The Experts below are selected from a list of 81 Experts worldwide ranked by ideXlab platform
Qing Zhong - One of the best experts on this subject based on the ideXlab platform.
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Histone deacetylase inhibitors and cell death
Cellular and Molecular Life Sciences, 2014Co-Authors: Jing Zhang, Qing ZhongAbstract:Histone deacetylases (HDACs) are a vast family of enzymes involved in chromatin remodeling and have crucial roles in numerous biological processes, largely through their repressive influence on transcription. In addition to modifying histones, HDACs also target many other Non-Histone Protein substrates to regulate gene expression. Recently, HDACs have gained growing attention as HDAC-inhibiting compounds are being developed as promising cancer therapeutics. Histone deacetylase inhibitors (HDACi) have been shown to induce differentiation, cell cycle arrest, apoptosis, autophagy and necrosis in a variety of transformed cell lines. In this review, we mainly discuss how HDACi may elicit a therapeutic response to human cancers through different cell death pathways, in particular, apoptosis and autophagy.
Abhishek Mohanty - One of the best experts on this subject based on the ideXlab platform.
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DNA damage response and repair pathway modulation by Non-Histone Protein methylation: implications in neurodegeneration
Journal of Cell Communication and Signaling, 2019Co-Authors: Madhusoodanan Urulangodi, Abhishek MohantyAbstract:Protein post-translational modifications (PTMs) have emerged to be combinatorial, essential mechanisms used by eukaryotic cells to regulate local chromatin structure, diversify and extend their Protein functions and dynamically coordinate complex intracellular signalling processes. Most common types of PTMs include enzymatic addition of small chemical groups resulting in phosphorylation, glycosylation, poly(ADP-ribosyl)ation, nitrosylation, methylation, acetylation or covalent attachment of complete Proteins such as ubiquitin and SUMO. Protein arginine methyltransferases (PRMTs) and Protein lysine methyltransferases (PKMTs) enzymes catalyse the methylation of arginine and lysine residues in target Proteins, respectively. Rapid progress in quantitative proteomic analysis and functional assays have not only documented the methylation of histone Proteins post-translationally but also identified their occurrence in Non-Histone Proteins which dynamically regulate a plethora of cellular functions including DNA damage response and repair. Emerging advances have now revealed the role of both histone and Non-Histone methylations in the regulating the DNA damage response (DDR) Proteins, thereby modulating the DNA repair pathways both in proliferating and post-mitotic neuronal cells. Defects in many cellular DNA repair processes have been found primarily manifested in neuronal tissues. Moreover, fine tuning of the dynamicity of methylation of Non-Histone Proteins as well as the perturbations in this dynamic methylation processes have recently been implicated in neuronal genomic stability maintenance. Considering the impact of methylation on chromatin associated pathways, in this review we attempt to link the evidences in Non-Histone Protein methylation and DDR with neurodegenerative research.
Jing Zhang - One of the best experts on this subject based on the ideXlab platform.
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Histone deacetylase inhibitors and cell death
Cellular and Molecular Life Sciences, 2014Co-Authors: Jing Zhang, Qing ZhongAbstract:Histone deacetylases (HDACs) are a vast family of enzymes involved in chromatin remodeling and have crucial roles in numerous biological processes, largely through their repressive influence on transcription. In addition to modifying histones, HDACs also target many other Non-Histone Protein substrates to regulate gene expression. Recently, HDACs have gained growing attention as HDAC-inhibiting compounds are being developed as promising cancer therapeutics. Histone deacetylase inhibitors (HDACi) have been shown to induce differentiation, cell cycle arrest, apoptosis, autophagy and necrosis in a variety of transformed cell lines. In this review, we mainly discuss how HDACi may elicit a therapeutic response to human cancers through different cell death pathways, in particular, apoptosis and autophagy.
Jan Pałyga - One of the best experts on this subject based on the ideXlab platform.
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Chromatin compaction in terminally differentiated avian blood cells: the role of linker histone H5 and Non-Histone Protein MENT
Chromosome Research, 2011Co-Authors: Andrzej Kowalski, Jan PałygaAbstract:Chromatin has a tendency to shift from a relatively decondensed (active) to condensed (inactive) state during cell differentiation due to interactions of specific architectural and/or regulatory Proteins with DNA. A promotion of chromatin folding in terminally differentiated avian blood cells requires the presence of either histone H5 in erythrocytes or Non-Histone Protein, myeloid and erythroid nuclear termination stage-specific Protein (MENT), in white blood cells (lymphocytes and granulocytes). These highly abundant Proteins assist in folding of nucleosome arrays and self-association of chromatin fibers into compacted chromatin structures. Here, we briefly review structural aspects and molecular mode of action by which these unrelated Proteins can spread condensed chromatin to form inactivated regions in the genome.
Madhusoodanan Urulangodi - One of the best experts on this subject based on the ideXlab platform.
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DNA damage response and repair pathway modulation by Non-Histone Protein methylation: implications in neurodegeneration
Journal of Cell Communication and Signaling, 2019Co-Authors: Madhusoodanan Urulangodi, Abhishek MohantyAbstract:Protein post-translational modifications (PTMs) have emerged to be combinatorial, essential mechanisms used by eukaryotic cells to regulate local chromatin structure, diversify and extend their Protein functions and dynamically coordinate complex intracellular signalling processes. Most common types of PTMs include enzymatic addition of small chemical groups resulting in phosphorylation, glycosylation, poly(ADP-ribosyl)ation, nitrosylation, methylation, acetylation or covalent attachment of complete Proteins such as ubiquitin and SUMO. Protein arginine methyltransferases (PRMTs) and Protein lysine methyltransferases (PKMTs) enzymes catalyse the methylation of arginine and lysine residues in target Proteins, respectively. Rapid progress in quantitative proteomic analysis and functional assays have not only documented the methylation of histone Proteins post-translationally but also identified their occurrence in Non-Histone Proteins which dynamically regulate a plethora of cellular functions including DNA damage response and repair. Emerging advances have now revealed the role of both histone and Non-Histone methylations in the regulating the DNA damage response (DDR) Proteins, thereby modulating the DNA repair pathways both in proliferating and post-mitotic neuronal cells. Defects in many cellular DNA repair processes have been found primarily manifested in neuronal tissues. Moreover, fine tuning of the dynamicity of methylation of Non-Histone Proteins as well as the perturbations in this dynamic methylation processes have recently been implicated in neuronal genomic stability maintenance. Considering the impact of methylation on chromatin associated pathways, in this review we attempt to link the evidences in Non-Histone Protein methylation and DDR with neurodegenerative research.