The Experts below are selected from a list of 18 Experts worldwide ranked by ideXlab platform
Jaya Shree Anireddy - One of the best experts on this subject based on the ideXlab platform.
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Design and synthesis of diaziridinyl quinone thiadiazole hybrids via Nitrile Sulfide cycloaddition reaction as a key step
Tetrahedron Letters, 2016Co-Authors: Anjaiah Aitha, Satyanarayana Yennam, Manoranjan Behera, Jaya Shree AnireddyAbstract:A series of novel diaziridinyl quinone thiadiazole hybrids (9a–9j) were synthesized starting from 2-hydroxy-5-methoxybenzoic acid 1 in a 7 step synthetic sequence. The key step in the scheme involves the Nitrile Sulfide cycloaddition reaction of oxathiazolone 4 with p-tosylcyanide to obtain 1,2,4-thiadiazole derivative 5. We have demonstrated that p-tosyl group of thiadiazole 5 can be displaced with various nitrogen heterocycles to generate unknown 3,5-disubstituted thiadiazole derivatives.
Edward R Biehl - One of the best experts on this subject based on the ideXlab platform.
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facile synthesis of 2 substituted 4h 1 3 thiazines and 3 substituted 1 2 isothiazoles via benzyne intermediates
Heterocycles, 2005Co-Authors: Hongming Zhang, Ramadas Sathunuru, Charles W Rees, Edward R BiehlAbstract:Substituted 2-dialkylamino-4H-1,3-benzothiazineswere Synthesizedby the reaction of (phenyl)[o-(trimethylsilyl)aryl]iodonium triflates and dialkyl-aminothiazadienes in the presence of 1.5 equivalent of Bu 4 NF. However, when these reactions were carried out in the presence of 4 equivalents of Bu 4 NF, 3-substituted 1,2-benzisothiazoles were obtained. Additionally, the reaction of phenyl[(3-trimethylsilyl)-2-naphthyl]iodonium triflate with dialkylaminothia-zadienes in the presence of Bu 4 NF gave 3-substituted 1,2-naphthisothiazoles. A possible mechaism for the latter reaction involving the trapping of a benzyne intermediate with a Nitrile Sulfide generated in situ by the reaction of dialkylaminothiazadiene, fluoride ion and trimethylsilyl fluoride is proposed.
Anjaiah Aitha - One of the best experts on this subject based on the ideXlab platform.
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Design and synthesis of diaziridinyl quinone thiadiazole hybrids via Nitrile Sulfide cycloaddition reaction as a key step
Tetrahedron Letters, 2016Co-Authors: Anjaiah Aitha, Satyanarayana Yennam, Manoranjan Behera, Jaya Shree AnireddyAbstract:A series of novel diaziridinyl quinone thiadiazole hybrids (9a–9j) were synthesized starting from 2-hydroxy-5-methoxybenzoic acid 1 in a 7 step synthetic sequence. The key step in the scheme involves the Nitrile Sulfide cycloaddition reaction of oxathiazolone 4 with p-tosylcyanide to obtain 1,2,4-thiadiazole derivative 5. We have demonstrated that p-tosyl group of thiadiazole 5 can be displaced with various nitrogen heterocycles to generate unknown 3,5-disubstituted thiadiazole derivatives.
Manoranjan Behera - One of the best experts on this subject based on the ideXlab platform.
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Design and synthesis of diaziridinyl quinone thiadiazole hybrids via Nitrile Sulfide cycloaddition reaction as a key step
Tetrahedron Letters, 2016Co-Authors: Anjaiah Aitha, Satyanarayana Yennam, Manoranjan Behera, Jaya Shree AnireddyAbstract:A series of novel diaziridinyl quinone thiadiazole hybrids (9a–9j) were synthesized starting from 2-hydroxy-5-methoxybenzoic acid 1 in a 7 step synthetic sequence. The key step in the scheme involves the Nitrile Sulfide cycloaddition reaction of oxathiazolone 4 with p-tosylcyanide to obtain 1,2,4-thiadiazole derivative 5. We have demonstrated that p-tosyl group of thiadiazole 5 can be displaced with various nitrogen heterocycles to generate unknown 3,5-disubstituted thiadiazole derivatives.
Satyanarayana Yennam - One of the best experts on this subject based on the ideXlab platform.
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Design and synthesis of diaziridinyl quinone thiadiazole hybrids via Nitrile Sulfide cycloaddition reaction as a key step
Tetrahedron Letters, 2016Co-Authors: Anjaiah Aitha, Satyanarayana Yennam, Manoranjan Behera, Jaya Shree AnireddyAbstract:A series of novel diaziridinyl quinone thiadiazole hybrids (9a–9j) were synthesized starting from 2-hydroxy-5-methoxybenzoic acid 1 in a 7 step synthetic sequence. The key step in the scheme involves the Nitrile Sulfide cycloaddition reaction of oxathiazolone 4 with p-tosylcyanide to obtain 1,2,4-thiadiazole derivative 5. We have demonstrated that p-tosyl group of thiadiazole 5 can be displaced with various nitrogen heterocycles to generate unknown 3,5-disubstituted thiadiazole derivatives.