves. The animals were randomised to a control group (n = 6) or to treatment with 1.25 mg.h-1 intravenous Nisoldipine (n = 6) during 2 h of ischaemia. Circulatory support by a ventricular assist device was performed throughout the experiment except for the time of haemodynamic measurements. Regional wall thickening of a normal and an ischaemic left ventricular region was determined using pairs of ultrasonic crystals. Left ventricular pressure was measured by micromanometry. Left ventricular wall thickness and regional wall stiffness at a common preload of 10 mm Hg were calculated using an elastic model with shifting asymptote. RESULTS: Ten animals survived after 6 h. No difference was observed in systolic function between controls and Nisoldipine treated animals. Systolic thickening of the ischaemic wall remained depressed 4 h after reperfusion and showed some recovery after dopamine infusion. Ischaemic wall stiffness at a common preload was lower after Nisoldipine during ischaemia and reperfusion than in controls. Control wall stiffness remained unchanged during the whole experiment with and without Nisoldipine. Diastolic thinning of the ischaemic wall was prevented by Nisoldipine during ischaemia and after reperfusion. CONCLUSIONS: Prolonged myocardial ischaemia is associated with increased myocardial stiffness of the ischaemic wall. Mechanical unloading can help to bridge the acute phase but cannot prevent postischaemic diastolic dysfunction of the ischaemic wall. Nisoldipine has a beneficial effect on regional diastolic function during ischaemia and reperfusion by decreasing regional wall stiffness and preventing diastolic thinning of the ischaemic wall.

F. Tartagni - One of the best experts on this subject based on the ideXlab platform.

  • Effects of Nisoldipine in coronary artery disease: a radioisotopic approach.
    Journal of Cardiovascular Pharmacology, 1992
    Co-Authors: F. Tartagni, Giovanni Melandri, I. De Tommaso, Fallani F, M. R. Di Niro, P. Antonioli, M. Dondi, Corbelli C, Bruno Magnani
    Abstract:

    The clinical, electrocardiographic, and scintigraphic effects of oral administration of Nisoldipine were investigated using two separate study protocols. In the first, the acute effects of Nisoldipine were evaluated by means of nuclear ventricolography and demonstrated no deleterious effects on global contractility and an amelioration of several hypokinetic segments. In the.second protocol, myocardial perfusion effects were evaluated by means of tomoscintigraphy. An improvement of segmental uptake of thallium was caused by Nisoldipine

  • Effects of Nisoldipine in coronary artery disease: a radioisotopic approach.
    Journal of cardiovascular pharmacology, 1992
    Co-Authors: F. Tartagni, Giovanni Melandri, I. De Tommaso, M. R. Di Niro, P. Antonioli, M. Dondi, F Fallani, C Corbelli, Bruno Magnani
    Abstract:

    The clinical, electrocardiographic, and scintigraphic effects of oral administration of Nisoldipine were investigated using two separate study protocols. In the first, the acute effects of Nisoldipine were evaluated by means of nuclear ventricolography and demonstrated no deleterious effects on global contractility and an amelioration of several hypokinetic segments. In the second protocol, myocardial perfusion effects were evaluated by means of tomoscintigraphy. An improvement of segmental uptake of thallium was caused by Nisoldipine. The addition of atenolol markedly reduced the rate-pressure product and further improved myocardial perfusion.