The Experts below are selected from a list of 111 Experts worldwide ranked by ideXlab platform
Bayram Yilmaz - One of the best experts on this subject based on the ideXlab platform.
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leptin modulates Noradrenaline release in the paraventricular nucleus and plasma oxytocin levels in female rats a microdialysis study
Brain Research, 2010Co-Authors: Selim Kutlu, Daniela Jezova, Mete Ozcan, Ergul Alcin, Jan Bakos, Mehmet Aydin, Bayram YilmazAbstract:The neural control and mutual interrelationships among individual factors involved in the regulation of food intake and simultaneously related to reproduction are far from being understood. We have suggested that at least some of the effects of orexigenic and anorexigenic peptides might be mediated via Noradrenalin release in the paraventricular nucleus (PVN). The main hypothesis was that leptin has an inhibitory action on oxytocin secretion and hypothalamic release of Noradrenalin. Non-pregnant female rats in their diestrus were subjected to cannulation of the carotid artery and a microdialysis procedure with the probes in the hypothalamic PVN. Intra-arterial administration of cholecystokinin-8 (CCK) at the dose of 50 mg/kg was used to induce oxytocin and Noradrenalin release. Leptin (10 mg/5 ml) was intracerebroventricularly injected in addition to CCK. Blood and microdialysis samples were collected at 20-min intervals for 80 min. Central administration of leptin significantly reduced both plasma oxytocin and hypothalamic Noradrenalin responses to CCK at 20 min following the treatments. In conclusion, leptin may inhibit oxytocin secretion by lowering noradrenergic neurotransmission in the PVN. The modulator effect of leptin on Noradrenalin release in the PVN may be related to feeding behavior.
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melatonin and ghrelin differentially modulate plasma oxytocin level and Noradrenalin release in hypothalamic paraventricular nucleus in female rats
2010Co-Authors: Mete Ozcan, Daniela Jezova, Ergul Alcin, Selim Kutlu, Jan Bakos, Mehmet Aydin, Bayram YilmazAbstract:th period in ghrelin group compared to control (p<0.05) while Noradrenalin concentrations in PVN did not change. The results of present study were brought into light that melatonin have inhibitory effect on CCK-induced oxytocin secretion to the circulation in virgin female rats. Melatonin also inhibits Noradrenalin release in PVN. As for ghrelin, this hormone stimulates plasma oxytocin secretion without affecting Noradrenalin release in PVN. These results reveal that melatonin and ghrelin have different modulatory effects on oxytocin secretion.
Selim Kutlu - One of the best experts on this subject based on the ideXlab platform.
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leptin modulates Noradrenaline release in the paraventricular nucleus and plasma oxytocin levels in female rats a microdialysis study
Brain Research, 2010Co-Authors: Selim Kutlu, Daniela Jezova, Mete Ozcan, Ergul Alcin, Jan Bakos, Mehmet Aydin, Bayram YilmazAbstract:The neural control and mutual interrelationships among individual factors involved in the regulation of food intake and simultaneously related to reproduction are far from being understood. We have suggested that at least some of the effects of orexigenic and anorexigenic peptides might be mediated via Noradrenalin release in the paraventricular nucleus (PVN). The main hypothesis was that leptin has an inhibitory action on oxytocin secretion and hypothalamic release of Noradrenalin. Non-pregnant female rats in their diestrus were subjected to cannulation of the carotid artery and a microdialysis procedure with the probes in the hypothalamic PVN. Intra-arterial administration of cholecystokinin-8 (CCK) at the dose of 50 mg/kg was used to induce oxytocin and Noradrenalin release. Leptin (10 mg/5 ml) was intracerebroventricularly injected in addition to CCK. Blood and microdialysis samples were collected at 20-min intervals for 80 min. Central administration of leptin significantly reduced both plasma oxytocin and hypothalamic Noradrenalin responses to CCK at 20 min following the treatments. In conclusion, leptin may inhibit oxytocin secretion by lowering noradrenergic neurotransmission in the PVN. The modulator effect of leptin on Noradrenalin release in the PVN may be related to feeding behavior.
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melatonin and ghrelin differentially modulate plasma oxytocin level and Noradrenalin release in hypothalamic paraventricular nucleus in female rats
2010Co-Authors: Mete Ozcan, Daniela Jezova, Ergul Alcin, Selim Kutlu, Jan Bakos, Mehmet Aydin, Bayram YilmazAbstract:th period in ghrelin group compared to control (p<0.05) while Noradrenalin concentrations in PVN did not change. The results of present study were brought into light that melatonin have inhibitory effect on CCK-induced oxytocin secretion to the circulation in virgin female rats. Melatonin also inhibits Noradrenalin release in PVN. As for ghrelin, this hormone stimulates plasma oxytocin secretion without affecting Noradrenalin release in PVN. These results reveal that melatonin and ghrelin have different modulatory effects on oxytocin secretion.
Kunihiko Yokotani - One of the best experts on this subject based on the ideXlab platform.
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role of brain thromboxane a2 in the release of Noradrenaline and adrenaline from adrenal medulla in rats
European Journal of Pharmacology, 2003Co-Authors: Shoshiro Okada, Yoshinori Murakami, Kunihiko YokotaniAbstract:Abstract Plasma Noradrenaline reflects the release from adrenal medulla and sympathetic nerves; however, the exact mechanisms of adrenal Noradrenaline release remain to be elucidated. The present study was designed to characterize the source of plasma Noradrenaline induced by centrally administered vasopressin and corticotropin-releasing hormone (CRH) in urethane-anesthetized rats. Intracerebroventricularly administered vasopressin (0.2 nmol/animal) and CRH (1.5 nmol/animal) elevated plasma levels of Noradrenaline and adrenaline. Intracerebroventricularly administered indomethacin [1.2 μmol (500 μg)/animal] (an inhibitor of cyclooxygenase) abolished the elevations of both Noradrenaline and adrenaline induced by vasopressin and CRH. Intracerebroventricularly administered furegrelate [1.8 μmol (500 μg)/animal] (an inhibitor of thromboxane A2 synthase) abolished the elevations of both Noradrenaline and adrenaline induced by vasopressin, while the reagent only attenuated the elevation of plasma adrenaline evoked by CRH. Acute bilateral adrenalectomy abolished the elevation of both Noradrenaline and adrenaline induced by vasopressin, while the procedure reduced only the elevation of adrenaline induced by CRH. These results suggest that the release of Noradrenaline from adrenal medulla and sympathetic nerves is mediated by different central mechanisms. The vasopressin-induced Noradrenaline release from adrenal medulla is mediated by brain thromboxane A2-mediated mechanisms, while the CRH-induced Noradrenaline release from sympathetic nerves is mediated by brain prostanoid (other than thromboxane A2)-mediated mechanisms. The vasopressin- and CRH-induced adrenaline release from adrenal medulla is also mediated by brain thromboxane A2-mediated mechanisms in rats.
Mete Ozcan - One of the best experts on this subject based on the ideXlab platform.
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leptin modulates Noradrenaline release in the paraventricular nucleus and plasma oxytocin levels in female rats a microdialysis study
Brain Research, 2010Co-Authors: Selim Kutlu, Daniela Jezova, Mete Ozcan, Ergul Alcin, Jan Bakos, Mehmet Aydin, Bayram YilmazAbstract:The neural control and mutual interrelationships among individual factors involved in the regulation of food intake and simultaneously related to reproduction are far from being understood. We have suggested that at least some of the effects of orexigenic and anorexigenic peptides might be mediated via Noradrenalin release in the paraventricular nucleus (PVN). The main hypothesis was that leptin has an inhibitory action on oxytocin secretion and hypothalamic release of Noradrenalin. Non-pregnant female rats in their diestrus were subjected to cannulation of the carotid artery and a microdialysis procedure with the probes in the hypothalamic PVN. Intra-arterial administration of cholecystokinin-8 (CCK) at the dose of 50 mg/kg was used to induce oxytocin and Noradrenalin release. Leptin (10 mg/5 ml) was intracerebroventricularly injected in addition to CCK. Blood and microdialysis samples were collected at 20-min intervals for 80 min. Central administration of leptin significantly reduced both plasma oxytocin and hypothalamic Noradrenalin responses to CCK at 20 min following the treatments. In conclusion, leptin may inhibit oxytocin secretion by lowering noradrenergic neurotransmission in the PVN. The modulator effect of leptin on Noradrenalin release in the PVN may be related to feeding behavior.
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melatonin and ghrelin differentially modulate plasma oxytocin level and Noradrenalin release in hypothalamic paraventricular nucleus in female rats
2010Co-Authors: Mete Ozcan, Daniela Jezova, Ergul Alcin, Selim Kutlu, Jan Bakos, Mehmet Aydin, Bayram YilmazAbstract:th period in ghrelin group compared to control (p<0.05) while Noradrenalin concentrations in PVN did not change. The results of present study were brought into light that melatonin have inhibitory effect on CCK-induced oxytocin secretion to the circulation in virgin female rats. Melatonin also inhibits Noradrenalin release in PVN. As for ghrelin, this hormone stimulates plasma oxytocin secretion without affecting Noradrenalin release in PVN. These results reveal that melatonin and ghrelin have different modulatory effects on oxytocin secretion.
Mehmet Aydin - One of the best experts on this subject based on the ideXlab platform.
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leptin modulates Noradrenaline release in the paraventricular nucleus and plasma oxytocin levels in female rats a microdialysis study
Brain Research, 2010Co-Authors: Selim Kutlu, Daniela Jezova, Mete Ozcan, Ergul Alcin, Jan Bakos, Mehmet Aydin, Bayram YilmazAbstract:The neural control and mutual interrelationships among individual factors involved in the regulation of food intake and simultaneously related to reproduction are far from being understood. We have suggested that at least some of the effects of orexigenic and anorexigenic peptides might be mediated via Noradrenalin release in the paraventricular nucleus (PVN). The main hypothesis was that leptin has an inhibitory action on oxytocin secretion and hypothalamic release of Noradrenalin. Non-pregnant female rats in their diestrus were subjected to cannulation of the carotid artery and a microdialysis procedure with the probes in the hypothalamic PVN. Intra-arterial administration of cholecystokinin-8 (CCK) at the dose of 50 mg/kg was used to induce oxytocin and Noradrenalin release. Leptin (10 mg/5 ml) was intracerebroventricularly injected in addition to CCK. Blood and microdialysis samples were collected at 20-min intervals for 80 min. Central administration of leptin significantly reduced both plasma oxytocin and hypothalamic Noradrenalin responses to CCK at 20 min following the treatments. In conclusion, leptin may inhibit oxytocin secretion by lowering noradrenergic neurotransmission in the PVN. The modulator effect of leptin on Noradrenalin release in the PVN may be related to feeding behavior.
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melatonin and ghrelin differentially modulate plasma oxytocin level and Noradrenalin release in hypothalamic paraventricular nucleus in female rats
2010Co-Authors: Mete Ozcan, Daniela Jezova, Ergul Alcin, Selim Kutlu, Jan Bakos, Mehmet Aydin, Bayram YilmazAbstract:th period in ghrelin group compared to control (p<0.05) while Noradrenalin concentrations in PVN did not change. The results of present study were brought into light that melatonin have inhibitory effect on CCK-induced oxytocin secretion to the circulation in virgin female rats. Melatonin also inhibits Noradrenalin release in PVN. As for ghrelin, this hormone stimulates plasma oxytocin secretion without affecting Noradrenalin release in PVN. These results reveal that melatonin and ghrelin have different modulatory effects on oxytocin secretion.
