The Experts below are selected from a list of 234 Experts worldwide ranked by ideXlab platform
Daniel Violon - One of the best experts on this subject based on the ideXlab platform.
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correlation of some geometric parameters derived from molecular models of monomer Nonionic Contrast Medium molecules with their octanol water partition coefficient
Investigative Radiology, 1996Co-Authors: Daniel ViolonAbstract:Rationale and objectives The author geometrically quantifies the concept of hydrophilic facial and lateral protection of the benzene ring in Nonionic monomer Contrast Medium molecules and verifies the validity of its incorporation in the design theory. The author also correlates this quantification with the octanol/water partition coefficient. Methods Six monomer Nonionic Contrast Medium molecules were studied using simple measuring techniques with respect to some geometric parameters quantifying the hydrophilic protection of the hydrophobic zones. The results were processed to obtain a quantifying parameter, which was correlated subsequently with the corresponding octanol/water partition coefficients. Results A high correlation (r = 0.90) of the developed quantifying parameter with log-P was calculated; its reliability is high. Conclusions The validity of the faciality/laterality concept and of its incorporation in the design theory was shown.
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Correlation of some geometric parameters derived from molecular models of monomer Nonionic Contrast Medium molecules with their octanol/water partition coefficient
Investigative radiology, 1996Co-Authors: Daniel ViolonAbstract:The author geometrically quantifies the concept of hydrophilic facial and lateral protection of the benzene ring in Nonionic monomer Contrast Medium molecules and verifies the validity of its incorporation in the design theory. The author also correlates this quantification with the octanol/water partition coefficient. Six monomer Nonionic Contrast Medium molecules were studied using simple measuring techniques with respect to some geometric parameters quantifying the hydrophilic protection of the hydrophobic zones. The results were processed to obtain a quantifying parameter, which was correlated subsequently with the corresponding octanol/water partition coefficients. A high correlation (r = 0.90) of the developed quantifying parameter with log-P was calculated; its reliability is high. The validity of the faciality/laterality concept and of its incorporation in the design theory was shown.
Sancho J - One of the best experts on this subject based on the ideXlab platform.
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Transient global amnesia after cerebral angiography with iohexol.
Neuroradiology, 1992Co-Authors: J. Juni, Morera J, J. Escudero, C. Ferrer, Sancho JAbstract:We describe a patient without a previous history of migraine or epilepsy and with no known vascular risk factors, who suffered subarachnoid haemorrhage. During vertebral angiography using Nonionic Contrast Medium (iohexol), spasm of the basilar artery was seen. The patient suffered transient global amnesia. Angiography 3 months later with the same Contrast Medium was normal and produced no further deficit. This case lends support to the supposed ischaemic aetiology of transient global amnesia; in patients without other evidence of cerebrovascular disease, arterial spasm may be responsible.
L. Court - One of the best experts on this subject based on the ideXlab platform.
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electrocorticographic evaluation of iobitridol a Nonionic Contrast Medium during selective cerebral arteriography in rabbits
American Journal of Neuroradiology, 1995Co-Authors: S. Trocherie, Faouzia Alaoui, J.-m. Idee, R. Santus, L. CourtAbstract:PURPOSE To study the effects of iobitridol, a Nonionic Contrast Medium, on the electrocorticography and the blood-brain barrier structure in rabbits. METHODS Iobitridol was compared with isoosmolar mannitol and isotonic saline after selective injection (2.5 mL per rabbit in 30 seconds) into the internal carotid artery in the rabbit (six per group). The electrocorticograms (two frontooccipital leads) were then subjected to spectral analysis (fast Fourier transform). Evans blue dye served as a marker of blood-brain barrier damage. RESULTS No blood-brain barrier damage was found, regardless of the treatment administered. Selective catheterization induced an increase in slow waves (0 to 4 Hz). Analyzed both spectrally (distribution of frequency bands, position of the maximum peak with respect to the distribution, and cerebral electric power) and conventionally, iobitridol did not modify the electrocorticograph parameters in the animals. This also applied to the mannitol and saline solutions. CONCLUSION No chemotoxic effects of iobitridol were found.
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Electrocorticographic evaluation of iobitridol, a Nonionic Contrast Medium, during selective cerebral arteriography in rabbits.
AJNR. American journal of neuroradiology, 1995Co-Authors: S. Trocherie, Faouzia Alaoui, J.-m. Idee, R. Santus, L. CourtAbstract:To study the effects of iobitridol, a Nonionic Contrast Medium, on the electrocorticography and the blood-brain barrier structure in rabbits. Iobitridol was compared with isoosmolar mannitol and isotonic saline after selective injection (2.5 mL per rabbit in 30 seconds) into the internal carotid artery in the rabbit (six per group). The electrocorticograms (two frontooccipital leads) were then subjected to spectral analysis (fast Fourier transform). Evans blue dye served as a marker of blood-brain barrier damage. No blood-brain barrier damage was found, regardless of the treatment administered. Selective catheterization induced an increase in slow waves (0 to 4 Hz). Analyzed both spectrally (distribution of frequency bands, position of the maximum peak with respect to the distribution, and cerebral electric power) and conventionally, iobitridol did not modify the electrocorticograph parameters in the animals. This also applied to the mannitol and saline solutions. No chemotoxic effects of iobitridol were found.
J. W. Ten Cate - One of the best experts on this subject based on the ideXlab platform.
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Increased plasma levels of PAI-1 after administration of Nonionic Contrast Medium in patients undergoing pulmonary angiography.
Radiology, 1994Co-Authors: E. J. R. Van Beek, Marcel Levi, Jim A. Reekers, C. E. Hack, H. R. Büller, J. W. Ten CateAbstract:PURPOSE: To compare the effects of ionic and Nonionic Contrast media on markers of the coagulation, fibrinolytic, and contact systems. MATERIALS AND METHODS: Low-osmolar ionic (ioxaglate) or Nonionic (iohexol) Contrast material was administered to 14 patients undergoing pulmonary angiography for suspected pulmonary embolism. Blood samples were obtained before and after the procedure and were analyzed for fibrinolysis and coagulation indicators such as plasminogen activator type 1 (PAI-1) activity, thrombin-antithrombin III (TAT) complexes, and platelet activation. RESULTS: Both Contrast agents caused a significant increase in TAT complexes. PAI-1 levels increased significantly in patients who received iohexol but not in those who received ioxaglate. Platelet activation was more pronounced in patients who received iohexol. CONCLUSION: The increase in PAI-1 levels in response to iohexol may explain clinical differences in postprocedural thrombogenicity in patients who undergo angiography.
J. Juni - One of the best experts on this subject based on the ideXlab platform.
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Transient global amnesia after cerebral angiography with iohexol.
Neuroradiology, 1992Co-Authors: J. Juni, Morera J, J. Escudero, C. Ferrer, Sancho JAbstract:We describe a patient without a previous history of migraine or epilepsy and with no known vascular risk factors, who suffered subarachnoid haemorrhage. During vertebral angiography using Nonionic Contrast Medium (iohexol), spasm of the basilar artery was seen. The patient suffered transient global amnesia. Angiography 3 months later with the same Contrast Medium was normal and produced no further deficit. This case lends support to the supposed ischaemic aetiology of transient global amnesia; in patients without other evidence of cerebrovascular disease, arterial spasm may be responsible.
