The Experts below are selected from a list of 42 Experts worldwide ranked by ideXlab platform

Naoki Miyata - One of the best experts on this subject based on the ideXlab platform.

  • visible light induced nitric oxide release from a novel Nitrobenzene Derivative cross conjugated with a coumarin fluorophore
    Bioorganic & Medicinal Chemistry Letters, 2014
    Co-Authors: Kai Kitamura, Kazuhiro Hishikawa, Kiyoshi Fukuhara, Takayoshi Suzuki, Naoki Miyata, Naoya Ieda, Hidehiko Nakagawa
    Abstract:

    Abstract Nitric oxide (NO) is a well-known free-radical molecule which is endogenously biosynthesised and shows various functions in mammals. To investigate NO functions, photocontrollable NO donors, compounds which release NO in response to light, are expected to be potentially useful. However, most of the conventional NO donors require harmful ultra-violet light for NO release. In this study, two dimethylNitrobenzene Derivatives conjugated with coumarins were designed, synthesized and evaluated as photocontrollable NO donors. The optical properties and efficiency of photo-induced NO release were dependent upon the nature of the conjugation system. One of these compounds, Bhc-DNB ( 1 ), showed spatiotemporally well-controlled NO release in cultured cells upon exposure to light in the less-cytotoxic visible wavelength range (400–430 nm).

  • peroxynitrite generation from a no releasing Nitrobenzene Derivative in response to photoirradiation
    Chemical Communications, 2011
    Co-Authors: Naoya Ieda, Kiyoshi Fukuhara, Hiroki Tsumoto, Takayoshi Suzuki, Hidehiko Nakagawa, Taeko Horinouchi, Tao Peng, Dan Yang, Naoki Miyata
    Abstract:

    Photocontrollable ONOO− generation from a Nitrobenzene Derivative was demonstrated. The designed compound released NO in response to photoirradiation, and the resulting semiquinone reduced molecular oxygen to generate O2˙−; reaction of the two generated ONOO−, as confirmed with an ONOO−fluorescent probe, HKGreen-3.

  • photoinduced nitric oxide release from a Nitrobenzene Derivative in mitochondria
    Chemistry: A European Journal, 2011
    Co-Authors: Taeko Horinouchi, Kiyoshi Fukuhara, Takayoshi Suzuki, Hidehiko Nakagawa, Naoki Miyata
    Abstract:

    We report a novel NO donor (RpNO), containing a 2,6-dimethylNitrobenzene moiety for photocontrollable NO release and a rhodamine moiety for targeting to mitochondria. Photorelease of NO from RpNO in aqueous solution was confirmed by means of ESR analysis. Cellular release of NO from RpNO was confirmed with the aid of DAF-FM DA, an NO-specific fluorescence probe. RpNO was colocalized with MitoTracker Green FM, a mitochondrial stain, in HCT116 colon cancer cells and exhibited photodependent cytotoxicity. Our results indicate that RpNO is an effective NO donor for time-controlled, mitochondria-specific NO treatment.

  • a novel mitochondria localizing Nitrobenzene Derivative as a donor for photo uncaging of nitric oxide
    Bioorganic & Medicinal Chemistry Letters, 2011
    Co-Authors: Taeko Horinouchi, Kiyoshi Fukuhara, Takayoshi Suzuki, Hidehiko Nakagawa, Naoki Miyata
    Abstract:

    We report a novel green-fluorescent NO donor, NBDNO, bearing a 2,6-dimethylNitrobenzene moiety for photocontrollable NO release and a triphenylphosphonium moiety for targeting to mitochondria. Photorelease of NO from NBDNO was confirmed by means of ESR analysis in aqueous solution. Intracellular release of NO from NBDNO was confirmed by using DAR-4M AM, an NO-specific fluorescence probe. NBDNO was colocalized with MitoRed, a mitochondrial stain, in HCT116 colon cancer cells. Our results indicate that NBDNO is an effective NO donor for time-controlled, mitochondria-specific NO treatment.

  • photoinduced nitric oxide release from a hindered Nitrobenzene Derivative by two photon excitation
    Journal of the American Chemical Society, 2009
    Co-Authors: Kazuhiro Hishikawa, Kiyoshi Fukuhara, Hiroki Tsumoto, Takayoshi Suzuki, Hidehiko Nakagawa, Toshiaki Furuta, Naoki Miyata
    Abstract:

    Here, we demonstrated photoinduced NO generation from a 2,6-dimethylNitrobenzene-based compound (Flu-DNB) via a two-photon excitation (TPE) process. After pulse laser irradiation to a solution of Flu-DNB, oxidation products of NO were observed. This is the first account of a non-nitrosyl-chelated metal ion containing NO donor which can be controlled by the TPE technique.

Hidehiko Nakagawa - One of the best experts on this subject based on the ideXlab platform.

  • visible light induced nitric oxide release from a novel Nitrobenzene Derivative cross conjugated with a coumarin fluorophore
    Bioorganic & Medicinal Chemistry Letters, 2014
    Co-Authors: Kai Kitamura, Kazuhiro Hishikawa, Kiyoshi Fukuhara, Takayoshi Suzuki, Naoki Miyata, Naoya Ieda, Hidehiko Nakagawa
    Abstract:

    Abstract Nitric oxide (NO) is a well-known free-radical molecule which is endogenously biosynthesised and shows various functions in mammals. To investigate NO functions, photocontrollable NO donors, compounds which release NO in response to light, are expected to be potentially useful. However, most of the conventional NO donors require harmful ultra-violet light for NO release. In this study, two dimethylNitrobenzene Derivatives conjugated with coumarins were designed, synthesized and evaluated as photocontrollable NO donors. The optical properties and efficiency of photo-induced NO release were dependent upon the nature of the conjugation system. One of these compounds, Bhc-DNB ( 1 ), showed spatiotemporally well-controlled NO release in cultured cells upon exposure to light in the less-cytotoxic visible wavelength range (400–430 nm).

  • peroxynitrite generation from a no releasing Nitrobenzene Derivative in response to photoirradiation
    Chemical Communications, 2011
    Co-Authors: Naoya Ieda, Kiyoshi Fukuhara, Hiroki Tsumoto, Takayoshi Suzuki, Hidehiko Nakagawa, Taeko Horinouchi, Tao Peng, Dan Yang, Naoki Miyata
    Abstract:

    Photocontrollable ONOO− generation from a Nitrobenzene Derivative was demonstrated. The designed compound released NO in response to photoirradiation, and the resulting semiquinone reduced molecular oxygen to generate O2˙−; reaction of the two generated ONOO−, as confirmed with an ONOO−fluorescent probe, HKGreen-3.

  • photoinduced nitric oxide release from a Nitrobenzene Derivative in mitochondria
    Chemistry: A European Journal, 2011
    Co-Authors: Taeko Horinouchi, Kiyoshi Fukuhara, Takayoshi Suzuki, Hidehiko Nakagawa, Naoki Miyata
    Abstract:

    We report a novel NO donor (RpNO), containing a 2,6-dimethylNitrobenzene moiety for photocontrollable NO release and a rhodamine moiety for targeting to mitochondria. Photorelease of NO from RpNO in aqueous solution was confirmed by means of ESR analysis. Cellular release of NO from RpNO was confirmed with the aid of DAF-FM DA, an NO-specific fluorescence probe. RpNO was colocalized with MitoTracker Green FM, a mitochondrial stain, in HCT116 colon cancer cells and exhibited photodependent cytotoxicity. Our results indicate that RpNO is an effective NO donor for time-controlled, mitochondria-specific NO treatment.

  • a novel mitochondria localizing Nitrobenzene Derivative as a donor for photo uncaging of nitric oxide
    Bioorganic & Medicinal Chemistry Letters, 2011
    Co-Authors: Taeko Horinouchi, Kiyoshi Fukuhara, Takayoshi Suzuki, Hidehiko Nakagawa, Naoki Miyata
    Abstract:

    We report a novel green-fluorescent NO donor, NBDNO, bearing a 2,6-dimethylNitrobenzene moiety for photocontrollable NO release and a triphenylphosphonium moiety for targeting to mitochondria. Photorelease of NO from NBDNO was confirmed by means of ESR analysis in aqueous solution. Intracellular release of NO from NBDNO was confirmed by using DAR-4M AM, an NO-specific fluorescence probe. NBDNO was colocalized with MitoRed, a mitochondrial stain, in HCT116 colon cancer cells. Our results indicate that NBDNO is an effective NO donor for time-controlled, mitochondria-specific NO treatment.

  • photoinduced nitric oxide release from a hindered Nitrobenzene Derivative by two photon excitation
    Journal of the American Chemical Society, 2009
    Co-Authors: Kazuhiro Hishikawa, Kiyoshi Fukuhara, Hiroki Tsumoto, Takayoshi Suzuki, Hidehiko Nakagawa, Toshiaki Furuta, Naoki Miyata
    Abstract:

    Here, we demonstrated photoinduced NO generation from a 2,6-dimethylNitrobenzene-based compound (Flu-DNB) via a two-photon excitation (TPE) process. After pulse laser irradiation to a solution of Flu-DNB, oxidation products of NO were observed. This is the first account of a non-nitrosyl-chelated metal ion containing NO donor which can be controlled by the TPE technique.

Takayoshi Suzuki - One of the best experts on this subject based on the ideXlab platform.

  • visible light induced nitric oxide release from a novel Nitrobenzene Derivative cross conjugated with a coumarin fluorophore
    Bioorganic & Medicinal Chemistry Letters, 2014
    Co-Authors: Kai Kitamura, Kazuhiro Hishikawa, Kiyoshi Fukuhara, Takayoshi Suzuki, Naoki Miyata, Naoya Ieda, Hidehiko Nakagawa
    Abstract:

    Abstract Nitric oxide (NO) is a well-known free-radical molecule which is endogenously biosynthesised and shows various functions in mammals. To investigate NO functions, photocontrollable NO donors, compounds which release NO in response to light, are expected to be potentially useful. However, most of the conventional NO donors require harmful ultra-violet light for NO release. In this study, two dimethylNitrobenzene Derivatives conjugated with coumarins were designed, synthesized and evaluated as photocontrollable NO donors. The optical properties and efficiency of photo-induced NO release were dependent upon the nature of the conjugation system. One of these compounds, Bhc-DNB ( 1 ), showed spatiotemporally well-controlled NO release in cultured cells upon exposure to light in the less-cytotoxic visible wavelength range (400–430 nm).

  • peroxynitrite generation from a no releasing Nitrobenzene Derivative in response to photoirradiation
    Chemical Communications, 2011
    Co-Authors: Naoya Ieda, Kiyoshi Fukuhara, Hiroki Tsumoto, Takayoshi Suzuki, Hidehiko Nakagawa, Taeko Horinouchi, Tao Peng, Dan Yang, Naoki Miyata
    Abstract:

    Photocontrollable ONOO− generation from a Nitrobenzene Derivative was demonstrated. The designed compound released NO in response to photoirradiation, and the resulting semiquinone reduced molecular oxygen to generate O2˙−; reaction of the two generated ONOO−, as confirmed with an ONOO−fluorescent probe, HKGreen-3.

  • photoinduced nitric oxide release from a Nitrobenzene Derivative in mitochondria
    Chemistry: A European Journal, 2011
    Co-Authors: Taeko Horinouchi, Kiyoshi Fukuhara, Takayoshi Suzuki, Hidehiko Nakagawa, Naoki Miyata
    Abstract:

    We report a novel NO donor (RpNO), containing a 2,6-dimethylNitrobenzene moiety for photocontrollable NO release and a rhodamine moiety for targeting to mitochondria. Photorelease of NO from RpNO in aqueous solution was confirmed by means of ESR analysis. Cellular release of NO from RpNO was confirmed with the aid of DAF-FM DA, an NO-specific fluorescence probe. RpNO was colocalized with MitoTracker Green FM, a mitochondrial stain, in HCT116 colon cancer cells and exhibited photodependent cytotoxicity. Our results indicate that RpNO is an effective NO donor for time-controlled, mitochondria-specific NO treatment.

  • a novel mitochondria localizing Nitrobenzene Derivative as a donor for photo uncaging of nitric oxide
    Bioorganic & Medicinal Chemistry Letters, 2011
    Co-Authors: Taeko Horinouchi, Kiyoshi Fukuhara, Takayoshi Suzuki, Hidehiko Nakagawa, Naoki Miyata
    Abstract:

    We report a novel green-fluorescent NO donor, NBDNO, bearing a 2,6-dimethylNitrobenzene moiety for photocontrollable NO release and a triphenylphosphonium moiety for targeting to mitochondria. Photorelease of NO from NBDNO was confirmed by means of ESR analysis in aqueous solution. Intracellular release of NO from NBDNO was confirmed by using DAR-4M AM, an NO-specific fluorescence probe. NBDNO was colocalized with MitoRed, a mitochondrial stain, in HCT116 colon cancer cells. Our results indicate that NBDNO is an effective NO donor for time-controlled, mitochondria-specific NO treatment.

  • photoinduced nitric oxide release from a hindered Nitrobenzene Derivative by two photon excitation
    Journal of the American Chemical Society, 2009
    Co-Authors: Kazuhiro Hishikawa, Kiyoshi Fukuhara, Hiroki Tsumoto, Takayoshi Suzuki, Hidehiko Nakagawa, Toshiaki Furuta, Naoki Miyata
    Abstract:

    Here, we demonstrated photoinduced NO generation from a 2,6-dimethylNitrobenzene-based compound (Flu-DNB) via a two-photon excitation (TPE) process. After pulse laser irradiation to a solution of Flu-DNB, oxidation products of NO were observed. This is the first account of a non-nitrosyl-chelated metal ion containing NO donor which can be controlled by the TPE technique.

Kiyoshi Fukuhara - One of the best experts on this subject based on the ideXlab platform.

  • visible light induced nitric oxide release from a novel Nitrobenzene Derivative cross conjugated with a coumarin fluorophore
    Bioorganic & Medicinal Chemistry Letters, 2014
    Co-Authors: Kai Kitamura, Kazuhiro Hishikawa, Kiyoshi Fukuhara, Takayoshi Suzuki, Naoki Miyata, Naoya Ieda, Hidehiko Nakagawa
    Abstract:

    Abstract Nitric oxide (NO) is a well-known free-radical molecule which is endogenously biosynthesised and shows various functions in mammals. To investigate NO functions, photocontrollable NO donors, compounds which release NO in response to light, are expected to be potentially useful. However, most of the conventional NO donors require harmful ultra-violet light for NO release. In this study, two dimethylNitrobenzene Derivatives conjugated with coumarins were designed, synthesized and evaluated as photocontrollable NO donors. The optical properties and efficiency of photo-induced NO release were dependent upon the nature of the conjugation system. One of these compounds, Bhc-DNB ( 1 ), showed spatiotemporally well-controlled NO release in cultured cells upon exposure to light in the less-cytotoxic visible wavelength range (400–430 nm).

  • peroxynitrite generation from a no releasing Nitrobenzene Derivative in response to photoirradiation
    Chemical Communications, 2011
    Co-Authors: Naoya Ieda, Kiyoshi Fukuhara, Hiroki Tsumoto, Takayoshi Suzuki, Hidehiko Nakagawa, Taeko Horinouchi, Tao Peng, Dan Yang, Naoki Miyata
    Abstract:

    Photocontrollable ONOO− generation from a Nitrobenzene Derivative was demonstrated. The designed compound released NO in response to photoirradiation, and the resulting semiquinone reduced molecular oxygen to generate O2˙−; reaction of the two generated ONOO−, as confirmed with an ONOO−fluorescent probe, HKGreen-3.

  • photoinduced nitric oxide release from a Nitrobenzene Derivative in mitochondria
    Chemistry: A European Journal, 2011
    Co-Authors: Taeko Horinouchi, Kiyoshi Fukuhara, Takayoshi Suzuki, Hidehiko Nakagawa, Naoki Miyata
    Abstract:

    We report a novel NO donor (RpNO), containing a 2,6-dimethylNitrobenzene moiety for photocontrollable NO release and a rhodamine moiety for targeting to mitochondria. Photorelease of NO from RpNO in aqueous solution was confirmed by means of ESR analysis. Cellular release of NO from RpNO was confirmed with the aid of DAF-FM DA, an NO-specific fluorescence probe. RpNO was colocalized with MitoTracker Green FM, a mitochondrial stain, in HCT116 colon cancer cells and exhibited photodependent cytotoxicity. Our results indicate that RpNO is an effective NO donor for time-controlled, mitochondria-specific NO treatment.

  • a novel mitochondria localizing Nitrobenzene Derivative as a donor for photo uncaging of nitric oxide
    Bioorganic & Medicinal Chemistry Letters, 2011
    Co-Authors: Taeko Horinouchi, Kiyoshi Fukuhara, Takayoshi Suzuki, Hidehiko Nakagawa, Naoki Miyata
    Abstract:

    We report a novel green-fluorescent NO donor, NBDNO, bearing a 2,6-dimethylNitrobenzene moiety for photocontrollable NO release and a triphenylphosphonium moiety for targeting to mitochondria. Photorelease of NO from NBDNO was confirmed by means of ESR analysis in aqueous solution. Intracellular release of NO from NBDNO was confirmed by using DAR-4M AM, an NO-specific fluorescence probe. NBDNO was colocalized with MitoRed, a mitochondrial stain, in HCT116 colon cancer cells. Our results indicate that NBDNO is an effective NO donor for time-controlled, mitochondria-specific NO treatment.

  • photoinduced nitric oxide release from a hindered Nitrobenzene Derivative by two photon excitation
    Journal of the American Chemical Society, 2009
    Co-Authors: Kazuhiro Hishikawa, Kiyoshi Fukuhara, Hiroki Tsumoto, Takayoshi Suzuki, Hidehiko Nakagawa, Toshiaki Furuta, Naoki Miyata
    Abstract:

    Here, we demonstrated photoinduced NO generation from a 2,6-dimethylNitrobenzene-based compound (Flu-DNB) via a two-photon excitation (TPE) process. After pulse laser irradiation to a solution of Flu-DNB, oxidation products of NO were observed. This is the first account of a non-nitrosyl-chelated metal ion containing NO donor which can be controlled by the TPE technique.

Kazuhiro Hishikawa - One of the best experts on this subject based on the ideXlab platform.

  • visible light induced nitric oxide release from a novel Nitrobenzene Derivative cross conjugated with a coumarin fluorophore
    Bioorganic & Medicinal Chemistry Letters, 2014
    Co-Authors: Kai Kitamura, Kazuhiro Hishikawa, Kiyoshi Fukuhara, Takayoshi Suzuki, Naoki Miyata, Naoya Ieda, Hidehiko Nakagawa
    Abstract:

    Abstract Nitric oxide (NO) is a well-known free-radical molecule which is endogenously biosynthesised and shows various functions in mammals. To investigate NO functions, photocontrollable NO donors, compounds which release NO in response to light, are expected to be potentially useful. However, most of the conventional NO donors require harmful ultra-violet light for NO release. In this study, two dimethylNitrobenzene Derivatives conjugated with coumarins were designed, synthesized and evaluated as photocontrollable NO donors. The optical properties and efficiency of photo-induced NO release were dependent upon the nature of the conjugation system. One of these compounds, Bhc-DNB ( 1 ), showed spatiotemporally well-controlled NO release in cultured cells upon exposure to light in the less-cytotoxic visible wavelength range (400–430 nm).

  • photoinduced nitric oxide release from a hindered Nitrobenzene Derivative by two photon excitation
    Journal of the American Chemical Society, 2009
    Co-Authors: Kazuhiro Hishikawa, Kiyoshi Fukuhara, Hiroki Tsumoto, Takayoshi Suzuki, Hidehiko Nakagawa, Toshiaki Furuta, Naoki Miyata
    Abstract:

    Here, we demonstrated photoinduced NO generation from a 2,6-dimethylNitrobenzene-based compound (Flu-DNB) via a two-photon excitation (TPE) process. After pulse laser irradiation to a solution of Flu-DNB, oxidation products of NO were observed. This is the first account of a non-nitrosyl-chelated metal ion containing NO donor which can be controlled by the TPE technique.

  • photoinduced nitric oxide release from a hindered Nitrobenzene Derivative by two photon excitation
    Journal of the American Chemical Society, 2009
    Co-Authors: Kazuhiro Hishikawa, Kiyoshi Fukuhara, Hiroki Tsumoto, Takayoshi Suzuki, Hidehiko Nakagawa, Toshiaki Furuta, Naoki Miyata
    Abstract:

    Here, we demonstrated photoinduced NO generation from a 2,6-dimethylNitrobenzene-based compound (Flu-DNB) via a two-photon excitation (TPE) process. After pulse laser irradiation to a solution of Flu-DNB, oxidation products of NO were observed. This is the first account of a non-nitrosyl-chelated metal ion containing NO donor which can be controlled by the TPE technique.