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  • Effect of triamcinolone acetonide nasal spray on allergic rhinitis
    Journal of Shenyang Pharmaceutical University, 2004
    Co-Authors: Li San-ming
    Abstract:

    Objective To observe the therapeutical effect of triamcinolone acetonide administered by the nasal cavity on experimental allergic rhinitis animal model and the relieve effect on the increasing Airway Resistance in rats induced by histamine.Method Allergic rhinitis model in guinea pigs and increasing Airway Resistance model in rats was selected.The secretion of the nasal cavity,times of sneeze and scratching Nose,histology of Nose in guinea pigs and Nose Airway Resistance in rats were observed to investigate the effect of triamcinolone acetonide nasal spray on allergic rhinitis.Result Triamcinolone acetonide nasal spray(5.0,10.0,(20 mg·kg~(-1)))can obviously improve all the symptoms of allergic rhinitis model in guinea pigs.With the control group,triamcinolone acetonide nasal spray can obviously decreased the secretion of the nasal cavity,times of sneeze and times of the scratching Nose .Which can resist the increasing Airway Resistance in rats.Conclusion Triamcinolone acetonide nasal spray can obviously improve all the symptoms and protect the nasal mucosa of allergic rhinitis model in guinea pigs.It can also obviously decrease the Airway Resistance of rats.