The Experts below are selected from a list of 60 Experts worldwide ranked by ideXlab platform
Ella H Sklan - One of the best experts on this subject based on the ideXlab platform.
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an n terminal amphipathic helix in dengue virus Nonstructural Protein 4A mediates oligomerization and is essential for replication
Journal of Virology, 2013Co-Authors: Omer Stern, Yufu Hung, Olga Valdau, Yakey Yaffe, Eva Harris, Silke Hoffmann, Dieter Willbold, Ella H SklanAbstract:Dengue virus (DENV) causes dengue fever, a major health concern worldwide. We identified an amphipathic helix (AH) in the N-terminal region of the viral Nonstructural Protein 4A (NS4A). Disruption of its amphipathic nature using mutagenesis reduced homo-oligomerization and abolished viral replication. These data emphasize the significance of NS4A in the life cycle of the dengue virus and demarcate it as a target for the design of novel antiviral therapy.
Dieter Willbold - One of the best experts on this subject based on the ideXlab platform.
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an n terminal amphipathic helix in dengue virus Nonstructural Protein 4A mediates oligomerization and is essential for replication
Journal of Virology, 2013Co-Authors: Omer Stern, Yufu Hung, Olga Valdau, Yakey Yaffe, Eva Harris, Silke Hoffmann, Dieter Willbold, Ella H SklanAbstract:Dengue virus (DENV) causes dengue fever, a major health concern worldwide. We identified an amphipathic helix (AH) in the N-terminal region of the viral Nonstructural Protein 4A (NS4A). Disruption of its amphipathic nature using mutagenesis reduced homo-oligomerization and abolished viral replication. These data emphasize the significance of NS4A in the life cycle of the dengue virus and demarcate it as a target for the design of novel antiviral therapy.
Omer Stern - One of the best experts on this subject based on the ideXlab platform.
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an n terminal amphipathic helix in dengue virus Nonstructural Protein 4A mediates oligomerization and is essential for replication
Journal of Virology, 2013Co-Authors: Omer Stern, Yufu Hung, Olga Valdau, Yakey Yaffe, Eva Harris, Silke Hoffmann, Dieter Willbold, Ella H SklanAbstract:Dengue virus (DENV) causes dengue fever, a major health concern worldwide. We identified an amphipathic helix (AH) in the N-terminal region of the viral Nonstructural Protein 4A (NS4A). Disruption of its amphipathic nature using mutagenesis reduced homo-oligomerization and abolished viral replication. These data emphasize the significance of NS4A in the life cycle of the dengue virus and demarcate it as a target for the design of novel antiviral therapy.
Silke Hoffmann - One of the best experts on this subject based on the ideXlab platform.
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an n terminal amphipathic helix in dengue virus Nonstructural Protein 4A mediates oligomerization and is essential for replication
Journal of Virology, 2013Co-Authors: Omer Stern, Yufu Hung, Olga Valdau, Yakey Yaffe, Eva Harris, Silke Hoffmann, Dieter Willbold, Ella H SklanAbstract:Dengue virus (DENV) causes dengue fever, a major health concern worldwide. We identified an amphipathic helix (AH) in the N-terminal region of the viral Nonstructural Protein 4A (NS4A). Disruption of its amphipathic nature using mutagenesis reduced homo-oligomerization and abolished viral replication. These data emphasize the significance of NS4A in the life cycle of the dengue virus and demarcate it as a target for the design of novel antiviral therapy.
Eva Harris - One of the best experts on this subject based on the ideXlab platform.
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an n terminal amphipathic helix in dengue virus Nonstructural Protein 4A mediates oligomerization and is essential for replication
Journal of Virology, 2013Co-Authors: Omer Stern, Yufu Hung, Olga Valdau, Yakey Yaffe, Eva Harris, Silke Hoffmann, Dieter Willbold, Ella H SklanAbstract:Dengue virus (DENV) causes dengue fever, a major health concern worldwide. We identified an amphipathic helix (AH) in the N-terminal region of the viral Nonstructural Protein 4A (NS4A). Disruption of its amphipathic nature using mutagenesis reduced homo-oligomerization and abolished viral replication. These data emphasize the significance of NS4A in the life cycle of the dengue virus and demarcate it as a target for the design of novel antiviral therapy.