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Richard H Fish - One of the best experts on this subject based on the ideXlab platform.
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A New, Aqueous 1H NMR Shift Reagent Based on Host−Guest Molecular Recognition Principles for Organic Compound Structural Analysis: Non-covalent π−π and Hydrophobic Interactions Using a Supramolecular Host, [Cp*Rh(2‘-deoxyadenosine)]3(OTf)3
Journal of Organic Chemistry, 1998Co-Authors: Shigeyuki Nakamura, Hong Chen, Kiyoshi Isobe, Yoshihito Watanabe, Richard H FishAbstract:We have discovered that the supramolecular host [Cp*Rh(2‘-deoxyadenosine)]3(OTf)3 (1, Cp* = η5-C5Me5, OTf = CF3SO3-) has utility as a new, aqueous 1H NMR Shift Reagent, via a host−guest molecular recognition process that occurs by non-covalent π−π and hydrophobic interactions, with a wide variety of H2O-soluble organic substrates. These organic compound guests that we present, to illustrate the utility of host 1 as a novel, aqueous 1H NMR Shift Reagent, encompass examples such as aromatic carboxylic acids, phenylacetic acid (G1), 1-naphthoic acid (G2), and 2-naphthoic acid (G3), an aliphatic carboxylic acid, cyclohexylacetic acid (G4), as well as biological compounds, a di- and a tetrapeptide containing terminal l-tryptophan (Trp) or l-phenylalanine (Phe) groups, l-Trp-l-Phe (G5) and l-Trp-l-Met-l-Asp-l-Phe amide (G6) in the pH range 5−10. A discussion of the molecular recognition parameters that effect the 1H NMR Shifts of the organic guests and a comparison with the water-soluble lanthanide Shift reagen...
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a new aqueous 1h NMR Shift Reagent based on host guest molecular recognition principles for organic compound structural analysis non covalent π π and hydrophobic interactions using a supramolecular host cp rh 2 deoxyadenosine 3 otf 3
Journal of Organic Chemistry, 1998Co-Authors: Shigeyuki Nakamura, Hong Chen, Kiyoshi Isobe, Yoshihito Watanabe, Richard H FishAbstract:We have discovered that the supramolecular host [Cp*Rh(2‘-deoxyadenosine)]3(OTf)3 (1, Cp* = η5-C5Me5, OTf = CF3SO3-) has utility as a new, aqueous 1H NMR Shift Reagent, via a host−guest molecular recognition process that occurs by non-covalent π−π and hydrophobic interactions, with a wide variety of H2O-soluble organic substrates. These organic compound guests that we present, to illustrate the utility of host 1 as a novel, aqueous 1H NMR Shift Reagent, encompass examples such as aromatic carboxylic acids, phenylacetic acid (G1), 1-naphthoic acid (G2), and 2-naphthoic acid (G3), an aliphatic carboxylic acid, cyclohexylacetic acid (G4), as well as biological compounds, a di- and a tetrapeptide containing terminal l-tryptophan (Trp) or l-phenylalanine (Phe) groups, l-Trp-l-Phe (G5) and l-Trp-l-Met-l-Asp-l-Phe amide (G6) in the pH range 5−10. A discussion of the molecular recognition parameters that effect the 1H NMR Shifts of the organic guests and a comparison with the water-soluble lanthanide Shift reagen...
Shigeyuki Nakamura - One of the best experts on this subject based on the ideXlab platform.
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A New, Aqueous 1H NMR Shift Reagent Based on Host−Guest Molecular Recognition Principles for Organic Compound Structural Analysis: Non-covalent π−π and Hydrophobic Interactions Using a Supramolecular Host, [Cp*Rh(2‘-deoxyadenosine)]3(OTf)3
Journal of Organic Chemistry, 1998Co-Authors: Shigeyuki Nakamura, Hong Chen, Kiyoshi Isobe, Yoshihito Watanabe, Richard H FishAbstract:We have discovered that the supramolecular host [Cp*Rh(2‘-deoxyadenosine)]3(OTf)3 (1, Cp* = η5-C5Me5, OTf = CF3SO3-) has utility as a new, aqueous 1H NMR Shift Reagent, via a host−guest molecular recognition process that occurs by non-covalent π−π and hydrophobic interactions, with a wide variety of H2O-soluble organic substrates. These organic compound guests that we present, to illustrate the utility of host 1 as a novel, aqueous 1H NMR Shift Reagent, encompass examples such as aromatic carboxylic acids, phenylacetic acid (G1), 1-naphthoic acid (G2), and 2-naphthoic acid (G3), an aliphatic carboxylic acid, cyclohexylacetic acid (G4), as well as biological compounds, a di- and a tetrapeptide containing terminal l-tryptophan (Trp) or l-phenylalanine (Phe) groups, l-Trp-l-Phe (G5) and l-Trp-l-Met-l-Asp-l-Phe amide (G6) in the pH range 5−10. A discussion of the molecular recognition parameters that effect the 1H NMR Shifts of the organic guests and a comparison with the water-soluble lanthanide Shift reagen...
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a new aqueous 1h NMR Shift Reagent based on host guest molecular recognition principles for organic compound structural analysis non covalent π π and hydrophobic interactions using a supramolecular host cp rh 2 deoxyadenosine 3 otf 3
Journal of Organic Chemistry, 1998Co-Authors: Shigeyuki Nakamura, Hong Chen, Kiyoshi Isobe, Yoshihito Watanabe, Richard H FishAbstract:We have discovered that the supramolecular host [Cp*Rh(2‘-deoxyadenosine)]3(OTf)3 (1, Cp* = η5-C5Me5, OTf = CF3SO3-) has utility as a new, aqueous 1H NMR Shift Reagent, via a host−guest molecular recognition process that occurs by non-covalent π−π and hydrophobic interactions, with a wide variety of H2O-soluble organic substrates. These organic compound guests that we present, to illustrate the utility of host 1 as a novel, aqueous 1H NMR Shift Reagent, encompass examples such as aromatic carboxylic acids, phenylacetic acid (G1), 1-naphthoic acid (G2), and 2-naphthoic acid (G3), an aliphatic carboxylic acid, cyclohexylacetic acid (G4), as well as biological compounds, a di- and a tetrapeptide containing terminal l-tryptophan (Trp) or l-phenylalanine (Phe) groups, l-Trp-l-Phe (G5) and l-Trp-l-Met-l-Asp-l-Phe amide (G6) in the pH range 5−10. A discussion of the molecular recognition parameters that effect the 1H NMR Shifts of the organic guests and a comparison with the water-soluble lanthanide Shift reagen...
Navin Bansal - One of the best experts on this subject based on the ideXlab platform.
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quantitation of intracellular na in vivo by using tmdotp5 as an NMR Shift Reagent and extracellular marker
Journal of Applied Physiology, 1998Co-Authors: Patrick M Winter, Viswanathan Seshan, Janice D Makos, Dean A Sherry, Craig R Malloy, Navin BansalAbstract:A method is presented to measure the absolute concentration of intracellular Na+([Na+]i) in vivo by using interleaved 23Na- and 31P-nuclear magnetic resonance (NMR) spectroscopy and TmDOTP5− as Shift Reagent and chemical marker of tissue extracellular space (ECS). The technique was used to determine [Na+]iand relative ECS in livers of control rats (21 ± 3 and 0.11 ± 0.02 mM, respectively) and in rats exposed to carbon tetrachloride (103 ± 29 and 0.23 ± 0.03 mM, respectively). The NMR measurements were confirmed independently on excised tissue samples by using atomic absorption spectroscopy. The results confirm that TmDOTP5− can be used as a combined cation Shift Reagent and ECS marker, thereby allowing quantitation of [Na+]iin vivo by NMR.
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Quantitation of intracellular [Na+] in vivo by using TmDOTP5- as an NMR Shift Reagent and extracellular marker.
Journal of Applied Physiology, 1998Co-Authors: Patrick M Winter, Viswanathan Seshan, Janice D Makos, Craig R Malloy, A. Dean Sherry, Navin BansalAbstract:A method is presented to measure the absolute concentration of intracellular Na+([Na+]i) in vivo by using interleaved 23Na- and 31P-nuclear magnetic resonance (NMR) spectroscopy and TmDOTP5− as Shift Reagent and chemical marker of tissue extracellular space (ECS). The technique was used to determine [Na+]iand relative ECS in livers of control rats (21 ± 3 and 0.11 ± 0.02 mM, respectively) and in rats exposed to carbon tetrachloride (103 ± 29 and 0.23 ± 0.03 mM, respectively). The NMR measurements were confirmed independently on excised tissue samples by using atomic absorption spectroscopy. The results confirm that TmDOTP5− can be used as a combined cation Shift Reagent and ECS marker, thereby allowing quantitation of [Na+]iin vivo by NMR.
Kiyoshi Isobe - One of the best experts on this subject based on the ideXlab platform.
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A New, Aqueous 1H NMR Shift Reagent Based on Host−Guest Molecular Recognition Principles for Organic Compound Structural Analysis: Non-covalent π−π and Hydrophobic Interactions Using a Supramolecular Host, [Cp*Rh(2‘-deoxyadenosine)]3(OTf)3
Journal of Organic Chemistry, 1998Co-Authors: Shigeyuki Nakamura, Hong Chen, Kiyoshi Isobe, Yoshihito Watanabe, Richard H FishAbstract:We have discovered that the supramolecular host [Cp*Rh(2‘-deoxyadenosine)]3(OTf)3 (1, Cp* = η5-C5Me5, OTf = CF3SO3-) has utility as a new, aqueous 1H NMR Shift Reagent, via a host−guest molecular recognition process that occurs by non-covalent π−π and hydrophobic interactions, with a wide variety of H2O-soluble organic substrates. These organic compound guests that we present, to illustrate the utility of host 1 as a novel, aqueous 1H NMR Shift Reagent, encompass examples such as aromatic carboxylic acids, phenylacetic acid (G1), 1-naphthoic acid (G2), and 2-naphthoic acid (G3), an aliphatic carboxylic acid, cyclohexylacetic acid (G4), as well as biological compounds, a di- and a tetrapeptide containing terminal l-tryptophan (Trp) or l-phenylalanine (Phe) groups, l-Trp-l-Phe (G5) and l-Trp-l-Met-l-Asp-l-Phe amide (G6) in the pH range 5−10. A discussion of the molecular recognition parameters that effect the 1H NMR Shifts of the organic guests and a comparison with the water-soluble lanthanide Shift reagen...
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a new aqueous 1h NMR Shift Reagent based on host guest molecular recognition principles for organic compound structural analysis non covalent π π and hydrophobic interactions using a supramolecular host cp rh 2 deoxyadenosine 3 otf 3
Journal of Organic Chemistry, 1998Co-Authors: Shigeyuki Nakamura, Hong Chen, Kiyoshi Isobe, Yoshihito Watanabe, Richard H FishAbstract:We have discovered that the supramolecular host [Cp*Rh(2‘-deoxyadenosine)]3(OTf)3 (1, Cp* = η5-C5Me5, OTf = CF3SO3-) has utility as a new, aqueous 1H NMR Shift Reagent, via a host−guest molecular recognition process that occurs by non-covalent π−π and hydrophobic interactions, with a wide variety of H2O-soluble organic substrates. These organic compound guests that we present, to illustrate the utility of host 1 as a novel, aqueous 1H NMR Shift Reagent, encompass examples such as aromatic carboxylic acids, phenylacetic acid (G1), 1-naphthoic acid (G2), and 2-naphthoic acid (G3), an aliphatic carboxylic acid, cyclohexylacetic acid (G4), as well as biological compounds, a di- and a tetrapeptide containing terminal l-tryptophan (Trp) or l-phenylalanine (Phe) groups, l-Trp-l-Phe (G5) and l-Trp-l-Met-l-Asp-l-Phe amide (G6) in the pH range 5−10. A discussion of the molecular recognition parameters that effect the 1H NMR Shifts of the organic guests and a comparison with the water-soluble lanthanide Shift reagen...
Hong Chen - One of the best experts on this subject based on the ideXlab platform.
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A New, Aqueous 1H NMR Shift Reagent Based on Host−Guest Molecular Recognition Principles for Organic Compound Structural Analysis: Non-covalent π−π and Hydrophobic Interactions Using a Supramolecular Host, [Cp*Rh(2‘-deoxyadenosine)]3(OTf)3
Journal of Organic Chemistry, 1998Co-Authors: Shigeyuki Nakamura, Hong Chen, Kiyoshi Isobe, Yoshihito Watanabe, Richard H FishAbstract:We have discovered that the supramolecular host [Cp*Rh(2‘-deoxyadenosine)]3(OTf)3 (1, Cp* = η5-C5Me5, OTf = CF3SO3-) has utility as a new, aqueous 1H NMR Shift Reagent, via a host−guest molecular recognition process that occurs by non-covalent π−π and hydrophobic interactions, with a wide variety of H2O-soluble organic substrates. These organic compound guests that we present, to illustrate the utility of host 1 as a novel, aqueous 1H NMR Shift Reagent, encompass examples such as aromatic carboxylic acids, phenylacetic acid (G1), 1-naphthoic acid (G2), and 2-naphthoic acid (G3), an aliphatic carboxylic acid, cyclohexylacetic acid (G4), as well as biological compounds, a di- and a tetrapeptide containing terminal l-tryptophan (Trp) or l-phenylalanine (Phe) groups, l-Trp-l-Phe (G5) and l-Trp-l-Met-l-Asp-l-Phe amide (G6) in the pH range 5−10. A discussion of the molecular recognition parameters that effect the 1H NMR Shifts of the organic guests and a comparison with the water-soluble lanthanide Shift reagen...
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a new aqueous 1h NMR Shift Reagent based on host guest molecular recognition principles for organic compound structural analysis non covalent π π and hydrophobic interactions using a supramolecular host cp rh 2 deoxyadenosine 3 otf 3
Journal of Organic Chemistry, 1998Co-Authors: Shigeyuki Nakamura, Hong Chen, Kiyoshi Isobe, Yoshihito Watanabe, Richard H FishAbstract:We have discovered that the supramolecular host [Cp*Rh(2‘-deoxyadenosine)]3(OTf)3 (1, Cp* = η5-C5Me5, OTf = CF3SO3-) has utility as a new, aqueous 1H NMR Shift Reagent, via a host−guest molecular recognition process that occurs by non-covalent π−π and hydrophobic interactions, with a wide variety of H2O-soluble organic substrates. These organic compound guests that we present, to illustrate the utility of host 1 as a novel, aqueous 1H NMR Shift Reagent, encompass examples such as aromatic carboxylic acids, phenylacetic acid (G1), 1-naphthoic acid (G2), and 2-naphthoic acid (G3), an aliphatic carboxylic acid, cyclohexylacetic acid (G4), as well as biological compounds, a di- and a tetrapeptide containing terminal l-tryptophan (Trp) or l-phenylalanine (Phe) groups, l-Trp-l-Phe (G5) and l-Trp-l-Met-l-Asp-l-Phe amide (G6) in the pH range 5−10. A discussion of the molecular recognition parameters that effect the 1H NMR Shifts of the organic guests and a comparison with the water-soluble lanthanide Shift reagen...