The Experts below are selected from a list of 7449 Experts worldwide ranked by ideXlab platform
Ricardo Miledi - One of the best experts on this subject based on the ideXlab platform.
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expression of caenorhabditis elegans neurotransmitter Receptors and ion channels in xenopus oocytes
Proceedings of the National Academy of Sciences of the United States of America, 2006Co-Authors: Ataulfo Martineztorres, Ricardo MilediAbstract:Injection of Caenorhabditis elegans polyA RNA into Xenopus laevis oocytes led to the expression of neurotransmitter Receptors that generated some unique responses, including ionotropic α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid Receptors as well as Receptors that coupled to G proteins, such as those to octopamine, Norepinephrine, and angiotensin, which activated the oocyte’s own phosphatidylinositol system and calcium-gated chloride channels. The oocytes also expressed chloride-conducting glutamate Receptors, muscarinic acetylcholine Receptors, and voltage-operated calcium channels. Unexpectedly, serotonin (5-hydroxytryptamine), dopamine, GABA, and kainate did not generate ionic currents, suggesting that the corresponding Receptors were not expressed or were not functional in the oocytes. The use of X. laevis oocytes for expressing worm RNA demonstrates that there are many molecular components whose role remains to be clarified in the nematode. Among them are the nature of the endogenous agonists for the octopamine and angiotensin Receptors and the subunits that compose the ionotropic α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid Receptors and the Norepinephrine Receptors that couple to the phosphoinositide cascade.
Tokuzo Matsuya - One of the best experts on this subject based on the ideXlab platform.
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effect of Norepinephrine Receptors on trigeminal rhythm generation in newborn rats
Brain Research Bulletin, 2000Co-Authors: Mikihiko Kogo, Atsuyuki Mori, Hidehiko Koizumi, Koji Ishihama, Seji Iida, Susumu Tanaka, Tokuzo MatsuyaAbstract:Abstract N-methyl-D,L-aspartate acid and bicuculline are required to enhance the trigeminal rhythmic activities in an in vitro isolated brainstem block preparation. In this study, we analyzed the effect of Norepinephrine on the trigeminal neural circuit underlying rhythmic jaw movements. Rhythmic trigeminal activity is observed in brainstem preparations (inferior colliculus to obex) only following blockade of α 2 -adrenoceptors with idazoxan. This observation, combined with the inhibition of rhythm by α 2 -adrenoceptor agonists suggests endogenous α 2 -adrenoceptor mediated inhibition of trigeminal networks. A complex noradrenergic modulation of trigeminal systems is further supported by the prazosin-sensitive potentiation of rhythm by bath application of the α 1 -adrenoceptor agonist phenylephrine.
Francois Georges - One of the best experts on this subject based on the ideXlab platform.
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prolonged activation of mesolimbic dopaminergic neurons by morphine withdrawal following clonidine participation of imidazoline and Norepinephrine Receptors
Neuropsychopharmacology, 2003Co-Authors: Francois Georges, Gary AstonjonesAbstract:Prolonged Activation of Mesolimbic Dopaminergic Neurons by Morphine Withdrawal Following Clonidine: Participation of Imidazoline and Norepinephrine Receptors
Gary Astonjones - One of the best experts on this subject based on the ideXlab platform.
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prolonged activation of mesolimbic dopaminergic neurons by morphine withdrawal following clonidine participation of imidazoline and Norepinephrine Receptors
Neuropsychopharmacology, 2003Co-Authors: Francois Georges, Gary AstonjonesAbstract:Prolonged Activation of Mesolimbic Dopaminergic Neurons by Morphine Withdrawal Following Clonidine: Participation of Imidazoline and Norepinephrine Receptors
Mikihiko Kogo - One of the best experts on this subject based on the ideXlab platform.
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effect of Norepinephrine Receptors on trigeminal rhythm generation in newborn rats
Brain Research Bulletin, 2000Co-Authors: Mikihiko Kogo, Atsuyuki Mori, Hidehiko Koizumi, Koji Ishihama, Seji Iida, Susumu Tanaka, Tokuzo MatsuyaAbstract:Abstract N-methyl-D,L-aspartate acid and bicuculline are required to enhance the trigeminal rhythmic activities in an in vitro isolated brainstem block preparation. In this study, we analyzed the effect of Norepinephrine on the trigeminal neural circuit underlying rhythmic jaw movements. Rhythmic trigeminal activity is observed in brainstem preparations (inferior colliculus to obex) only following blockade of α 2 -adrenoceptors with idazoxan. This observation, combined with the inhibition of rhythm by α 2 -adrenoceptor agonists suggests endogenous α 2 -adrenoceptor mediated inhibition of trigeminal networks. A complex noradrenergic modulation of trigeminal systems is further supported by the prazosin-sensitive potentiation of rhythm by bath application of the α 1 -adrenoceptor agonist phenylephrine.
