The Experts below are selected from a list of 219 Experts worldwide ranked by ideXlab platform
David J Kupfer - One of the best experts on this subject based on the ideXlab platform.
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correlation of Nocturnal Penile Tumescence and daytime affect intensity in depressed men
Psychiatry Research-neuroimaging, 1993Co-Authors: Eric A Nofzinger, Michael E Thase, Charles F Reynolds, Richard J Jennings, Ellen Frank, Gregory L Garamoni, Amy L Fasiczka, Robert M Schwartz, David J KupferAbstract:Abstract Although depressed patients have been shown to have diminished Nocturnal Penile Tumescence (NPT), there remains considerable variability of NPT in depression. We hypothesized that affective experience during the day accounts for some of this variability. Forty-five depressed men had assessments of affect intensity and affect balance, NPT, and daytime sexual function, both before and after treatment with Beck's cognitive behavior therapy (CBT). Forty-three normal control subjects were studied for comparison. Daytime affect intensity in depressed men, but not in control subjects, correlated significantly and positively with measures of NPT duration and rigidity both before and after treatment, regardless of the adequacy of daytime sexual function. When the effect of daytime affect on REM activity was controlled, the observed correlations became nonsignificant at pretreatment, but remained significant at posttreatment. Neuropharmacologically mediated changes in arousal responsivity associated with depression may underlie the observed relation between daytime affect intensity, rapid eye movement activity, and NPT.
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sexual function in depressed men assessment by self report behavioral and Nocturnal Penile Tumescence measures before and after treatment with cognitive behavior therapy
Archives of General Psychiatry, 1993Co-Authors: Eric A Nofzinger, Michael E Thase, Charles F Reynolds, Richard J Jennings, Ellen Frank, Gregory L Garamoni, Amy L Fasiczka, David J KupferAbstract:• Clinicians have long associated depression with alterations in sexual function, predominantly loss of sexual interest. In a longitudinal study measuring self-report, behavioral, and Nocturnal Penile Tumescence variables before and after treatment with cognitive behavior therapy in an unmedicated sample of 40 outpatient depressed men, we found, contrary to expectation, that sexual activity per se was not reduced during the depressed state. Rather, loss of sexual interest appeared to be related to the cognitive set of depression, ie, loss of sexual satisfaction that then improved with remission from depression. Depressed men were heterogeneous, however, with respect to sexual behavior, eg, an anxious and more chronically depressed subgroup of men who did not have remissions with cognitive behavior therapy reported increased sexual interest and sexual activity. Also, contrary to expectation, Nocturnal Penile Tumescence abnormalities in depressed men did not reverse when measured in early remission, nor did Nocturnal Penile Tumescence measures correlate significantly with behavioral measures of sexual function. Nocturnal Penile Tumescence alterations in depression may thus be similar to other persistent electroencephalographic sleep abnormalities seen in depressed patients in remission, in being more traitlike than statelike.
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diminished Nocturnal Penile Tumescence in depression a replication study
Biological Psychiatry, 1992Co-Authors: Michael E Thase, Charles F Reynolds, Richard J Jennings, Ellen Frank, Gregory L Garamoni, Eric A Nofzinger, Amy L Fascizka, David J KupferAbstract:Abstract A descriptive study was conducted in a new sample of 51 men with DSM-III-R research diagnostic criteria (RDC) major depression in order to replicate earlier observations that measures of Nocturnal Penile Tumescence (NPT) and Penile rigidity are disturbed in depressive states. When compared to both the age-equated patient (n = 34) and normal control (n = 28) groups reported in our 1988 study, the new sample manifested significant abnormalities of NPT and diminished Penile rigidity. Such disturbances were not, however, significantly correlated with psychobiological indicators of severe or endogenous depression.
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results of Nocturnal Penile Tumescence studies are abnormal in sexually functional diabetic men
JAMA Internal Medicine, 1992Co-Authors: Eric A Nofzinger, Michael E Thase, Charles F Reynolds, Richard J Jennings, Ellen Frank, Amy L Yeager, David J KupferAbstract:Nocturnal Penile Tumescence (NPT) studies are commonly used in the assessment of sexual dysfunction in diabetic men. While much of the evidence in favor of its use has come from the observation of markedly abnormal NPT in impotent diabetic men, little research has focused on the quality of Nocturnal erections in sexually functional diabetics. Ten diabetic men who reported normal daytime sexual function were studied with 4 nights of polysomnography, including NPT assessment. They had significantly diminished NPT profiles when compared with that of an agematched, nondiabetic, healthy control group. Without controlling for the effect of diabetes on NPT, between 70% and 90% of sexually functional diabetics had NPT profiles in a range that would be classified as indicative of organic sexual dysfunction for a man presenting for evaluation of sexual dysfunction. The finding of NPT abnormalities in a diabetic man should not be taken as evidence for irreversible sexual dysfunction. Rather, the condition of diabetes appears to result in NPT abnormalities, regardless of the adequacy of daytime sexual function. ( Arch Intern Med . 1992;152:114-118)
John Bancroft - One of the best experts on this subject based on the ideXlab platform.
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the clinical assessment of erectile dysfunction a comparison of Nocturnal Penile Tumescence monitoring and intracavernosal injections
International Journal of Impotence Research, 1995Co-Authors: John Bancroft, N MaloneAbstract:: One hundred and fifty-nine men with erectile dysfunction were assessed with Rigiscan monitoring of Nocturnal Penile Tumescence (NPT) and response to intracavernosal injections (ICI) of papaverine or prostaglandin E1. A satisfactory NPT, suggestive of psychogenic causation, was recorded in 58%, whereas 15% had clearly impaired NPT. There was a significant association between presence of vascular disease, diabetes and impairment of NPT. For ICI, only 32% showed a satisfactory response, with 48% clearly impaired. Of the 92 men with satisfactory NPT, 40% HAD clearly impaired and 41% satisfactory ICI response. Of the 51 men with satisfactory ICI response, 8% had clearly impaired and 74.5% satisfactory NPT. There was no association between ICI response and history of vascular disease. We conclude that monitoring of NPT by Rigiscan, and without sleep monitoring, is a valuable diagnostic procedure. In contrast, because of the high proportion of false negative results. ICI monitoring is of very limited diagnostic value. The explanation for false negative ICI responses, however, could prove to be of considerable theoretical and clinical importance.
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erectile response to visual erotic stimuli before and after intracavernosal papaverine and its relationship to Nocturnal Penile Tumescence and psychometric assessment
BJUI, 1991Co-Authors: John Bancroft, G Smith, M Munoz, P RonaldAbstract:Three methods of assessing erectile capacity-Nocturnal Penile Tumescence (NPT), response to visual erotic stimuli (VES) and to intracavernosal papaverine (ICI)-have been assessed in 42 men presenting with erectile dysfunction. There was some overlap but also important differences between the 3 measures. Subjects were divided into «high» and «low» NPT groups. The «high» group produced greater erectile responses to both VES and ICI
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the effects of testosterone administration and visual erotic stimuli on Nocturnal Penile Tumescence in normal men
Hormones and Behavior, 1990Co-Authors: Cesare Carani, A Scuteri, P Marrama, John BancroftAbstract:Abstract Nocturnal Penile Tumescence (NPT), as circumference change and rigidity, and REM sleep were measured in eight normal eugonadal men in two controlled experiments. In the first, exposure to erotic film prior to sleep had no effect on frequency of REM or on NPT. In the second placebo controlled experiment 150 mg im testosterone enanthate administration was associated with enhanced rigidity of NPT but with no effect on frequency or circumference change of NPT and no effect on frequency of REM.
Eric A Nofzinger - One of the best experts on this subject based on the ideXlab platform.
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correlation of Nocturnal Penile Tumescence and daytime affect intensity in depressed men
Psychiatry Research-neuroimaging, 1993Co-Authors: Eric A Nofzinger, Michael E Thase, Charles F Reynolds, Richard J Jennings, Ellen Frank, Gregory L Garamoni, Amy L Fasiczka, Robert M Schwartz, David J KupferAbstract:Abstract Although depressed patients have been shown to have diminished Nocturnal Penile Tumescence (NPT), there remains considerable variability of NPT in depression. We hypothesized that affective experience during the day accounts for some of this variability. Forty-five depressed men had assessments of affect intensity and affect balance, NPT, and daytime sexual function, both before and after treatment with Beck's cognitive behavior therapy (CBT). Forty-three normal control subjects were studied for comparison. Daytime affect intensity in depressed men, but not in control subjects, correlated significantly and positively with measures of NPT duration and rigidity both before and after treatment, regardless of the adequacy of daytime sexual function. When the effect of daytime affect on REM activity was controlled, the observed correlations became nonsignificant at pretreatment, but remained significant at posttreatment. Neuropharmacologically mediated changes in arousal responsivity associated with depression may underlie the observed relation between daytime affect intensity, rapid eye movement activity, and NPT.
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are buckling force measurements reliable in Nocturnal Penile Tumescence studies
Sleep, 1993Co-Authors: Eric A Nofzinger, Michael E Thase, Charles F Reynolds, Ellen Frank, Gregory L Garamoni, Amy L Fasiczka, J R Jennings, Jan Matzzie, D J KupferAbstract:: The study of Nocturnal Penile Tumescence (NPT) is frequently used to evaluate male erectile dysfunction. Buckling force, a measure of rigidity, is an important part of this evaluation, but its reliability is unknown. Accordingly, we studied the reliability of buckling force measurement and the stability of "maximum buckling force" between consecutive NPT series repeated in the same subject. For individual subjects, we correlated buckling forces for separate episodes of sleep-related Tumescence that were of comparable fullness (0-100%) as rated by a technician's visual estimates. For healthy control subjects, test-retest correlations were > 0.8 both within-night and across study series separated by an average of 70 weeks. In depressed men, correlations within nights were > 0.9, but fell to 0.64 across study series separated by an average of 21 weeks. Despite the high reliability of buckling force measurement, we found little stability of "maximum buckling force" between NPT series for individual subjects. Considerable variability in the maximum degree of Penile rigidity was seen over time despite a constant level of reported daytime erectile function. We conclude that although Penile rigidity is one of the more important variables in the assessment of male erectile dysfunction and can be measured reliably, the instability of maximum rigidity during sleep-related erections suggests that it is, at best, an imprecise correlate of daytime erectile function.
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sexual function in depressed men assessment by self report behavioral and Nocturnal Penile Tumescence measures before and after treatment with cognitive behavior therapy
Archives of General Psychiatry, 1993Co-Authors: Eric A Nofzinger, Michael E Thase, Charles F Reynolds, Richard J Jennings, Ellen Frank, Gregory L Garamoni, Amy L Fasiczka, David J KupferAbstract:• Clinicians have long associated depression with alterations in sexual function, predominantly loss of sexual interest. In a longitudinal study measuring self-report, behavioral, and Nocturnal Penile Tumescence variables before and after treatment with cognitive behavior therapy in an unmedicated sample of 40 outpatient depressed men, we found, contrary to expectation, that sexual activity per se was not reduced during the depressed state. Rather, loss of sexual interest appeared to be related to the cognitive set of depression, ie, loss of sexual satisfaction that then improved with remission from depression. Depressed men were heterogeneous, however, with respect to sexual behavior, eg, an anxious and more chronically depressed subgroup of men who did not have remissions with cognitive behavior therapy reported increased sexual interest and sexual activity. Also, contrary to expectation, Nocturnal Penile Tumescence abnormalities in depressed men did not reverse when measured in early remission, nor did Nocturnal Penile Tumescence measures correlate significantly with behavioral measures of sexual function. Nocturnal Penile Tumescence alterations in depression may thus be similar to other persistent electroencephalographic sleep abnormalities seen in depressed patients in remission, in being more traitlike than statelike.
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diminished Nocturnal Penile Tumescence in depression a replication study
Biological Psychiatry, 1992Co-Authors: Michael E Thase, Charles F Reynolds, Richard J Jennings, Ellen Frank, Gregory L Garamoni, Eric A Nofzinger, Amy L Fascizka, David J KupferAbstract:Abstract A descriptive study was conducted in a new sample of 51 men with DSM-III-R research diagnostic criteria (RDC) major depression in order to replicate earlier observations that measures of Nocturnal Penile Tumescence (NPT) and Penile rigidity are disturbed in depressive states. When compared to both the age-equated patient (n = 34) and normal control (n = 28) groups reported in our 1988 study, the new sample manifested significant abnormalities of NPT and diminished Penile rigidity. Such disturbances were not, however, significantly correlated with psychobiological indicators of severe or endogenous depression.
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results of Nocturnal Penile Tumescence studies are abnormal in sexually functional diabetic men
JAMA Internal Medicine, 1992Co-Authors: Eric A Nofzinger, Michael E Thase, Charles F Reynolds, Richard J Jennings, Ellen Frank, Amy L Yeager, David J KupferAbstract:Nocturnal Penile Tumescence (NPT) studies are commonly used in the assessment of sexual dysfunction in diabetic men. While much of the evidence in favor of its use has come from the observation of markedly abnormal NPT in impotent diabetic men, little research has focused on the quality of Nocturnal erections in sexually functional diabetics. Ten diabetic men who reported normal daytime sexual function were studied with 4 nights of polysomnography, including NPT assessment. They had significantly diminished NPT profiles when compared with that of an agematched, nondiabetic, healthy control group. Without controlling for the effect of diabetes on NPT, between 70% and 90% of sexually functional diabetics had NPT profiles in a range that would be classified as indicative of organic sexual dysfunction for a man presenting for evaluation of sexual dysfunction. The finding of NPT abnormalities in a diabetic man should not be taken as evidence for irreversible sexual dysfunction. Rather, the condition of diabetes appears to result in NPT abnormalities, regardless of the adequacy of daytime sexual function. ( Arch Intern Med . 1992;152:114-118)
Michael E Thase - One of the best experts on this subject based on the ideXlab platform.
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correlation of Nocturnal Penile Tumescence and daytime affect intensity in depressed men
Psychiatry Research-neuroimaging, 1993Co-Authors: Eric A Nofzinger, Michael E Thase, Charles F Reynolds, Richard J Jennings, Ellen Frank, Gregory L Garamoni, Amy L Fasiczka, Robert M Schwartz, David J KupferAbstract:Abstract Although depressed patients have been shown to have diminished Nocturnal Penile Tumescence (NPT), there remains considerable variability of NPT in depression. We hypothesized that affective experience during the day accounts for some of this variability. Forty-five depressed men had assessments of affect intensity and affect balance, NPT, and daytime sexual function, both before and after treatment with Beck's cognitive behavior therapy (CBT). Forty-three normal control subjects were studied for comparison. Daytime affect intensity in depressed men, but not in control subjects, correlated significantly and positively with measures of NPT duration and rigidity both before and after treatment, regardless of the adequacy of daytime sexual function. When the effect of daytime affect on REM activity was controlled, the observed correlations became nonsignificant at pretreatment, but remained significant at posttreatment. Neuropharmacologically mediated changes in arousal responsivity associated with depression may underlie the observed relation between daytime affect intensity, rapid eye movement activity, and NPT.
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are buckling force measurements reliable in Nocturnal Penile Tumescence studies
Sleep, 1993Co-Authors: Eric A Nofzinger, Michael E Thase, Charles F Reynolds, Ellen Frank, Gregory L Garamoni, Amy L Fasiczka, J R Jennings, Jan Matzzie, D J KupferAbstract:: The study of Nocturnal Penile Tumescence (NPT) is frequently used to evaluate male erectile dysfunction. Buckling force, a measure of rigidity, is an important part of this evaluation, but its reliability is unknown. Accordingly, we studied the reliability of buckling force measurement and the stability of "maximum buckling force" between consecutive NPT series repeated in the same subject. For individual subjects, we correlated buckling forces for separate episodes of sleep-related Tumescence that were of comparable fullness (0-100%) as rated by a technician's visual estimates. For healthy control subjects, test-retest correlations were > 0.8 both within-night and across study series separated by an average of 70 weeks. In depressed men, correlations within nights were > 0.9, but fell to 0.64 across study series separated by an average of 21 weeks. Despite the high reliability of buckling force measurement, we found little stability of "maximum buckling force" between NPT series for individual subjects. Considerable variability in the maximum degree of Penile rigidity was seen over time despite a constant level of reported daytime erectile function. We conclude that although Penile rigidity is one of the more important variables in the assessment of male erectile dysfunction and can be measured reliably, the instability of maximum rigidity during sleep-related erections suggests that it is, at best, an imprecise correlate of daytime erectile function.
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sexual function in depressed men assessment by self report behavioral and Nocturnal Penile Tumescence measures before and after treatment with cognitive behavior therapy
Archives of General Psychiatry, 1993Co-Authors: Eric A Nofzinger, Michael E Thase, Charles F Reynolds, Richard J Jennings, Ellen Frank, Gregory L Garamoni, Amy L Fasiczka, David J KupferAbstract:• Clinicians have long associated depression with alterations in sexual function, predominantly loss of sexual interest. In a longitudinal study measuring self-report, behavioral, and Nocturnal Penile Tumescence variables before and after treatment with cognitive behavior therapy in an unmedicated sample of 40 outpatient depressed men, we found, contrary to expectation, that sexual activity per se was not reduced during the depressed state. Rather, loss of sexual interest appeared to be related to the cognitive set of depression, ie, loss of sexual satisfaction that then improved with remission from depression. Depressed men were heterogeneous, however, with respect to sexual behavior, eg, an anxious and more chronically depressed subgroup of men who did not have remissions with cognitive behavior therapy reported increased sexual interest and sexual activity. Also, contrary to expectation, Nocturnal Penile Tumescence abnormalities in depressed men did not reverse when measured in early remission, nor did Nocturnal Penile Tumescence measures correlate significantly with behavioral measures of sexual function. Nocturnal Penile Tumescence alterations in depression may thus be similar to other persistent electroencephalographic sleep abnormalities seen in depressed patients in remission, in being more traitlike than statelike.
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diminished Nocturnal Penile Tumescence in depression a replication study
Biological Psychiatry, 1992Co-Authors: Michael E Thase, Charles F Reynolds, Richard J Jennings, Ellen Frank, Gregory L Garamoni, Eric A Nofzinger, Amy L Fascizka, David J KupferAbstract:Abstract A descriptive study was conducted in a new sample of 51 men with DSM-III-R research diagnostic criteria (RDC) major depression in order to replicate earlier observations that measures of Nocturnal Penile Tumescence (NPT) and Penile rigidity are disturbed in depressive states. When compared to both the age-equated patient (n = 34) and normal control (n = 28) groups reported in our 1988 study, the new sample manifested significant abnormalities of NPT and diminished Penile rigidity. Such disturbances were not, however, significantly correlated with psychobiological indicators of severe or endogenous depression.
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results of Nocturnal Penile Tumescence studies are abnormal in sexually functional diabetic men
JAMA Internal Medicine, 1992Co-Authors: Eric A Nofzinger, Michael E Thase, Charles F Reynolds, Richard J Jennings, Ellen Frank, Amy L Yeager, David J KupferAbstract:Nocturnal Penile Tumescence (NPT) studies are commonly used in the assessment of sexual dysfunction in diabetic men. While much of the evidence in favor of its use has come from the observation of markedly abnormal NPT in impotent diabetic men, little research has focused on the quality of Nocturnal erections in sexually functional diabetics. Ten diabetic men who reported normal daytime sexual function were studied with 4 nights of polysomnography, including NPT assessment. They had significantly diminished NPT profiles when compared with that of an agematched, nondiabetic, healthy control group. Without controlling for the effect of diabetes on NPT, between 70% and 90% of sexually functional diabetics had NPT profiles in a range that would be classified as indicative of organic sexual dysfunction for a man presenting for evaluation of sexual dysfunction. The finding of NPT abnormalities in a diabetic man should not be taken as evidence for irreversible sexual dysfunction. Rather, the condition of diabetes appears to result in NPT abnormalities, regardless of the adequacy of daytime sexual function. ( Arch Intern Med . 1992;152:114-118)
Ellen Frank - One of the best experts on this subject based on the ideXlab platform.
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correlation of Nocturnal Penile Tumescence and daytime affect intensity in depressed men
Psychiatry Research-neuroimaging, 1993Co-Authors: Eric A Nofzinger, Michael E Thase, Charles F Reynolds, Richard J Jennings, Ellen Frank, Gregory L Garamoni, Amy L Fasiczka, Robert M Schwartz, David J KupferAbstract:Abstract Although depressed patients have been shown to have diminished Nocturnal Penile Tumescence (NPT), there remains considerable variability of NPT in depression. We hypothesized that affective experience during the day accounts for some of this variability. Forty-five depressed men had assessments of affect intensity and affect balance, NPT, and daytime sexual function, both before and after treatment with Beck's cognitive behavior therapy (CBT). Forty-three normal control subjects were studied for comparison. Daytime affect intensity in depressed men, but not in control subjects, correlated significantly and positively with measures of NPT duration and rigidity both before and after treatment, regardless of the adequacy of daytime sexual function. When the effect of daytime affect on REM activity was controlled, the observed correlations became nonsignificant at pretreatment, but remained significant at posttreatment. Neuropharmacologically mediated changes in arousal responsivity associated with depression may underlie the observed relation between daytime affect intensity, rapid eye movement activity, and NPT.
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are buckling force measurements reliable in Nocturnal Penile Tumescence studies
Sleep, 1993Co-Authors: Eric A Nofzinger, Michael E Thase, Charles F Reynolds, Ellen Frank, Gregory L Garamoni, Amy L Fasiczka, J R Jennings, Jan Matzzie, D J KupferAbstract:: The study of Nocturnal Penile Tumescence (NPT) is frequently used to evaluate male erectile dysfunction. Buckling force, a measure of rigidity, is an important part of this evaluation, but its reliability is unknown. Accordingly, we studied the reliability of buckling force measurement and the stability of "maximum buckling force" between consecutive NPT series repeated in the same subject. For individual subjects, we correlated buckling forces for separate episodes of sleep-related Tumescence that were of comparable fullness (0-100%) as rated by a technician's visual estimates. For healthy control subjects, test-retest correlations were > 0.8 both within-night and across study series separated by an average of 70 weeks. In depressed men, correlations within nights were > 0.9, but fell to 0.64 across study series separated by an average of 21 weeks. Despite the high reliability of buckling force measurement, we found little stability of "maximum buckling force" between NPT series for individual subjects. Considerable variability in the maximum degree of Penile rigidity was seen over time despite a constant level of reported daytime erectile function. We conclude that although Penile rigidity is one of the more important variables in the assessment of male erectile dysfunction and can be measured reliably, the instability of maximum rigidity during sleep-related erections suggests that it is, at best, an imprecise correlate of daytime erectile function.
-
sexual function in depressed men assessment by self report behavioral and Nocturnal Penile Tumescence measures before and after treatment with cognitive behavior therapy
Archives of General Psychiatry, 1993Co-Authors: Eric A Nofzinger, Michael E Thase, Charles F Reynolds, Richard J Jennings, Ellen Frank, Gregory L Garamoni, Amy L Fasiczka, David J KupferAbstract:• Clinicians have long associated depression with alterations in sexual function, predominantly loss of sexual interest. In a longitudinal study measuring self-report, behavioral, and Nocturnal Penile Tumescence variables before and after treatment with cognitive behavior therapy in an unmedicated sample of 40 outpatient depressed men, we found, contrary to expectation, that sexual activity per se was not reduced during the depressed state. Rather, loss of sexual interest appeared to be related to the cognitive set of depression, ie, loss of sexual satisfaction that then improved with remission from depression. Depressed men were heterogeneous, however, with respect to sexual behavior, eg, an anxious and more chronically depressed subgroup of men who did not have remissions with cognitive behavior therapy reported increased sexual interest and sexual activity. Also, contrary to expectation, Nocturnal Penile Tumescence abnormalities in depressed men did not reverse when measured in early remission, nor did Nocturnal Penile Tumescence measures correlate significantly with behavioral measures of sexual function. Nocturnal Penile Tumescence alterations in depression may thus be similar to other persistent electroencephalographic sleep abnormalities seen in depressed patients in remission, in being more traitlike than statelike.
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diminished Nocturnal Penile Tumescence in depression a replication study
Biological Psychiatry, 1992Co-Authors: Michael E Thase, Charles F Reynolds, Richard J Jennings, Ellen Frank, Gregory L Garamoni, Eric A Nofzinger, Amy L Fascizka, David J KupferAbstract:Abstract A descriptive study was conducted in a new sample of 51 men with DSM-III-R research diagnostic criteria (RDC) major depression in order to replicate earlier observations that measures of Nocturnal Penile Tumescence (NPT) and Penile rigidity are disturbed in depressive states. When compared to both the age-equated patient (n = 34) and normal control (n = 28) groups reported in our 1988 study, the new sample manifested significant abnormalities of NPT and diminished Penile rigidity. Such disturbances were not, however, significantly correlated with psychobiological indicators of severe or endogenous depression.
-
results of Nocturnal Penile Tumescence studies are abnormal in sexually functional diabetic men
JAMA Internal Medicine, 1992Co-Authors: Eric A Nofzinger, Michael E Thase, Charles F Reynolds, Richard J Jennings, Ellen Frank, Amy L Yeager, David J KupferAbstract:Nocturnal Penile Tumescence (NPT) studies are commonly used in the assessment of sexual dysfunction in diabetic men. While much of the evidence in favor of its use has come from the observation of markedly abnormal NPT in impotent diabetic men, little research has focused on the quality of Nocturnal erections in sexually functional diabetics. Ten diabetic men who reported normal daytime sexual function were studied with 4 nights of polysomnography, including NPT assessment. They had significantly diminished NPT profiles when compared with that of an agematched, nondiabetic, healthy control group. Without controlling for the effect of diabetes on NPT, between 70% and 90% of sexually functional diabetics had NPT profiles in a range that would be classified as indicative of organic sexual dysfunction for a man presenting for evaluation of sexual dysfunction. The finding of NPT abnormalities in a diabetic man should not be taken as evidence for irreversible sexual dysfunction. Rather, the condition of diabetes appears to result in NPT abnormalities, regardless of the adequacy of daytime sexual function. ( Arch Intern Med . 1992;152:114-118)