The Experts below are selected from a list of 1365 Experts worldwide ranked by ideXlab platform
Sideris Delaroudis - One of the best experts on this subject based on the ideXlab platform.
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Normochromic Normocytic Anemia in a postmenopausal woman with severe osteoporosis treated with intermittent parathyroid hormone
Journal of Bone and Mineral Metabolism, 2010Co-Authors: Athanasios D Anastasilakis, Mattheos Savvides, Stergios A Polyzos, Christos Georgopoulos, Sideris DelaroudisAbstract:Intermittent exogenous parathyroid hormone (PTH) is a potent osteoanabolic agent used for the treatment of severe osteoporosis. Two molecules of recombinant PTH are commercially available: the full-length PTH (PTH 1-84) and teriparatide (PTH 1-34). We present the first report of PTH-induced mild, asymptomatic, Normochromic Normocytic Anemia in a postmenopausal woman treated sequentially with PTH 1-84 and PTH 1-34. Anemia was more pronounced with PTH 1-84 compared to PTH 1-34 and was reversed with each regimen discontinuation. We suggest monitoring of hematocrit and hemoglobin in PTH-treated patients, especially when PTH 1-84 is used.
James Huang - One of the best experts on this subject based on the ideXlab platform.
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does normal reticulocyte hemoglobin rule out iron deficiency as a cause of Normocytic Normochromic Anemia
Blood, 2016Co-Authors: Zhou Yu, Leann Blankenship, Bolanle Gbadamosi, Michael Stender, Ishmael Jaiyesimi, Joseph Anderson, Mohammed Ibrahim, James HuangAbstract:Background: Normochromic, Normocytic Anemia is the most frequently encountered type of Anemia with a wide differential diagnosis. Iron studies are frequently ordered as part of the Anemia work up as iron deficiency Anemia could be potentially Normocytic and Normochromic. Recently reticulocyte hemoglobin has emerged as a marker to help identify early stages of iron deficiency at a time that other traditional biochemical studies for iron deficiency are non-informative. We hypothesize that normal reticulocyte hemoglobin level is a sensitive negative predictor of iron deficiency. Aim:To evaluate whether a normal reticulocyte hemoglobin level can be used to exclude iron deficiency Anemia in patients with Normocytic Normochromic Anemia. Methods:We reviewed the results of all hematological tests obtained as a part of hematopathology consults which were requested between January to April of 2016. Electronic medical records were screened for inclusion criteria. We included patient with hemoglobin less than 12g/dl, normal MCV (80-100) and normal reticulocyte hemoglobin level (>31 pg). We calculated the percentage of patients who had normal iron store suggested by ferritin, total iron binding capacity and iron saturation studies. Results:We included 41 patients who has Normocytic Normochromic Anemia with normal reticulocyte hemoglobin level. 39 out of 41 patients have normal iron studies indicating iron deficiency Anemia was not the cause of Anemia. The overall negative predictive value is 95.1%. Among the two patients whose ferritin levels are mildly decreased, suggesting possible iron deficiency, one patient had a blood transfusion prior to checking reticulocyte hemoglobin level. The other patient donates blood frequently and was started on oral iron supplementation trial without any hemoglobin improvement after two weeks. It appeared that these two patients might not have true iron deficiency. Conclusion: Measurement reticulocyte hemoglobin level can serve as a useful marker to rule out iron deficiency as a cause of Normocytic Normochromic Anemia. Serum Iron and ferritin studies are not indicated in patients with Normocytic Normochromic Anemia with normal reticulocyte hemoglobin. Disclosures No relevant conflicts of interest to declare.
Athanasios D Anastasilakis - One of the best experts on this subject based on the ideXlab platform.
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Normochromic Normocytic Anemia in a postmenopausal woman with severe osteoporosis treated with intermittent parathyroid hormone
Journal of Bone and Mineral Metabolism, 2010Co-Authors: Athanasios D Anastasilakis, Mattheos Savvides, Stergios A Polyzos, Christos Georgopoulos, Sideris DelaroudisAbstract:Intermittent exogenous parathyroid hormone (PTH) is a potent osteoanabolic agent used for the treatment of severe osteoporosis. Two molecules of recombinant PTH are commercially available: the full-length PTH (PTH 1-84) and teriparatide (PTH 1-34). We present the first report of PTH-induced mild, asymptomatic, Normochromic Normocytic Anemia in a postmenopausal woman treated sequentially with PTH 1-84 and PTH 1-34. Anemia was more pronounced with PTH 1-84 compared to PTH 1-34 and was reversed with each regimen discontinuation. We suggest monitoring of hematocrit and hemoglobin in PTH-treated patients, especially when PTH 1-84 is used.
Alessandro Campanella - One of the best experts on this subject based on the ideXlab platform.
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erythroblast apoptosis and microenvironmental iron restriction trigger Anemia in the vk myc model of multiple myeloma
Haematologica, 2015Co-Authors: Jessica Bordini, Maria Teresa Sabrina Bertilaccio, Maurilio Ponzoni, Isabella Fermo, Marta Chesi, Leif P Bergsagel, Clara Camaschella, Alessandro CampanellaAbstract:Multiple myeloma is a malignant disorder characterized by bone marrow proliferation of plasma cells and by overproduction of monoclonal immunoglobulin detectable in the sera (M-spike). Anemia is a common complication of multiple myeloma, but the underlying pathophysiological mechanisms have not been completely elucidated. We aimed to identify the different determinants of Anemia using the Vk*MYC mouse, which spontaneously develops an indolent bone marrow localized disease with aging. Affected Vk*MYC mice develop a mild Normochromic Normocytic Anemia. We excluded the possibility that Anemia results from defective erythropoietin production, inflammation or increased hepcidin expression. Mature erythroid precursors are reduced in Vk*MYC bone marrow compared with wild-type. Malignant plasma cells express the apoptogenic receptor Fas ligand and, accordingly, active caspase 8 is detected in maturing erythroblasts. Systemic iron homeostasis is not compromised in Vk*MYC animals, but high expression of the iron importer CD71 by bone marrow plasma cells and iron accumulation in bone marrow macrophages suggest that iron competition takes place in the local multiple myeloma microenvironment, which might contribute to Anemia. In conclusion, the mild Anemia of the Vk*MYC model is mainly related to the local effect of the bone marrow malignant clone in the absence of an overt inflammatory status. We suggest that this reproduces the initial events triggering Anemia in patients.
Mattheos Savvides - One of the best experts on this subject based on the ideXlab platform.
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Normochromic Normocytic Anemia in a postmenopausal woman with severe osteoporosis treated with intermittent parathyroid hormone
Journal of Bone and Mineral Metabolism, 2010Co-Authors: Athanasios D Anastasilakis, Mattheos Savvides, Stergios A Polyzos, Christos Georgopoulos, Sideris DelaroudisAbstract:Intermittent exogenous parathyroid hormone (PTH) is a potent osteoanabolic agent used for the treatment of severe osteoporosis. Two molecules of recombinant PTH are commercially available: the full-length PTH (PTH 1-84) and teriparatide (PTH 1-34). We present the first report of PTH-induced mild, asymptomatic, Normochromic Normocytic Anemia in a postmenopausal woman treated sequentially with PTH 1-84 and PTH 1-34. Anemia was more pronounced with PTH 1-84 compared to PTH 1-34 and was reversed with each regimen discontinuation. We suggest monitoring of hematocrit and hemoglobin in PTH-treated patients, especially when PTH 1-84 is used.